The importance of the one carbon cycle nutritional support in human male fertility: A preliminary clinical report

Reproductive Biology and Endocrinology

Volumn 12, Issue 1, 2014, Pages

  Dattilo, Maurizio ^a   Cornet, Dominique ^b   Amar, Edouard ^c   Cohen, Marc ^d   Menezo, Yves ^e  

^a Parthenogen   (Switzerland)

^b Cabinet d'Andrologie ^*  (France)

^c Cabinet d'Andrologie   (France)

^d Procrelys Association de recherche en Infertilite   (France)

^e Laboratoire Clément   (France)

Author keywords

Homocysteine; Methylation; One carbon cycle; Oxidative damage; Sperm fertilizing ability

Indexed keywords

ACETYLCYSTEINE; ALPHA TOCOPHEROL; ANILINE; CONDENSYL; OPUNTIA EXTRACT; UNCLASSIFIED DRUG; VITAMIN B GROUP; ZINC; ANILINE BLUE; ANTIOXIDANT; BETALAIN; CARBON; CYANOCOBALAMIN; DNA; DYE; FOLIC ACID; NICOTINAMIDE; OPUNTIA FIG EXTRACT; PLANT EXTRACT; PYRIDOXINE; QUERCETIN; RIBOFLAVIN; HOMOCYSTEINE; VITAMIN B COMPLEX;

ADULT; ARTICLE; CARBON CYCLE; CLINICAL EFFECTIVENESS; DNA FRAGMENTATION; FEMALE; HUMAN; INFERTILITY THERAPY; LIVE BIRTH; MAJOR CLINICAL STUDY; MALE; MALE FERTILITY; MALE INFERTILITY; NICK END LABELING; NUCLEAR DECONDENSATION INDEX; NUCLEIC ACID STRUCTURE, METABOLISM AND FUNCTION; NUTRITIONAL SUPPORT; PARTHENOGENESIS; PREGNANCY RATE; STAINING; SUBFERTILITY; TABLET FORMULATION; TREATMENT RESPONSE; VITAMIN SUPPLEMENTATION; CLINICAL ASSESSMENT; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DNA FRAGMENTATION INDEX; DRUG EFFICACY; FERTILIZATION IN VITRO; FIG; INTRACYTOPLASMIC SPERM INJECTION; INTRAUTERINE INSEMINATION; MALE SUBFERTILITY; NUCLEIC ACID ANALYSIS; OPUNTIA; PREDICTIVE VALUE; PREGNANCY OUTCOME; RISK FACTOR; TREATMENT DURATION; TREATMENT OUTCOME; ARTIFICIAL INSEMINATION; BIRTH RATE; CHEMISTRY; CLINICAL TRIAL; COMPARATIVE STUDY; DIET SUPPLEMENTATION; DIET THERAPY; EPIDEMIOLOGY; FAMILY SIZE; FRUIT; METABOLISM; MIDDLE AGED; NIDATION; PREGNANCY; SWITZERLAND;

OPUNTIA;

ACETYLCYSTEINE; ADULT; BIRTH RATE; DIETARY SUPPLEMENTS; EMBRYO IMPLANTATION; FAMILY CHARACTERISTICS; FEMALE; FERTILIZATION IN VITRO; FRUIT; HOMOCYSTEINE; HUMANS; INFERTILITY, MALE; INSEMINATION, ARTIFICIAL, HOMOLOGOUS; MALE; MIDDLE AGED; OPUNTIA; PLANT EXTRACTS; PREGNANCY; PREGNANCY RATE; SWITZERLAND; VITAMIN B COMPLEX; VITAMIN E; ZINC;

EID: 84904782595     PISSN: None     EISSN: 14777827     Source Type: Journal    
DOI: 10.1186/1477-7827-12-71     Document Type: Article

References (36)

1. Jungwirth A, Diemer T, Dohle GR, Giwercman A, Kopa Z, Tournaye H, Krausz C. Guidelines in male infertility. European Association of Urology 2013. http://www.uroweb.org/gls/pdf/16_Male_Infertility_LR.pdf. Accessed January 3, 2014.
2. Rolland M, Le Moal J, Wagner V, Royere D, De Mouzon J. Decline in semen concentration and morphology in a sample of 26 609 men close to general population between 1989 and 2005 in France. Hum Reprod 2013, 28(2):462-470.
3. Gharagozloo P, Aitken RJ. The role of sperm oxidative stress in male infertility and the significance of oral antioxidant therapy. Hum Reprod 2011, 26(7):1628-1640.
4. Showell MG, Brown J, Yazdani A, Stankiewicz MT, Hart RJ. Antioxidants for male subfertility. Cochrane Database Syst Rev 2011, 1:CD007411.
5. Lombardo F, Sansone A, Romanelli F, Paoli D, Gandini L, Lenzi A. The role of antioxidant therapy in the treatment of male infertility: an overview. Asian J Androl 2011, 13:690-697.
6. Fujii J, Tsunoda S. Redox regulation of fertilisation and the spermatogenic process. Asian J Androl 2011, 13:420-423.
7. Giustarini D, Dalle-Donne I, Colombo R, Milzani A, Rossi R. Is ascorbate able to reduce disulfide bridges? A cautionary note. Nitric Oxide 2008, 19(3):252-258.
8. Ménézo YJ, Hazout A, Panteix G, Robert F, Rollet J, Cohen-Bacrie P, Chapuis F, Clément P, Benkhalifa M. Antioxidants to reduce sperm DNA fragmentation: an unexpected adverse effect. Reprod Biomed Online 2007, 14:418-421.
9. Banerjee R, Zou CG. Redox regulation and reaction mechanism of human cystathionine-beta-synthase: a PLP-dependent hemesensor protein. Arch Biochem Biophys 2005, 433(1):144-156.
10. Janosík M, Kery V, Gaustadnes M, Maclean KN, Kraus JP. Regulation of human cystathionine beta-synthase by S-adenosyl-L-methionine: evidence for two catalytically active conformations involving an autoinhibitory domain in the C-terminal region. Biochemistry 2001, 40(35):10625-10633.
11. Boxmeer JC, Smit M, Utomo E, Romijn JC, Eijkemans MJ, Lindemans J, Laven JS, Macklon NS, Steegers EA, Steegers-Theunissen RP. Low folate in seminal plasma is associated with increased sperm DNA damage. Fertil Steril 2009, 92(2):548-556.
12. Tunc O, Tremellen K. Oxidative DNA damage impairs global sperm DNA methylation in infertile men. J Assist Reprod Genet 2009, 9-10:537-544.
13. Ebisch IM, Peters WH, Thomas CM, Wetzels AM, Peer PG, Steegers-Theunissen RP. Homocysteine, glutathione and related thiols affect fertility parameters in the (sub) fertile couple. Hum Reprod 2006, 21:1725-1733.
14. Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992, 119(3):493-501.
15. Hofmann N, Hilscher B. Use of aniline blue to assess chromatin condensation in morphologically normal spermatozoa in normal and infertile men. Hum Reprod 1991, 6:979-982.
16. Cohen Bacrie P, Belloc S, Ménézo YJ, Clement P, Hamidi J, Benkhalifa M. Correlation between DNA damage and sperm parameters: a prospective study of 1,633 patients. Fertil Steril 2009, 91:1801-1805.
17. Belloc S, Benkhalifa M, Junca AM, Dumont M, Cohen-Bacrie M, Cohen Bacrie P, Ménézo Y. Paternal age and sperm DNA decay: discrepancy between chromomycin and aniline blue staining. Reprod Biomed Online 2009, 19:264-269.
18. Sharma RK, Sabanegh E, Mahfouz R, Gupta S, Thiyagarajan A, Agarwal A. TUNEL as a test for sperm DNA damage in the evaluation of male infertility. Urology 2010, 76:1380-1386.
19. Lewis SEM, Aitken RJ, Conner SJ, De Iuliis G, Evenson DP, Henkel R, Giwercman A, Gharagozloo P. The impact of sperm DNA damage in assisted conception and beyond: recent advances in diagnosis and treatment. Reprod Biomed Online 2013, 27:325-337.
20. Bungum M, Humaidan P, Spano M, Jepson K, Bungum L, Giwercman A. The predictive value of sperm chromatin structure assay (SCSA) parameters for the outcome of intrauterine insemination. IVF and ICSI. Hum Reprod 2004, 19(6):1401-1408.
21. Bungum M, Humaidan P, Axmon A, Spano M, Bungum L, Erenpreiss J, Giwercman A. Sperm DNA integrity assessment in prediction of assisted reproduction technology outcome. Hum Reprod 2007, 22(1):174-179.
22. Boe-Hansen GB, Fedder J, Ersbøll AK, Christensen P. The sperm chromatin structure assay as a diagnostic tool in the human fertility clinic. Hum Reprod 2006, 21(6):1576-1582.
23. Walschaerts M, Bujan L, Isus F, Parinaud J, Mieusset R, Thonneau P. Cumulative parenthood rates in 1735 couples: impact of male factor infertility. Hum Reprod 2012, 27(4):1184-1190.
24. Evenson DP, Larson KL, Jost LK. Sperm chromatin structure assay: its clinical use for detecting sperm DNA fragmentation in male infertility and comparisons with other techniques. J Androl 2002, 23(1):25-43.
25. Menezo Y, Evenson D, Cohen M, Dale B. Effect of antioxidants on sperm genetic damage. Adv Exp Med Biol 2014, 791:173-189.
26. Junca A, Gonzalez Marti B, Tosti E, Cohen M, De la Fontaine D, Benkhalifa M, Ménézo Y. Sperm nucleus decondensation, hyaluronic acid (HA) binding and oocyte activation capacity: different markers of sperm immaturity? Case reports. J Assist Reprod Genet 2012, 29(4):353-355.
27. Ménézo Y, Dale B, Cohen M. DNA damage and repair in human oocytes and embryos: a review. Zygote 2010, 18(4):357-365.
28. Azizollahi G, Azizollahi S, Babaei H, Kianinejad M, Baneshi MR, Nematollahi-mahani SN. Effects of supplement therapy on sperm parameters, protamine content and acrosomal integrity of varicocelectomized subjects. J Assist Reprod Genet 2013, 30:593-599.
29. Ciftci H, Verit A, Savas M, Yeni E, Erel O. Effects of N-acetylcysteine on semen parameters and oxidative/antioxidant status. Urology 2009, 74(1):73-76.
30. Omu AE, Al-Azemi MK, Kehinde EO, Anim JT, Oriowo MA, Mathew TC. Indications of the mechanisms involved in improved sperm parameters by zinc therapy. Med Princ Pract 2008, 17(2):108-116.
31. Schmid TE, Eskenazi B, Marchetti F, Young S, Weldon RH, Baumgartner A, Anderson D, Wyrobek AJ. Micronutrients intake is associated with improved sperm DNA quality in older men. Fertil Steril 2012, 98(5):1130-1137.
32. Bast A, Haenen GRMM. Ten misconceptions about antioxidants. Trends Pharmacol Sci 2013, 34(8):430-436.
33. Rushworth GF, Megson IL. Existing and potential therapeutic uses for N-acetylcysteine: The need for conversion to intracellular glutathione for antioxidant benefits. Pharmacol Ther 2014, 141(2):150-159.
34. Tesoriere L, Allegra M, Butera D, Livrea MA. Absorption, excretion, and distribution of dietary antioxidant betalains in LDLs: potential health effects of betalains in humans. Am J Clin Nutr 2004, 80:941-945.
35. da Silva EL, Piskulab MK, Yamamotoc N, Moond JH, Terao J. Quercetin metabolites inhibit copper ion-induced lipid peroxidation in rat plasma. FEBS Lett 1998, 430:405-408.
36. Suleiman SA, Ali ME, Zaki ZM, El-Malik EM, Nasr MA. Lipid peroxidation and human sperm motility: protective role of vitamin E. J Androl 1996, 17:530-537.