Oxygen in critical care

Trends in Anaesthesia and Critical Care

Volumn 4, Issue 4, 2014, Pages 102-108

  Tan, Hon Liang ^a   Wijeweera, Olivia ^b  

^a SINGAPORE GENERAL HOSPITAL   (Singapore)

^b KK WOMEN'S AND CHILDREN'S HOSPITAL   (Singapore)

Author keywords

Acute respiratory distress syndrome; Cardiac failure; Hemorrhagic shock; Hyperoxia; Ischemic stroke; Myocardial ischemia; Oxygen; Post cardiac arrest; Sepsis; Traumatic brain injury

Indexed keywords

OXYGEN;

ACUTE KIDNEY FAILURE; ACUTE LUNG INJURY; ADULT RESPIRATORY DISTRESS SYNDROME; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; CRITICALLY ILL PATIENT; HEART ARREST; HEART FAILURE; HEART INFARCTION; HEART MUSCLE ISCHEMIA; HEMORRHAGIC SHOCK; HUMAN; HYPEROXIA; INTENSIVE CARE; OXYGEN TENSION; OXYGEN THERAPY; PRIORITY JOURNAL; REVIEW; SEPSIS; SEPTIC SHOCK; TRAUMATIC BRAIN INJURY;

EID: 84904751453     PISSN: 22108440     EISSN: 22108467     Source Type: Journal    
DOI: 10.1016/j.tacc.2014.05.001     Document Type: Review

References (107)

1. Grainge C. Breath of life: the evolution of oxygen therapy. JR Soc Med 2004 Oct, 97(10):489-493.
2. Leach R.M., Treacher D.F. The pulmonary physician in critical care 2: oxygen delivery and consumption in the critically ill. Thorax 2002, 57:170-177.
3. McLellan S.A., Walsh T.S. Oxygen delivery and haemoglobin. Contin Educ Anaesth Crit Care Pain 2004, 4(4):123-126.
4. Bitterman H. Bench-to-bedside review: oxygen as a drug. Crit Care 2009, 13(1):205.
5. Thom S.R., Elbuken M.E. Oxygen-dependent antagonism of lipid peroxidation. Free Radic Biol Med 1991, 10:413-426.
6. Cabigas B.P., Su J., Hutchins W., Shi Y., Schaefer R.B., Recinos R.F., et al. Hyperoxic and hyper- baric-induced cardioprotection: role of nitric oxide synthase 3. Cardiovasc Res 2006, 72:143-151.
7. Bhandari V., Elias J.A. Cytokines in tolerance to hyperoxia-induced injury in the developing and adult lung. Free Radic Biol Med 2006, 41(1):4-18.
8. Tjarnstrom J., Wikstrom T., Bagge U., Risberg B., Braide M. Effects of hyperbaric oxygen treatment on neutrophil activation and pulmonary sequestration in intestinal ischemia-reperfusion in rats. Eur Surg Res 1999, 31:147-154.
9. Sun Q., Liu Y., Sun X., Tao H. Anti-apoptotic effect of hyperbaric oxygen preconditioning on a rat model of myocardial infarction. JSurg Res 2011, 171:41-46.
10. Zhang J.H., Lo T., Mychaskiw G., Colohan A. Mechanisms of hyperbaric oxygen and neuroprotection in stroke. Pathophysiology 2005, 12:63-77.
11. Matchett G.A., Martin R.D., Zhang J.H. Hyperbaric oxygen therapy and cerebral ischemia: neuroprotective mechanisms. Neurol Res 2009, 31:114-121.
12. Li J.S., Zhang W., Kang Z.M., Ding S.J., Liu W.W., Zhang J.H., et al. Hyperbaric oxygen precon-ditioning reduces ischemia-reperfusion injury by inhibition of apoptosis via mitochondrial pathway in rat brain. Neuroscience 2009, 159:1309-1315.
13. Badr A.E., Yin W., Mychaskiw G., Zhang J.H. Effect of hyperbaric oxygen on striatal metabolites: a microdialysis study in awake freely moving rats after MCA occlusion. Brain Res 2001, 916:85-90.
14. Bigdeli M.R., Rahnema M., Khoshbaten A. Preconditioning with sublethal ischemia or intermittent normobaric hyperoxia up-regulates glutamate transporters and tumor necrosis factor-alpha converting enzyme in the rat brain. JStroke Cerebrovasc Dis 2009, 18:336-342.
15. Veltkamp R., Siebing D.A., Sun L., Heiland S., Bieber K., Marti H.H., et al. Hyperbaric oxygen reduces blood-brain barrier damage and edema after tran-sient focal cerebral ischemia. Stroke 2005, 36:1679-1683.
16. Veltkamp R., Bieber K., Wagner S., Beynon C., Siebing D.A., Veltkamp C., et al. Hyperbaric oxygen reduces basal lamina degradation after transient focal cerebral ischemia in rats. Brain Res 2006, 1076:231-237.
17. Liu W., Hendren J., Qin X.J., Shen J., Liu K.J. Normobaric hyperoxia attenuates early blood-brain barrier disruption by inhibiting MMP-9-mediated occludin degradation in focal cerebral ischemia. JNeurochem 2009, 108:811-820.
18. Dellinger E.P. Increasing inspired oxygen to decrease surgical site infection: time to shift the quality improvement research paradigm. JAMA 2005, 294:2091-2092.
19. Belda F.J., Aguilera L., García de la Asunción J., Alberti J., Vicente R., Ferrándiz L., et al. Supplemental perioperative oxygen and the risk of surgical wound infection: a randomized controlled trial. JAMA 2005, 294:2035-2042.
20. Watson N.A., Beards S.C., Altaf N., Kassner A., Jackson A. The effect of hyperoxia on cerebral blood flow: a study in healthy volunteers using magnetic resonance phase-contrast angiography. Eur J Anaesthesiol. 2000 Mar, 17(3):152-159.
21. Crawford P., Good P.A., Gutierrez E., Feinberg J.H., Boehmer J.P., Silber D.H., et al. Effects of supplemental oxygen on forearm vasodilation in humans. JAppl Physiol 1997 May, 82(5):1601-1606.
22. Rousseau A., Steinwall I., Woodson R.D., Sjoberg F. Hyperoxia decreases cutaneous blood flow in high-perfusion areas. Microvasc Res 2007, 74:15-22.
23. Thom S.R. Oxidative stress is fundamental to hyperbaric oxygen therapy. JAppl Physiol 2009, 106:988-995.
24. Bredle D.L., Bradley W.E., Chapler C.K., Cain S.M. Muscle perfusion and oxygenation during local hyperoxia. JAppl Physiol 1988 Nov, 65(5):2057-2062.
25. Russek H.I., Regan F.D., Naegele C.F. One hundred percent oxygen in the treatment of acute myocardial infarction and severe angina pectoris. JAMA 1950, 144:373-375.
26. Kenmure A.C., Beatson J.M., Cameron A.J., Horton P.W. Effects of oxygen on myocardial blood flow and metabolism. Cardiovasc Res. 1971 Oct, 5(4):483-489.
27. Kenmure A.C.F., Murdoch W.R., Beattie A.D., Marshall J.C.B., Cameron A.J.V. Circulatory and metabolic effects of oxygen in myocardial in-farction. Br Med J 1968, 4(5627):360-364.
28. Rousseau A., Bak Z., Janerot-Sjoberg B., Sjoberg F. Acute hyperoxaemia-induced effects on regional blood flow, oxygen consumption and central circulation in man. Acta Physiol Scand 2005, 183:231-240.
29. McNulty P.H., King N., Scott S., Hartman G., McCann J., Kozak M., et al. Effects of supplemental oxygen administration on coronary blood flow in patients undergoing cardiac catheterization. Am J Physiol Heart Circ Physiol 2005, 288:H1057-H1062.
30. Milone S.D., Newton G.E., Parker J.D. Hemodynamic and biochemical effects of 100% oxygen breathing in humans. Can J Physiol Pharmacol 1999, 77:124-130.
31. McNulty P.H., Robertson B.J., Tulli M.A., Hess J., Harach L.A., Scott S., et al. Effect of hyper-oxia and vitamin C on coronary blood flow in patients with ischemic heart disease. JAppl Physiol 2007, 102:2040-2045.
32. Thomas M., Malmcrona R., Shillingford J. Haemodynamic effects of oxygen in patients with acute myocardial infarction. Br Heart J 1965, 27:401-407.
33. Hedenstierna G. Alveolar collapse and closure of airways: regular effects of anaesthesia. Clin Physiol Funct Imaging 2003, 23:123-129.
34. Konradova V., Janota J., Sulova J., Sukova B., Copova M. Effects of 90% oxygen exposure on the ultrastructure of the tracheal epithelium in rabbits. Respiration 1988, 54:24-32.
35. Deneke S.M., Fanburg B.L. Normobaric oxygen toxicity of the lung. NEngl J Med 1980, 303(2):76-86.
36. Shapiro B.A. Temperature correction of blood gas values. Respir Care Clin N Am 1995 Sep, 1(1):69-76.
37. Cerveri I., Zoia M.C., Fanfulla F., Spagnolatti L., Berrayah L., Grassi M., et al. Reference values of arterial oxygen tension in the middle-aged and elderly. Am J Respir Crit Care Med 1995 Sep, 152(3):934-941.
38. Spiropoulos K., Prodromaki E., Tsapanos V. Effect of body position on PaO2 and PaCO2 during pregnancy. Gynecol Obstet Invest 2004, 58(1):22-25.
39. Cornet A.D., Kooter A.J., Peters M.J., Smulders Y.M. The potential harm of oxygen therapy in medical emergencies. Crit Care 2013, 17:313.
40. Go A.S., Turner M.B. American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Executive summary: heart disease and stroke statistics-2014 update: a report from the American Heart Association. Circulation 2014 Jan 21, 129(3):399-410.
41. Grocott M.P., Martin D.S., Levett D.Z., McMorrow R., Windsor J., Montgomery H.E. Arterial blood gases and oxygen content in climbers on Mount Everest. NEngl J Med 2009, 360:140-149. Caudwell Xtreme Everest Research Group.
42. Michalski D., Hartig W., Schneider D., Hobohm C. Use of normobaric and hyperbaric oxygen in acute focal cerebral ischemia - a preclinical and clinical review. Acta Neurol Scand 2011, 123:85-97.
43. Qi Z., Liu W., Luo Y., Ji X., Liu K.J. Normobaric hyperoxia-based neuroprotective therapies in ischemic stroke. Med Gas Res 2013 Jan 9, 3(1):2.
44. Singhal A.B. Areview of oxygen therapy in ischemic stroke. Neurol Res 2007, 29:173-183.
45. Rønning O.M., Guldvog B. Should stroke victims routinely receive supplemental oxygen? A quasi-randomized controlled trial. Stroke 1999, 30:2033-2037.
46. Singhal A.B., Benner T., Roccatagliata L., Koroshetz W.J., Schaefer P.W., Lo E.H., et al. Apilot study of normobaric oxygen therapy in acute ischemic stroke. Stroke 2005 Apr, 36(4):797-802.
47. Normobaric oxygen therapy in acute ischemic stroke trial; [accessed 29.04.14]. http://www.clinicaltrials.gov/ct2/show/NCT00414726.
48. Padma M.V., Bhasin A., Bhatia R., Garg A., Singh M.B., Tripathi M., et al. Normobaric oxygen therapy in acute ischemic stroke: a pilot study in Indian patients. Ann Indian Acad Neurol 2010, 13(4):284-288.
49. Roffe C., Ali K., Warusevitane A., Sills S., Pountain S., Allen M., et al. The SOS pilotstudy: a RCT of routine oxygen supplementation early after acute stroke-effect on recovery of neurological function at one week. PLoS ONE 2011, 6:e19113.
50. Rincon F., Kang J., Maltenfort M. Association between hyperoxia and mortality after stroke: a multicenter cohort study. Crit Care Med 2014 Feb, 42(2):387-396.
51. Jauch E.C., Saver J.L., Adams H.P., Bruno A., Connors J.J., Demaerschalk B.M., et al. Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American heart Association/American Stroke Association. Stroke 2013 Mar, 44(3):870-947. American Heart Association Stroke Council, Council on Cardiovascular NursingCouncil on Cardiovascular Nursing, Council on Peripheral Vascular DiseaseCouncil on Peripheral Vascular Disease, Council on Clinical CardiologyCouncil on Clinical Cardiology.
52. Hlatky R., Valadka A.B., Gopinath S.P., Robertson C.S. Brain tissue oxygen tension response to induced hyperoxia reduced in hypoperfused brain. JNeurosurg 2008, 108:53-58.
53. Tolias C.M., Reinert M., Seiler R. Normobaric hyperoxia - induced improvement in cerebral metabolism and reduction in intracranial pressure in patients with severe head injury: a prospective historical cohort-matched study. JNeurosurg 2004, 101:435-444.
54. Raj R., Bendel S., Reinikainen M., Kivisaari R., Siironen J., Lang M., et al. Hyperoxemia and long-term outcome after traumatic brain injury. Crit Care 2013, 17:R177.
55. Nangunoori R., Maloney-Wilensky E., Stiefel M., Park S., Andrew Kofke W., Levine J.M., et al. Brain tissue oxygen-based therapy and outcome after severe traumatic brain injury: a systematic literature review. Neurocrit Care 2012 Aug, 17(1):131-138.
56. Rockswold S.B., Rockswold G.L., Zaun D.A., Liu J. Aprospective, randomized phase II clinical trial to evaluate the effect of combined hyperbaric and normobaric hyperoxia on cerebral metabolism, intracranial pressure, oxygen toxicity, and clinical outcome in severe traumatic brain injury. JNeurosurg 2013 Jun, 118(6):1317-1328.
57. Foadoddini M., Esmailidehaj M., Mehrani H., Sadraei S.H., Golmanesh L., Wahhabaghai H., et al. Pretreatment with hyperoxia reduces invivo infarct size and cell death by apoptosis with an early and delayed phase of protection. Eur J Cardiothorac Surg 2011 Feb, 39(2):233-240.
58. Petrosillo G., Di Venosa N., Moro N., Colantuono G., Paradies V., Tiravanti E., et al. Invivo hyperoxic preconditioning protects against rat-heart ischemia/reperfusion injury by inhibiting mitochondrial permeability transition pore opening and cytochrome c release. Free Radic Biol Med 2011 Feb 1, 50(3):477-483.
59. Neill W.A. Effects of arterial hypoxemia and hyperoxia on oxygen availability for myocardial metabolism: patients with and without coronary heart disease. Am J Cardiol 1969, 24:166-171.
60. Bourassa M.G., Campeau L., Bois M.A., Rico O. The effects of inhalation of 100 per cent oxygen on myocardial lactate metabolism in coronary heart disease. Am J Cardiol 1969, 24:172-177.
61. Sukumalchantra Y., Levy S., Danzig R., Rubins S., Alpern H., Swan H.J. Correcting arterial hypoxemia by oxygen therapy in patients with acute myocardial infarction. Am J Cardiol 1969, 24:838-852.
62. Cabello J.B., Burls A., Emparanza J.I., Bayliss S., Quinn T. Oxygen therapy for acute myocardial infarction. Cochrane Database Syst Rev 2010, 6. CD007160.
63. O'Driscoll B.R., Howard L.S., Davison A.G. Oxygen in myocardial infarction. Maintain normoxaemia until more evidence is available. BMJ 2010, 341. c3715.
64. Steg P.G., James S.K., Atar D., Badano L.P., Blömstrom-Lundqvist C., Borger M.A., et al. ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. Eur Heart J 2012 Oct, 33(20):2569-2619. Task Force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology (ESC).
65. Air versus oxygen in myocardial infarction study (AVOID); [accessed: 27.0.14]. http://www.clinicaltrials.gov/ct2/show/study/NCT01272713.
66. Supplemental oxygen in catheterized coronary emergency reperfusion (SOCCER); [accessed: 27.04.14]. http://www.clinicaltrials.gov/ct2/show/NCT01423929.
67. Richards E.M., Fiskum G., Rosenthal R.E. Hyperoxic reperfusion after global ischemia decreases hippocampal energy metabolism. Stroke 2007, 38:1578-1584.
68. Zwemer C.F., Whitesall S.E., D'Alecy L.G. Cardiopulmonary-cerebral resuscitation with 100% oxygen exacerbates neurological dysfunction following nine minutes of normothermic cardiac arrest in dogs. Resuscitation 1994, 27:159-170.
69. Liu Y., Rosenthal R.E., Haywood Y. Normoxic ventilation after cardiac arrest reduces oxidation of brain lipids and improves neurological outcome. Stroke 1998, 29:1679-1686.
70. Vereczki V., Martin E., Rosenthal R.E. Normoxic resuscitation after cardiac arrest protects against hippocampal oxidative stress, metabolic dysfunction, and neuronal death. JCereb Blood Flow Metab 2006, 26:821-835.
71. Kilgannon J.H., Jones A.E., Shapiro N.I. Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality. JAMA 2010, 303(21):2165-2171. Emergency Medicine Shock Research Network (EMShockNet) Investigators.
72. Kilgannon J.H., Jones A.E., Parillo J.E., Dellinger R.P., Milcared B., Hunter K., et al. Relationship between supranormal oxygen tension and outcome resuscitation from cardiac arrest. Circulation 2011, 123:2717-2722. Emergency Medicine Shock Research Network (EMShockNet) Investigators.
73. Janz D.R., Hollenbeck R.D., Pollock J.S., McPherson J.A., Rice T.W. Hyperoxia is associated with increased mortality in patients treated with mild therapeutic hypothermia after sudden cardiac arrest. Crit Care Med 2012, 40:3135-3139.
74. Bellomo R., Bailey M., Eastwood G.M., Nichol A., Pilcher D., Hart G.K., et al. Arterial hyperoxia and in-hospital mortality after resuscitation from cardiac arrest. Crit Care 2011, 15:R90. Study of Oxygen in Criticial Care (SOCC) Group.
75. Kuisma M., Boyd J., Voipio V., Alaspää A., Roine R.O., Rosenberg P. Comparison of 30 and the 100% inspired oxygen concentrations during early post-resuscitation period: a randomized controlled pilot study. Resuscitation 2006, 69:199-206.
76. Field J.M., Hazinski M.F., Sayre M.R., et al. Part 1: executive summary: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 2010, 122(Suppl.3):S640-S656.
77. Skinner J.S., Smeeth L., Kendall J.M., Adams P.C., Timmis A., Chest Pain Guideline Development Group, National Clinical Guideline Centre for Acute and Chronic Conditions Chest pain of recent onset: assessment and diagnosis of recent onset chest pain or discomfort of suspected cardiac origin March 2010, 95. NICE Clinical Guidelines, [accessed 27.04.14]. http://www.nice.org.uk/nicemedia/pdf/CG95NICEGuidance.pdf.
78. Booth S., Kelly M., Cox N., Adams L., Guz A. Does oxygen help dyspnea in patients with cancer?. Am J Respir Crit Care Med 1996, 153:1515-1518.
79. Shoemaker W.C., Appel P.L., Kram H.B. Role of oxygen debt in the development of organ failure sepsis, and death in high-risk surgical patients. Chest 1992 Jul, 102(1):208-215.
80. Rivers E., Nguyen B., Havstad S., Ressler J., Muzzin A., Knoblich B., et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. NEngl J Med 2001 Nov 8, 345(19):1368-1377. Early Goal-Directed Therapy Collaborative Group.
81. Arandomized trial of protocol-based care for early septic shock. NEngl J Med 2014 Mar 18, The Process Investigators, [Epub ahead of print].
82. Hayes M.A., Timmins A.C., Yau E., Palazzo M., Hinds C.J., Watson D. Elevation of systemic oxygen delivery in the treatment of critically ill patients. NEngl J Med 1994 Jun 16, 330(24):1717-1722.
83. Marik P.E., Sibbald W.J. Effect of stored-blood transfusion on oxygen delivery in patients with sepsis. JAMA 1993 Jun, 269(23):3024-3029.
84. Dellinger R.P., Levy M.M., Rhodes A., Annane D., Gerlach H., Opal S.M., et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 2013 Feb, 41(2):580-637. Surviving Sepsis Campaign Guidelines Committee including the Pediatric Subgroup.
85. Daniels R., Nutbeam T., McNamara G., Galvin C. The sepsis six and the severe sepsis resuscitation bundle: a prospective observational cohort study. Emerg Med J 2011 Jun, 28(6):507-512.
86. Hyperoxia and Hypertonic Saline in Septic Shock (Hyper2S); [accessed 27.04.14]. http://www.clinicaltrials.gov/ct2/show/NCT01722422.
87. Kallet R.H., Matthay M.A. Hyperoxic acute lung injury. Respir Care 2013 Jan, 58(1):123-141.
88. Parad R., Simmons G., Feldman N., Huber G. Impairment of adaptive tolerance to oxygen toxicity by systemic immunosuppression. Chest 1975, 67(Suppl.2):42-43.
89. Quinn D.A., Moufarrej R.K., Volokhov A., Hales C.A. Interactions of the lung stretch, hyperoxia, MIP-2 Production in ventilator-induced lung injury. JAppl Physiol 2002, 93(2):517-525.
90. Wolfe W.G., Robinson L.A., Moran J.F., Lowe J.E. Reversible pulmonary O2 toxicity in the primate. Ann Surg 1978, 188(4):530-543.
91. Thiel M., Chrouker A., Ohta A., Jackson E., Caldwell C., Smith P., et al. Oxygenation inhibits the physiological tissue-protecting mechanism and thereby exacerbate acute laboratory lung injury. PLoS Biol 2005, 3(6):1088-1100.
92. Kafer E.R. Pulmonary O2 toxicity. Br J Anaesth 1971, 43(7):687-695.
93. Rangel-Frausto M.S., Pittet D., Costigan M., Hwang T., Davis C.S., Wenzel R.P. The natural history of the systemic inflammatory response syndrome (SIRS): a prospective study. JAMA 1995, 273:117-123.
94. Lerolle N., Nochy D., Guérot E., Bruneval P., Fagon J.Y., Diehl J.L., et al. Histopathology of septic shock induced acute kidney injury: apoptosis and leukocytic infiltration. Intensive Care Med 2010 Mar, 36(3):471-478.
95. Langenberg C., Bagshaw S.M., May C.N., Bellomo R. The histopathology of septic acute kidney injury: a systematic review. Crit Care 2008, 12(2):R38.
96. Wan L., Bagshaw S.M., Langenberg C., Saotome T., May C., Bellomo R. Pathophysiology of septic acute kidney injury: what do we really know?. Crit Care Med 2008, 36:S198-S203.
97. Bitterman H., Reissman P., Bitterman N., et al. Oxygen therapy in hemorrhagic shock. Circ Shock 1991, 33:183-191.
98. Kemming G.I., Meisner F.G., Meier J., et al. Hyperoxic ventilation at the critical hematocrit: effects on myocardial perfusion and function. Acta Anaesthesiol Scand 2004, 48:951-995.
99. Takasu A., Prueckner S., Tisherman S.A., Stezoski S.W., Stezoski J., Safar P. Effects of increased oxygen breathing in a volume controlled hemorrhagic shock outcome model in rats. Resuscitation 2000, 45:209-220.
100. Sukhotnik I., Krausz M.M., Brod V., Balan M., Turkieh A., Siplovich L., et al. Divergent effects of oxygen therapy in four models of uncontrolled hemorrhagic shock. Shock 2002, 18:277-284.
101. Marshall J.C. Critical illness is an iatrogenic disorder. Crit Care Med 2010 Oct, 38(Suppl.10):S582-S589.
102. Helmerhorst H.J., Schultz M.J., Van der Voort P.H., De Jonge E., Van Westerloo D.J. Beliefs and actual practice of oxygen theraphy in the ICU. Crit Care 2013, 17(Suppl.2):P89.
103. Martin D.S., Grocott M.P. Oxygen therapy in critical illness: precise control of arterial oxygenation and permissive hypoxemia. Crit Care Med 2013 Feb, 41(2):423-432.
104. Hebert P.C., Wells G., Blajchman M.A., et al. Amulticentre randomized controlled clinical trial of transfusion requirements in critical care. NEngl J Med 1999, 340:409-417.
105. Finfer S., Chittock D.R., Su S.Y., et al. Intensive versus conventional glucose control in critically ill patients. NEngl J Med 2009, 360:1283-1297.
106. Brower R.G., Matthay M.A., Morris A., D Schoenfeld, Thompson B.T., The Acute Respiratory Distress Syndrome Network Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. NEngl J Med 2000, 342:1301-1308.
107. Narotam P.K. Eubaric hyperoxia: controversies in the management of acute traumatic brain injury. Crit Care 2013 Oct 16, 17(5):197.