Nature and extent of left/right axis defects in TWis/TWis mutant mouse embryos

Developmental Dynamics

Volumn 243, Issue 8, 2014, Pages 1046-1053

  Concepcion, Daniel ^a   Papaioannou, Virginia E ^a  

^a Department of Medicine   (United States)

Author keywords

Brachyury; Cer2; Dll1; Embryonic node; Gdf1; Left right asymmetry; Nodal

Indexed keywords

GROWTH DIFFERENTIATION FACTOR 1; PROTEIN NODAL; DLK1 PROTEIN, MOUSE; GDF1 PROTEIN, MOUSE; SIGNAL PEPTIDE;

ALLELE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; EMBRYO; EUKARYOTIC FLAGELLUM; GENE; GENE EXPRESSION; GENE LOCUS; MESODERM; MORPHOLOGY; MOUSE; MOUSE EMBRYO; MOUSE MUTANT; NONHUMAN; OBSERVATIONAL STUDY; PHENOTYPE; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SPONTANEOUS MUTATION; TWIS GENE; ANIMAL; ANIMAL EMBRYO; FEMALE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MORPHOGENESIS; PHYSIOLOGY; PREGNANCY;

ANIMALS; BODY PATTERNING; EMBRYO, MAMMALIAN; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GROWTH DIFFERENTIATION FACTOR 1; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; NODAL PROTEIN; PREGNANCY;

EID: 84904750084     PISSN: 10588388     EISSN: 10970177     Source Type: Journal    
DOI: 10.1002/dvdy.24144     Document Type: Article

References (43)

1. Abdelkhalek HB, Beckers A, Schuster-Gossler K, Pavlova MN, Burkhardt H, Lickert H, Rossant J, Reinhardt R, Schalkwyk LC, Muller I, Herrmann BG, Ceolin M, Rivera-Pomar R, Gossler A. 2004. The mouse homeobox gene Not is required for caudal notochord development and affected by the truncate mutation. Genes Dev 18:1725-1736.
2. Amack JD, Wang X, Yost HJ. 2007. Two T-box genes play independent and cooperative roles to regulate morphogenesis of ciliated Kupffer's vesicle in zebrafish. Dev Biol 310:196-210.
3. Amack JD, Yost HJ. 2004. The T box transcription factor no tail in ciliated cells controls zebrafish left-right asymmetry. Curr Biol 14:685-690.
4. Ang S, Rossant J. 1994. HNF-3b is essential for node and notochord formation in mouse development. Cell 78:561-574.
5. Beckers A, Alten L, Viebahn C, Andre P, Gossler A. 2007. The mouse homeobox gene Noto regulates node morphogenesis, notochordal ciliogenesis, and left-right patterning. Proc Natl Acad Sci U S A 104:15765-15770.
6. Beddington RSP, Rashbass P, Wilson V. 1992. Brachyury-a gene affecting mouse gastrulation and early organogenesis. Dev Suppl 1992:157-165.
7. Brennan J, Norris DP, Robertson EJ. 2002. Nodal activity in the node governs left-right asymmetry. Genes Dev 16:2339-2344.
8. Chu J, Ding J, Jeays-Ward K, Price SM, Placzek M, Shen MM. 2005. Non-cell-autonomous role for Cripto in axial midline formation during vertebrate embryogenesis. Development 132:5539-5551.
9. Wis mutation on notochord formation and mesodermal patterning. Mech Dev 49:201-209.
10. Dobrovolskaïa-Zavadskaïa N. 1927. Sur la mortification spontanée de la queue che la souris nouveau-née et sur l'existence d'un caractère (facteur) héréditaire "non viable". C R Seanc Soc Biol 97:114-116.
11. Gardner RL. 2010. Normal bias in the direction of fetal rotation depends on blastomere composition during early cleavage in the mouse. PLoS One 5:e9610.
12. Goldin SN, Papaioannou VE. 2003. Unusual misregulation of RNA splicing caused by insertion of a transposable element into the T (Brachyury) locus. BMC Genomics 4:14.
13. Grüneberg H. 1958. Genetical studies on the skeleton of the mouse XXIII. The development of brachyury and Anury. J Embryol Exp Morphol 6:424-443.
14. Hadjantonakis A-K, Pisano E, Papaioannou VE. 2008. Tbx6 regulates left/right patterning in mouse embryos through effects on nodal cilia and perinodal signaling. PloS One 3:e2511.
15. Hamada H, Meno C, Watanabe D, Saijoh Y. 2002. Establishment of vertebrate left-right asymmetry. Nat Rev Genet 3:103-113.
16. Herrmann BG, Labiet S, Poustka A, King TR, Lehrach H. 1990. Cloning of the T gene required in mesoderm formation in the mouse. Nature 343:617-622.
17. Hofmann M, Schuster-Gossler K, Watabe-Rudolph M, Aulehla A, Herrmann BG, Gossler A. 2004. WNT signaling, in synergy with T/TBX6, controls Notch signaling by regulating Dll1 expression in the presomitic mesoderm of mouse embryos. Genes Dev 18:2712-2717.
18. Inman KE, Downs KM. 2006. Brachyury is required for elongation and vasculogenesis in the murine allantois. Development 133:2947-2959.
19. Jeong Y, Epstein D. 2003. Distinct regulators of Shh transcription in the floor plate and notochord indicate separate origins for these tissues in the mouse node. Development 130:3891-3902.
20. Jiang Z, Zhu L, Hu L, Slesnick TC, Pautler RG, Justice MJ, Belmont JW. 2013. Zic3 is required in the extra-cardiac perinodal region of the lateral plate mesoderm for left-right patterning and heart development. Hum Mol Genet 22:879-889.
21. Kinder SJ, Tsang TE, Wakamiya M, Sasaki H, Behringer RR, Nagy A, Tam PPL. 2001. The organizer of the mouse gastrula is composed of a dynamic population of progenitor cells for the axial mesoderm. Development 128:3623-3634.
22. King T, Beddington RSP, Brown NA. 1998. The role of the brachyury gene in heart development and left-right specification in the mouse. Mech Dev 79:29-37.
23. Kitaguchi T, Mizugishi K, Hatayama M, Aruga J, Mikoshiba K. 2002. Xenopus Brachyury regulates mesodermal expression of Zic3, a gene controlling left-right asymmetry. Dev Growth Differ 44:55-61.
24. Kitajima K, Oki S, Ohkawa Y, Sumi T, Meno C. 2013. Wnt signaling regulates left-right axis formation in the node of mouse embryos. Dev Biol 380:222-232.
25. Krebs LT, Iwai N, Nonaka S, Welsh IC, Lan Y, Jiang R, Saijoh Y, O'Brien TP, Hamada H, Gridley T. 2003. Notch signaling regulates left-right asymmetry determination by inducing Nodal expression. Genes Dev 17:1207-1212.
26. Lin CR, Kioussi C, O'Connell S, Briata P, Szeto D, Liu F, Izpisúa-Belmonte JC, Rosenfeld MG. 1999. Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis. Nature 401:279-282.
27. Miller SA, White RD. 1998. Right-left asymmetry of cell proliferation predominates in mouse embryos undergoing clockwise axial rotation. Anatomical Record 250:103-108.
28. Naiche LA, Harrelson Z, Kelly RG, Papaioannou VE. 2005. T-box genes in vertebrate development. Annu Rev Genet 39:219-239.
29. Nakamura T, Saito D, Kawasumi A, Shinohara K, Asai Y, Takaoka K, Dong F, Takamatsu A, Belo JA, Mochizuki A, Hamada H. 2012. Fluid flow and interlinked feedback loops establish left-right asymmetric decay of Cerl2 mRNA. Nat Commun 3:1322.
30. Nakaya MA, Biris K, Tsukiyama T, Jaime S, Rawls JA, Yamaguchi TP. 2005. Wnt3a links left-right determination with segmentation and anteroposterior axis elongation. Development 132:5425-5436.
31. Nonaka S, Tanaka Y, Okada Y, Takeda S, Harada A, Kanai Y, Kido M, Hirokawa N. 1998. Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein. Cell 95:829-837.
32. Przemeck GKH, Heinzmann U, Beckers J, Hrabe de Angelis M. 2003. Node and midline defects are associated with left-right development in Delta1 mutant embryos. Development 130:3-13.
33. Rankin CT, Bunton T, Lawler AM, Lee S-J. 2000. Regulation of left-right patterning in mice by growth/differentiation factor-1. Nat Genet 24:262-265.
34. Rivera-Perez JA, Mallo M, Gendron-Maguire M, Gridley T, Behringer RR. 1995. Goosecoid is not an essential component of the mouse gastrula organizer but is required for craniofacial and rib development. Development 121:3005-3012.
35. Satoh N, Tagawa K, Takahashi H. 2013. How was the notochord born? Evol Dev 14:56-75.
36. Shedlovsky A, Guenet J-L, Johnson LL, Dove WF. 1986. Induction of recessive lethal mutations in the T/t-H2 region of the mouse genome by a point mutagen. Genet Res 47:135-142.
37. Shedlovsky A, King TR, Dove WF. 1988. Saturation germ line mutagenesis of the murine t region including a lethal allele at the quaking locus. Proc Natl Acad Sci U S A 85:180-184.
38. Shinohara K, Kawasumi A, Takamatsu A, Yoshiba S, Botilde Y, Motoyama N, Reith W, Durand B, Shiratori H, Hamada H. 2012. Two rotating cilia in the node cavity are sufficient to break left-right symmetry in the mouse embryo. Nat Commun 3:622.
39. Showell C, Binder O, Conlon FL. 2004. T-box genes in early embryogenesis. Dev Dyn 229:201-218.
40. Sutherland MJ, Wang S, Quinn ME, Haaning A, Ware SM. 2013. Zic3 is required in the migrating primitive streak for node morphogenesis and left-right patterning. Hum Mol Genet 22:1913-1923.
41. Tanaka C, Sakuma R, Nakamura T, Hamada H, Siajoh Y. 2007. Long-range action of Nodal requirees interaction with GDF-1. Genes Dev 21:3272-3282.
42. Wilkinson DG. 1992. Whole mount in situ hybridization of vertebrate embryos. Oxford: IRL Press.
43. Yoshiba S, Shiratori H, Kuo IY, Kawasumi A, Shinohara K, Nonaka S, Asai Y, Sasaki G, Belo JA, Sasaki H, Nakai J, Dworniczak B, Ehrlich BE, Pennekamp P, Hamada H. 2012. Cilia at the node of mouse embryos sense fluid flow for left-right determination via Pkd2. Science 338:226-231.