Wnt signaling regulates left-right axis formation in the node of mouse embryos

Developmental Biology

Volumn 380, Issue 2, 2013, Pages 222-232

  Kitajima, Keiko ^a   Oki, Shinya ^a   Ohkawa, Yasuyuki ^a   Sumi, Tomoyuki ^a   Meno, Chikara ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

Left right axis; Mouse embryo; Node; Notch signaling; Wnt

Indexed keywords

BETA CATENIN; HEPATOCYTE NUCLEAR FACTOR 3BETA; NOTCH RECEPTOR; PROTEIN NODAL; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RBPJ; UNCLASSIFIED DRUG; WNT PROTEIN; WNT3 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; CERL2 GENE; CONTROLLED STUDY; EMBRYO; EMBRYO AXIS; EMBRYO DEVELOPMENT; ENHANCER REGION; ENZYME INHIBITION; GDF1 GENE; GENE; GENE ACTIVITY; GENE AMPLIFICATION; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; GENE INDUCTION; GENE REPRESSION; HUMAN; HUMAN CELL; MESODERM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REGULATORY MECHANISM; TRANSCRIPTION REGULATION; WNT SIGNALING PATHWAY;

EID: 84879890158     PISSN: 00121606     EISSN: 1095564X     Source Type: Journal    
DOI: 10.1016/j.ydbio.2013.05.011     Document Type: Article

References (44)

1. Bain J., Plater L., Elliott M., Shpiro N., Hastie C.J., McLauchlan H., Klevernic I., Arthur J.S., Alessi D.R., Cohen P. The selectivity of protein kinase inhibitors: a further update. Biochem. J. 2007, 408:297-315.
2. Bellomo D., Lander A., Harragan I., Brown N.A. Cell proliferation in mammalian gastrulation: the ventral node and notochord are relatively quiescent. Dev. Dyn. 1996, 205:471-485.
3. Borggrefe T., Oswald F. The Notch signaling pathway: transcriptional regulation at Notch target genes. Cell Mol. Life Sci. 2009, 66:1631-1646.
4. Brennan J., Norris D.P., Robertson E.J. Nodal activity in the node governs left-right asymmetry. Genes Dev. 2002, 16:2339-2344.
5. Caron A., Xu X., Lin X. Wnt/beta-catenin signaling directly regulates Foxj1 expression and ciliogenesis in zebrafish Kupffer's vesicle. Development 2012, 139:514-524.
6. Chen F., Zhu Y., Tang X., Sun Y., Jia W., Han X. Dynamic regulation of PDX-1 and FoxO1 expression by FoxA2 in dexamethasone-induced pancreatic beta-cells dysfunction. Endocrinology 2011, 152:1779-1788.
7. Collignon J., Varlet I., Robertson E.J. Relationship between asymmetric nodal expression and the direction of embryonic turning. Nature 1996, 381:155-158.
8. Feller J., Schneider A., Schuster-Gossler K., Gossler A. Noncyclic Notch activity in the presomitic mesoderm demonstrates uncoupling of somite compartmentalization and boundary formation. Genes Dev. 2008, 22:2166-2171.
9. Huang S.M., Mishina Y.M., Liu S., Cheung A., Stegmeier F., Michaud G.A., Charlat O., Wiellette E., Zhang Y., Wiessner S., Hild M., Shi X., Wilson C.J., Mickanin C., Myer V., Fazal A., Tomlinson R., Serluca F., Shao W., Cheng H., Shultz M., Rau C., Schirle M., Schlegl J., Ghidelli S., Fawell S., Lu C., Curtis D., Kirschner M.W., Lengauer C., Finan P.M., Tallarico J.A., Bouwmeester T., Porter J.A., Bauer A., Cong F. Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature 2009, 461:614-620.
10. Kato H., Sakai T., Tamura K., Minoguchi S., Shirayoshi Y., Hamada Y., Tsujimoto Y., Honjo T. Functional conservation of mouse Notch receptor family members. FEBS Lett. 1996, 395:221-224.
11. Kawasumi A., Nakamura T., Iwai N., Yashiro K., Saijoh Y., Belo J.A., Shiratori H., Hamada H. Left-right asymmetry in the level of active Nodal protein produced in the node is translated into left-right asymmetry in the lateral plate of mouse embryos. Dev. Biol. 2011, 353:321-330.
12. Krebs L.T., Iwai N., Nonaka S., Welsh I.C., Lan Y., Jiang R., Saijoh Y., O'Brien T.P., Hamada H., Gridley T. Notch signaling regulates left-right asymmetry determination by inducing Nodal expression. Genes Dev. 2003, 17:1207-1212.
13. Liu P., Wakamiya M., Shea M.J., Albrecht U., Behringer R.R., Bradley A. Requirement for Wnt3 in vertebrate axis formation. Nat. Genet. 1999, 22:361-365.
14. Lowe L.A., Supp D.M., Sampath K., Yokoyama T., Wright C.V., Potter S.S., Overbeek P., Kuehn M.R. Conserved left-right asymmetry of nodal expression and alterations in murine situs inversus. Nature 1996, 381:158-161.
15. Lubman O.Y., Ilagan M.X., Kopan R., Barrick D. Quantitative dissection of the Notch:CSL interaction: insights into the Notch-mediated transcriptional switch. J. Mol. Biol. 2007, 365:577-589.
16. Marques S., Borges A.C., Silva A.C., Freitas S., Cordenonsi M., Belo J.A. The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis. Genes Dev. 2004, 18:2342-2347.
17. McGrath J., Somlo S., Makova S., Tian X., Brueckner M. Two populations of node monocilia initiate left-right asymmetry in the mouse. Cell 2003, 114:61-73.
18. Meno C., Shimono A., Saijoh Y., Yashiro K., Mochida K., Ohishi S., et al. lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal. Cell 1998, 94:287-297.
19. Meno C., Takeuchi J., Sakuma R., Koshiba-Takeuchi K., Ohishi S., Saijoh Y., Miyazaki J., ten Dijke P., Ogura T., Hamada H. Diffusion of nodal signaling activity in the absence of the feedback inhibitor Lefty2. Dev. Cell 2001, 1:127-138.
20. Mizushima S., Nagata S. pEF-BOS, a powerful mammalian expression vector. Nucleic Acids Res. 1990, 18:5322.
21. Morohashi Y., Kan T., Tominari Y., Fuwa H., Okamura Y., Watanabe N., Sato C., Natsugari H., Fukuyama T., Iwatsubo T., Tomita T. C-terminal fragment of presenilin is the molecular target of a dipeptidic γ-secretase-specific inhibitor DAPT (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester. J. Biol. Chem. 2006, 281:14670-14676.
22. Nakamura T., Mine N., Nakaguchi E., Mochizuki A., Yamamoto M., Yashiro K., Meno C., Hamada H. Generation of robust left-right asymmetry in the mouse embryo requires a self-enhancement and lateral-inhibition system. Dev. Cell 2006, 11:495-504.
23. Nakaya M.A., Biris K., Tsukiyama T., Jaime S., Rawls J.A., Yamaguchi T.P. Wnt3a links left-right determination with segmentation and anteroposterior axis elongation. Development 2005, 132:5425-5436.
24. Nonaka S., Tanaka Y., Okada Y., Takeda S., Harada A., Kanai Y., Kido M., Hirokawa N. Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein. Cell 1998, 95:829-837.
25. Norris D.P., Brennan J., Bikoff E.K., Robertson E.J. The Foxh1-dependent autoregulatory enhancer controls the level of nodal signals in the mouse embryo. Development 2002, 129:3455-3468.
26. Oki S., Hashimoto R., Okui Y., Shen M.M., Mekada E., Otani H., Saijoh Y., Hamada H. Sulfated glycosaminoglycans are necessary for nodal signal transmission from the node to the left lateral plate in the mouse embryo. Development 2007, 134:3893-3904.
27. Oki S., Kitajima K., Marques S., Belo J.A., Yokoyama T., Hamada H., Meno C. Reversal of left-right asymmetry induced by aberrant nodal signaling in the node of mouse embryos. Development 2009, 136:3917-3925.
28. Overdier D.G., Porcella A., Costa R.H. The DNA-binding specificity of the hepatocyte nuclear factor 3/forkhead domain is influenced by amino-acid residues adjacent to the recognition helix. Mol. Cell. Biol. 1994, 14:2755-2766.
29. Pearce J.J., Penny G., Rossant J. A mouse cerberus/Dan-related gene family. Dev. Biol. 1999, 209:98-110.
30. Przemeck G.K., Heinzmann U., Beckers J., Hrabe de Angelis M. Node and midline defects are associated with left-right development in Delta1 mutant embryos. Development 2003, 130:3-13.
31. Rankin C.T., Bunton T., Lawler A.M., Lee S.J. Regulation of left-right patterning in mice by growth/differentiation factor-1. Nat. Genet. 2000, 24:262-265.
32. Raya A., Kawakami Y., Rodriguez-Esteban C., Buscher D., Koth C.M., Itoh T., Morita M., Raya R.M., Dubova I., Bessa J.G., de la Pompa J.L., Izpisua Belmonte J.C. Notch activity induces nodal expression and mediates the establishment of left-right asymmetry in vertebrate embryos. Genes Dev. 2003, 17:1213-1218.
33. Saijoh Y., Adachi H., Sakuma R., Yeo C.Y., Yashiro K., Watanabe M., Hashiguchi H., Mochida K., Ohishi S., Kawabata M., Miyazono K., Whitman M., Hamada H. Left-right asymmetric expression of lefty2 and nodal is induced by a signaling pathway that includes the transcription factor FAST2. Mol. Cell 2000, 5:35-47.
34. Saijoh Y., Oki S., Ohishi S., Hamada H. Left-right patterning of the mouse lateral plate requires nodal produced in the node. Dev. Biol. 2003, 256:160-172.
35. Sasaki H., Hogan B.L. Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo. Development 1993, 118:47-59.
36. Scott G.K., Daniel J.C., Xiong X., Maki R.A., Kabat D., Benz C.C. Binding of an ETS-related protein within the DNase I hypersensitive site of the HER2/neu promoter in human breast cancer cells. J. Biol. Chem. 1994, 269:19848-19858.
37. Shiratori H., Hamada H. The left-right axis in the mouse: from origin to morphology. Development 2006, 133:2095-2104.
38. Sulik K., Dehart D.B., Iangaki T., Carson J.L., Vrablic T., Gesteland K., Schoenwolf G.C. Morphogenesis of the murine node and notochordal plate. Dev. Dyn. 1994, 201:260-278.
39. Tanaka C., Sakuma R., Nakamura T., Hamada H., Saijoh Y. Long-range action of Nodal requires interaction with GDF1. Genes Dev. 2007, 21:3272-3282.
40. Tanaka Y., Okada Y., Hirokawa N. FGF-induced vesicular release of Sonic hedgehog and retinoic acid in leftward nodal flow is critical for left-right determination. Nature 2005, 435:172-177.
41. Tun T., Hamaguchi Y., Matsunami N., Furukawa T., Honjo T., Kawaichi M. Recognition sequence of a highly conserved DNA binding protein RBP-J kappa. Nucleic Acids Res. 1994, 22:965-971.
42. Walentek P., Beyer T., Thumberger T., Schweickert A., Blum M. ATP4a is required for Wnt-dependent Foxj1 expression and leftward flow in Xenopus left-right development. Cell Rep. 2012, 1:516-527.
43. Yamamoto M., Mine N., Mochida K., Sakai Y., Saijoh Y., Meno C., Hamada H. Nodal signaling induces the midline barrier by activating nodal expression in the lateral plate. Development 2003, 130:1795-1804.
44. Yan Y.T., Gritsman K., Ding J., Burdine R.D., Corrales J.D., Price S.M., Talbot W.S., Schier A.F., Shen M.M. Conserved requirement for EGF-CFC genes in vertebrate left-right axis formation. Genes Dev. 1999, 13:2527-2537.