Fibrocytes in the fibrotic lung: Altered phenotype detected by flow cytometry

Frontiers in Pharmacology

Volumn 5 JUN, Issue , 2014, Pages

  Reese, Charles ^a   Lee, Rebecca ^a   Bonner, Michael ^a   Perry, Beth ^a   Heywood, Jonathan ^a   Silver M , Richard ^a   Tourkina, Elena ^a   Visconti, Richard P ^a   Hoffman, Stanley ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Caveolin 1; CCR5; CD44; CD45; Collagen; CXCR4; HSP47; Scleroderma

Indexed keywords

CAVEOLIN 1; CD14 ANTIGEN; CD34 ANTIGEN; CD45 ANTIGEN; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; COLLAGEN TYPE 1; HEAT SHOCK PROTEIN 47; HERMES ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; FLOW CYTOMETRY; LEUKOCYTE; LUNG ALVEOLUS CELL; LUNG FIBROCYTE; LUNG FIBROSIS; MALE; MOUSE; NONHUMAN;

EID: 84904747722     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2014.00141     Document Type: Article

References (23)

1. Falk, E. (2006). Pathogenesis of atherosclerosis. J. Am. Coll. Cardiol. 47, C7-C12. doi: 10.1016/j.jacc.2005.09.068.
2. Hagiwara, S., Iwasaka, H., Matsumoto, S., and Noguchi, T. (2007). Antisense oligonucleotide inhibition of heat shock protein (HSP) 47 improves bleomycin-induced pulmonary fibrosis in rats. Respir. Res. 8:37. doi: 10.1186/1465-9921-8-37.
3. Haudek, S. B., Xia, Y., Huebener, P., Lee, J. M., Carlson, S., Crawford, J. R., et al. (2006). Bone marrow-derived fibroblast precursors mediate ischemic cardiomyopathy in mice. Proc. Natl. Acad. Sci. U.S.A. 103, 18284-18289. doi: 10.1073/pnas.0608799103.
4. Herzog, E. L., and Bucala, R. (2010). Fibrocytes in health and disease. Exp. Hematol. 38, 548-556. doi: 10.1016/j.exphem.2010.03.004.
5. Ishida, Y., Kimura, A., Kondo, T., Hayashi, T., Ueno, M., Takakura, N., et al. (2007). Essential roles of the CC chemokine ligand 3-CC chemokine receptor 5 axis in bleomycin-induced pulmonary fibrosis through regulation of macrophage and fibrocyte infiltration. Am. J. Pathol. 170, 843-854. doi: 10.2353/ajpath.2007.051213.
6. Ishida, Y., Kubota, H., Yamamoto, A., Kitamura, A., Bachinger, H. P., and Nagata, K. (2006). Type I collagen in Hsp47-null cells is aggregated in endoplasmic reticulum and deficient in N-propeptide processing and fibrillogenesis. Mol. Biol. Cell 17, 2346-2355. doi: 10.1091/mbc.E05-11-1065.
7. Keeley, E. C., Mehrad, B., and Strieter, R. M. (2009). The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of fibrotic disorders. Thromb. Haemost. 101, 613-618. doi: 10.1160/TH08-11-0726.
8. Kisseleva, T., Uchinami, H., Feirt, N., Quintana-Bustamante, O., Segovia, J. C., Schwabe, R. F., et al. (2006). Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis. J. Hepatol. 45, 429-438. doi: 10.1016/j.jhep.2006.04.014.
9. Lee, R., Reese, C., Bonner, M., Tourkina, E., Hajdu, Z., Riemer, E. C., et al. (2014). Bleomycin delivery by osmotic mini-pump: similarity to human scleroderma interstitial lung disease. Am. J. Physiol. Lung Cell. Mol. Physiol. 306, L736-L748. doi: 10.1152/ajplung.00210.2013.
10. Maharjan, A. S., Pilling, D., and Gomer, R. H. (2011). High and low molecular weight hyaluronic acid differentially regulate human fibrocyte differentiation. PLoS ONE 6:e26078. doi: 10.1371/journal.pone.0026078.
11. Mathai, S. K., Gulati, M., Peng, X., Russell, T. R., Shaw, A. C., Rubinowitz, A. N., et al. (2010). Circulating monocytes from systemic sclerosis patients with interstitial lung disease show an enhanced profibrotic phenotype. Lab. Invest. 90, 812-823. doi: 10.1038/labinvest.2010.73.
12. Mehrad, B., Burdick, M. D., and Strieter, R. M. (2009). Fibrocyte CXCR4 regulation as a therapeutic target in pulmonary fibrosis. Int. J. Biochem. Cell Biol. 41, 1708-1718. doi: 10.1016/j.biocel.2009.02.020.
13. Moeller, A., Gilpin, S. E., Ask, K., Cox, G., Cook, D., Gauldie, J., et al. (2009). Circulating fibrocytes are an indicator of poor prognosis in idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 179, 588-594. doi: 10.1164/rccm.200810-1534OC.
14. Murray, L. A., Chen, Q., Kramer, M. S., Hesson, D. P., Argentieri, R. L., Peng, X., et al. (2011). TGF-beta driven lung fibrosis is macrophage dependent and blocked by Serum amyloid P. Int. J. Biochem. Cell Biol. 43, 154-162. doi: 10.1016/j.biocel.2010.10.013.
15. Nakashima, T., Liu, T., Yu, H., Ding, L., Ullenbruch, M., Hu, B., et al. (2013). Lung bone marrow-derived hematopoietic progenitor cells enhance pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 188, 976-984. doi: 10.1164/rccm.201303-0479OC.
16. Niedermeier, M., Reich, B., Rodriguez Gomez, M., Denzel, A., Schmidbauer, K., Gobel, N., et al. (2009). CD4+ T cells control the differentiation of Gr1+ monocytes into fibrocytes. Proc. Natl. Acad. Sci. U.S.A. 106, 17892-17897. doi: 10.1073/pnas.0906070106.
17. Nikam, V. S., Wecker, G., Schermuly, R., Rapp, U., Szelepusa, K., Seeger, W., et al. (2011). Treprostinil inhibits the adhesion and differentiation of fibrocytes via the cyclic adenosine monophosphate-dependent and Ras-proximate protein-dependent inactivation of extracellular regulated kinase. Am. J. Respir. Cell Mol. Biol. 45, 692-703. doi: 10.1165/rcmb.2010-0240OC.
18. Phillips, R. J., Burdick, M. D., Hong, K., Lutz, M. A., Murray, L. A., Xue, Y. Y., et al. (2004). Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis. J. Clin. Invest. 114, 438-446. doi: 10.1172/JCI20997..
19. Pilling, D., Fan, T., Huang, D., Kaul, B., and Gomer, R. H. (2009). Identification of markers that distinguish monocyte-derived fibrocytes from monocytes, macrophages, and fibroblasts. PLoS ONE 4:e7475. doi: 10.1371/journal.pone.0007475.
20. Tourkina, E., Richard, M., Gooz, P., Bonner, M., Pannu, J., Harley, R., et al. (2008). Antifibrotic properties of caveolin-1 scaffolding domain in vitro and in vivo. Am. J. Physiol. Lung Cell. Mol. Physiol. 294, L843-L861. doi: 10.1152/ajplung.00295.2007.
21. Vakil, V., Sung, J. J., Piecychna, M., Crawford, J. R., Kuo, P., Abu-Alfa, A. K., et al. (2009). Gadolinium-containing magnetic resonance image contrast agent promotes fibrocyte differentiation. J. Magn. Reson. Imaging 30, 1284-1288. doi: 10.1002/jmri.21800.
22. Visconti, R. P., Ebihara, Y., Larue, A. C., Fleming, P. A., McQuinn, T. C., Masuya, M., et al. (2006). An in vivo analysis of hematopoietic stem cell potential: hematopoietic origin of cardiac valve interstitial cells. Circ. Res. 98, 690-696. doi: 10.1161/01.RES.0000207384.81818.d4.
23. Wang, C. H., Huang, C. D., Lin, H. C., Lee, K. Y., Lin, S. M., Liu, C. Y., et al. (2008). Increased circulating fibrocytes in asthma with chronic airflow obstruction. Am. J. Respir. Crit. Care Med. 178, 583-591. doi: 10.1164/rccm.200710-1557OC