Treprostinil inhibits the adhesion and differentiation of fibrocytes via the cyclic adenosine monophosphate-dependent and ras-proximate protein-dependent inactivation of extracellular regulated kinase

American Journal of Respiratory Cell and Molecular Biology

Volumn 45, Issue 4, 2011, Pages 692-703

  Nikam, Vandana S ^a   Wecker, Gesa ^b   Schermuly, Ralph ^a   Rapp, Ulf ^a   Szelepusa, Kirsten ^a   Seeger, Werner ^a,b   Voswinckel, Robert ^a,b  

^a MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

^b JUSTUS LIEBIG UNIVERSITY GIESSEN   (Germany)

Author keywords

cAMP; ERK1 2; Prostacyclin; Pulmonary circulation; Rap

Indexed keywords

ALPHA5 INTEGRIN; B RAF KINASE; BETA1 INTEGRIN; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROSTAGLANDIN E RECEPTOR 1; PROSTAGLANDIN E RECEPTOR 2; PROSTAGLANDIN I RECEPTOR; PROSTAGLANDIN RECEPTOR; PROTEIN C RAF; PROTEIN SERINE THREONINE KINASE; RAP PROTEIN; RAS PROTEIN; UNCLASSIFIED DRUG; UNIPROST;

ARTICLE; CELL ADHESION; CELL DIFFERENTIATION; CELL TYPE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; EXTRACELLULAR MATRIX; FIBROCYTE; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG BLOOD VESSEL; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PULMONARY HYPERTENSION;

ANTIGENS, CD29; CELL ADHESION; CELL DIFFERENTIATION; CELLS, CULTURED; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; EPOPROSTENOL; EXTRACELLULAR MATRIX; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; HYPERTENSION, PULMONARY; INTEGRIN ALPHA5; LEUKOCYTES, MONONUCLEAR; MUTATION; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-RAF; RAP1 GTP-BINDING PROTEINS; RAS PROTEINS; RECEPTORS, PROSTAGLANDIN; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION;

EID: 80053645799     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2010-0240OC     Document Type: Article

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