CCAT2 is a lung adenocarcinoma-specific long non-coding RNA and promotes invasion of non-small cell lung cancer

Tumor Biology

Volumn 35, Issue 6, 2014, Pages 5375-5380

  Qiu, Mantang ^a   Xu, Youtao ^a   Yang, Xin ^a   Wang, Jie ^a   Hu, Jingwen ^a   Xu, Lin ^a   Yin, Rong ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

CCAT2; Expression; Long non coding RNA; Lung adenocarcinoma

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; COLON CANCER ASSOCIATED TRANSCRIPT 2; LIPOFECTAMINE; LONG UNTRANSLATED RNA; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CANCER STAGING; CELL PROLIFERATION; CELL PROLIFERATION ASSAY; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN GENOME; HUMAN TISSUE; IN VITRO STUDY; LUNG ADENOCARCINOMA; LUNG CANCER CELL LINE; LUNG NON SMALL CELL CANCER; LUNG PARENCHYMA; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PREDICTIVE VALUE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; TISSUE SPECIFICITY; TUMOR INVASION; UPREGULATION;

ADENOCARCINOMA; ADULT; AGED; CARCINOMA, NON-SMALL-CELL LUNG; FEMALE; HUMANS; LUNG NEOPLASMS; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM INVASIVENESS; RNA, LONG NONCODING;

EID: 84904741838     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-014-1700-z     Document Type: Article

References (32)

1. Parkin DM, Pisani P, Ferlay J. Estimates of the worldwide incidence of 25 major cancers in 1990. Int J Cancer. 1999;80(6):827-41. (Pubitemid 29108856)
2. Jemal A, Thomas A, Murray T, Thun M. Cancer statistics, 2002. CA Cancer J Clin. 2002;52(1):23-47. (Pubitemid 34110469)
3. Rosell R, Bivona TG, Karachaliou N. Genetics and biomarkers in personalisation of lung cancer treatment. Lancet. 2013;382(9893):720-31.
4. Yang X, Zhang Z, Qiu M, Hu J, Fan X, Wang J, et al. Glypican-5 Is a novel metastasis suppressor gene in non-small cell lung cancer. Cancer Lett. 2013;341(2):265-73.
5. Birney E, Stamatoyannopoulos JA, Dutta A, Guigo R, Gingeras TR, Margulies EH, et al. Identification and analysis of functional elements in 1% of the human genome by the Encode Pilot Project. Nature. 2007;447(7146):799-816. (Pubitemid 46920138)
6. Esteller M. Non-coding RNAs in human disease. Nat Rev Genet. 2011;12(12):861-74.
7. Carthew RW, Sontheimer EJ. Origins and mechanisms of miRNAs and siRNAs. Cell. 2009;136(4):642-55.
8. Gupta RA, Shah N, Wang KC, Kim J, Horlings HM, Wong DJ, et al. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature. 2010;464(7291):1071-6.
9. Takayama K, Horie-Inoue K, Katayama S, Suzuki T, Tsutsumi S, Ikeda K, et al. Androgen-responsive long noncoding RNA Ctbp1-as promotes prostate cancer. EMBO J. 2013;32(12):1665-80.
10. Ji P, Diederichs S, Wang W, Boing S, Metzger R, Schneider PM, et al. MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer. Oncogene. 2003;22(39):8031-41. (Pubitemid 37175867)
11. Tsai MC, Manor O, Wan Y, Mosammaparast N, Wang JK, Lan F, et al. Long noncoding RNA as modular scaffold of histone modification complexes. Science. 2010;329(5992):689-93.
12. Gutschner T, Hammerle M, Eissmann M, Hsu J, Kim Y, Hung G, et al. The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells. Cancer Res. 2013;73(3):1180-9.
13. Panzitt K, Tschernatsch MM, Guelly C, Moustafa T, Stradner M, Strohmaier HM, et al. Characterization of HULC, a novel gene with striking up-regulation in hepatocellular carcinoma, as noncoding RNA. Gastroenterology. 2007;132(1):330-42. (Pubitemid 46108730)
14. Geng YJ, Xie SL, Li Q, Ma J, Wang GY. Large intervening noncoding RNA HOTAIR is associated with hepatocellular carcinoma progression. J Int Med Res. 2011;39(6):2119-28.
15. Yang Z, Zhou L, Wu LM, Lai MC, Xie HY, Zhang F, et al. Overexpression of long non-coding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation. Ann Surg Oncol. 2011;18(5):1243-50.
16. Ren S, Wang F, Shen J, Sun Y, Xu W, Lu J, et al. Long non-coding RNA metastasis associated in lung adenocarcinoma transcript 1 derived miniRNA as a novel plasma-based biomarker for diagnosing prostate cancer. Eur J Cancer. 2013. doi:10.1016/j.ejca.2013.04.026.
17. Schmidt LH, Spieker T, Koschmieder S, Schaffers S, Humberg J, Jungen D, et al. The long noncodingMALAT-1RNAindicates a poor prognosis in non-small cell lung cancer and induces migration and tumor growth. J Thorac Oncol. 2011;6(12):1984-92.
18. Ling H, Spizzo R, Atlasi Y, Nicoloso M, Shimizu M, Redis RS, et al. CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer. Genome Res. 2013;23(9):1446-61.
19. Redis RS, Sieuwerts AM, Look MP, Tudoran O, Ivan C, Spizzo R, et al. CCAT2, a novel long non-coding RNA in breast cancer: expression study and clinical correlations. Oncotarget. 2013;4(10):1748-62.
20. Yin R, Zhang S, Wu Y, Fan X, Jiang F, Zhang Z, et al. Microrna-145 suppresses lung adenocarcinoma-initiating cell proliferation by targeting Oct4. Oncol Rep. 2011;25(6):1747-54.
21. Ponting CP, Oliver PL, Reik W. Evolution and functions of long noncoding RNAs. Cell. 2009;136(4):629-41.
22. Qiu MT, Hu JW, Yin R, Xu L. Long noncoding RNA: an emerging paradigm of cancer research. Tumour Biol. 2013;34(2):613-20.
23. Yang F, Huo XS, Yuan SX, Zhang L, Zhou WP, Wang F, et al. Repression of the long noncoding RNA - let by histone deacetylase 3 contributes to hypoxia-mediated metastasis. Mol Cell. 2013. doi:10.1016/j.molcel.2013.01.010.
24. Kretz M, Siprashvili Z, Chu C, Webster DE, Zehnder A, Qu K, et al. Control of somatic tissue differentiation by the long non-coding RNA Tincr. Nature. 2013;493(7431):231-5.
25. Wu W, Bhagat TD, Yang X, Song JH, Cheng Y, Agarwal R, et al. Hypomethylation of noncoding DNA Regions and overexpression of the long noncoding RNA, Afap1-As1, in Barrett's esophagus and esophageal adenocarcinoma. Gastroenterology. 2013. doi:10.1053/j.gastro.2013.01.019.
26. Bertozzi D, Iurlaro R, Sordet O, Marinello J, Zaffaroni N, Capranico G. Characterization of novel antisense Hif-1alpha transcripts in human cancers. Cell Cycle. 2011;10(18):3189-97.
27. Guo F, Li Y, Liu Y, Wang J, Li G. Inhibition of metastasis-associated lung adenocarcinoma transcript 1 in Caski human cervical cancer cells suppresses cell proliferation and invasion. Acta Biochim Biophys Sin (Shanghai). 2010;42(3):224-9.
28. Ren S, Wang F, Shen J, Sun Y, Xu W, Lu J, et al. Long non-coding RNA metastasis associated in lung adenocarcinoma transcript 1 derived miniRNA as a novel plasma-based biomarker for diagnosing prostate cancer. Eur J Cancer. 2013;49(13):2949-59.
29. Haiman CA, Le Marchand L, Yamamato J, Stram DO, Sheng X, Kolonel LN, et al. A common genetic risk factor for colorectal and prostate cancer. Nat Genet. 2007;39(8):954-6. (Pubitemid 47185184)
30. Tomlinson I, Webb E, Carvajal-Carmona L, Broderick P, Kemp Z, Spain S, et al. A genome-wide association scan of tag Snps identifies a susceptibility variant for colorectal cancer at 8q24.21. Nat Genet. 2007;39(8):984-8. (Pubitemid 47185182)
31. Ghoussaini M, Song H, Koessler T, Al Olama AA, Kote-Jarai Z, Driver KE, et al. Multiple loci with different cancer specificities within the 8q24 gene desert. J Natl Cancer Inst. 2008;100(13):962-6. (Pubitemid 351957516)
32. Zhang X, Chen Q, He C, Mao W, Zhang L, Xu X, et al. Polymorphisms on 8q24 are associated with lung cancer risk and survival in Han Chinese. PLoS One. 2012;7(7):e41930.