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Volumn 30, Issue 8, 2014, Pages 401-411

Discovering a vaccine against neosporosis using computers: Is it feasible?

Author keywords

Apicomplexa; In silico vaccine discovery; Neospora caninum; Neosporosis; Reverse vaccinology; Vaccinomics

Indexed keywords

ANTIGEN; VACCINE;

EID: 84904725957     PISSN: 14714922     EISSN: 14715007     Source Type: Journal    
DOI: 10.1016/j.pt.2014.06.004     Document Type: Review
Times cited : (26)

References (91)
  • 1
    • 84873140040 scopus 로고    scopus 로고
    • What is the global economic impact of Neospora caninum in cattle: the billion dollar question
    • Reichel M.P., et al. What is the global economic impact of Neospora caninum in cattle: the billion dollar question. Int. J. Parasitol. 2013, 43:133-142.
    • (2013) Int. J. Parasitol. , vol.43 , pp. 133-142
    • Reichel, M.P.1
  • 2
    • 50349101879 scopus 로고    scopus 로고
    • Re-evaluating the economics of neosporosis control
    • Reichel M.P., Ellis J.T. Re-evaluating the economics of neosporosis control. Vet. Parasitol. 2008, 156:361-362.
    • (2008) Vet. Parasitol. , vol.156 , pp. 361-362
    • Reichel, M.P.1    Ellis, J.T.2
  • 3
    • 84655161479 scopus 로고    scopus 로고
    • Efficacy of a Neospora caninum killed tachyzoite vaccine in preventing abortion and vertical transmission in dairy cattle
    • Weston J.F., et al. Efficacy of a Neospora caninum killed tachyzoite vaccine in preventing abortion and vertical transmission in dairy cattle. Prev. Vet. Med. 2012, 103:136-144.
    • (2012) Prev. Vet. Med. , vol.103 , pp. 136-144
    • Weston, J.F.1
  • 4
    • 67650499884 scopus 로고    scopus 로고
    • Neospora caninum: how close are we to development of an efficacious vaccine that prevents abortion in cattle?
    • Reichel M.P., Ellis J.T. Neospora caninum: how close are we to development of an efficacious vaccine that prevents abortion in cattle?. Int. J. Parasitol. 2009, 39:1173-1187.
    • (2009) Int. J. Parasitol. , vol.39 , pp. 1173-1187
    • Reichel, M.P.1    Ellis, J.T.2
  • 5
    • 79960306192 scopus 로고    scopus 로고
    • Neosporosis in animals: the last five years
    • Dubey J.P., Schares G. Neosporosis in animals: the last five years. Vet. Parasitol. 2011, 180:90-108.
    • (2011) Vet. Parasitol. , vol.180 , pp. 90-108
    • Dubey, J.P.1    Schares, G.2
  • 6
    • 84870309144 scopus 로고    scopus 로고
    • A review of the infection, genetics, and evolution of Neospora caninum: from the past to the present
    • Goodswen S.J., et al. A review of the infection, genetics, and evolution of Neospora caninum: from the past to the present. Infect. Genet. Evol. 2013, 13:133-150.
    • (2013) Infect. Genet. Evol. , vol.13 , pp. 133-150
    • Goodswen, S.J.1
  • 7
    • 84899123083 scopus 로고    scopus 로고
    • Vaccines against neosporosis: what can we learn from the past studies?
    • Monney T., Hemphill A. Vaccines against neosporosis: what can we learn from the past studies?. Exp. Parasitol. 2014, 140:52-70.
    • (2014) Exp. Parasitol. , vol.140 , pp. 52-70
    • Monney, T.1    Hemphill, A.2
  • 8
    • 63149118743 scopus 로고    scopus 로고
    • Interaction between parasitophorous vacuolar membrane-associated GRA3 and calcium modulating ligand of host cell endoplasmic reticulum in the parasitism of Toxoplasma gondii
    • Kim J.Y., et al. Interaction between parasitophorous vacuolar membrane-associated GRA3 and calcium modulating ligand of host cell endoplasmic reticulum in the parasitism of Toxoplasma gondii. Korean J. Parasitol. 2008, 46:209-216.
    • (2008) Korean J. Parasitol. , vol.46 , pp. 209-216
    • Kim, J.Y.1
  • 9
    • 57549111055 scopus 로고    scopus 로고
    • The immunobiology of the innate response to Toxoplasma gondii
    • Miller C.M., et al. The immunobiology of the innate response to Toxoplasma gondii. Int. J. Parasitol. 2009, 39:23-39.
    • (2009) Int. J. Parasitol. , vol.39 , pp. 23-39
    • Miller, C.M.1
  • 10
    • 70449481755 scopus 로고    scopus 로고
    • Endogenous and exogenous transplacental transmission of Neospora caninum: how the route of transmission impacts on epidemiology and control of disease
    • Williams D.J.L., et al. Endogenous and exogenous transplacental transmission of Neospora caninum: how the route of transmission impacts on epidemiology and control of disease. Parasitology 2009, 136:1895-1900.
    • (2009) Parasitology , vol.136 , pp. 1895-1900
    • Williams, D.J.L.1
  • 11
    • 84904763953 scopus 로고    scopus 로고
    • Control options for Neospora caninum: is there anything new or are we going backwards?
    • Reichel M.P., et al. Control options for Neospora caninum: is there anything new or are we going backwards?. Parasitology 2014, 10.1017/S0031182014000158.
    • (2014) Parasitology
    • Reichel, M.P.1
  • 12
    • 33744487386 scopus 로고    scopus 로고
    • Pathogenesis of bovine neosporosis
    • Dubey J.P., et al. Pathogenesis of bovine neosporosis. J. Comp. Pathol. 2006, 134:267-289.
    • (2006) J. Comp. Pathol. , vol.134 , pp. 267-289
    • Dubey, J.P.1
  • 13
    • 24944490057 scopus 로고    scopus 로고
    • The host-parasite relationship in bovine neosporosis
    • Innes E.A., et al. The host-parasite relationship in bovine neosporosis. Vet. Immunol. Immunopathol. 2005, 108:29-36.
    • (2005) Vet. Immunol. Immunopathol. , vol.108 , pp. 29-36
    • Innes, E.A.1
  • 14
    • 18744392538 scopus 로고    scopus 로고
    • Immune responses during pregnancy in heifers naturally infected with Neospora caninum with and without immunization
    • Andrianarivo A.G., et al. Immune responses during pregnancy in heifers naturally infected with Neospora caninum with and without immunization. Parasitol. Res. 2005, 96:24-31.
    • (2005) Parasitol. Res. , vol.96 , pp. 24-31
    • Andrianarivo, A.G.1
  • 15
    • 46249103012 scopus 로고    scopus 로고
    • Upregulation of cytokines is detected in the placentas of cattle infected with Neospora caninum and is more marked early in gestation when fetal death is observed
    • Rosbottom A., et al. Upregulation of cytokines is detected in the placentas of cattle infected with Neospora caninum and is more marked early in gestation when fetal death is observed. Infect. Immun. 2008, 76:2352-2361.
    • (2008) Infect. Immun. , vol.76 , pp. 2352-2361
    • Rosbottom, A.1
  • 16
    • 33847760357 scopus 로고    scopus 로고
    • Immunization of cattle with live tachyzoites of Neospora caninum confers protection against fetal death
    • Williams D.J.L., et al. Immunization of cattle with live tachyzoites of Neospora caninum confers protection against fetal death. Infect. Immun. 2007, 75:1343-1348.
    • (2007) Infect. Immun. , vol.75 , pp. 1343-1348
    • Williams, D.J.L.1
  • 17
    • 0142124303 scopus 로고    scopus 로고
    • First demonstration of protective immunity against foetopathy in cattle with latent Neospora caninum infection
    • Williams D.J.L., et al. First demonstration of protective immunity against foetopathy in cattle with latent Neospora caninum infection. Int. J. Parasitol. 2003, 33:1059-1065.
    • (2003) Int. J. Parasitol. , vol.33 , pp. 1059-1065
    • Williams, D.J.L.1
  • 18
    • 22244476152 scopus 로고    scopus 로고
    • Reduced infection and protection from clinical signs of cerebral neosporosis in C57BL/6 mice vaccinated with recombinant microneme antigen NcMIC1
    • Alaeddine F., et al. Reduced infection and protection from clinical signs of cerebral neosporosis in C57BL/6 mice vaccinated with recombinant microneme antigen NcMIC1. J. Parasitol. 2005, 91:657-665.
    • (2005) J. Parasitol. , vol.91 , pp. 657-665
    • Alaeddine, F.1
  • 19
    • 84865006690 scopus 로고    scopus 로고
    • Maternal and foetal immune responses of cattle following an experimental challenge with Neospora caninum at day 70 of gestation
    • Bartley P.M., et al. Maternal and foetal immune responses of cattle following an experimental challenge with Neospora caninum at day 70 of gestation. Vet. Res. 2012, 43:38.
    • (2012) Vet. Res. , vol.43 , pp. 38
    • Bartley, P.M.1
  • 20
    • 17844367149 scopus 로고    scopus 로고
    • Protective efficacy of vaccination with Neospora caninum multiple recombinant antigens against experimental Neospora caninum infection
    • Cho J-H., et al. Protective efficacy of vaccination with Neospora caninum multiple recombinant antigens against experimental Neospora caninum infection. Korean J. Parasitol. 2005, 43:19-25.
    • (2005) Korean J. Parasitol. , vol.43 , pp. 19-25
    • Cho, J.-H.1
  • 21
    • 77949653962 scopus 로고    scopus 로고
    • Intraperitoneal and intra-nasal vaccination of mice with three distinct recombinant Neospora caninum antigens results in differential effects with regard to protection against experimental challenge with Neospora caninum tachyzoites
    • Debache K., et al. Intraperitoneal and intra-nasal vaccination of mice with three distinct recombinant Neospora caninum antigens results in differential effects with regard to protection against experimental challenge with Neospora caninum tachyzoites. Parasitology 2010, 137:229-240.
    • (2010) Parasitology , vol.137 , pp. 229-240
    • Debache, K.1
  • 22
    • 55049087149 scopus 로고    scopus 로고
    • Evaluation of recombinant proteins of Neospora caninum as vaccine candidates (in a mouse model)
    • Ellis J., et al. Evaluation of recombinant proteins of Neospora caninum as vaccine candidates (in a mouse model). Vaccine 2008, 26:5989-5996.
    • (2008) Vaccine , vol.26 , pp. 5989-5996
    • Ellis, J.1
  • 23
    • 26944480044 scopus 로고    scopus 로고
    • Immunization with native surface protein NcSRS2 induces a Th2 immune response and reduces congenital Neospora caninum transmission in mice
    • Haldorson G.J., et al. Immunization with native surface protein NcSRS2 induces a Th2 immune response and reduces congenital Neospora caninum transmission in mice. Int. J. Parasitol. 2005, 35:1407-1415.
    • (2005) Int. J. Parasitol. , vol.35 , pp. 1407-1415
    • Haldorson, G.J.1
  • 24
    • 34147188155 scopus 로고    scopus 로고
    • Immunogenicity and protective effect against murine cerebral neosporosis of recombinant NcSRS2 in different iscom formulations
    • Pinitkiatisakul S., et al. Immunogenicity and protective effect against murine cerebral neosporosis of recombinant NcSRS2 in different iscom formulations. Vaccine 2007, 25:3658-3668.
    • (2007) Vaccine , vol.25 , pp. 3658-3668
    • Pinitkiatisakul, S.1
  • 25
    • 34548678210 scopus 로고    scopus 로고
    • Prevention of vertical transmission of Neospora caninum in C57BL/6 mice vaccinated with Brucella abortus strain RB51 expressing N-caninum protective antigens
    • Ramamoorthy S., et al. Prevention of vertical transmission of Neospora caninum in C57BL/6 mice vaccinated with Brucella abortus strain RB51 expressing N-caninum protective antigens. Int. J. Parasitol. 2007, 37:1531-1538.
    • (2007) Int. J. Parasitol. , vol.37 , pp. 1531-1538
    • Ramamoorthy, S.1
  • 26
    • 0034973240 scopus 로고    scopus 로고
    • In the absence of endogenous gamma interferon, mice acutely infected with Neospora caninum succumb to a lethal immune response characterized by inactivation of peritoneal macrophages
    • Nishikawa Y., et al. In the absence of endogenous gamma interferon, mice acutely infected with Neospora caninum succumb to a lethal immune response characterized by inactivation of peritoneal macrophages. Clin. Diagn. Lab. Immunol. 2001, 8:811-817.
    • (2001) Clin. Diagn. Lab. Immunol. , vol.8 , pp. 811-817
    • Nishikawa, Y.1
  • 27
    • 15544364760 scopus 로고    scopus 로고
    • Identification of vaccine candidate peptides in the NcSRS2 surface protein of Neospora caninum by using CD4(+) cytotoxic T lymphocytes and gamma interferon-secreting T lymphocytes of infected Holstein cattle
    • Staska L.M., et al. Identification of vaccine candidate peptides in the NcSRS2 surface protein of Neospora caninum by using CD4(+) cytotoxic T lymphocytes and gamma interferon-secreting T lymphocytes of infected Holstein cattle. Infect. Immun. 2005, 73:1321-1329.
    • (2005) Infect. Immun. , vol.73 , pp. 1321-1329
    • Staska, L.M.1
  • 28
    • 84891893462 scopus 로고    scopus 로고
    • Protective effect of intranasal immunization with Neospora caninum membrane antigens against murine neosporosis established through the gastrointestinal tract
    • Ferreirinha P., et al. Protective effect of intranasal immunization with Neospora caninum membrane antigens against murine neosporosis established through the gastrointestinal tract. Immunology 2014, 141:256-267.
    • (2014) Immunology , vol.141 , pp. 256-267
    • Ferreirinha, P.1
  • 29
    • 32644484729 scopus 로고    scopus 로고
    • Neospora caninum: antibodies directed against tachyzoite surface protein NcSRS2 inhibit parasite attachment and invasion of placental trophoblasts in vitro
    • Haldorson G.J., et al. Neospora caninum: antibodies directed against tachyzoite surface protein NcSRS2 inhibit parasite attachment and invasion of placental trophoblasts in vitro. Exp. Parasitol. 2006, 112:172-178.
    • (2006) Exp. Parasitol. , vol.112 , pp. 172-178
    • Haldorson, G.J.1
  • 30
    • 16644362016 scopus 로고    scopus 로고
    • Monoclonal antibodies preventing invasion of Neospora caninum tachyzoites into host cells
    • Uchida Y., et al. Monoclonal antibodies preventing invasion of Neospora caninum tachyzoites into host cells. J. Vet. Med. Sci. 2004, 66:1355-1358.
    • (2004) J. Vet. Med. Sci. , vol.66 , pp. 1355-1358
    • Uchida, Y.1
  • 31
    • 33845968518 scopus 로고    scopus 로고
    • Apical membrane antigen 1 is a cross-reactive antigen between Neospora caninum and Toxoplasma gondii, and the anti-NcAMA1 antibody inhibits host cell invasion by both parasites
    • Zhang H., et al. Apical membrane antigen 1 is a cross-reactive antigen between Neospora caninum and Toxoplasma gondii, and the anti-NcAMA1 antibody inhibits host cell invasion by both parasites. Mol. Biochem. Parasitol. 2007, 151:205-212.
    • (2007) Mol. Biochem. Parasitol. , vol.151 , pp. 205-212
    • Zhang, H.1
  • 32
    • 84870596055 scopus 로고    scopus 로고
    • Evaluating high-throughput ab initio gene finders to discover proteins encoded in eukaryotic pathogen genomes missed by laboratory techniques
    • Goodswen S.J., et al. Evaluating high-throughput ab initio gene finders to discover proteins encoded in eukaryotic pathogen genomes missed by laboratory techniques. PLoS ONE 2012, 7:e50609.
    • (2012) PLoS ONE , vol.7
    • Goodswen, S.J.1
  • 33
    • 67349281966 scopus 로고    scopus 로고
    • Genome-based approaches to develop vaccines against bacterial pathogens
    • Serruto D., et al. Genome-based approaches to develop vaccines against bacterial pathogens. Vaccine 2009, 27:3245-3250.
    • (2009) Vaccine , vol.27 , pp. 3245-3250
    • Serruto, D.1
  • 34
    • 0035925596 scopus 로고    scopus 로고
    • Reverse vaccinology, a genome-based approach to vaccine development
    • Rappuoli R. Reverse vaccinology, a genome-based approach to vaccine development. Vaccine 2001, 19:2688-2691.
    • (2001) Vaccine , vol.19 , pp. 2688-2691
    • Rappuoli, R.1
  • 35
    • 70349214860 scopus 로고    scopus 로고
    • Vaccinology in the genome era
    • Rinaudo C.D., et al. Vaccinology in the genome era. J. Clin. Invest. 2009, 119:2515-2525.
    • (2009) J. Clin. Invest. , vol.119 , pp. 2515-2525
    • Rinaudo, C.D.1
  • 36
    • 0036893688 scopus 로고    scopus 로고
    • Search for potential vaccine candidate open reading frames in the Bacillus anthracis virulence plasmid pXO1: in silico and in vitro screening
    • Ariel N., et al. Search for potential vaccine candidate open reading frames in the Bacillus anthracis virulence plasmid pXO1: in silico and in vitro screening. Infect. Immun. 2002, 70:6817-6827.
    • (2002) Infect. Immun. , vol.70 , pp. 6817-6827
    • Ariel, N.1
  • 37
    • 0036139286 scopus 로고    scopus 로고
    • Genomic approach for analysis of surface proteins in Chlamydia pneumoniae
    • Montigiani S., et al. Genomic approach for analysis of surface proteins in Chlamydia pneumoniae. Infect. Immun. 2002, 70:368-379.
    • (2002) Infect. Immun. , vol.70 , pp. 368-379
    • Montigiani, S.1
  • 38
    • 0035919532 scopus 로고    scopus 로고
    • Identification of vaccine candidate antigens from a genomic analysis of Porphyromonas gingivalis
    • Ross B.C., et al. Identification of vaccine candidate antigens from a genomic analysis of Porphyromonas gingivalis. Vaccine 2001, 19:4135-4142.
    • (2001) Vaccine , vol.19 , pp. 4135-4142
    • Ross, B.C.1
  • 39
    • 33748991877 scopus 로고    scopus 로고
    • Meningococcus B: from genome to vaccine
    • John Wiley & Sons Ltd, G. Grandi (Ed.)
    • Serruto D., et al. Meningococcus B: from genome to vaccine. Genomics, Proteomics and Vaccines 2004, 185-204. John Wiley & Sons Ltd. G. Grandi (Ed.).
    • (2004) Genomics, Proteomics and Vaccines , pp. 185-204
    • Serruto, D.1
  • 40
    • 0035114563 scopus 로고    scopus 로고
    • Use of a whole genome approach to identify vaccine molecules affording protection against Streptococcus pneumoniae infection
    • Wizemann T.M., et al. Use of a whole genome approach to identify vaccine molecules affording protection against Streptococcus pneumoniae infection. Infect. Immun. 2001, 69:1593-1598.
    • (2001) Infect. Immun. , vol.69 , pp. 1593-1598
    • Wizemann, T.M.1
  • 41
    • 84863408501 scopus 로고    scopus 로고
    • Reverse vaccinology on the cusp
    • Jones D. Reverse vaccinology on the cusp. Nat. Rev. Drug Discov. 2012, 11:175-176.
    • (2012) Nat. Rev. Drug Discov. , vol.11 , pp. 175-176
    • Jones, D.1
  • 42
    • 84874252669 scopus 로고    scopus 로고
    • Infection and treatment immunizations for successful parasite vaccines
    • Mutapi F., et al. Infection and treatment immunizations for successful parasite vaccines. Trends Parasitol. 2013, 29:135-141.
    • (2013) Trends Parasitol. , vol.29 , pp. 135-141
    • Mutapi, F.1
  • 43
    • 84887669298 scopus 로고    scopus 로고
    • A guide to in silico vaccine discovery for eukaryotic pathogens
    • Goodswen S.J., et al. A guide to in silico vaccine discovery for eukaryotic pathogens. Brief. Bioinform. 2013, 14:753-774.
    • (2013) Brief. Bioinform. , vol.14 , pp. 753-774
    • Goodswen, S.J.1
  • 44
    • 42949139524 scopus 로고    scopus 로고
    • A systematic assessment of MHC class II peptide binding predictions and evaluation of a consensus approach
    • Wang P., et al. A systematic assessment of MHC class II peptide binding predictions and evaluation of a consensus approach. PLoS Comput. Biol. 2008, 4:e1000048.
    • (2008) PLoS Comput. Biol. , vol.4
    • Wang, P.1
  • 45
    • 78149352601 scopus 로고    scopus 로고
    • State of the art and challenges in sequence based T-cell epitope prediction
    • Lundegaard C., et al. State of the art and challenges in sequence based T-cell epitope prediction. Immunome Res. 2010, 6(Suppl. 2):S3.
    • (2010) Immunome Res. , vol.6 , Issue.SUPPL. 2
    • Lundegaard, C.1
  • 46
    • 21344466799 scopus 로고    scopus 로고
    • Automated generation and evaluation of specific MHC binding predictive tools: ARB matrix applications
    • Bui H-H., et al. Automated generation and evaluation of specific MHC binding predictive tools: ARB matrix applications. Immunogenetics 2005, 57:304-314.
    • (2005) Immunogenetics , vol.57 , pp. 304-314
    • Bui, H.-H.1
  • 47
    • 47249105168 scopus 로고    scopus 로고
    • Association of BLV infection profiles with alleles of the BoLA-DRB3.2 gene
    • Juliarena M.A., et al. Association of BLV infection profiles with alleles of the BoLA-DRB3.2 gene. Anim. Genet. 2008, 39:432-438.
    • (2008) Anim. Genet. , vol.39 , pp. 432-438
    • Juliarena, M.A.1
  • 48
    • 34547180254 scopus 로고    scopus 로고
    • Study on the association of BoLA-DRB3.2 alleles with clinical mastitis in Norwegian Red cows
    • Kulberg S., et al. Study on the association of BoLA-DRB3.2 alleles with clinical mastitis in Norwegian Red cows. J. Anim. Breed. Genet. 2007, 124:201-207.
    • (2007) J. Anim. Breed. Genet. , vol.124 , pp. 201-207
    • Kulberg, S.1
  • 49
    • 84876532090 scopus 로고    scopus 로고
    • IPD: the Immuno Polymorphism Database
    • Robinson J., et al. IPD: the Immuno Polymorphism Database. Nucleic Acids Res. 2013, 41:D1234-D1240.
    • (2013) Nucleic Acids Res. , vol.41
    • Robinson, J.1
  • 50
    • 0034234611 scopus 로고    scopus 로고
    • Duplicated DQ haplotypes increase the complexity of restriction element usage in cattle
    • Glass E.J., et al. Duplicated DQ haplotypes increase the complexity of restriction element usage in cattle. J. Immunol. 2000, 165:134-138.
    • (2000) J. Immunol. , vol.165 , pp. 134-138
    • Glass, E.J.1
  • 51
    • 78650804427 scopus 로고    scopus 로고
    • The diversity of bovine MHC class II DRB3 and DQA1 alleles in different herds of Japanese Black and Holstein cattle in Japan
    • Miyasaka T., et al. The diversity of bovine MHC class II DRB3 and DQA1 alleles in different herds of Japanese Black and Holstein cattle in Japan. Gene 2011, 472:42-49.
    • (2011) Gene , vol.472 , pp. 42-49
    • Miyasaka, T.1
  • 52
    • 55949095313 scopus 로고    scopus 로고
    • Evidence for cattle major histocompatibility complex (BoLA) class II DQA1 gene heterozygote advantage against clinical mastitis caused by Streptococci and Escherichia species
    • Takeshima S., et al. Evidence for cattle major histocompatibility complex (BoLA) class II DQA1 gene heterozygote advantage against clinical mastitis caused by Streptococci and Escherichia species. Tissue Antigens 2008, 72:525-531.
    • (2008) Tissue Antigens , vol.72 , pp. 525-531
    • Takeshima, S.1
  • 53
    • 70349481982 scopus 로고    scopus 로고
    • Association of BoLA DRB3 and DQA1 alleles with susceptibly to Neospora caninum and reproductive outcome in Quebec Holstein cattle
    • Schwab A.E., et al. Association of BoLA DRB3 and DQA1 alleles with susceptibly to Neospora caninum and reproductive outcome in Quebec Holstein cattle. Vet. Parasitol. 2009, 165:136-140.
    • (2009) Vet. Parasitol. , vol.165 , pp. 136-140
    • Schwab, A.E.1
  • 54
    • 84861207409 scopus 로고    scopus 로고
    • Comparative genomics of the apicomplexan parasites Toxoplasma gondii and Neospora caninum: coccidia differing in host range and transmission strategy
    • Reid A.J., et al. Comparative genomics of the apicomplexan parasites Toxoplasma gondii and Neospora caninum: coccidia differing in host range and transmission strategy. PLoS Pathog. 2012, 8:e1002567.
    • (2012) PLoS Pathog. , vol.8
    • Reid, A.J.1
  • 55
    • 34248210832 scopus 로고    scopus 로고
    • Epidemiology and control of neosporosis and Neospora caninum
    • Dubey J.P., et al. Epidemiology and control of neosporosis and Neospora caninum. Clin. Microbiol. Rev. 2007, 20:323.
    • (2007) Clin. Microbiol. Rev. , vol.20 , pp. 323
    • Dubey, J.P.1
  • 57
    • 78149354807 scopus 로고    scopus 로고
    • NetMHCIIpan-2.0: improved pan-specific HLA-DR predictions using a novel concurrent alignment and weight optimization training procedure
    • Nielsen M., et al. NetMHCIIpan-2.0: improved pan-specific HLA-DR predictions using a novel concurrent alignment and weight optimization training procedure. Immunome Res. 2010, 6:9.
    • (2010) Immunome Res. , vol.6 , pp. 9
    • Nielsen, M.1
  • 58
    • 84876426871 scopus 로고    scopus 로고
    • Conformational B-cell epitope prediction on antigen protein structures: a review of current algorithms and comparison with common binding site prediction methods
    • Yao B., et al. Conformational B-cell epitope prediction on antigen protein structures: a review of current algorithms and comparison with common binding site prediction methods. PLoS ONE 2013, 8:e62249.
    • (2013) PLoS ONE , vol.8
    • Yao, B.1
  • 59
    • 64049090391 scopus 로고    scopus 로고
    • An introduction to epitope prediction methods and software
    • Yang X., Yu X. An introduction to epitope prediction methods and software. Rev. Med. Virol. 2009, 19:77-96.
    • (2009) Rev. Med. Virol. , vol.19 , pp. 77-96
    • Yang, X.1    Yu, X.2
  • 60
    • 78149293634 scopus 로고    scopus 로고
    • Recent advances in B-cell epitope prediction methods
    • EL-Manzalawy Y., Honavar V. Recent advances in B-cell epitope prediction methods. Immunome Res. 2010, 6:S2.
    • (2010) Immunome Res. , vol.6
    • EL-Manzalawy, Y.1    Honavar, V.2
  • 61
    • 77954543849 scopus 로고    scopus 로고
    • EPSVR and EPMeta: prediction of antigenic epitopes using support vector regression and multiple server results
    • Liang S., et al. EPSVR and EPMeta: prediction of antigenic epitopes using support vector regression and multiple server results. BMC Bioinformatics 2010, 11:381.
    • (2010) BMC Bioinformatics , vol.11 , pp. 381
    • Liang, S.1
  • 62
    • 78149297469 scopus 로고    scopus 로고
    • Computer aided selection of candidate vaccine antigens
    • Flower D.R., et al. Computer aided selection of candidate vaccine antigens. Immunome Res. 2010, 6(Suppl. 2):S1.
    • (2010) Immunome Res. , vol.6 , Issue.SUPPL. 2
    • Flower, D.R.1
  • 64
    • 33748681096 scopus 로고    scopus 로고
    • Microbial genomes and vaccine design: refinements to the classical reverse vaccinology approach
    • Mora M., et al. Microbial genomes and vaccine design: refinements to the classical reverse vaccinology approach. Curr. Opin. Microbiol. 2006, 9:532-536.
    • (2006) Curr. Opin. Microbiol. , vol.9 , pp. 532-536
    • Mora, M.1
  • 65
    • 84890694181 scopus 로고    scopus 로고
    • Reverse vaccinology: revolutionizing the approach to vaccine design
    • Wiley-VCH Verlag GmbH & Co, J. Hacker, U. Dobrindt (Eds.)
    • Serino L., et al. Reverse vaccinology: revolutionizing the approach to vaccine design. Pathogenomics 2006, 533-554. Wiley-VCH Verlag GmbH & Co. J. Hacker, U. Dobrindt (Eds.).
    • (2006) Pathogenomics , pp. 533-554
    • Serino, L.1
  • 66
    • 40849147099 scopus 로고    scopus 로고
    • Computer-aided biotechnology: from immuno-informatics to reverse vaccinology
    • Vivona S., et al. Computer-aided biotechnology: from immuno-informatics to reverse vaccinology. Trends Biotechnol. 2008, 26:190-200.
    • (2008) Trends Biotechnol. , vol.26 , pp. 190-200
    • Vivona, S.1
  • 67
    • 84886737285 scopus 로고    scopus 로고
    • A novel strategy for classifying the output from an in silico vaccine discovery pipeline for eukaryotic pathogens using machine learning algorithms
    • Goodswen S., et al. A novel strategy for classifying the output from an in silico vaccine discovery pipeline for eukaryotic pathogens using machine learning algorithms. BMC Bioinformatics 2013, 14:315.
    • (2013) BMC Bioinformatics , vol.14 , pp. 315
    • Goodswen, S.1
  • 68
    • 77958471315 scopus 로고    scopus 로고
    • Systems vaccinology
    • Pulendran B., et al. Systems vaccinology. Immunity 2010, 33:516-529.
    • (2010) Immunity , vol.33 , pp. 516-529
    • Pulendran, B.1
  • 69
    • 70349451542 scopus 로고    scopus 로고
    • Learning immunology from the yellow fever vaccine: innate immunity to systems vaccinology
    • Pulendran B. Learning immunology from the yellow fever vaccine: innate immunity to systems vaccinology. Nat. Rev. Immunol. 2009, 9:741-747.
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 741-747
    • Pulendran, B.1
  • 70
    • 84896446035 scopus 로고    scopus 로고
    • Protective immunity against lethal F. tularensis holarctica LVS provided by vaccination with selected novel CD8(+) T cell epitopes
    • Rotem S., et al. Protective immunity against lethal F. tularensis holarctica LVS provided by vaccination with selected novel CD8(+) T cell epitopes. PLoS ONE 2014, 9:e85215.
    • (2014) PLoS ONE , vol.9
    • Rotem, S.1
  • 71
    • 79956322512 scopus 로고    scopus 로고
    • Whole-genome immunoinformatic analysis of F. tularensis: predicted CTL epitopes clustered in hotspots are prone to elicit a T-cell response
    • Zvi A., et al. Whole-genome immunoinformatic analysis of F. tularensis: predicted CTL epitopes clustered in hotspots are prone to elicit a T-cell response. PLoS ONE 2011, 6:e20050.
    • (2011) PLoS ONE , vol.6
    • Zvi, A.1
  • 72
    • 80051671207 scopus 로고    scopus 로고
    • Vaccines for leishmaniasis: from proteome to vaccine candidates
    • Schroeder J., Aebischer T. Vaccines for leishmaniasis: from proteome to vaccine candidates. Hum. Vaccin. 2011, 7:10-15.
    • (2011) Hum. Vaccin. , vol.7 , pp. 10-15
    • Schroeder, J.1    Aebischer, T.2
  • 73
    • 77955360252 scopus 로고    scopus 로고
    • Vaxign: the first web-based vaccine design program for reverse vaccinology and applications for vaccine development
    • He Y., et al. Vaxign: the first web-based vaccine design program for reverse vaccinology and applications for vaccine development. J. Biomed. Biotechnol. 2010, 10.1155/2010/297505.
    • (2010) J. Biomed. Biotechnol.
    • He, Y.1
  • 74
    • 33749035486 scopus 로고    scopus 로고
    • NERVE: New Enhanced Reverse Vaccinology Environment
    • Vivona S., et al. NERVE: New Enhanced Reverse Vaccinology Environment. BMC Biotechnol. 2006, 6:35.
    • (2006) BMC Biotechnol. , vol.6 , pp. 35
    • Vivona, S.1
  • 75
    • 84904732727 scopus 로고    scopus 로고
    • Vacceed: a high-throughput in silico vaccine candidate discovery pipeline for eukaryotic pathogens based on reverse vaccinology
    • Goodswen S.J., et al. Vacceed: a high-throughput in silico vaccine candidate discovery pipeline for eukaryotic pathogens based on reverse vaccinology. Bioinformatics 2014, 10.1093/bioinformatics/btu300.
    • (2014) Bioinformatics
    • Goodswen, S.J.1
  • 76
    • 79957627493 scopus 로고    scopus 로고
    • A 2020 vision for vaccines against HIV, tuberculosis and malaria
    • Rappuoli R., Aderem A. A 2020 vision for vaccines against HIV, tuberculosis and malaria. Nature 2011, 473:463-469.
    • (2011) Nature , vol.473 , pp. 463-469
    • Rappuoli, R.1    Aderem, A.2
  • 77
    • 84878194846 scopus 로고    scopus 로고
    • Reverse vaccinology in the 21st century: improvements over the original design
    • Donati C., Rappuoli R. Reverse vaccinology in the 21st century: improvements over the original design. Year Immunol. 2013, 1285:115-132.
    • (2013) Year Immunol. , vol.1285 , pp. 115-132
    • Donati, C.1    Rappuoli, R.2
  • 78
    • 55549114992 scopus 로고    scopus 로고
    • Structure-based antigen design: a strategy for next generation vaccines
    • Dormitzer P.R., et al. Structure-based antigen design: a strategy for next generation vaccines. Trends Biotechnol. 2008, 26:659-667.
    • (2008) Trends Biotechnol. , vol.26 , pp. 659-667
    • Dormitzer, P.R.1
  • 79
    • 84904736092 scopus 로고    scopus 로고
    • Successful vaccines for naturally occurring protozoal diseases of animals should guide human vaccine research. A review of protozoal vaccines and their designs
    • McAllister M.M. Successful vaccines for naturally occurring protozoal diseases of animals should guide human vaccine research. A review of protozoal vaccines and their designs. Parasitology 2014, 141:624-640.
    • (2014) Parasitology , vol.141 , pp. 624-640
    • McAllister, M.M.1
  • 80
    • 34548035780 scopus 로고    scopus 로고
    • Design and development of synthetic peptide vaccines: past, present and future
    • Bijker M.S., et al. Design and development of synthetic peptide vaccines: past, present and future. Expert Rev. Vaccines 2007, 6:591-603.
    • (2007) Expert Rev. Vaccines , vol.6 , pp. 591-603
    • Bijker, M.S.1
  • 81
    • 77956357957 scopus 로고    scopus 로고
    • Computational immunology meets bioinformatics: the use of prediction tools for molecular binding in the simulation of the immune system
    • Rapin N., et al. Computational immunology meets bioinformatics: the use of prediction tools for molecular binding in the simulation of the immune system. PLoS ONE 2010, 5:e9862.
    • (2010) PLoS ONE , vol.5
    • Rapin, N.1
  • 82
    • 38049136890 scopus 로고    scopus 로고
    • The basic immune simulator: an agent-based model to study the interactions between innate and adaptive immunity
    • Folcik V.A., et al. The basic immune simulator: an agent-based model to study the interactions between innate and adaptive immunity. Theor. Biol. Med. Model. 2007, 4:39.
    • (2007) Theor. Biol. Med. Model. , vol.4 , pp. 39
    • Folcik, V.A.1
  • 83
    • 33646448179 scopus 로고    scopus 로고
    • Computational modelling and simulation of the immune system
    • Kalita J.K., et al. Computational modelling and simulation of the immune system. Int. J. Bioinform. Res. Appl. 2006, 2:63-88.
    • (2006) Int. J. Bioinform. Res. Appl. , vol.2 , pp. 63-88
    • Kalita, J.K.1
  • 84
    • 58149216348 scopus 로고    scopus 로고
    • New horizons in adjuvants for vaccine development
    • Reed S.G., et al. New horizons in adjuvants for vaccine development. Trends Immunol. 2009, 30:23-32.
    • (2009) Trends Immunol. , vol.30 , pp. 23-32
    • Reed, S.G.1
  • 85
    • 0036862091 scopus 로고    scopus 로고
    • Immune responses to Neospora caninum and prospects for vaccination
    • Innes E.A., et al. Immune responses to Neospora caninum and prospects for vaccination. Trends Parasitol. 2002, 18:497-504.
    • (2002) Trends Parasitol. , vol.18 , pp. 497-504
    • Innes, E.A.1
  • 86
    • 78049288264 scopus 로고    scopus 로고
    • Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns
    • Bachmann M.F., Jennings G.T. Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns. Nat. Rev. Immunol. 2010, 10:787-796.
    • (2010) Nat. Rev. Immunol. , vol.10 , pp. 787-796
    • Bachmann, M.F.1    Jennings, G.T.2
  • 87
    • 77958498224 scopus 로고    scopus 로고
    • Vaccine adjuvants: putting innate immunity to work
    • Coffman R.L., et al. Vaccine adjuvants: putting innate immunity to work. Immunity 2010, 33:492-503.
    • (2010) Immunity , vol.33 , pp. 492-503
    • Coffman, R.L.1
  • 88
    • 78649326737 scopus 로고    scopus 로고
    • Recognition by toll-like receptor 2 induces antigen-presenting cell activation and Th1 programming during infection by Neospora caninum
    • Mineo T.W.P., et al. Recognition by toll-like receptor 2 induces antigen-presenting cell activation and Th1 programming during infection by Neospora caninum. Immunol. Cell Biol. 2010, 88:825-833.
    • (2010) Immunol. Cell Biol. , vol.88 , pp. 825-833
    • Mineo, T.W.P.1
  • 89
    • 78650573649 scopus 로고    scopus 로고
    • DNA vaccines: an historical perspective and view to the future
    • Liu M.A. DNA vaccines: an historical perspective and view to the future. Immunol. Rev. 2011, 239:62-84.
    • (2011) Immunol. Rev. , vol.239 , pp. 62-84
    • Liu, M.A.1
  • 90
    • 67849119414 scopus 로고    scopus 로고
    • A paradigm for peptide vaccine delivery using viral epitopes encapsulated in degradable polymer hydrogel capsules
    • Chong S.F., et al. A paradigm for peptide vaccine delivery using viral epitopes encapsulated in degradable polymer hydrogel capsules. Biomaterials 2009, 30:5178-5186.
    • (2009) Biomaterials , vol.30 , pp. 5178-5186
    • Chong, S.F.1
  • 91
    • 77955557497 scopus 로고    scopus 로고
    • Bacterial ghosts (BGs)-Advanced antigen and drug delivery system
    • Kudela P., et al. Bacterial ghosts (BGs)-Advanced antigen and drug delivery system. Vaccine 2010, 28:5760-5767.
    • (2010) Vaccine , vol.28 , pp. 5760-5767
    • Kudela, P.1


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