Evaluating the treatment of a synthetic wastewater containing a pharmaceutical and personal care product chemical cocktail: Compound removal efficiency and effects on juvenile rainbow trout

Water Research

Volumn 62, Issue , 2014, Pages 271-280

  Osachoff, Heather L ^a,b   Mohammadali, Mehrnoush ^c   Skirrow, Rachel C ^b   Hall, Eric R ^c   Brown, Lorraine L Y ^b   van Aggelen, Graham C ^b   Kennedy, Christopher J ^a   Helbing, Caren C ^d  

^a SIMON FRASER UNIVERSITY   (Canada)

^b ENVIRONMENT CANADA   (Canada)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d UNIVERSITY OF VICTORIA   (Canada)

Author keywords

Conventional activated sludge; Oncorhynchus mykiss; Synthetic wastewater; Vitellogenin protein

Indexed keywords

ACTIVATED SLUDGE PROCESS; DRUG PRODUCTS; EFFICIENCY; EFFLUENTS; FISH; GENE EXPRESSION; INDICATORS (CHEMICAL); INTEGRATED CIRCUITS; METHANOL; ORGANIC CHEMICALS; ORGANIC SOLVENTS; SEWAGE TREATMENT PLANTS; THIN FILMS; WASTEWATER TREATMENT;

CONVENTIONAL ACTIVATED SLUDGE TREATMENTS; CONVENTIONAL ACTIVATED SLUDGES; EXPOSED TO; ONCORHYNCHUS MYKISS; PHARMACEUTICAL AND PERSONAL CARE PRODUCTS; PLASMA VITELLOGENIN; SEWAGE-TREATMENT PLANTS; SYNTHETIC WASTEWATER; VITELLOGENIN; VITELLOGENIN PROTEIN;

PROTEINS;

4 NONYLPHENOL; ACYL COENZYME A OXIDASE; ACYL COENZYME A OXIDASE 1; AROMATASE; CAFFEINE; CHEMICAL COMPOUND; CYTOCHROME P450 19B; ENVELOPE PROTEIN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR ALPHA1; ESTROGEN RECEPTOR ALPHA2; ESTRONE; ETHINYLESTRADIOL; HIGH DENSITY LIPOPROTEIN; HIGH DENSITY LIPOPROTEIN BINDING PROTEIN; IBUPROFEN; MESSENGER RNA; METHANOL; NAPROXEN; PHARMACEUTICAL AND PERSONAL CARE PRODUCT; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; SOMATOMEDIN C; TATA BINDING PROTEIN; THIOREDOXIN; TONALIDE; TRICLOCARBAN; TRICLOSAN; UNCLASSIFIED DRUG; VITELLINE ENVELOPE PROTEIN ALPHA; VITELLOGENIN; DOMESTIC CHEMICAL; DRUG; WASTE WATER; WATER POLLUTANT;

ACTIVATED SLUDGE; AQUATIC ORGANISM; BIODEGRADATION; DRUG; EFFLUENT; GENE EXPRESSION; JUVENILE; METHANOL; ORGANIC COMPOUND; POLLUTANT REMOVAL; PROTEIN; SALMONID; SEWAGE TREATMENT; WASTEWATER;

ACTIVATED SLUDGE; ANIMAL EXPERIMENT; AQUATIC SPECIES; ARTICLE; CHEMICAL ANALYSIS; CONTROLLED STUDY; EFFLUENT; FEMALE; GENE EXPRESSION; JUVENILE; MALE; NONHUMAN; PRIORITY JOURNAL; PRODUCTIVITY; PROTEIN BLOOD LEVEL; RAINBOW TROUT; REDUCTION; SEWAGE TREATMENT PLANT; SYNTHETIC WASTEWATER; WASTE WATER; WASTE WATER MANAGEMENT; ANIMAL; CHEMISTRY; DRUG EFFECTS; ENVIRONMENTAL EXPOSURE; EVALUATION STUDY; GENE EXPRESSION REGULATION; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; PROCEDURES; SEWAGE; TOXICITY; WATER MANAGEMENT; WATER POLLUTANT;

ANIMALS; ENVIRONMENTAL EXPOSURE; FEMALE; GENE EXPRESSION REGULATION; HOUSEHOLD PRODUCTS; MALE; ONCORHYNCHUS MYKISS; PHARMACEUTICAL PREPARATIONS; RNA, MESSENGER; VITELLOGENINS; WASTE DISPOSAL, FLUID; WASTE WATER; WATER POLLUTANTS, CHEMICAL; WATER PURIFICATION;

EID: 84904691937     PISSN: 00431354     EISSN: 18792448     Source Type: Journal    
DOI: 10.1016/j.watres.2014.05.057     Document Type: Article

References (71)

1. Afonso L.O., Smith J.L., Ikonomou M.G., Devlin R.H. Y-chromosomal DNA markers for discrimination of chemical substance and effluent effects on sexual differentiation in salmon. Environ. Health Perspect. 2002, 110:881-887.
2. Andersen H., Siegrist H., Halling-Sorensen B., Ternes T.A. Fate of estrogens in a municipal sewage treatment plant. Environ. Sci. Technol. 2003, 37:4021-4026.
3. Anderson P.D., D'Aco V.J., Shanahan P., Chapra S.C., Buzby M.E., Cunningham V.L., DuPlessie B.M., Hayes E.P., Mastrocco F.J., Parke N.J., Rader J.C., Samuelian J.H., Schwab B.W. Screening analysis of human pharmaceutical compounds in U.S. surface waters. Environ. Sci. Technol. 2004, 38:838-849.
4. Arukwe A., Goksoyr A. Eggshell and egg yolk proteins in fish: hepatic proteins for the next generation: oogenetic, population, and evolutionary implications of endocrine disruption. Comp. Hepatol. 2003, 2:4.
5. Arukwe A., Knudsen F.R., Goksoyr A. Fish zona radiata (eggshell) protein: a sensitive biomarker for environmental estrogens. Environ. Health Perspect. 1997, 105:418-422.
6. Barber L.B., Keefe S.H., Brown G.K., Furlong E.T., Gray J.L., Kolpin D.W., Meyer M.T., Sandstrom M.W., Zaugg S.D. Persistence and potential effects of complex organic contaminant mixtures in wastewater-impacted streams. Environ. Sci. Technol. 2013, 47:2177-2188.
7. Barber L.B., Lee K.E., Swackhamer D.L., Schoenfuss H.L. Reproductive responses of male fathead minnows exposed to wastewater treatment plant effluent, effluent treated with XAD8 resin, and an environmentally relevant mixture of alkylphenol compounds. Aquat. Toxicol. 2007, 82:36-46.
8. Basile T., Petrella A., Petrella M., Boghetich G., Petruzzelli V., Colasuonno S., Petruzzelli D. Review of endocrine-disrupting-compound removal technologies in water and wastewater treatment plants: an EU perspective. Ind. Eng. Chem. Res. 2012, 50:8389-8401.
9. Batty J., Lim R. Morphological and reproductive characteristics of male mosquitofish (Gambusia affinis holbrooki) inhabiting sewage-contaminated waters in New South Wales, Australia. Arch. Environ. Contam. Toxicol. 1999, 36:301-307.
10. BC Ministry of Environment BC Ministry of Environment Water Quality Guidelines for Pharmaceutically-active Compounds (PhACs): 17alpha-ethinylestradiol (EE2) 2010, Pages 1-8.
11. Brun G.L., Bernier M., Losier R., Doe K., Jackman P., Lee H. Pharmaceutically active compounds in Atlantic Canadian sewage treatment plant effluents and receiving waters, and potential for environmental effects as measured by acute and chronic aquatic toxicity. Environ. Toxicol. Chem. 2006, 25:2163-2176.
12. Carlson J.C., Anderson J.C., Low J.E., Cardinal P., MacKenzie S.D., Beattie S.A., Challis J.K., Bennett R.J., Meronek S.S., Wilks R.P.A., Buhay W.M., Wong C.S., Hanson M.L. Presence and hazards of nutrients and emerging organic micropollutants from sewage lagoon discharges into Dead Horse Creek, Manitoba, Canada. Sci. Total Environ. 2013, 445-446:64-78.
13. Carnevali O., Tosti L., Speciale C., Peng C., Zhu Y., Maradonna F. DEHP impairs zebrafish reproduction by affecting critical factors in oogenesis. PLoS One 2010, 5:e10201.
14. CCME (Canadian Council of Ministers of the Environment) Canada Wide Strategy for the Management of Municipal Wastewater 2012, (accessed 21.02 13.). http://www.ccme.ca/ourwork/water.html?category_id=81.
15. Celius T., Matthews J.B., Giesy J.P., Zacharewski T.R. Quantification of rainbow trout (Oncorhynchus mykiss) zona radiata and vitellogenin mRNA levels using real-time PCR after invivo treatment with estradiol-17β or α-zearalenol. J. Steroid Biochem Mol. Biol. 2000, 75:109-119.
16. Corcoran J., Winter M.J., Tyler C.R. Pharmaceuticals in the aquatic environment: a critical review of the evidence for health effects in fish. Crit. Rev. Toxicol. 2010, 40:287-304.
17. Corominas L., Acuna V., Ginebreda A., Poch M. Integration of freshwater environmental policies and wastewater treatment plant management. Sci. Total Environ. 2013, 445-446:185-191.
18. Dargnat C., Teil M., Chevreuil M., Blanchard M. Phthalate removal throughout wastewater treatment plant: case study of Marne Aval station (France). Sci. Total Environ. 2009, 407:1235-1244.
19. Environment Canada Biological Test Method: Reference Method for Determining Acute Lethality of Effluents to rainbow Trout Reference Method EPS 1/RM/13 ed 1990, 1-18.
20. Escher B.I., Lawrence M., Macova M., Mueller J.F., Poussade Y., Robillot C., Roux A., Gernjak W. Evaluation of contaminant removal of reverse osmosis and advanced oxidation in full-scale pperation by combining passive sampling with chemical analysis and bioanalytical tools. Environ. Sci. Technol. 2011, 45:5387-5394.
21. Filby A.L., Thorpe K.L., Tyler C.R. Multiple molecular effect pathways of an environmental oestrogen in fish. J. Mol. Endocrinol. 2006, 37:121-134.
22. Filby A.L., Tyler C.R. Molecular characterization of estrogen receptors 1, 2a, and 2b and their tissue and ontogenic expression profiles in fathead minnow (Pimephales promelas). Biol. Reprod. 2005, 73:648-662.
23. Filby A.L., Shears J.A., Drage B.E., Churchley J.H., Tyler C.R. Effects of advanced treatments of wastewater effluents on estrogenic and reproductive health impacts in fish. Environ. Sci. Technol. 2010, 44:4348-4354.
24. Furtula V., Liu J., Chambers P., Osachoff H., Kennedy C., Harkness J. Sewage treatment plants efficiencies in removal of sterols and sterol ratios as indicators of fecal contamination sources. Water Air Soil. Pollut. 2012, 223:1017-1031.
25. Gao P., Ding Y., Li H., Xagoraraki I. Occurrence of pharmaceuticals in a municipal wastewater treatment plant: mass balance and removal processes. Chemosphere 2012, 88:17-24.
26. Gerrity D., Stanford B.D., Trenholm R.A., Snyder S.A. An evaluation of a pilot-scale nonthermal plasma advanced oxidation process for trace organic compound degradation. Water Res. 2010, 44:493-504.
27. Heidler J., Sapkota A., Halden R.U. Partitioning, persistence, and accumulation in digested sludge of the topical antiseptic triclocarban during wastewater treatment. Environ. Sci. Technol. 2006, 40:3634-3639.
28. Ings J.S., Servos M.R., Vijayan M.M. Hepatic transcriptomics and protein expression in rainbow trout exposed to municipal wastewater effluent. Environ. Sci. Technol. 2011, 45:2368-2376.
29. Jeffries K.M., Jackson L.J., Ikonomou M.G., Habibi H.R. Presence of natural and anthropogenic organic contaminants and potential fish health impacts along two river gradients in Alberta, Canada. Environ. Toxicol. Chem. 2010, 29:2379-2387.
30. Jobling S., Nolan M., Tyler C.R., Brighty G., Sumpter J.P. Widespread sexual disruption in wild fish. Environ. Sci. Technol. 1998, 32:2498-2506.
31. Jobling S., Williams R., Johnson A., Taylor A., Gross-Sorokin M., Nolan M., Tyler C.R., van Aerle R., Santos E., Brighty G. Predicted exposures to steroid estrogens in U.K. rivers correlate with widespread sexual disruption in wild fish populations. Environ. Health Perspect. 2006, 114(Suppl. 1):32-39.
32. Johnson A.C., Sumpter J.P. Removal of endocrine-disrupting chemicals in activated sludge treatment works. Environ. Sci. Technol. 2001, 35:4697.
33. Johnson A.C., Aerni H., Gerritsen A., Gibert M., Giger W., Hylland K., Jürgens M., Nakari T., Pickering A., Suter M.J., Svenson A., Wettstein F.E. Comparing steroid estrogen, and nonylphenol content across a range of European sewage plants with different treatment and management practices. Water Res. 2005, 39:47-58.
34. Khanal S.K., Xie B., Thompson M.L., Sung S., Ong S.K., Van Leeuwent J. Fate, transport, and biodegradation of natural estrogens in the environment and engineered systems. Environ. Sci. Technol. 2006, 40:6537-6546.
35. Kidd K.A., Blanchfield P.J., Mills K.H., Palace V.P., Evans R.E., Lazorchak J.M., Flick R.W. Collapse of a fish population after exposure to a synthetic estrogen. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:8897-8901.
36. Kolpin D.W., Furlong E.T., Meyer M.T., Thurman E.M., Zaugg S.D., Barber L.B., Buxton H.T. Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. Streams, 1999-2000: a national reconnaissance. Environ. Sci. Technol. 2002, 36:1202-1211.
37. Larsson D.G.J., Adolfsson-Erici M., Parkkonen J., Pettersson M., Berg A.H., Olsson P.E., Förlin L. Ethinylestradiol - an undesired fish contraceptive?. Aquat. Toxicol. 1999, 45:91-97.
38. Lee K.E., Langer S.K., Barber L.B., Writer J.H., Ferrey M.L., Schoenfuss H.L., Furlong E.T., William T., Foreman G., ReVello R.C., Martinovic D., Woodruff O.P., Keefe S.H., Brown G.K., Taylor H.E., Ferrer I., Thurman E.M. Endocrine active chemicals, pharmaceuticals, and other chemicals of concern in surface water, wastewater-treatment plant effluent, and bed sediment, and biological characteristics in selected streams, Minnesota-design, methods, and data, 2009. U.S. Geol. Surv. Data Ser. 2011, 575:1-54.
39. Legler J., Zeinstra L.M., Schuitemaker F., Lanser P.H., Bogerd J., Brouwer A., Vethaak A.D., de Voogt P., Murk A.J., van der Burg B. Comparison of invivo and invitro reporter gene assays for short-term screening of estrogenic activity. Environ. Sci. Technol. 2002, 36:4410-4415.
40. Liebig M., Moltmann J., Knacker T. Evaluation of measured and predicted environmental concentrations of selected human pharmaceuticals and personal care products. Environ. Sci. Pollut. Res. Int. 2006, 13:110-119.
41. Lishman L., Smyth S.A., Sarafin K., Kleywegt S., Toito J., Peart T., Lee B., Servos M., Beland M., Seto P. Occurrence and reductions of pharmaceuticals and personal care products and estrogens by municipal wastewater treatment plants in Ontario, Canada. Sci. Total Environ. 2006, 367:544-558.
42. Madsen S.S., Skovbølling S., Nielsen C., Korsgaard B. 17-β estradiol and 4-nonylphenol delay smolt development and downstream migration in Atlantic salmon, Salmo salar. Aquat. Toxicol. 2004, 68:109-120.
43. Martel R.R., Botros I.W., Rounseville M.P., Hinton J.P., Staples R.R., Morales D.A., Farmer J.B., Seligmann B.E. Multiplexed screening assay for mRNA combining nuclease protection with luminescent array detection. Assay. Drug. Dev. Technol. 2002, 1:61-71.
44. Marttinen S.K., Kettunen R.H., Sormunen K.M., Rintala J.A. Removal of bis(2-ethylhexyl) phthalate at a sewage treatment plant. Water Res. 2003, 37:1385-1393.
45. Metcalfe C.D., Metcalfe T.L., Kiparissis Y., Koenig B.G., Khan C., Hughes R.J., Croley T.R., March R.E., Potter T. Estrogenic potency of chemicals detected in sewage treatment plant effluents as determined by invivo assays with Japanese medaka (Oryzias latipes). Environ. Toxicol. Chem. 2001, 20:297-308.
46. Metcalfe C.D., Koenig B.G., Bennie D.T., Servos M., Ternes T.A., Hirsch R. Occurrence of neutral and acidic drugs in the effluents of Canadian sewage treatment plants. Environ. Toxicol. Chem. 2003, 22:2872-2880.
47. Metcalfe C.D., Miao X., Koenig B.G., Struger J. Distribution of acidic and neutral drugs in surface waters near sewage treatment plants in the lower Great Lakes, Canada. Environ. Toxicol. Chem. 2003, 22:2881-2889.
48. Omil F., Suárez S., Carballa M., Reif R., Lema J.M. Chapter 16: criteria for designing sewage treatment plants for enhanced removal of organic micropollutants. Environ. Pollut. 2010, 16:283-306. Springer Netherlands.
49. Onesios K., Yu J., Bouwer E. Biodegradation and removal of pharmaceuticals and personal care products in treatment systems: a review. Biodegradation 2009, 20:441-466.
50. Osachoff H.L., Shelley L.K., Furtula V., van Aggelen G.C., Kennedy C.J. Induction and recovery of estrogenic effects following short-term 17β-estradiol exposure in juvenile rainbow trout (Oncorhynchus mykiss). Arch. Environ. Contam. Toxicol. 2013, 65:276-285.
51. Oulton R.L., Kohn T., Cwiertny D.M. Pharmaceuticals and personal care products in effluent matrices: a survey of transformation and removal during wastewater treatment and implications for wastewater management. J. Environ. Monit. 2010, 12:1956-1978.
52. Potera C. Caffeine in wastewater is a tracer for human fecal contamination. Env. Health Persp. 2012, 120:a108-a109.
53. Richardson S.D., Ternes T.A. Water Analysis: emerging contaminants and current issues. Anal. Chem. 2011, 83:4614-4648.
54. Rodgers-Gray T.P., Jobling S., Kelly C., Morris S., Brighty G., Waldock M.J., Sumpter J.P., Tyler C.R. Exposure of juvenile roach (Rutilus rutilus) to treated sewage effluent induces dose-dependent and persistent disruption in gonadal duct development. Environ. Sci. Technol. 2001, 35:462-470.
55. Sabo-Attwood T., Kroll K.J., Denslow N.D. Differential expression of largemouth bass (Micropterus salmoides) estrogen receptor isotypes alpha, beta, and gamma by estradiol. Mol. Cell. Endocrinol. 2004, 218:107-118.
56. Shelley L.K., Osachoff H.L., van Aggelen G.C., Ross P.S., Kennedy C.J. Alteration of immune function endpoints and differential expression of estrogen receptor isoforms in leukocytes from 17β-estradiol exposed rainbow trout (Oncorhynchus mykiss). Gen. Comp. Endocrinol. 2013, 180:24-32.
57. Shelley L.K., Ross P.S., Miller K.M., Kaukinen K.H., Kennedy C.J. Toxicity of atrazine and nonylphenol in juvenile rainbow trout (Oncorhynchus mykiss): effects on general health, disease susceptibility and gene expression. Aquat. Toxicol. 2012, 124-125:217-226.
58. Shrestha S.L., Casey F.X.M., Hakk H., Smith D.J., Padmanabhan G. Fate and transformation of an estrogen conjugate and its metabolites in agricultural soils. Environ. Sci. Technol. 2012, 46:11047-11053.
59. Spengler P., Korner W., Metzger J.W. Substances with estrogenic activity in effluents of sewage treatment plants in southwestern Germany. 1. Chemical analysis. Environ. Toxicol. Chem. 2001, 20:2133-2141.
60. Suárez S., Carballa M., Omil F., Lema J. How are pharmaceutical and personal care products (PPCPs) removed from urban wastewaters?. Rev. Environ. Sci. Biotech. 2008, 7:125-138.
61. Sumpter J.P., Jobling S. Vitellogenesis as a biomarker for estrogenic contamination of the aquatic environment. Environ. Health Perspect. 1995, 103(Suppl. 7):173-178.
62. Sumpter J.P., Johnson A.C. Lessons from endocrine disruption and their application to other issues concerning trace organics in the aquatic environment. Environ. Sci. Technol. 2005, 39:4321-4332.
63. Ternes T.A., Stumpf M., Mueller J., Haberer K., Wilken R.D., Servos M. Behavior and occurrence of estrogens in municipal sewage treatment plants - I. Investigations in Germany, Canada and Brazil. Sci. Total Environ. 1999, 225:81-90.
64. Thomas-Jones E., Thorpe K., Harrison N., Thomas G., Morris C., Hutchinson T., Woodhead S., Tyler C.R. Dynamics of estrogen biomarker responses in rainbow trout exposed to 17beta-estradiol and 17alpha-ethinylestradiol. Environ. Toxicol. Chem. 2003, 22:3001-3008.
65. Thorpe K.L., Benstead R., Hutchinson T.H., Tyler C.R. Associations between altered vitellogenin concentrations and adverse health effects in fathead minnow (Pimephales promelas). Aquat. Toxicol. 2007, 85:176-183.
66. Thorpe K.L., Cummings R.I., Hutchinson T.H., Scholze M., Brighty G., Sumpter J.P., Tyler C.R. Relative potencies and combination effects of steroidal estrogens in fish. Environ. Sci. Technol. 2003, 37:1142-1149.
67. Vajda A.M., Barber L.B., Gray J.L., Lopez E.M., Woodling J.D., Norris D.O. Reproductive disruption in fish downstream from an estrogenic wastewater effluent. Environ. Sci. Technol. 2008, 42:3407-3414.
68. Van den Belt K., Berckmans P., Vangenechten C., Verheyen R., Witters H. Comparative study on the invitro/invivo estrogenic potencies of 17beta-estradiol, estrone, 17alpha-ethynylestradiol and nonylphenol. Aquat. Toxicol. 2004, 66:183-195.
69. Wenger M., Sattler U., Goldschmidt-Clermont E., Segner H. 17Beta-estradiol affects the response of complement components and survival of rainbow trout (Oncorhynchus mykiss) challenged by bacterial infection. Fish. Shellfish Immunol. 2011, 31:90-97.
70. Westerhoff P., Yoon Y., Snyder S., Wert E. Fate of endocrine-disruptor, pharmaceutical, and personal care product chemicals during simulated drinking water treatment processes. Environ. Sci. Technol. 2005, 39:6649-6663.
71. Yang X., Flowers R.C., Weinberg H.S., Singer P.C. Occurrence and removal of pharmaceuticals and personal care products (PPCPs) in an advanced wastewater reclamation plant. Water Res. 2011, 45:5218-5228.