Attenuation of hyperglycemia-mediated oxidative stress by indole-3-carbinol and its metabolite 3, 3′-diindolylmethane in C57BL/6J mice

Journal of Physiology and Biochemistry

Volumn 70, Issue 2, 2014, Pages 525-534

  Jayakumar, Poornima ^a   Pugalendi, Kodukkur Vishwanath ^a   Sankaran, Mirunalini ^a  

^a ANNAMALAI UNIVERSITY   (India)

Author keywords

Antioxidant; Diabetes mellitus; Drug treatment; Free radicals; Glucose

Indexed keywords

3 INDOLEMETHANOL; 3,3' DIINDOLYLMETHANE; ALKADIENE; ALPHA TOCOPHEROL; ASCORBIC ACID; CATALASE; GLUCOSE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HEMOGLOBIN; HEMOGLOBIN A1C; INSULIN; LIPID HYDROPEROXIDE; METFORMIN; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; 3,3'-DIINDOLYLMETHANE; ANTIOXIDANT; GLUCOSE BLOOD LEVEL; INDOLE DERIVATIVE; INDOLE-3-CARBINOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; C57BL 6 MOUSE; CONTROLLED STUDY; DRUG EFFECT; ERYTHROCYTE; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HEART; HYPERGLYCEMIA; KIDNEY; LIPID DIET; LIVER; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE STRESS; ANIMAL; C57BL MOUSE; COMPLICATION; DRUG EFFECTS; METABOLISM;

MUS;

ANIMALS; ANTIOXIDANTS; BLOOD GLUCOSE; CATALASE; GLUTATHIONE PEROXIDASE; HEMOGLOBINS; HYPERGLYCEMIA; INDOLES; MICE; MICE, INBRED C57BL; OXIDATIVE STRESS; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 84904689002     PISSN: 11387548     EISSN: 18778755     Source Type: Journal    
DOI: 10.1007/s13105-014-0332-5     Document Type: Article

References (42)

1. Aggarwal BB, Ichikawa H (2005) Molecular targets and anticancer potential of indole-3-carbinol and its derivatives. Cell Cycle 4:1201-1215 (Pubitemid 41365390)
2. Arnao MB, Sanchez-Bravo J, Acosta M (1996) Indole-3-carbinol as a scavenger of free radicals. Biochem Mol Biol Int 39:1125-1134 (Pubitemid 26306508)
3. Baker H, Frank O, De Angelis B, Feingold S (1980) Plasma tocopherol in man at various times after ingesting free or acetylated tocopherol. Nutr Res 21:531-536 (Pubitemid 10069712)
4. Biesalski HK, Vadivel V (2011) Contribution of phenolic compounds to the antioxidant potential and type II diabetes related enzyme inhibition properties of Pongamia pinnata L. Pierre seeds. Process Biochem 46:1973-1980
5. Blum J, Fridovich I (1985) Inactivation of glutathione peroxidase by superoxide dismutase radical. Arch Biochem Biophys 240:500-508 (Pubitemid 15250062)
6. Bonnefont-Rousselot D, Raji B, Walrand S, Gardes-Albert M, Jore D, Legrand A (2003) An intracellular modulation of free radical production could contribute to the beneficial effects of metformin towards oxidative stress. Metabolism 52:586-589 (Pubitemid 36896285)
7. Burgi W, Briner M, Franken N, Kessler ACH (1988) One step sandwich enzyme immunoassay for insulin using monoclonal antibodies. Clin Biochem 21:311-314
8. Butterfeild JD, Mc Graw CP (1978) Free radical pathology. Stroke 9:443
9. Ceriello A (2000) Oxidative stress and glycemic regulation. Metabolism 49:27-29
10. Chang HP, Wang ML, Hsu CY, Liu ME, Chan MH, Chen YH (2011) Suppression of inflammation-associated factors by indole-3-carbinol in mice fed high-fat diets and in isolated, co-cultured macrophages and adipocytes. Int J Obes 3:1530- 1538
11. Chanwitheesuk A, Teerawutgulrag N, Rakariyatham (2005) Screening of antioxidant activity and antioxidant compounds of some edible plants of Thailand. Food Chem 92:491-497 (Pubitemid 40445509)
12. De Kruif CA, Marsman JW, Venekamp JC, Falke HE, Noordhoek J, Blaauboer BJ, Wortelboer HM (1991) Structure elucidation of acid reaction products of indole-3- carbinol: detection in vivo and enzyme induction in vitro. Chem Biol Interact 80:303-315
13. Drabkin DL, Austin JM (1932) Spectrophotometric constants for common haemoglobin derivatives in human, dog and rabbit blood. J Biol Chem 98:719-733
14. Dunn SE, Leblanc GA (1994) Hypocholesterolemic properties of plant indoles: inhibition of acyl-coa: cholesterol acyltransferase activity and reduction of serum LDL/VLDL cholesterol levels by glucobrassicin derivatives. Biochem Pharmacol 41:359-364
15. Ellman GL (1959) Tissue sulfhydryl groups. Arch Biochem Biophys 82:70-77
16. Evans JL, Goldfine ID, Maddux BA, Grodsky GM (2002) Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr Rev 23:599-622 (Pubitemid 35191625)
17. Geoffrey KM, Joan EK, Adele C, Andre GT (2007) Cruciferous indole-3-carbinol inhibits apolipoprotein B secretion in HepG2 cells1-3. J Nutr 137:2185-2189
18. Gregus Z, Fekete T, Halaszi E, Klaassen CD (1996) Lipoic acid impairs glycine conjugation of benzoic acid and renal excretion of benzoylglycine. Drug Metab Dispos 24:682-688 (Pubitemid 26000773)
19. Habig WH, Pabst MJ, Jakoby WBC (1974) Glutathione-S-transferases: the first enzymatic step in mercapturic acid formation. J Biol Chem 249:7130-7139
20. Jiang ZY, Hunt JV, Wolff SP (1992) Ferrous ion oxidation in the presence of xylenol orange for the detection of lipid hydroperoxides in low density lipoprotein. Anal Biochem 202:384-389
21. Kakkar P, Das B, Viswanathan PN (1984) A modified spectrophotometric assay of superoxide dismutase. Indian J Biochem Biophys 21:130-132 (Pubitemid 15207169)
22. Kesavulu MM, Giri R, Kameswara Rao B, Apparao C (2000) Lipid peroxidation and antioxidant enzyme levels in type 2 diabetics with microvascular complications. Diabetes Metab 26:387-392
23. Kim HW, Kim J, Kim J, Lee S, Choi BR, Han JS, Lee KW, Lee HJ (2014) 3,3′ Diindolylmethane inhibits lipopolysaccharide-induced microglial hyperactivation and attenuates brain inflammation. Toxicol Sci 137:158-167
24. Kim YS, Milner JA (2005) Targets for indole-3-carbinol in cancer prevention. J Nutr Biochem 16:65-73 (Pubitemid 40170355)
25. Lampe JW (1999) Health effects of vegetables and fruit: assessing mechanisms of action in human experimental studies. Am J Clin Nutr 70:475-490
26. Li W, Zhang M, Gu J, Meng ZJ, Zhao LC, Zheng YN, Chen L, Yang GL (2012) Hypoglycemic effect of protopanaxadiol-type ginsenosides and compound K on type 2 diabetes mice induced by high-fat diet combining with streptozotocin via suppression of hepatic gluconeogenesis. Fitoterapia 83:192-198
27. Lowry OH, Roseborough NJ, Farr AL, Randall RJ (1951) Protein measurement with Folin's phenol reagent. J Biol Chem 193:265-275
28. Mark JA, Margaret MM, Richard V, Andreas G, William PS, Marion LW, Donald EM (2004) Physiological modeling of formulated and crystalline 3,3-diindolylmethane pharmacokinetics following oral administration in mice. Drug Metab Dispos 32:632-638
29. Niehaus WG, Samuelsson B (1968) Formation of malondialdehyde from phospholipid arachidonate during microsomal lipid peroxidation. Eur J Biochem 6:126-130
30. Niskanen LK, Salonen JT, Nyssonen K, Uusitupa MIJ (1995) Plasma lipid peroxidation and hyperglycemia: a connection through hyperinsulinaemia? Diabet Med 12:802-808
31. Rao KS, Recknagel RO (1968) Early onset of lipoperoxidation in rat liver after carbon tetrachloride administration. Exp Mol Pathol 9:271-278
32. Roe JH, Kuether CA (1943) The determination of ascorbic acid in whole blood and urine through the 2, 4-dinitrophenylhydrazine derivative of dehydroascorbic acid. J Biol Chem 11:145-164
33. Rogan EG (2006) The natural chemopreventive compound indole-3-carbinol: state of the science. In Vivo 20:221-228
34. Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG (1973) Selenium: biochemical role as a component of glutathione peroxidase. Science 179:588-590
35. Sepkovic DW, Bradlow HL, Bell M (2001) Quantitative determination of 3,3 -diindolylmethane in urine of individuals receiving indole-3-carbinol. Nutr Cancer 41:57-63 (Pubitemid 34666221)
36. Sharpe PC, Liu W-H, Yue KK, McMaster D, Catherwood MA, McGinty AM, Trimble ER (1998) Glucose induced oxidative stress in vascular contractile cells. Diabetes 47:801-809
37. Sinha AK (1972) Colorimetric assay of catalase. Anal Biochem 47:389-394
38. Staub RE, Feng C, Onisko B, Bailey GS, Firestone GL, Bjeldanes LF (2002) Fate of indole-3-carbinol in cultured human breast tumor cells. Chem Res Toxicol 15:101-109 (Pubitemid 34163789)
39. Sudhakar NS, Pattabiraman TN (1981) A new colorimetric method for the estimation of glycosylated haemoglobin. Clin Chim Acta 109:267-274
40. Sundaresan A, Pugalendi KV (2012) Combined effect of ursolic acid and rosiglitazone on redox status in high fat diet induced C57BL/6J mice. J Pharm Res 5:2380-2384
41. Weng J-R, Tsai C-H, Kulp SK, Che C-S (2008) Indole-3-carbinol as a chemopreventive and anti-cancer agent. Cancer Lett 262:153-163
42. Zimmet P (2003) The burden of type 2 diabetes: are we doing enough? Diabetes Metab 29:9-18