V̇O2peak, Myocardial hypertrophy, and myocardial blood flow in endurance-trained men

Medicine and Science in Sports and Exercise

Volumn 46, Issue 8, 2014, Pages 1498-1505

  Laaksonen, Marko S ^a   Heinonen, Ilkka ^b,d   Luotolahti, Matti ^c   Knuuti, Juhani ^b   Kalliokoski, Kari K ^b  

^a MID SWEDEN UNIVERSITY   (Sweden)

^b TURKU PET CENTRE   (Finland)

^c UNIVERSITY OF TURKU   (Finland)

^d UNIVERSITY OF TURKU   (Finland)

Author keywords

Endurance training; Heart; Perfusion; Positron emission tomography

Indexed keywords

ADENOSINE; VASODILATOR AGENT;

ADULT; ANATOMY AND HISTOLOGY; CORONARY ARTERY BLOOD FLOW; DRUG EFFECTS; ECHOCARDIOGRAPHY; ENDURANCE; HEART; HUMAN; MALE; OXYGEN CONSUMPTION; PHYSICAL EDUCATION; PHYSIOLOGY; POSITRON EMISSION TOMOGRAPHY;

ADENOSINE; ADULT; CORONARY CIRCULATION; ECHOCARDIOGRAPHY; HEART; HUMANS; MALE; OXYGEN CONSUMPTION; PHYSICAL EDUCATION AND TRAINING; PHYSICAL ENDURANCE; POSITRON-EMISSION TOMOGRAPHY; VASODILATOR AGENTS;

EID: 84904682956     PISSN: 01959131     EISSN: 15300315     Source Type: Journal    
DOI: 10.1249/MSS.0000000000000264     Document Type: Article

References (47)

1. Barbier J, Lebiller E, Ville N, Rannou-Bekono F, Carre F. Relationships between sports-specific characteristics of athletes heart and maximal oxygen uptake. Eur J Cardiovasc Prev Rehabil. 2006;13(1):115-21.
2. Batterham A, George KP, Whyte G, Sharma S, McKenna W. Scaling cardiac structural data by body dimensions: a review of theory, practise, and problems. Int J Sports Med. 1999; 20(8):495-502.
3. Breisch EA, White FC, Nimmo LE, McKirnan MD, Bloor CM. Exercise-induced cardiac hypertrophy: a correlation of blood flow and microvasculature. J Appl Physiol (1985). 1986;60(4): 1259-67.
4. Camici PG, Crea F. Coronary microvascular dysfunction. N Engl J Med. 2007;356(8):830-40.
5. Chan SY, Brunken RC, Czernin J, et al. Comparison of maximal myocardial blood flow during adenosine infusion with that of intravenous dipyridamole in normal men. J Am Coll Cardiol. 1992;20(4):979-85.
6. Cheng TO. Hypertrophic cardiomyopathy vs athletes heart. Int J Cardiol. 2009;131(2):151-5.
7. Devereux RB, Alonso DR, Lutas EM, et al. Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings. Am J Cardiol. 1986;57(6):450-8.
8. Dewey FE, Rosenthal D, Murphy DJJ, Froelicher VF, Ashley EA. Does size matter? Clinical applications of scaling cardiac size and function for body size. Circulation. 2008;117(17): 2279-87.
9. Dodge JTJ, Brown BG, Bolson EL, Dodge HT. Lumen diameter of normal human coronary arteries. Influence of age, sex, anatomic variation, and left ventricular hypertrophy or dilation. Circulation. 1992;86(1):232-46.
10. Green DJ, Spence A, Rowley N, Thijssen DH, Naylor LH. Vascular adaptations in athletes: is there an Fathletes artery? Exp Physiol. 2012;97(3):295-304.
11. Gwirtz PA, Dodd-o JM, Brandt MA, Jones CE. Augmentation of coronary flow improves myocardial function in exercise. J Cardiovasc Pharmacol. 1990;15(5):752-8.
12. Haskell WL, Sims C, Myll J, Bortz WM, St Goar FG, Alderman EL. Coronary artery size and dilating capacity in ultradistance runners. Circulation. 1993;87(4):1076-82.
13. Heinonen I, Nesterov SV, Liukko K, et al. Myocardial blood flow and adenosine A2A receptor density in endurance athletes and untrained men. J Physiol. 2008;586(Pt 21):5193-202.
14. Hepple RT, Babits TL, Plyley MJ, Goodman JM. Dissociation of peak vascular conductance and V(O2) max among highly trained athletes. J Appl Physiol (1985). 1999;87(4):1368-72.
15. Iida H, Takahashi A, Tamura Y, Ono Y, Lammertsma AA. Myocardial blood flow: comparison of oxygen-15-water bolus injection, slow infusion and oxygen-15-carbon dioxide slow inhalation. J Nucl Med. 1995;36(1):78-85.
16. Ishibashi Y, Zhang J, Duncker DJ, Klassen C, Pavek T, Bache RJ. Coronary hyperperfusion augments myocardial oxygen consumption. Am J Physiol. 1996;271(4 Pt 2):H1384-93.
17. Kalliokoski KK, Nuutila P, Laine H, et al. Myocardial perfusion and perfusion reserve in endurance-trained men. Med Sci Sports Exerc. 2002;34(6):948-53.
18. Kjaer A, Meyer C, Wachtell K, et al. Positron emission tomographic evaluation of regulation of myocardial perfusion in physiological (elite athletes) and pathological (systemic hypertension) left ventricular hypertrophy. Am J Cardiol. 2005; 96(12):1692-8.
19. Knaapen P, Germans T, Camici PG, et al. Determinants of coronary microvascular dysfunction in symptomatic hypertrophic cardiomyopathy. Am J Physiol Heart Circ Physiol. 2008;294(2): H986-93.
20. Kozakova M, de Simone G, Morizzo C, Palombo C. Coronary vasodilator capacity and hypertension-induced increase in left ventricular mass. Hypertension. 2003;41(2):224-9.
21. Krams R, Kofflard MJ, Duncker DJ, et al. Decreased coronary flow reserve in hypertrophic cardiomyopathy is related to remodeling of the coronary microcirculation. Circulation. 1998;97(3): 230-3.
22. Laine H, Raitakari OT, Niinikoski H, et al. Early impairment of coronary flow reserve in young men with borderline hypertension. J Am Coll Cardiol. 1998;32(1):147-53.
23. Laughlin MH. Effects of exercise training on coronary transport capacity. J Appl Physiol (1985). 1985;58(2):468-76.
24. Laughlin MH, Bowles DK, Duncker DJ. The coronary circulation in exercise training. Am J Physiol Heart Circ Physiol. 2012; 302(1):H10-23.
25. Laughlin MH, Overholser KA, Bhatte MJ. Exercise training increases coronary transport reserve in miniature swine. J Appl Physiol (1985). 1989;67(3):1140-9.
26. Laughlin MH, Tomanek RJ. Myocardial capillarity and maximal capillary diffusion capacity in exercise-trained dogs. J Appl Physiol (1985). 1987;63(4):1481-6.
27. Massie BM, Schaefer S, Garcia J, et al. Myocardial highenergy phosphate and substrate metabolism in swine with moderate left ventricular hypertrophy. Circulation. 1995;91(6): 1814-23.
28. Noakes TD. Physiological models to understand exercise fatigue and the adaptations that predict or enhance athletic performance. Scand J Med Sci Sports. 2000;10(3):123-45.
29. Noakes TD. Fatigue is a brain-derived emotion that regulates the exercise behavior to ensure the protection of whole-body homeostasis. Front Physiol. 2012;3(82):82.
30. Noakes TD, St Clair Gibson A. Logical limitations to the catastrophe models of fatigue during exercise in humans. Br J Sports Med. 2004;38(5):648-9.
31. Pelliccia A, Maron BJ, Spataro A, Proschan MA, Spirito P. The upper limit of physiologic cardiac hypertrophy in highly trained elite athletes. N Engl J Med. 1991;324(5):295-301.
32. Radvan J, Choudhury L, Sheridan DJ, Camici PG. Comparison of coronary vasodilator reserve in elite rowing athletes versus hypertrophic cardiomyopathy. Am J Cardiol. 1997;80(12): 1621-3.
33. Reading JL, Goodman JM, Plyley MJ, et al. Vascular conductance and aerobic power in sedentary and active subjects and heart failure patients. J Appl Physiol (1985). 1993;74(2): 567-73.
34. Roberts JR, Wearn JI. Quantitative changes in the capillary muscle relationship in human hearts during normal growth and hypertrophy. Am Heart J. 1941;21:617-33.
35. Rowley NJ, Dawson EA, Hopman MT, et al. Conduit artery and wall remodelling in elite athletes and spinal cord injury. Med Sci Sports Exerc. 2012;44(5):844-9.
36. Scharhag J, Schneider G, Urhausen A, Rochette V, Kramann B, Kindermann W. Athletes heart: right and left ventricular mass and function in male endurance athletes and untrained individuals determined by magnetic resonance imaging. J Am Coll Cardiol. 2002;40(10):1856-63.
37. Schwartzkopff B, Mundhenke M, Strauer BE. Alterations of the architecture of subendocardial arterioles in patients with hypertrophic cardiomyopathy and impaired coronary vasodilator reserve: a possible cause for myocardial ischemia. J Am Coll Cardiol. 1998; 31(5):1089-96.
38. 2O production system for heart and brain studies. J Labelled Compd Rad. 2001;44:S1066-8.
39. Snell PG, Martin WH, Buckey JC, Blomqvist CG. Maximal vascular leg conductance in trained and untrained men. J Appl Physiol (1985). 1987;62(2):606-10.
40. Spence AL, Naylor LH, Carter HH, et al. A prospective randomised longitudinal MRI study of left ventricular adaptation to endurance and resistance exercise training in humans. J Physiol. 2011;589(Pt 22):5443-52.
41. Steding K, Engblom H, Buhre T, et al. Relation between cardiac dimensions and peak oxygen uptake. J Cardiovasc Magn Reson. 2010;12(8):8.
42. Stone HL. Coronary flow, myocardial oxygen consumption, and exercise training in dogs. J Appl Physiol Respir Environ Exerc Physiol. 1980;49(5):759-68.
43. Toraa M, Pouillard F, Merlet P, Friemel F. Cardiac hypertrophy and coronary reserve in endurance athletes [in French]. Can J Appl Physiol. 1999;24(1):87-95.
44. Utomi V, Oxborough D, Whyte GP, et al. Systematic review and meta-analysis of training mode, imaging modality and body size influences on the morphology and function of the male athletes heart. Heart. 2013;99(23):1727-33.
45. White FC, Bloor CM, McKirnan MD, Carroll SM. Exercise training in swine promotes growth of arteriolar bed and capillary angiogenesis in heart. J Appl Physiol (1985). 1998; 85(3):1160-8.
46. White FC, McKirnan MD, Breisch EA, Guth BD, Liu YM, Bloor CM. Adaptation of the left ventricle to exerciseinduced hypertrophy. J Appl Physiol (1985). 1987;62(3): 1097-110.
47. Heiss HW, Barmeyer J, Wink K, et al. Studies on the regulation of myocardial blood flow in man. I.: Training effects on blood flow and metabolism of the healthy heart at rest and during standardized heavy exercise. Basic Res Cardiol. 1976; 71:658-75.