Myocardial blood flow and adenosine A2A receptor density in endurance athletes and untrained men

Journal of Physiology

Volumn 586, Issue 21, 2008, Pages 5193-5202

  Heinonen, Ilkka ^a,b,c   Nesterov, Sergey V ^a,f   Liukko, Kaisa ^a   Kemppainen, Jukka ^b   Någren, Kjell ^a   Luotolahti, Matti ^b   Virsu, Pauliina ^a   Oikonen, Vesa ^a   Nuutila, Pirjo ^a,b   Kujala, Urho M ^c   Kainulainen, Heikki ^c   Boushel, Robert ^d,e   Knuuti, Juhani ^a   Kalliokoski, Kari K ^a  

^a TURKU PET CENTRE   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

^c UNIVERSITY OF JYVÄSKYLÄ   (Finland)

^d Gina Cody School of Engineering and Computer Science   (Canada)

^e UNIVERSITY OF COPENHAGEN   (Denmark)

^f SECHENOV INSTITUTE OF EVOLUTIONARY PHYSIOLOGY AND BIOCHEMISTRY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE A2A RECEPTOR; TRACER;

ADAPTATION; ADULT; ARTICLE; ATHLETE; CARDIOVASCULAR PARAMETERS; CONTROLLED STUDY; ECHOCARDIOGRAPHY; FITNESS; HEART LEFT VENTRICLE MASS; HEART LEFT VENTRICLE SIZE; HEART LEFT VENTRICLE WORK; HEART MUSCLE BLOOD FLOW; HUMAN; HUMAN EXPERIMENT; HYPEREMIA; MALE; MUSCLE EXERCISE; NORMAL HUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RECEPTOR DENSITY; REST; ADENOSINE-INDUCED HYPEREMIA; CORONARY ARTERY DILATATION; CORONARY VASCULAR RESISTANCE; ENDURANCE TRAINING; HEART VENTRICLE WORK;

ADULT; BLOOD FLOW VELOCITY; CORONARY CIRCULATION; EXERCISE; HEART; HUMANS; MALE; PHYSICAL ENDURANCE; RECEPTOR, ADENOSINE A2A;

EID: 55349100125     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2008.158113     Document Type: Article

References (50)

1. 2A adenosine receptor mediates coronary vasodilation. J Pharmacol Exp Ther 284, 1066-1073.
2. Camici PG & Crea F (2007). Coronary microvascular dysfunction. N Engl J Med 356, 830-840.
3. Chan SY, Brunken RC, Czernin J, Porenta G, Kuhle W, Krivokapich J, Phelps ME & Schelbert HR (1992). Comparison of maximal myocardial blood flow during adenosine infusion with that of intravenous dipyridamole in normal men. J Am Coll Cardiol 20, 979-985.
4. Dodge JT Jr, Brown BG, Bolson EL & Dodge HT (1992). Lumen diameter of normal human coronary arteries. Influence of age, sex, anatomic variation, and left ventricular hypertrophy or dilation. Circulation 86, 232-246.
5. Duncker DJ & Bache RJ (2008). Regulation of coronary blood flow during exercise. Physiol Rev 88, 1009-1086.
6. Edlund A & Sollevi A (1995). Theophylline increases coronary vascular tone in humans: Evidence for a role of endogenous adenosine in flow regulation. Acta Physiol Scand 155, 303-311.
7. Feigl EO (1983). Coronary physiology. Physiol Rev 63, 1-205.
8. Hannukainen JC, Janatuinen T, Toikka JO, Jarvisalo MJ, Heinonen OJ, Kapanen J, Nagren K, Nuutila P, Kujala UM, Kaprio J, Knuuti J & Kalliokoski KK (2007). Myocardial and peripheral vascular functional adaptation to exercise training. Scand J Med Sports 17, 139-147.
9. 2A receptors mediate coronary microvascular dilation to adenosine: Role of nitric oxide and ATP-sensitive potassium channels. J Pharmacol Exp Ther 291, 655-664.
10. Hein TW, Wang W, Zoghi B, Muthuchamy M & Kuo L (2001). Functional and molecular characterization of receptor subtypes mediating coronary microvascular dilation to adenosine. J Mol Cell Cardiol 33, 271-282.
11. Heinicke K, Wolfarth B, Winchenbach P, Biermann B, Schmid A, Huber G, Friedmann B & Schmidt W (2001). Blood volume and hemoglobin mass in elite athletes of different disciplines. Int J Sports Med 22, 504-512.
12. Heiss HW, Barmeyer J, Wink K, Hell G, Cerny FJ, Keul J & Reindell H (1976). Studies on the regulation of myocardial blood flow in man. I. Training effects on blood flow and metabolism of the healthy heart at rest and during standardized heavy exercise. Basic Res Cardiol 71, 658-675.
13. Hildick-Smith DJ, Johnson PJ, Wisbey CR, Winter EM & Shapiro LM (2000). Coronary flow reserve is supranormal in endurance athletes: An adenosine transthoracic echocardiographic study. Heart 84, 383-389.
14. Hudlicka O (1982). Growth of capillaries in skeletal and cardiac muscle. Circ Res 50, 451-461.
15. Iida H, Takahashi A, Tamura Y, Ono Y & Lammertsma AA (1995). Myocardial blood flow: Comparison of oxygen-15-water bolus injection, slow infusion and oxygen-15-carbon dioxide slow inhalation. J Nucl Med 36, 78-85.
16. Iskandrian AE, Bateman TM, Belardinelli L, Blackburn B, Cerqueira MD, Hendel RC, Lieu H, Mahmarian JJ, Olmsted A, Underwood SR, Vitola J & Wang W (2007). Adenosine versus regadenoson comparative evaluation in myocardial perfusion imaging: Results of the ADVANCE phase 3 multicenter international trial. J Nucl Cardiol 14, 645-658.
17. Kalliokoski KK, Nuutila P, Laine H, Luotolahti M, Janatuinen T, Raitakari OT, Takala TO & Knuuti J (2002). Myocardial perfusion and perfusion reserve in endurance-trained men. Med Sports Exerc 34, 948-953.
18. Karjalainen J, Kujala UM, Kaprio J, Sarna S & Viitasalo M (1998). Lone atrial fibrillation in vigorously exercising middle aged men: case-control study. BMJ 316, 1784-1785.
19. Kaufmann PA, Rimoldi OE, Gnecchi-Ruscone T, Luscher TF & Camici PG (2007). Systemic nitric oxide synthase inhibition improves coronary flow reserve to adenosine in patients with significant stenoses. Am J Physiol Heart Circ Physiol 293, H2178-H2182.
20. Kjaer A, Meyer C, Wachtell K, Olsen MH, Ibsen H, Opie L, Holm S & Hesse B (2005). Positron emission tomographic evaluation of regulation of myocardial perfusion in physiological (elite athletes) and pathological (systemic hypertension) left ventricular hypertrophy. Am J Cardiol 96, 1692-1698.
21. Knaapen P, Germans T, Camici PG, Rimoldi OE, ten Cate FJ, ten Berg JM, Dijkmans PA, Boellaard R, van Dockum WG, Gotte MJ, Twisk JW, van Rossum AC, Lammertsma AA & Visser FC (2008). Determinants of coronary microvascular dysfunction in symptomatic hypertrophic cardiomyopathy. Am J Physiol Heart Circ Physiol 294, H986-H993.
22. Laaksonen MS, Kalliokoski KK, Luotolahti M, Kemppainen J, Teras M, Kyrolainen H, Nuutila P & Knuuti J (2007). Myocardial perfusion during exercise in endurance-trained and untrained humans. Am J Physiol Regul Integr Comp Physiol 293, R837-R843.
23. Laughlin MH, Oltman CL & Bowles DK (1998). Exercise training-induced adaptations in the coronary circulation. Med Sports Exerc 30, 352-360.
24. Leung WH, Stadius ML & Alderman EL (1991). Determinants of normal coronary artery dimensions in humans. Circulation 84, 2294-2306.
25. Lewis BS & Gotsman MS (1973). Relation between coronary artery size and left ventricular wall mass. Br Heart J 35, 1150-1153.
26. Loffler M, Morote-Garcia JC, Eltzschig SA, Coe IR & Eltzschig HK (2007). Physiological roles of vascular nucleoside transporters. Arterioscler Thromb Vasc Biol 27, 1004-1013.
27. 11C-methyl]-(-)-cocaine PET studies in human subjects. J Cereb Blood Flow Metab 10, 740-747.
28. Maron BJ & Pelliccia A (2006). The heart of trained athletes: cardiac remodeling and the risks of sports, including sudden death. Circulation 114, 1633-1644.
29. Martin WH III, Montgomery J, Snell PG, Corbett JR, Sokolov JJ, Buckey JC, Maloney DA & Blomqvist CG (1987). Cardiovascular adaptations to intense swim training in sedentary middle-aged men and women. Circulation 75, 323-330.
30. 2A receptor. Mol Pharmacol 69, 1083-1094.
31. 11 C]TMSX PET study. Nucl Med Biol 32, 831-836.
32. Moser GH, Schrader J & Deussen A (1989). Turnover of adenosine in plasma of human and dog blood. Am J Physiol Cell Physiol 256, C799-C806.
33. Namdar M, Koepfli P, Grathwohl R, Siegrist PT, Klainguti M, Schepis T, Delaloye R, Wyss CA, Fleischmann SP, Gaemperli O & Kaufmann PA (2006). Caffeine decreases exercise-induced myocardial flow reserve. J Am Coll Cardiol 47, 405-410.
34. O'Keefe JH Jr, Owen RM & Bove AA (1987). Influence of left ventricular mass on coronary artery cross-sectional area. Am J Cardiol 59, 1395-1397.
35. Pelliccia A, Culasso F, Di Paolo FM & Maron BJ (1999). Physiologic left ventricular cavity dilatation in elite athletes. Ann Intern Med 130, 23-31.
36. Pelliccia A, Maron BJ, Spataro A, Proschan MA & Spirito P (1991). The upper limit of physiologic cardiac hypertrophy in highly trained elite athletes. N Engl J Medical 324, 295-301.
37. Pluim BM, Zwinderman AH, Van Der Laarse A & Van Der Wall EE (2000). The athlete's heart. A meta-analysis of cardiac structure and function. Circulation 101, 336-344.
38. Radvan J, Choudhury L, Sheridan DJ & Camici PG (1997). Comparison of coronary vasodilator reserve in elite rowing athletes versus hypertrophic cardiomyopathy. Am J Cardiol 80, 1621-1623.
39. Roberts JT & Wearn JT (1941). Quantitative changes in the capillary-muscle relationship in human hearts during normal growth and hypertrophy. Am Heart J 21, 617-633.
40. Rodriguez Reguero JJ, Iglesias Cubero G, Lòpez de la Iglesia J, Terrados N, Gonzalez V, Cortina R & Cortina A (1995). Prevalence and upper limit of cardiac hypertrophy in professional cyclists. Eur J Appl Physiol Occup Physiol 70, 375-378.
41. Rodriguez FL & Robbins SL (1959). Capacity of human coronary arteries; a postmortem study. Circulation 19, 570-578.
42. Shryock JC & Belardinelli L (1997). Adenosine and adenosine receptors in the cardiovascular system: Biochemistry, physiology, and pharmacology. Am J Cardiol 79, 2-10.
43. 2O production system for heart and brain studies. J Labelled Comp Radiopharm 44, S1066-S1068.
44. Snell PG, Martin WH, Buckey JC & Blomqvist CG (1987). Maximal vascular leg conductance in trained and untrained men. J Appl Physiol 62, 606-610.
45. Takala TO, Nuutila P, Katoh C, Luotolahti M, Bergman J, Maki M, Oikonen V, Ruotsalainen U, Gronroos T, Haaparanta M, Kapanen J & Knuuti J (1999). Myocardial blood flow, oxygen consumption, and fatty acid uptake in endurance athletes during insulin stimulation. Am J Physiol Endocrinol Metab 277, E585-E590.
46. 2B receptors in mice. J Cardiovasc Pharmacol 41, 562-570.
47. Thompson PD, Franklin BA, Balady GJ, Blair SN, Corrado D, Estes NA III, Fulton JE, Gordon NF, Haskell WL, Link MS, Maron BJ, Mittleman MA, Pelliccia A, Wenger NK, Willich SN & Costa F (2007). Exercise and acute cardiovascular events placing the risks into perspective: A scientific statement from the American Heart Association Council on Nutrition, Physical Activity, and Metabolism and the Council on Clinical Cardiology. Circulation 115, 2358-2368.
48. Toraa M, Pouillard F, Merlet P & Friemel F (1999). [Cardiac hypertrophy and coronary reserve in endurance athletes]. Can J Appl Physiol 24, 87-95.
49. Tune JD, Gorman MW & Feigl EO (2004). Matching coronary blood flow to myocardial oxygen consumption. J Appl Physiol 97, 404-415.
50. 2A receptor agonist binodenoson for pharmacological stress as an adjunct to myocardial perfusion imaging. Circulation 109, 457-464.