Coronary hyperperfusion augments myocardial oxygen consumption

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 271, Issue 4 40-4, 1996, Pages

  Ishibashi, Yutaka ^a   Zhang, Jianyi ^a   Duncker, Dirk J ^a,b   Klassen, Christopher ^a   Pavek, Todd ^a   Bache, Robert J ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

adenosine; coronary blood flow; nitroglycerin; vasodilation

Indexed keywords

ADENOSINE; GLYCERYL TRINITRATE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORONARY HEMODYNAMICS; DOG; HEART CONTRACTION; HEART LEFT VENTRICLE WALL; HEART MUSCLE OXYGEN CONSUMPTION; HEART RATE; HEMODYNAMICS; INTRACORONARY INFUSION; LEFT ANTERIOR DESCENDING CORONARY ARTERY; NONHUMAN; PRIORITY JOURNAL; TREADMILL EXERCISE; VASODILATATION;

EID: 33750839062     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1996.271.4.h1384     Document Type: Article

References (34)

1. Allen, D. G., and J. C. Kentish. The cellular basis of the length-tension relation in cardiac muscle. J. Mol. Cell. Cardiol. 17: 821-840, 1985.
2. Altman, J. D., J. Kinn, D. J. Duncker, and R. J. Bache. Effect of inhibition of nitric oxide formation on coronary blood flow during exercise in the dog. Cardiovasc. Res. 28: 119-124, 1994.
3. Arnold, G., F. Kosche, E. Miessner, A. Neitzert, and W. Lochner. The importance of the perfusion pressure in the coronary arteries for the contractility and oxygen consumption of the heart. Pfluegers Arch. 299: 339-356, 1968.
4. Austin, R. E., Jr., G. S. Aldea, D. L. Coggins, A. E. Flynn, and J. I. E. Hoffman. Profound spatial heterogeneity of coronary reserve. Discordance between patterns of resting and maximal myocardial blood flow. Circ. Res. 67: 319-331, 1990.
5. Bache, R. J., D. C. Homans, J. S. Schwartz, and X. Z. Dai. Differences in the effects of alpha-1 adrenergic blockade with prazosin and indoramin on coronary blood flow during exercise. J. Pharmacol. Exp. Ther. 245: 232-237, 1988.
6. Barnard, R. J., H. W. Duncan, J. J. Livesay, and G. D. Buckberg. Coronary vasodilator reserve and flow distribution during near-maximal exercise in dogs. J. Appl. Physiol. 43: 988-992, 1977.
7. Belardinelli, L., J. Linden, and R. M. Berne. The cardiac actions of adenosine. Prog. Cardiovasc. Dis. 32: 73-97, 1989.
8. Buffer, S.A. J., S. J. Dong, P. S. Hees, G. M. Hutchins, J. L. Weiss, E. P. Shapiro, and F. E. Rademakers. Predominant influence of epicardial over endocardial fiber angle on the regional variation of left ventricular torsion (Abstract). Circulation 90, Suppl. I:I-13, 1994.
9. Chilian, W. M., S. M. Layne, E. C. Klausner, C. L. Eastham, and M. L. Marcus. Redistribution of coronary microvascular resistance produced by dipyridamole. Am. J. Physiol. 256 (Heart Circ. Physiol. 25): H383-H390, 1989.
10. 2-adrenergic blockade. Am. J. Physiol. 256 (Heart Circ. Physiol. 25): H1148-H1155, 1989.
11. ATP channels in coronary vasodilation during exercise. Circulation 88: 1245-1253, 1993.
12. 1-adrenergic tone. Am. J. Physiol. 266 (Heart Circ. Physiol. 35): H795-H810, 1994.
13. Feigl, E. O. Control of myocardial oxygen tension by sympathetic coronary vasoconstriction in the dog. Circ. Res. 37: 88-95, 1975.
14. Gregg, D. Effect of coronary perfusion pressure or coronary flow on oxygen usage of the myocardium. Circ. Res. 13: 497-500, 1963.
15. Gwirtz, P. A., J. M. Dodd-O, M. A. Brandt, and C. J. Jones. Augmentation of coronary flow improves myocardial function in exercise. J. Cardiovasc. Pharmacol. 15: 752-758, 1990.
16. 1-Adrenergic constriction limits coronary flow and cardiac function in running dogs. Am J. Physiol. 250 (Heart Circ. Physiol. 19): H1117-H1126, 1986.
17. Gwirtz, P. A., and H. L. Stone. Coronary blood flow and myocardial oxygen consumption after alpha-adrenergic blockade during submaximal exercise. J. Pharmacol. Exp. Ther. 217: 92-98, 1981.
18. Heyndrick, G., P. Muylaert, and J. Pannier. α-Adrenergic control of oxygen delivery to myocardium during exercise in conscious dogs. Am. J. Physiol. 242 (Heart Circ. Physiol. 11): H805-H809, 1982.
19. Hohorst, H. Method of Enzymatic Analysis. New York: Academic, 1963, p. 266.
20. Iwamoto, T., X.-J. Bai, and H. F. Downey. Coronary perfusion related changes in myocardial contractile force and systolic ventricular stiffness. Cardiovasc. Res. 28: 1331-1136, 1994.
21. Khouri, E. M., D. E. Gregg, and E. R. Rayford. Effect of exercise on cardiac output, left coronary flow and myocardial metabolism in the unanesthetized dog. Circ. Res. 17: 427-437, 1965.
22. Kuo, L., M. J. Davis, and W. M. Chilian. Endothelium-dependent, flow-induced dilation of isolated coronary arterioles. Am. J. Physiol. 259 (Heart Circ. Physiol. 28): H1063-H1070, 1990.
23. Langer, S. Z. Presynaptic receptors and their role in the regulation of transmitter release. Br. J. Pharmacol. 60: 481-497, 1977.
24. Massie, B. M., G. G. Schwartz, J. Garcia, J. A. Wisneski, M. W. Weiner, and T. Owens. Myocardial metabolism during increased work states in the porcine left ventricle in vivo. Circ. Res. 74: 64-73, 1994.
25. McKenzie, J. E., R. P. Steffen, and F. J. Haddy. Relationships between adenosine and coronary resistance in conscious exercising dogs. Am. J. Physiol. 242 (Heart Circ. Physiol. 11): H24-H29, 1982.
26. Peronnet, F, R. A. Nadeau, J. DeChamplain, P. Magrassi, and C. Chatrand. Exercise plasma catecholamines in dogs: role of adrenals and cardiac nerve endings. Am. J. Physiol. 241 (Heart Circ. Physiol. 10): H243-H247, 1981.
27. Parent, R., R. Pare, and M. Lavallee. Contribution of nitric oxide to dilation of resistance coronary vessels in conscious dogs. Am. J. Physiol. 262 (Heart Circ. Physiol. 31): H10-H16, 1992.
28. Schouten, V. J. A., C. P. Allaart, and N. Westerhof. Effect of perfusion pressure on force of contraction in thin papillary muscles and trabeculae from rat heart. J. Physiol. Lond. 451: 585-604, 1992.
29. Schwartz, G. G., S. Schaefer, S. D. Trocha, J. Garcia, S. Steinman, B. M. Massie, and M. W. Weiner. Effect of supranormal coronary blood flow on energy metabolism and systolic function of porcine left ventricle. Cardiovasc. Res. 26: 1001-1006, 1992.
30. Von Restorff, W., J. Hortz, and E. Bassenge. Exercise induced augmentation of myocardial oxygen extraction in spite of normal coronary dilatory capacity in dogs. Pfluegers Arch. 372: 181-185, 1977.
31. Wang, J., M. S. Wolin, and T. H. Hintze. Chronic exercise enhances endothelium-mediated dilation of epicardial coronary artery in conscious dogs. Circ. Res. 73: 829-838, 1993.
32. Watkinson, W. P., D. H. Foley, R. Rubio, and R. M. Berne. Myocardial adenosine formation with increased cardiac performance in the dog. Am. J. Physiol. 236 (Heart Circ. Physiol. 5): H13-H21, 1979.
33. White, F., M. Sanders, and C. M. Bloor. Coronary reserve at maximal heart rate in the exercising swine. Cardiac Rehab. 1: 31-39, 1981.
34. Zhang, J., D. J. Duncker, Y. X. Zhang, G. Path, H. Merkle, K. Hendrich, A. H. L. From, R. J. Bache, and K. Ugurbil. Transmural bioenergetic responses of normal myocardium to high workstates. Am J. Physiol. 268 (Heart Circ. Physiol. 37): H1891-H1905, 1995.