Etifoxine provides benefits in nerve repair with acellular nerve grafts

Muscle and Nerve

Volumn 50, Issue 2, 2014, Pages 235-243

  Zhou, Xiang ^a   He, Bo ^a   Zhu, Zhaowei ^a   He, Xinhua ^b   Zheng, Canbin ^a   Xu, Jian ^a   Jiang, Li ^a   Gu, Liqiang ^a   Zhu, Jiakai ^a   Zhu, Qingtang ^a   Liu, Xiaolin ^a  

^a THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

^b SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

Author keywords

Acellular nerve grafts; Etifoxine; Nerve regeneration; Neurotrophins expression; TSPO

Indexed keywords

ANXIOLYTIC AGENT; ETIFOXINE; MESSENGER RNA; NEUROTROPHIN; UNCLASSIFIED DRUG;

ACELLULAR NERVE GRAFT; ADULT; ANIMAL TISSUE; ARTICLE; AUTOGRAFT; BEHAVIOR; CONTROLLED STUDY; ELECTROPHYSIOLOGY; HISTOPATHOLOGY; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; MALE; NERVE CONDUCTION; NERVE FIBER; NERVE GRAFT; NERVE REGENERATION; NEUROFILAMENT; NONHUMAN; PERIPHERAL NERVE INJURY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RAT; SCIATIC NERVE; SCIATIC NERVE INJURY; WALKING;

ACELLULAR NERVE GRAFTS; ETIFOXINE; NERVE REGENERATION; NEUROTROPHINS EXPRESSION; TSPO;

ANIMALS; DISEASE MODELS, ANIMAL; ELECTRIC STIMULATION; EVOKED POTENTIALS; GENE EXPRESSION; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; LOCOMOTION; MALE; NERVE GROWTH FACTOR; NERVE REGENERATION; NEURAL CONDUCTION; NEUROFILAMENT PROTEINS; OXAZINES; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; SCIATIC NEUROPATHY; SKIN; TRANSPLANTATION, AUTOLOGOUS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84904664184     PISSN: 0148639X     EISSN: 10974598     Source Type: Journal    
DOI: 10.1002/mus.24131     Document Type: Article

References (47)

1. Kline DG, Hudson AR. Vertebral artery compression. J Neurosurg 1995;83:759.
2. Schmidt CE, Leach JB. Neural tissue engineering: strategies for repair and regeneration. Annu Rev Biomed Eng 2003;5:293-347.
3. Wang D, Liu XL, Zhu JK, Jiang L, Hu J, Zhang Y, et al. Bridging small-gap peripheral nerve defects using acellular nerve allograft implanted with autologous bone marrow stromal cells in primates. Brain Res 2008;1188:44-53.
4. Wang D, Liu X L, Zhu J K, Hu J, Jiang L, Zhang Y, et al. Repairing large radial nerve defects by acellular nerve allografts seeded with autologous bone marrow stromal cells in a monkey model. J Neurotrauma 2010;27:1935-1943.
5. Hou SY, Zhang HY, Quan DP, Liu XL, Zhu JK. Tissue-engineered peripheral nerve grafting by differentiated bone marrow stromal cells. Neuroscience 2006;140:101-110.
6. Walsh S, Biernaskie J, Kemp SW, Midha R. Supplementation of acellular nerve grafts with skin derived precursor cells promotes peripheral nerve regeneration. Neuroscience 2009;164:1097-1107.
7. Yu H, Peng J, Guo Q, Zhang L, Li Z, Zhao B, et al. Improvement of peripheral nerve regeneration in acellular nerve grafts with local release of nerve growth factor. Microsurgery 2009;29:330-336.
8. Girard C, Liu S, Cadepond F, Adams D, Lacroix C, Verleye M, et al. Etifoxine improves peripheral nerve regeneration and functional recovery. Proc Natl Acad Sci USA 2008;105: 20505-20510.
9. Girard C, Liu S, Adams D, Lacroix C, Sineus M, Boucher C, et al. Axonal regeneration and neuroinflammation: roles for the translocator protein 18 kDa. J Neuroendocrinol 2011;24:71-81.
10. Verleye M, Akwa Y, Liere P, Ladurelle N, Pianos A, Eychenne B, et al. The anxiolytic etifoxine activates the peripheral benzodiazepine receptor and increases the neurosteroid levels in rat brain. Pharmacol Biochem Behav 2005;82:712-720.
11. Schlichter R, Rybalchenko V, Poisbeau P, Verleye M, Gillardin J. Modulation of GABAergic synaptic transmission by the non-benzodiazepine anxiolytic etifoxine. Neuropharmacology 2000;39:1523-1535.
12. Papadopoulos V, Baraldi M, Guilarte TR, Knudsen TB, Lacapere JJ, Lindemann P, et al. Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function. Trends Pharmacol Sci 2006;27:402-409.
13. Campioli E, Carnevale G, Avallone R, Guerra D, Baraldi M. Morphological and receptorial changes in the epididymal adipose tissue of rats subjected to a stressful stimulus. Obesity (Silver Spring) 2011;19:703-708.
14. Rechichi M, Salvetti A, Chelli B, Costa B, Da Pozzo E, Spinetti F, et al. TSPO over-expression increases motility, transmigration and proliferation properties of C6 rat glioma cells. Biochim Biophys Acta 2008;1782:118-125.
15. Lacor P, Benavides J, Ferzaz B. Enhanced expression of the peripheral benzodiazepine receptor (PBR) and its endogenous ligand octadecaneuropeptide (ODN) in the regenerating adult rat sciatic nerve. Neurosci Lett 1996;220:61-65.
16. Karchewski LA, Bloechlinger S, Woolf CJ. Axonal injury-dependent induction of the peripheral benzodiazepine receptor in small-diameter adult rat primary sensory neurons. Eur J Neurosci 2004;20:671-683.
17. Torres SR, Frode T, Nardi GM, Vita N, Reeb R, Ferrara P, et al. Anti-inflammatory effects of peripheral benzodiazepine receptor ligands in two mouse models of inflammation. Eur J Pharmacol 2000;408:199-211.
18. Veiga S, Azcoitia I, Garcia-Segura LM. Ro5-4864, a peripheral benzodiazepine receptor ligand, reduces reactive gliosis and protects hippocampal hilar neurons from kainic acid excitotoxicity. J Neurosci Res 2005;80:129-137.
19. Ferzaz B, Brault E, Bourliaud G, Robert JP, Poughon G, Claustre Y, et al. SSR180575 (7-chloro-N, N, 5-trimethyl-4-oxo-3-phenyl-3, 5-dihydro-4H-pyridazino[4, 5-b]indole-1-acetamide), a peripheral benzodiazepine receptor ligand, promotes neuronal survival and repair. J Pharmacol Exp Ther 2002;301:1067-1078.
20. Leonelli E, Yague JG, Ballabio M, Azcoitia I, Magnaghi V, Schumacher M, et al. Ro5-4864, a synthetic ligand of peripheral benzodiazepine receptor, reduces aging-associated myelin degeneration in the sciatic nerve of male rats. Mech Ageing Dev 2005;126:1159-1163.
21. Mills CD, Bitler JL, Woolf CJ. Role of the peripheral benzodiazepine receptor in sensory neuron regeneration. Mol Cell Neurosci 2005;30:228-237.
22. Mills C, Makwana M, Wallace A, Benn S, Schmidt H, Tegeder I, et al. Ro5-4864 promotes neonatal motor neuron survival and nerve regeneration in adult rats. Eur J Neurosci 2008;27:937-946.
23. Sondell M, Lundborg G, Kanje M. Regeneration of the rat sciatic nerve into allografts made acellular through chemical extraction. Brain Res 1998;795:44-54.
24. de Medinaceli L, Freed WJ, Wyatt RJ. An index of the functional condition of rat sciatic nerve based on measurements made from walking tracks. Exp Neurol 1982;77:634-643.
25. Omura K, Ohbayashi M, Sano M, Omura T, Hasegawa T, Nagano A. The recovery of blood-nerve barrier in crush nerve injury-a quantitative analysis utilizing immunohistochemistry. Brain Res 2004;1001:13-21.
26. Wang X, Hu W, Cao Y, Yao J, Wu J, Gu X. Dog sciatic nerve regeneration across a 30-mm defect bridged by a chitosan/PGA artificial nerve graft. Brain 2005;128:1897-1910.
27. Liu XL, Arai T, Sondell M, Lundborg G, Kanje M, Dahlin LB. Use of chemically extracted muscle grafts to repair extended nerve defects in rats. Scand J Plast Reconstr Surg Hand Surg 2001;35:337-345.
28. Zeng C, Sheng P, Xie G, Zhu J, Dong P, Quan D. Fabrication of PLLA nanofibrous multi-channel conduits for neural tissue engineering. J Control Release 2011;152(suppl 1):e234-236.
29. Panaite PA, Barakat-Walter I. Thyroid hormone enhances transected axonal regeneration and muscle reinnervation following rat sciatic nerve injury. J Neurosci Res 2010;88:1751-1763.
30. Moore AM, MacEwan M, Santosa KB, Chenard KE, Ray WZ, Hunter DA, et al. Acellular nerve allografts in peripheral nerve regeneration: a comparative study. Muscle Nerve 2011;44:221-234.
31. Varejao AS, Meek MF, Ferreira AJ, Patricio JA, Cabrita AM. Functional evaluation of peripheral nerve regeneration in the rat: walking track analysis. J Neurosci Methods 2001;108:1-9.
32. Werdin F, Grussinger H, Jaminet P, Kraus A, Manoli T, Danker T, et al. An improved electrophysiological method to study peripheral nerve regeneration in rats. J Neurosci Methods 2009;182:71-77.
33. Radtke C, Aizer AA, Agulian SK, Lankford KL, Vogt PM, Kocsis JD. Transplantation of olfactory ensheathing cells enhances peripheral nerve regeneration after microsurgical nerve repair. Brain Res 2009;1254:10-17.
34. Delgado-Garcia JM, Del Pozo F, Spencer RF, Baker R. Behavior of neurons in the abducens nucleus of the alert cat-III. Axotomized motoneurons. Neuroscience 1988;24:143-160.
35. Huang J, Hu X, Lu L, Ye Z, Wang Y, Luo Z. Electrical stimulation accelerates motor functional recovery in autograft-repaired 10 mm femoral nerve gap in rats. J Neurotrauma 2009;26:1805-1813.
36. Rosen JM, Pham HN, Hentz VR. Fascicular tubulization: a comparison of experimental nerve repair techniques in the cat. Ann Plast Surg 1989;22:467-478.
37. Aminoff I. [Caution: hemorrhoidal prolapse]. Harefuah 1999;136:993-996.
38. Snider WD, Johnson EM Jr. Neurotrophic molecules. Ann Neurol 1989;26:489-506.
39. Rich KM, Yip HK, Osborne PA, Schmidt RE, Johnson EM Jr. Role of nerve growth factor in the adult dorsal root ganglia neuron and its response to injury. J Comp Neurol 1984;230:110-118.
40. Taniuchi M, Clark HB, Johnson EM Jr. Induction of nerve growth factor receptor in Schwann cells after axotomy. Proc Natl Acad Sci USA 1986;83:4094-4098.
41. Rich KM, Alexander TD, Pryor JC, Hollowell JP. Nerve growth factor enhances regeneration through silicone chambers. Exp Neurol 1989;105:162-170.
42. Fine EG, Decosterd I, Papaloizos M, Zurn AD, Aebischer P. GDNF and NGF released by synthetic guidance channels support sciatic nerve regeneration across a long gap. Eur J Neurosci 2002;15:589-601.
43. Lin LF, Doherty DH, Lile JD, Bektesh S, Collins F. GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science 1993;260:1130-1132.
44. Bergerot A, Shortland PJ, Anand P, Hunt SP, Carlstedt T. Co-treatment with riluzole and GDNF is necessary for functional recovery after ventral root avulsion injury. Exp Neurol 2004;187:359-366.
45. Storkebaum E, Lambrechts D, Dewerchin M, Moreno-Murciano MP, Appelmans S, Oh H, et al. Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS. Nat Neurosci 2005;8:85-92.
46. Micallef J, Soubrouillard C, Guet F, Le Guern ME, Alquier C, Bruguerolle B, et al. A double blind parallel group placebo controlled comparison of sedative and mnesic effects of etifoxine and lorazepam in healthy subjects [corrected]. Fundam Clin Pharmacol 2001;15:209-216.
47. Nguyen N, Fakra E, Pradel V, Jouve E, Alquier C, Le Guern ME, et al. Efficacy of etifoxine compared to lorazepam monotherapy in the treatment of patients with adjustment disorders with anxiety: a double-blind controlled study in general practice. Hum Psychopharmacol 2006;21:139-149.