Spermbots: Potential impact for drug delivery and assisted reproductive technologies

Expert Opinion on Drug Delivery

Volumn 11, Issue 8, 2014, Pages 1125-1129

  Magdanz, Veronika ^a   Schmidt, Oliver G ^a,b,c  

^a IFW DRESDEN   (Germany)

^b CHEMNITZ UNIVERSITY OF TECHNOLOGY   (Germany)

^c CENTER FOR ADVANCING ELECTRONICS DRESDEN CFAED   (Germany)

Author keywords

Assisted reproduction technology; Drug delivery; Micromotors; Spermatozoa; Spermbot

Indexed keywords

DRUG DELIVERY DEVICE; DRUG DELIVERY SYSTEM; INFERTILITY THERAPY; OOCYTE; REVIEW; ROBOTICS; SPERMATOZOON; SPERMBOT;

ASSISTED REPRODUCTION TECHNOLOGY; DRUG DELIVERY; MICROMOTORS; SPERMATOZOA; SPERMBOT;

DRUG DELIVERY SYSTEMS; HUMANS; MALE; NANOTECHNOLOGY; REPRODUCTIVE TECHNIQUES, ASSISTED; ROBOTICS; SPERMATOZOA;

EID: 84904650990     PISSN: 17425247     EISSN: 17447593     Source Type: Journal    
DOI: 10.1517/17425247.2014.924502     Document Type: Review

References (15)

1. Zhang L, Abbot JJ, Dong D, et al. Artificial bacterial flagella: Fabrication and magnetic control. Appl Phys Lett 2009;94:06410
2. Dreyfus R, Baudry J, Roper ML, et al. Microscopic artificial swimmers. Nature 2005;437:862-5
3. Gao W, Feng X, Pei A, et al. Bioinspired helical microswimmers based on vascular plants. Nano Lett 2014;14:305-10
4. Mukal C, Bergkvist M, Nelson J, Travis AJ. Sequential reactions of surface-Tethered glycolytic enzymes. Chem Biol 2009;16:1013-20
5. Behkam B, Sitti M. Bacterial flagella-based propulsion and on/off motion control of microscale objects. Appl Phys Lett 2007;90:23902-4
6. Williams BJ, Anand SV, Rajagopalan J, Saif MTA. A self-propelled biohybrid swimmer at low Reynolds number. Nature 2014;5:3081
7. Magdanz V, Sanchez S, Schmidt OG. Development of a sperm-flagella driven micro-bio-robot. Adv Mater 2013;25(45):6581-8
8. Khademhosseini A, Borenstein J, Toner M, Takayama S. Micro and nanoengineering of the cell microenvironment. Artech House, Norwood, USA; 2008
9. Quick facts about infertility. American Society for Reproductive Medicine. http://www.reproductivefacts.org/detail. aspx?id=2322 [Last accessed 6 March 2014]
10. Scott MA. A glimpse at sperm function in vivo: Sperm transport and epithelial interaction in the female reproductive tract. Anim Reprod Sci 2000;60-61:337-48
11. Suarez SS, Pacey AA. Sperm transport in the female reproductive tract. Hum Reprod Update 2006;12(1):23-37
12. Martel S, Mathieu JB, Felfoul O, et al. Automatic navigation of an untethered device in the artery of a living animal using a conventional clinical magnetic resonance imaging system. Appl Phys Lett 2007;90:114105
13. Pouponneau P, Leroux JC, Soulez G, et al. Co-encapsulation of magnetic nanoparticles and doxorubicin into biodegradable microcarriers for deep tissue targeting by vascular MRI navigation. Biomaterials 2011;32:3481-6
14. Meijas R, Gutierrez L, Salas G, et al. Long term biotransformation and toxicity of dimercaptosuccinic acid-coated magnetic nanoparticles support their use in biomedical applications. J Control Release 2013;171:225-33
15. Levy M, Luciani N, Alloyeau D, et al. Long term in vivo biotransformation of iron oxide nanoparticles. Biomaterials 2011;32:3988-99.