Intracerebral interleukin-10 injection modulates post-ischemic neuroinflammation: An experimental microarray study

Neuroscience Letters

Volumn 579, Issue , 2014, Pages 18-23

  Liesz, Arthur ^a,b,c   Bauer, Andrea ^d   Hoheisel, Jörg D ^d   Veltkamp, Roland ^a,e  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c Germany 3 Munich Cluster for Systems Neurology   (Germany)

^d GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^e IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Experimental brain ischemia; Interleukin 10; Microarray; Neuroinflammation; Stroke

Indexed keywords

BOVINE SERUM ALBUMIN; INTERLEUKIN 10; NEUROPROTECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; COMPARATIVE STUDY; CONTROLLED STUDY; DOWN REGULATION; EXPERIMENTAL STROKE; EXPERIMENTAL STUDY; GENE CONTROL; GENE EXPRESSION; IMMUNE RESPONSE; IMMUNOTHERAPY; MALE; MICROARRAY ANALYSIS; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; ACUTE PHASE RESPONSE; ANIMAL; C57BL MOUSE; CEREBROVASCULAR ACCIDENT; COMPLICATION; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; INFLAMMATION; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; PATHOLOGY; PREVENTION AND CONTROL;

ACUTE-PHASE REACTION; ANIMALS; BRAIN ISCHEMIA; GENE EXPRESSION REGULATION; INFLAMMATION; INJECTIONS, INTRAVENTRICULAR; INTERLEUKIN-10; MALE; MICE; MICE, INBRED C57BL; MICROARRAY ANALYSIS; NEUROPROTECTIVE AGENTS; STROKE;

EID: 84904640995     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2014.07.003     Document Type: Article

References (30)

1. Becker K., Kindrick D., Relton J., Harlan J., Winn R. Antibody to the alpha4 integrin decreases infarct size in transient focal cerebral ischemia in rats. Stroke 2001, 32:206-211.
2. Benjamini Y., Hochberg Y. Controlling the false discovery rate - a practical and powerful approach to multiple testing. J. R. Stat. Soc. Ser. B - Methodol. 1995, 57:289-300.
3. Bodhankar S., Chen Y., Vandenbark A.A., Murphy S.J., Offner H. IL-10-producing B-cells limit CNS inflammation and infarct volume in experimental stroke. Metab. Brain Dis. 2013, 28:375-386.
4. Bodhankar S., Chen Y., Vandenbark A.A., Murphy S.J., Offner H. PD-L1 enhances CNS inflammation and infarct volume following experimental stroke in mice in opposition to PD-1. J. Neuroinflamm. 2013, 10:111.
5. Bodhankar S., Chen Y., Vandenbark A.A., Murphy S.J., Offner H. Treatment of experimental stroke with IL-10-producing B-cells reduces infarct size and peripheral and CNS inflammation in wild-type B-cell-sufficient mice. Metab. Brain Dis. 2014, 29:59-73.
6. Chamorro A., Meisel A., Planas A.M., Urra X., van de Beek D., Veltkamp R. The immunology of acute stroke. Nat. Rev. Neurol. 2012, 8:401-410.
7. Couper K.N., Blount D.G., Riley E.M. IL-10: the master regulator of immunity to infection. J. Immunol. 2008, 180:5771-5777.
8. de Bilbao F., Arsenijevic D., Moll T., Garcia-Gabay I., Vallet P., Langhans W., Giannakopoulos P. In vivo over-expression of interleukin-10 increases resistance to focal brain ischemia in mice. J. Neurochem. 2009, 110:12-22.
9. Dirnagl U. Inflammation in stroke: the good, the bad, and the unknown. Ernst Scher. Res Found Workshop 2004, 47:87-99.
10. Fickenscher H., Hor S., Kupers H., Knappe A., Wittmann S., Sticht H. The interleukin-10 family of cytokines. Trends Immunol. 2002, 23:89-96.
11. Gelderblom M., Leypoldt F., Steinbach K., Behrens D., Choe C.U., Siler D.A., Arumugam T.V., Orthey E., Gerloff C., Tolosa E., Magnus T. Temporal and spatial dynamics of cerebral immune cell accumulation in stroke. Stroke 2009, 40:1849-1857.
12. Grilli M., Barbieri I., Basudev H., Brusa R., Casati C., Lozza G., Ongini E. Interleukin-10 modulates neuronal threshold of vulnerability to ischaemic damage. Eur. J. Neurosci. 2000, 12:2265-2272.
13. Iadecola C., Anrather J. The immunology of stroke: from mechanisms to translation. Nat. Med. 2011, 17:796-808.
14. Ledeboer A., Breve J.J.P., Wierinckx A., van der Jagt S., Bristow A.F., Leysen J.E., Tilders F.J., Van Dam A.M., Jagt S.V.D. Expression and regulation of interleukin-10 and interleukin-10 receptor in rat astroglial and microglial cells. Eur. J. Neurosci. 2002, 16:1175-1185.
15. Li P., Gan Y., Sun B.L., Zhang F., Lu B., Gao Y., Liang W., Thomson A.W., Chen J., Hu X. Adoptive regulatory T-cell therapy protects against cerebral ischemia. Ann. Neurol. 2013, 74:458-471.
16. Li P., Mao L., Liu X., Gan Y., Zheng J., Thomson A.W., Gao Y., Chen J., Hu X. Essential role of program death 1-ligand 1 in regulatory T-cell-afforded protection against blood-brain barrier damage after stroke. Stroke 2014, 45:857-864.
17. Liesz A., Suri-Payer E., Veltkamp C., Doerr H., Sommer C., Rivest S., Giese T., Veltkamp R. Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke. Nat. Med. 2009, 15:192-199.
18. Liesz A., Zhou W., Mracsko E., Karcher S., Bauer H., Schwarting S., Sun L., Bruder D., Stegemann S., Cerwenka A., Sommer C., Dalpke A.H., Veltkamp R. Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke. Brain 2011, 134:704-720.
19. Liesz A., Zhou W., Na S.Y., Hammerling G.J., Garbi N., Karcher S., Mracsko E., Backs J., Rivest S., Veltkamp R. Boosting regulatory T cells limits neuroinflammation in permanent cortical stroke. J. Neurosci. 2013, 33:17350-17362.
20. Llovera G., Roth S., Plesnila N., Veltkamp R., Liesz A. Modeling stroke in mice: permanent coagulation of the distal middle cerebral artery. J. Vis. Exp. 2014, e51729.
21. Lucas S.M., Rothwell N.J., Gibson R.M. The role of inflammation in CNS injury and disease. Br. J. Pharmacol. 2006, 147(Suppl.):S232-S240.
22. McLaren J.E., Michael D.R., Ashlin T.G., Ramji D.P. Cytokines, macrophage lipid metabolism and foam cells: implications for cardiovascular disease therapy. Prog. Lipid Res. 2011, 50:331-347.
23. Moore K.W., de Waal Malefyt R., Coffman R.L., O'Garra A. Interleukin-10 and the interleukin-10 receptor. Annu. Rev. Immunol. 2001, 19:683-765.
24. Ren X., Akiyoshi K., Dziennis S., Vandenbark A.A., Herson P.S., Hurn P.D., Offner H. Regulatory B cells limit CNS inflammation and neurologic deficits in murine experimental stroke. J. Neurosci. 2011, 31:8556-8563.
25. Ren X., Akiyoshi K., Vandenbark A.A., Hurn P.D., Offner H. Programmed death-1 pathway limits central nervous system inflammation and neurologic deficits in murine experimental stroke. Stroke 2011, 42:2578-2583.
26. Spera P.A., Ellison J.A., Feuerstein G.Z., Barone F.C. IL-10 reduces rat brain injury following focal stroke. Neurosci. Lett. 1998, 251:189-192.
27. Strle K., Zhou J.H., Shen W.H., Broussard S.R., Johnson R.W., Freund G.G., Dantzer R., Kelley K.W. Interleukin-10 in the brain. Crit. Rev. Immunol. 2001, 21:427-449.
28. Swanson R.A., Morton M.T., Tsao-Wu G., Savalos R.A., Davidson C., Sharp F.R. A semiautomated method for measuring brain infarct volume. J. Cereb. Blood Flow Metab. 1990, 10:290-293.
29. Xiong X., White R.E., Xu L., Yang L., Sun X., Zou B., Pascual C., Sakurai T., Giffard R.G., Xie X.S. Mitigation of murine focal cerebral ischemia by the hypocretin/orexin system is associated with reduced inflammation. Stroke 2013, 44:764-770.
30. Zhou W., Liesz A., Bauer H., Sommer C., Lahrmann B., Valous N., Grabe N., Veltkamp R. Postischemic brain infiltration of leukocyte subpopulations differs among murine permanent and transient focal cerebral ischemia models. Brain Pathol. 2013, 23:34-44.