A subset of circulating blood mycobacteria-specific CD4 T cells can predict the time to Mycobacterium tuberculosis sputum culture conversion

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Riou, Catherine ^a   Gray, Clive M ^a   Lugongolo, Masixole ^b   Gwala, Thabisile ^b   Kiravu, Agano ^a   Deniso, Pamela ^c   Stewart Isherwood, Lynsey ^c   Omar, Shaheed Vally ^b   Grobusch, Martin P ^d   Coetzee, Gerrit ^b   Conradie, Francesca ^c   Ismail, Nazir ^b   Kaplan, Gilla ^e   Fallows, Dorothy ^e  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b NATIONAL INSTITUTE FOR COMMUNICABLE DISEASES   (South Africa)

^c UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^d UNIVERSITY OF AMSTERDAM   (Netherlands)

^e PUBLIC HEALTH RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ETHAMBUTOL; ETHIONAMIDE; GAMMA INTERFERON; HLA DR ANTIGEN; INTERLEUKIN 2; ISONIAZID; KI 67 ANTIGEN; MITOGENIC AGENT; OFLOXACIN; PYRAZINAMIDE; RIFAMPICIN; STREPTOMYCIN; TUBERCULIN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ANTIGEN EXPRESSION; ANTIMICROBIAL THERAPY; ARTICLE; BACTERIUM CULTURE; CD4+ T LYMPHOCYTE; CELL SPECIFICITY; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG MEGADOSE; DRUG RESPONSE; FEMALE; HUMAN; HUMAN CELL; LYMPHOCYTE DIFFERENTIATION; MALE; MEMORY T LYMPHOCYTE; MIDDLE AGED; MULTIDRUG RESISTANT TUBERCULOSIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PROGNOSIS; SPUTUM CULTURE; T LYMPHOCYTE SUBPOPULATION; TREATMENT DURATION; TUBERCULIN TEST; YOUNG ADULT; CD4 LYMPHOCYTE COUNT; COHORT ANALYSIS; DRUG EFFECTS; HIV INFECTIONS; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNOLOGY; ISOLATION AND PURIFICATION; MICROBIOLOGY; SPUTUM; TUBERCULOSIS;

ADULT; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; COHORT STUDIES; FEMALE; HIV; HIV INFECTIONS; HUMANS; MALE; MIDDLE AGED; MYCOBACTERIUM TUBERCULOSIS; SPUTUM; TUBERCULOSIS;

EID: 84904617566     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0102178     Document Type: Article

References (40)

1. Nunn A, Phillips PP, Abubakar I (2013) Treatment of pulmonary tuberculosis. Curr Opin Pulm Med 19: 273-279.
2. Wong EB, Cohen KA, Bishai WR (2013) Rising to the challenge: new therapies for tuberculosis. Trends Microbiol 21: 493-501.
3. Holtz TH, Sternberg M, Kammerer S, Laserson KF, Riekstina V, et al. (2006) Time to sputum culture conversion in multidrug-resistant tuberculosis: predictors and relationship to treatment outcome. Ann Intern Med 144: 650-659. (Pubitemid 46780649)
4. Wallis R, Johnson JL (2005) The Role of Surrogate Markers in the Clinical Evaluation of Anti-tuberculous Chemotherapy. Curr Med Chem - Anti-Infective Agents 4: 1-8.
5. Wallis RS, Wang C, Doherty M, Onyebujoh P, Vahedi M, et al. (2010) Biomarkers for tuberculosis disease activity, cure, and relapse. The Lancet Infectious Diseases 10: 70-71.
6. Wallis RS, Pai M, Menzies D, Doherty TM, Walzl G, et al. (2010) Biomarkers and diagnostics for tuberculosis: progress, needs, and translation into practice. Lancet 375: 1920-1937.
7. Ottenhoff TH, Ellner JJ, Kaufmann SH (2012) Ten challenges for TB biomarkers. Tuberculosis (Edinb) 92 Suppl 1: S17-20.
8. Parida SK, Kaufmann SH (2010) The quest for biomarkers in tuberculosis. Drug Discov Today 15: 148-157.
9. Jacobsen M, Mattow J, Repsilber D, Kaufmann SH (2008) Novel strategies to identify biomarkers in tuberculosis. Biol Chem 389: 487-495. (Pubitemid 351874187)
10. Walzl G, Ronacher K, Djoba Siawaya JF, Dockrell HM (2008) Biomarkers for TB treatment response: challenges and future strategies. J Infect 57: 103-109.
11. Riou C, Perez Peixoto B, Roberts L, Ronacher K, Walzl G, et al. (2012) Effect of standard tuberculosis treatment on plasma cytokine levels in patients with active pulmonary tuberculosis. PLoS One 7: e36886.
12. Baumann R, Kaempfer S, Chegou NN, Nene NF, Veenstra H, et al. (2013) Serodiagnostic markers for the prediction of the outcome of intensive phase tuberculosis therapy. Tuberculosis (Edinb) 93: 239-245.
13. Berry MP, Graham CM, McNab FW, Xu Z, Bloch SA, et al. (2010) An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis. Nature 466: 973-977.
14. Bloom CI, Graham CM, Berry MP, Rozakeas F, Redford PS, et al. (2013) Transcriptional blood signatures distinguish pulmonary tuberculosis, pulmonary sarcoidosis, pneumonias and lung cancers. PLoS One 8: e70630.
15. Wang X, Cao Z, Jiang J, Niu H, Dong M, et al. (2010) Association of mycobacterial antigen-specific CD4(+) memory T cell subsets with outcome of pulmonary tuberculosis. J Infect 60: 133-139.
16. Schluger NW (2013) Advances in the diagnosis of latent tuberculosis infection. Semin Respir Crit Care Med 34: 60-66.
17. Eum SY, Lee YJ, Min JH, Kwak HK, Hong MS, et al. (2010) Association of antigen-stimulated release of tumor necrosis factor-alpha in whole blood with response to chemotherapy in patients with pulmonary multidrug-resistant tuberculosis. Respiration 80: 275-284.
18. Tudor C, Mphahlele M, Van der Walt M, Farley JE (2013) Health care workers' fears associated with working in multidrug- and or extensively- resistant tuberculosis wards in South Africa. Int J Tuberc Lung Dis 17: 22-29.
19. Wells CD, Cegielski JP, Nelson LJ, Laserson KF, Holtz TH, et al. (2007) HIV infection and multidrug-resistant tuberculosis: the perfect storm. J Infect Dis 196 Suppl 1: S86-107.
20. Lienhardt C, Davies G (2010) Methodological issues in the design of clinical trials for the treatment of multidrug-resistant tuberculosis: challenges and opportunities. Int J Tuberc Lung Dis 14: 528-537.
21. Health SADo (2011) Management of drug-resistant Tuberculosis: policy guidelines. www.doh.org.za.
22. Hanekom WA, Hughes J, Mavinkurve M, Mendillo M, Watkins M, et al. (2004) Novel application of a whole blood intracellular cytokine detection assay to quantitate specific T-cell frequency in field studies. Journal of immunological methods 291: 185-195. (Pubitemid 39164348)
23. Roederer M, Nozzi JL, Nason MC (2011) SPICE: exploration and analysis of post-cytometric complex multivariate datasets. Cytometry A 79: 167-174.
24. Petruccioli E, Petrone L, Vanini V, Sampaolesi A, Gualano G, et al. (2013) IFNgamma/TNFalpha specific-cells and effector memory phenotype associate with active tuberculosis. J Infect 66: 475-486.
25. Jiang J, Wang X, Cao Z, Liu Y, Dong M, et al. (2010) Reduced CD27 expression on antigen-specific CD4+ T cells correlates with persistent active tuberculosis. J Clin Immunol 30: 566-573.
26. Gerdes J, Lemke H, Baisch H, Wacker HH, Schwab U, et al. (1984) Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol 133: 1710-1715. (Pubitemid 14035254)
27. Day CL, Abrahams DA, Lerumo L, Janse van Rensburg E, Stone L, et al. (2011) Functional capacity of Mycobacterium tuberculosis-specific T cell responses in humans is associated with mycobacterial load. J Immunol 187: 2222-2232.
28. Harari A, Rozot V, Enders FB, Perreau M, Stalder JM, et al. (2011) Dominant TNF-alpha+ Mycobacterium tuberculosis-specific CD4+ T cell responses discriminate between latent infection and active disease. Nat Med 17: 372-376.
29. Foo DG, Tay HC, Siew JY, Singhal A, Camacho L, et al. (2011) T cell monitoring of chemotherapy in experimental rat tuberculosis. Antimicrob Agents Chemother 55: 3677-3683.
30. Sester U, Fousse M, Dirks J, Mack U, Prasse A, et al. (2011) Whole-blood flow-cytometric analysis of antigen-specific CD4 T-cell cytokine profiles distinguishes active tuberculosis from non-active states. PLoS One 6: e17813.
31. Young JM, Adetifa IM, Ota MO, Sutherland JS (2010) Expanded polyfunctional T cell response to mycobacterial antigens in TB disease and contraction post-treatment. PLoS One 5: e11237.
32. Millington KA, Innes JA, Hackforth S, Hinks TS, Deeks JJ, et al. (2007) Dynamic relationship between IFN-gamma and IL-2 profile of Mycobacterium tuberculosis-specific T cells and antigen load. Journal of immunology 178: 5217-5226. (Pubitemid 46595306)
33. Caccamo N, Guggino G, Joosten SA, Gelsomino G, Di Carlo P, et al. (2010) Multifunctional CD4(+) T cells correlate with active Mycobacterium tuberculosis infection. Eur J Immunol 40: 2211-2220.
34. Veenstra H, Crous I, Brahmbhatt S, Lukey P, Beyers N, et al. (2007) Changes in the kinetics of intracellular IFN-gamma production in TB patients during treatment. Clinical immunology 124: 336-344. (Pubitemid 47260591)
35. Beveridge NE, Price DA, Casazza JP, Pathan AA, Sander CR, et al. (2007) Immunisation with BCG and recombinant MVA85A induces long-lasting, polyfunctional Mycobacterium tuberculosis-specific CD4+ memory T lymphocyte populations. Eur J Immunol 37: 3089-3100. (Pubitemid 350131288)
36. Day CL, Mkhwanazi N, Reddy S, Mncube Z, van der Stok M, et al. (2008) Detection of polyfunctional Mycobacterium tuberculosis-specific T cells and association with viral load in HIV-1-infected persons. J Infect Dis 197: 990-999. (Pubitemid 351590027)
37. Lindenstrom T, Agger EM, Korsholm KS, Darrah PA, Aagaard C, et al. (2009) Tuberculosis subunit vaccination provides long-term protective immunity characterized by multifunctional CD4 memory T cells. J Immunol 182: 8047-8055.
38. Derrick SC, Yabe IM, Yang A, Morris SL (2011) Vaccine-induced anti-tuberculosis protective immunity in mice correlates with the magnitude and quality of multifunctional CD4 T cells. Vaccine 29: 2902-2909.
39. Riou C, Ganusov VV, Campion S, Mlotshwa M, Liu MK, et al. (2012) Distinct kinetics of Gag-specific CD4+ and CD8+ T cell responses during acute HIV-1 infection. J Immunol 188: 2198-2206.
40. Gray CM, Lawrence J, Schapiro JM, Altman JD, Winters MA, et al. (1999) Frequency of class I HLA-restricted anti-HIV CD8+ T cells in individuals receiving highly active antiretroviral therapy (HAART). J Immunol 162: 1780-1788. (Pubitemid 29307058)