Factor xi regulates pathological thrombus formation on acutely ruptured atherosclerotic plaques

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 34, Issue 8, 2014, Pages 1668-1673

  Van Montfoort, Maurits L ^a   Kuijpers, Marijke J E ^b   Knaup, Véronique L ^a   Bhanot, Sanjay ^c   Monia, Brett P ^c   Roelofs, Joris J T H ^a   Heemskerk, Johan W M ^b   Meijers, Joost C M ^a,d  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c ISIS PHARMACEUTICALS   (United States)

^d SANQUIN RESEARCH   (Netherlands)

Author keywords

Atherosclerosis; Blood coagulation; Factor XI; Thrombosis

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; BLOOD CLOTTING FACTOR 11 ANTISENSE OLIGONUCLEOTIDE; COLLAGEN; PLACEBO; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTISENSE THERAPY; ARTICLE; BLEEDING TENDENCY; BLOOD CLOTTING; CAROTID ARTERY; CAROTID ATHEROSCLEROSIS; CONTROLLED STUDY; FIBRIN DEPOSITION; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MACROPHAGE; MICROSCOPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RUPTURED ATHEROSCLEROTIC PLAQUE; THROMBOCYTE ADHESION; THROMBOSIS PREVENTION; THROMBUS;

ATHEROSCLEROSIS; BLOOD COAGULATION; FACTOR XI; THROMBOSIS;

ANIMALS; APOLIPOPROTEINS E; ATHEROSCLEROSIS; BLOOD COAGULATION; BLOOD PLATELETS; CAROTID ARTERIES; CAROTID ARTERY DISEASES; CHOLESTEROL, DIETARY; COLLAGEN; DISEASE MODELS, ANIMAL; FACTOR XI; FIBRIN; INFLAMMATION; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OLIGONUCLEOTIDES, ANTISENSE; PLAQUE, ATHEROSCLEROTIC; PLATELET ADHESIVENESS; PLATELET AGGREGATION; RUPTURE, SPONTANEOUS; THROMBOSIS; TIME FACTORS;

EID: 84904573568     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.114.303209     Document Type: Article

References (30)

1. Lusis AJ. Atherosclerosis. Nature. 2000;407:233-241.
2. Guyatt GH, Akl EA, Crowther M, Gutterman DD, Schuunemann HJ. Executive summary: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012:141:7S-47S.
3. Levine MN, Raskob G, Beyth RJ, Kearon C, Schulman S. Hemorrhagic complications of anticoagulant treatment: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest. 2004;126(suppl 3):287S-310S.
4. Bouma BN, von dem Borne PA, Meijers JC. Factor XI and protection of the fibrin clot against lysis-a role for the intrinsic pathway of coagulation in fibrinolysis. Thromb Haemost. 1998;80:24-27.
5. Gailani D, Renné T. The intrinsic pathway of coagulation: a target for treating thromboembolic disease? J Thromb Haemost. 2007;5:1106-1112.
6. Gailani D, Renné T. Intrinsic pathway of coagulation and arterial thrombosis. Arterioscler Thromb Vasc Biol. 2007;27:2507-2513.
7. Löwenberg EC, Meijers JC, Monia BP, Levi M. Coagulation factor XI as a novel target for antithrombotic treatment. J Thromb Haemost. 2010;8:2349-2357.
8. Rosen ED, Gailani D, Castellino FJ. FXI is essential for thrombus formation following FeCl3-induced injury of the carotid artery in the mouse. Thromb Haemost. 2002;87:774-776.
9. Wang X, Cheng Q, Xu L, Feuerstein GZ, Hsu MY, Smith PL, Seiffert DA, Schumacher WA, Ogletree ML, Gailani D. Effects of facto r IX or factor XI deficiency on ferric chloride-induced carotid artery occlusion in mice. J Thromb Haemost. 2005;3:695-702.
10. Wang X, Smith PL, Hsu MY, Gailani D, Schumacher WA, Ogletree ML, Seiffert DA. Effects of factor XI deficiency on ferric chloride-induced vena cava thrombosis in mice. J Thromb Haemost. 2006;4:1982-1988.
11. Zhang H, Löwenberg EC, Crosby JR, MacLeod AR, Zhao C, Gao D, Black C, Revenko AS, Meijers JC, Stroes ES, Levi M, Monia BP. Inhibition of the intrinsic coagulation pathway factor XI by antisense oligonucleotides: a novel antithrombotic strategy with lowered bleeding risk. Blood. 2010;116:4684-4692.
12. Crosby JR, Marzec U, Revenko AS, Zhao C, Gao D, Matafonov A, Gailani D, MacLeod AR, Tucker EI, Gruber A, Hanson SR, Monia BP. Antithrombotic effect of ant isense factor XI oligonucleotide treatment in primates. Arterioscler Thromb Vasc Biol. 2013;33:1670-1678.
13. Salomon O, Steinberg DM, Zucker M, Varon D, Zivelin A, Seligsohn U. Patients with severe factor XI deficiency have a reduced incidence of deepvein thrombosis. Thromb Haemost. 2011;105:269-273.
14. Salomon O, Steinberg DM, Koren-Morag N, Tanne D, Seligsohn U. Reduced incidence of ischemic stroke in patients with severe factor XI deficiency. Blood. 2008;111:4113-4117.
15. Kuijpers MJ, Gilio K, Reitsma S, Nergiz-Unal R, Prinzen L, Heeneman S, Lutgens E, van Zandvoort MA, Nieswa ndt B, Egbrink MG, Heemskerk JW. Complementary roles of platelets and coagulation in thrombus formation on plaques acutely ruptured by targeted ultrasound treatment: a novel intravital model. J Thromb Haemost. 2009;7:152-161.
16. Libby P. Mechanisms of acute coronary syndromes and their implications for therapy. N Engl J Med. 2013;368:2004-2013.
17. Cheng Q, Tucker EI, Pine MS, Sisler I, Matafonov A, Sun MF, White- Adams TC, Smith SA, Hanson SR, McCarty OJ, Renné T, Gruber A, Gailani D. A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo. Blood. 2010;116:3981-3989.
18. van Montfoort ML, Knaup VL, Marquart JA, Bak htiari K, Castellino FJ, Hack CE, Meijers JC. Two novel inhibitory anti-human factor XI antibodies prevent cessation of blood flow in a murine venous thrombosis model. Thromb Haemost. 2013;110:1065-1073.
19. von Brühl ML, Stark K, Steinhart A, et al. Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo. J Exp Med. 2012;209:819-835.
20. Nergiz-Unal R, Cosemans JM, Feijge MA, van der Meijden PE, Storey RF, van Giezen JJ, oude Egbrink MG, Heemskerk JW, Kuijpers MJ. Stabilizing role of platelet P2Y(12) receptors in shear-dependent thrombus formation on ruptured plaques. PLoS One. 2010;5:e10130.
21. van Montfoort ML, Meijers JC. Anticoagulation beyond direct thrombin and factor Xa inhibitors: indications for targeting the intrinsic pathway? Thromb Haemost. 2013;110:223-232.
22. Renné T, Pozgajová M, Grüner S, Schuh K, Pauer HU, Burfeind P, Gailani D, Nieswandt B. Defective thrombus formation in mice lacking coagulation factor XII. J Exp Med. 2005;202:271-281.
23. Johnson JL, Jackson CL. Atherosclerotic plaque rupture in the apolipoprotein E knockout mouse. Atherosclerosis. 2001;154:399-406.
24. Westrick RJ, Winn ME, Eitzman DT. Murine models of vascular thrombosis (Eitzman series). Arterioscler Thromb Vasc Biol. 2007;27:2079-2093.
25. Schwartz SM, Galis ZS, Rosenfeld ME, Falk E. Plaque rupture in humans and mice. Arterioscler Thromb Vasc Biol. 2007;27:705-713.
26. Virmani R, Kolodgie FD, Burke AP, Farb A, Schwartz SM. Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol. 2000;20:1262-1275.
27. Tucker EI, Verbout NG, Leung PY, Hurst S, McCarty OJ, Gailani D, Gruber A. Inhibition of factor XI activation attenu ates inflammation and coagulopathy while improving the survival of mouse polymicrobial sepsis. Blood. 2012;119:4762-4768.
28. Itakura A, Verbout NG, Phillips KG, Insall RH, Gailani D, Tucker EI, Gruber A, McCarty OJ. Activated factor XI inhibits chemotaxis of polymorphonuclear leukocytes. J Leukoc Biol. 2011;90:923-927.
29. Renné T. The procoagulant and proinflammatory plasma contact system. Semin Immunopathol. 2012;34:31-41.
30. Borissoff JI, Otten JJ, Heeneman S, et al. Genetic and pharmacological modifications of thrombin formation in apolipoprotein e-deficient mice determine atherosclerosis se verity and atherothrombosis onset in a neutrophil- dependent manner. PLoS One. 2013;8:e55784.