Synthesis and biological evaluation of 2,3-dihydroimidazo[1,2-a] benzimidazole derivatives against Leishmania donovani and Trypanosoma cruzi

European Journal of Medicinal Chemistry

Volumn 84, Issue , 2014, Pages 395-403

  Oh, Sangmi ^a   Kim, Sungbum ^a   Kong, Sunju ^a   Yang, Gyongseon ^b   Lee, Nakyung ^b   Han, Dawoon ^b   Goo, Junghyun ^b   Siqueira Neto, Jair L ^b,c   Freitas Junior, Lucio H ^b,d   Song, Rita ^a  

^a Institute Pasteur Korea   (South Korea)

^b Institut Pasteur Korea   (South Korea)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d BRAZILIAN CENTER FOR RESEARCH IN ENERGY AND MATERIALS CNPEM   (Brazil)

Author keywords

2,3 Dihydroimidazo 1, 2 a benzimidazole; Anti parasitic activity; Chagas disease; Leishmaniasis

Indexed keywords

2,3 DIHYDROIMIDAZO[1,2 A]BENZIMIDAZOLE DERIVATIVE; 9 (3,5 DIMETHYLBENZYL) 2,9 DIHYDRO 3H BENZO[D]IMIDAZO [1,2 A]IMIDAZOLE; 9 (4 CYANOBENZYL) 3,9 DIHYDRO 2H BENZO[D]IMIDAZO[1,2 A] IMIDAZOLE; 9 (4 CYCLOHEXYLBENZYL) 2,9 DIHYDRO 3H BENZO[D]IMIDAZO [1,2 A]IMIDAZOLE; 9 (4 ETHYLBENZYL) 2,3 DIHYDROIMIDAZO[1,2 A]BENZIMIDAZOLE; 9 (4 ISOPROPYLBENZYL) 2,9 DIHYDRO 3H BENZO[D]IMIDAZO[1,2 A]IMIDAZOLE; 9 (4 PHENOXYBENZYL) 2,9 DIHYDRO 3H BENZO[D]IMIDAZO[1,2 A]IMIDAZOLE; 9 (4 PHENYLBENZYL) 2,3 DIHYDROIMIDAZO[1,2 A]BENZIMIDAZOLE; 9 (4 TERT BUTYLPHENOXYETHYL) 2,3 DIHYDROIMIDAZO[1,2 A]BENZIMIDAZOLE; 9 [3 (METHYLSULFONYLL)BENZYL] 2,9 DIHYDRO 3H BENZO[D]IMIDAZO [1,2 A]IMIDAZOLE; 9 [3 (TERT BUTYL)BENZYL] 2,9 DIHYDRO 3H BENZO[D]IMIDAZO [1,2 A]IMIDAZOLE; 9 [3 (TRIFLUOROMETHOXY)BENZYL] 3,9 DIHYDRO 2H BENZO[D]IMIDAZO [1,2 A]IMIDAZOLE; 9 [4 (TERT BUTYL)BENZYL] 6 CHLORO 3,9 DIHYDRO 2H BENZO[D] IMIDAZO[1,2 A]IMIDAZOLE; 9 [4 (TERT BUTYL)BENZYL] 6 FLUORO 2,9 DIHYDRO 3H BENZO[D] IMIDAZO[1,2 A]IMIDAZOLE; 9 [4 (TERT BUTYL)BENZYL] 6 METHYL 3,9 DIHYDRO 3H BENZO[D] IMIDAZO[1,2 A]IMIDAZOLE; 9 [4 (TERT BUTYL)BENZYL] 6,7 DIMETHYL 3,9 DIHYDRO 2H BENZO[D] IMIDAZO[1,2 A]IMIDAZOLE; 9 [4 (TERT BUTYL)PHENETHYL] 2,9 DIHYDRO 3H BENZO[D]IMIDAZO[1,2 A]IMIDAZOLE; 9 [[2',6' DIFLUORO (1,1' BIPHENYL) 4 YL]METHYL] 2,9 DIHYDRO 3H BENZO[D]IMIDAZO[1,2 A]IMIDAZOLE; 9 [[4' (TRIFLUOROMETHOXY) (1,1' BIPHENYL) 4 YL]METHYL] 3,9 DIHYDRO 2H BENZO[D]IMIDAZO[1,2 A]IMIDAZOLE; 9 [[4' CHLORO (1,1' BIPHENYL) 4 YL]METHYL] 3,9 DIHYDRO 2H BENZO[D]IMIDAZO[1,2 A]IMIDAZOLE; 9 [[4' METHOXY (1,1' BIPHENYL) 4 YL]METHYL] 3,9 DIHYDRO 2H BENZO[D]IMIDAZO[1,2 A]IMIDAZOLE; 9 [[4', FLUORO (1,1' BIPHENYL) 4 YL]METHYL] 3,9 DIHYDRO 2H BENZO[D]IMIDAZO[1,2 A]IMIDAZOLE; 9 [[4', METHYL (1,1' BIPHENYL) 4 YL]METHYL] 3,9 DIHYDRO 2H BENZO[D]IMIDAZO[1,2 A]IMIDAZOLE; ANTILEISHMANIAL AGENT; ANTITRYPANOSOMAL AGENT; BENZIMIDAZOLE DERIVATIVE; UNCLASSIFIED DRUG; 9-(4-PHENYLBENZYL)-2,3-DIHYDROIMIDAZO(1,2-A)BENZIMIDAZOLE; ANTIPARASITIC AGENT; FUSED HETEROCYCLIC RINGS;

ANTILEISHMANIAL ACTIVITY; ANTITRYPANOSOMAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHLORINATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SCREENING; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; LEISHMANIA DONOVANI; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; TRYPANOSOMA CRUZI; TRYPOMASTIGOTE; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SENSITIVITY; SYNTHESIS;

ANTIPARASITIC AGENTS; BENZIMIDAZOLES; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; LEISHMANIA DONOVANI; MOLECULAR STRUCTURE; PARASITIC SENSITIVITY TESTS; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOSOMA CRUZI;

EID: 84904557798     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.07.038     Document Type: Article

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