Analysis of 1,3 dimethylamylamine concentrations in Geraniaceae, geranium oil and dietary supplements

Drug Testing and Analysis

Volumn 6, Issue 7-8, 2014, Pages 797-804

  Austin, Krista G ^a,b   Travis, John ^c   Pace, Gerry ^c   Lieberman, Harris R ^a  

^a U S ARMY RESEARCH INSTITUTE OF ENVIRONMENTAL MEDICINE   (United States)

^b OAK RIDGE INSTITUTE FOR SCIENCE AND EDUCATION   (United States)

^c NSF INTERNATIONAL   (United States)

Author keywords

DMAA; DSHEA; Ephedra; Pelargonium; Stimulant; Synthetic

Indexed keywords

ESSENTIAL OILS; FOOD ADDITIVES; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NUTRITION; VITAMINS;

1,3-DIMETHYLAMYLAMINE; DSHEA; EPHEDRA; FINISHED PRODUCTS; GERANIACEAE; PELARGONIA; PLANT SPECIES; STIMULANT; SYNTHETIC; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY (UPLC MS/MS);

DIETARY SUPPLEMENTS;

1,3 DIMETHYLAMYLANINE; ADRENERGIC RECEPTOR STIMULATING AGENT; AMPHETAMINE; CAFFEINE; ESSENTIAL OIL; OXEDRINE; PSEUDOEPHEDRINE; UNCLASSIFIED DRUG; 1,3-DIMETHYLAMYLAMINE; AMINE; VEGETABLE OIL;

ANIMAL EXPERIMENT; ARTICLE; DIET SUPPLEMENTATION; DRUG DETERMINATION; EPHEDRA; GERANIACEAE; LIMIT OF DETECTION; NONHUMAN; PELARGONIUM; PRIORITY JOURNAL; RAT; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ANALYSIS; CHEMISTRY;

AMINES; DIETARY SUPPLEMENTS; GERANIACEAE; OILS, VOLATILE; PLANT OILS;

EID: 84904549854     PISSN: 19427603     EISSN: 19427611     Source Type: Journal    
DOI: 10.1002/dta.1491     Document Type: Article

References (35)

1. J. Gahche, R. Bailey, V. Burt, J. Hughes, E. Yetley, J. Dwyer, et al. Dietary supplement use among U.S. adults has increased since NHANES III (1988-1994). NCHS data brief, no 61. National Center for Health Statistics, Hyattsville, MD. Available at: http://www.cdc.gov/nchs/data/databriefs/db61.htm [8 July 2012].
2. R.L. Bailey, J.J. Gahche, C.V. Lentino, J.T. Dwyer, J.S. Engel, P.R. Thomas, et al. Dietary supplement use in the United States, 2003-2006. J. Nutr. 2011, 141, 261.
3. H.R. Lieberman, T.B. Stavinoha, S.M. McGraw, A. White, L.S. Hadden, B.P. Marriott . Use of dietary supplements among active-duty US Army soldiers. Am. J. Clin. Nutr. 2010, 92, 985.
4. M. Adams, US Weight Loss Market Worth $46.3 Billion in 2004-Forecast to Reach $61 Billion by 2008. Available at: http://www.naturalnews.com/006133.html [8 July 2012].
5. I.G. Jacobson, J.L. Horton, B. Smith, T.S. Wells, E.J. Boyko, H.R. Lieberman, et al. Bodybuilding, energy, and weight-loss supplements are associated with deployment and physical activity in U.S. military personnel. Ann. Epidemiol. 2012, 22, 318.
6. US Food and Drug Administration (FDA). Available at: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/2004/ucm108379.htm [8 July 2012].
7. D. Miller, in The Taxonomy of Pelargonium Species and Cultivars, (Ed: M. Lis-Balchin ), Taylor & Francis, London and New York, 2002, pp. 49-79.
8. Office of Dietary Supplements (ODS). Dietary supplement health and education act of 1994. Available at: http://www.ods.od.nih.gov/About/DSHEA_Wording.aspx [4 September 2012].
9. E.M. Williamson, in Use of Geranium Species Extracts as Herbal Medicines, (Ed: M. Lis-Balchin ), Taylor & Francis, London and New York, 2002, pp. 40-46.
10. S. Hart, M. Lis-Balchin . Pharmacology of Pelargonium essential oils and extracts in vitro and in vivo, in Geranium and Pelargonium: The genera Geranium and Pelargonium, (Ed: M. Lis-Balchin ), Taylor & Francis, London and New York, 2002, pp. 116-131.
11. C.A. Williams, J.B. Harborne . Phytochemistry of the Genus Pelargonium, in Geranium and Pelargonium: The genera Geranium and Pelargonium, (Ed: M. Lis-Balchin ), Taylor & Francis, London and New York, 2002, pp. 99-115.
12. M. Lis-Balchin . Essential Oils from Different Pelargonium Species and Cultivars: Their Chemical Composition (using GC, GC/MS) and Appearance of Trichomes, in (Ed: M. Lis-Balchin ), Taylor & Francis, London and New York, 2002, pp. 147-165.
13. Z. Ping, Q. Jun, L. Qing . A study on the chemical constituents of geranium oil. J. Guizhou Institut. Technol. 1996, 25, 82.
14. R. Shellie, P. Marriott . Comprehensive two-dimensional gas chromatography-mass spectrometry analysis of Pelargonium graveolens essential oil using rapid scanning quadrupole mass spectrometry. Analyst 2003, 128, 879.
15. B.M. Matsuda, G.A. Surgeoner, J.D. Heal, A.O. Tucker, M.J. Maciearello . Essential oil analysis and field evaluation of the citrosa plant 'pelargonium citrosum' as a repellent against populations of AEDES mosquitoes. J. Am. Mosq. Control Assoc. 1996, 12, 69.
16. M.A. ElSohly, W. Gul, K.M. ElSohly, T.P. Murphy, A. Weerasooriya, A.G. Chittiboyina . Pelargonium oil and methyl hexaneamine (MHA): Analytical approaches supporting the absence of MHA in authenticated Pelargonium graveolens plant material and oil. J. Anal. Toxicol. 2012, 36, 457.
17. Y. Zhang, R.M. Woods, Z.S. Breitbach, D.W. Armstrong . 1, 3 Dimethylamylamine (DMAA) in supplements and geranium products: natural or synthetic? Drug Test. Anal. 2012, 4, 986.
18. MSDS: Pseudoephedrine, L-(+)-. J. Pharmacol. Exp. Ther. 1965, 148, 158.
19. MSDS. Amphetamine. Hazardous Substances Data Bank (HSDB), a database of the National Library of Medicine's TOXNET system. Available at: http://toxnet.nlm.nih.gov [4 May 2011].
20. J.M. Peters . Factors affecting caffeine toxicity: A review of the literature. J. Clin. Pharmacol. J. New Drugs 1967, 7, 131.
21. S.J. Stohs, H.G. Preuss, M. Shara . The safety of citrus aurantium (bitter orange) and its primary protoalkaloid p-synephrine. Phytother. Res. 2011, 25, 1421.
22. MSDS: Pentylamine, 1, 3-dimethyl-, sulfate. J. Am. Pharm. Assoc. (Scientific Edn) 1953, 42, 107.
23. R. Charlier . Pharmacology of 2-amino-4-methylhexane. Arch. Int. Pharmacodyn. Ther. 1950, 83, 573.
24. Council on pharmacy and chemistry methylhexamine forthane (Lilly). JAMA 1950, 143, 1155.
25. T.M. Farney, C.G. McCarthy, R.E. Canale, R.J. Allman Jr, R.J. Bloomer . Hemodynamic and hematologic profile of healthy adults ingesting dietary supplements containing 1, 3-dimethylamylamine and caffeine. Nutr. Metab. Insights 2012, 5, 1.
26. H.A. Shonle, E. Rohrmann . US Patent 2350318, 1944.
27. Anonymous. New and nonofficial remedies: Methylhexamine; forthane. J. Am. Med. Assoc. 1950, 143, 1156.
28. R.J. Bloomer, I.C. Harvey, T.M. Farney, Z.W. Bell, R.E. Canale . Effects of 1, 3-dimethylamylamine and caffeine alone or in combination on heart rate and blood pressure in healthy men and women. Phys. Sportsmed. 2011, 39, 111.
29. U. S. Food and Drug Administration (FDA). FDA challenges marketing of DMAA products for lack of safety evidence. Available at: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm302133.htm [14 August 2012].
30. A. Lisi, N. Hasicki, R. Kazlauskas, C. Goebel . Studies of methylhexaneamine in supplements and geranium oil. Drug Test. Anal. 2011, 3, 873.
31. C.D. Lorenzo, E. Moro, A.D. Santos, F. Uberti, P. Restani . Could 1, 3 dimethylamylamine (DMAA) in food supplements have a natural origin? Drug Test. Anal. 2013, 5, 116.
32. L.T. Bui, D.T. Nguyen, P.J. Ambrose . Blood pressure and heart rate effects following a single dose of bitter orange. Ann. Pharmacother. 2006, 40, 53.
33. W.A. Blom, S.L. Abrahamse, R. Bradford, G.S. Duchateau, W. Theis, A. Orsi, et al. Effects of 15-d repeated consumption of Hoodia gordonii purified extract on safety, ad libitum energy intake, and body weight in healthy, overweight women: A randomized controlled trial. Am. J. Clin. Nutr. 2011, 94, 1171.
34. L.M. White, S.F. Gardner, B.J. Gurley, M.A. Marx, P.L. Wang, M. Estes . Pharmacokinetics and cardiovascular effects of ma-huang (Ephedra sinica) in normotensive adults. J. Clin. Pharmacol. 1997, 37, 116.
35. D.F. Marsh, A. Howard, D.A. Herring . The comparative pharmacology of the isomeric nitrogen methyl substituted heptylamines. J. Pharmacol. Exp. Ther. 1951, 103, 325.