Could 1,3 dimethylamylamine (DMAA) in food supplements have a natural origin?

Drug Testing and Analysis

Volumn 5, Issue 2, 2013, Pages 116-121

  Di Lorenzo, Chiara ^a   Moro, Enzo ^a   Dos Santos, Ariana ^a   Uberti, Francesca ^a   Restani, Patrizia ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

1,3 dimethylamylamine; DMAA; Doping; pelargonium

Indexed keywords

ESSENTIAL OILS; FOOD ADDITIVES; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NUTRITION; SPORTS; VITAMINS;

1,3-DIMETHYLAMYLAMINE; DIMETHYLAMYLAMINE; DOPING AGENT; FOOD SUPPLEMENTS; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY; PELARGONIA; PELARGONIUM GRAVEOLENS; PHYSIOLOGICAL EFFECTS; SPORT SUPPLEMENTS;

DIETARY SUPPLEMENTS;

4 METHYL 2 HEXYLAMINE; GERANIUM OIL; PELARGONIUM GRAVEOLENS EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG; VEGETABLE OIL;

ARTICLE; CONTROLLED STUDY; CULTIVAR; DIET SUPPLEMENTATION; GERANIUM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; PELARGONIUM GRAVEOLENS; PLANT LEAF; PLANT STEM; PRIORITY JOURNAL; SOLVENT EXTRACTION; SPORT; VALIDATION PROCESS;

EID: 84873747120     PISSN: 19427603     EISSN: 19427611     Source Type: Journal    
DOI: 10.1002/dta.1391     Document Type: Article

References (19)

1. Z. Ping, Q. Jun, L. Qing . A study on the chemical constituents of geranium oil. Journal of Guizhou Institute of Technology 1996, 25, 82.
2. H.A. Shonle, E. Rohrmann . Aminoalkanes. US Pat. 2, 350, 318. Patented 30 May 1944.
3. S.P. Vorce, J.M. Holler, B.M. Cawrse, J. Magluilo . Dimethylamylamine: a drug causing positive immunoassay results for amphetamines. J. Anal. Toxicol. 2011, 35, 183.
4. D.F. Marsh, A. Howard, D.A. Herring. The comparative pharmacology of the isomeric nitrogen methyl substituted heptylamines. J. Pharmacol. Exp. Ther. 1951, 103, 325.
5. S. Ellis . The effect of amines on the blood sugar of the rat. J. Pharmacol. Exp. Ther. 1951, 101, 92.
6. Health Canada. Classification of 1, 3-Dimethylamylamine (DMAA), 2011. Available at: http://www.scribd.com/doc/82744576/DMAA-Health-Canada-2011 [February 2012]
7. Health Canada. Recall of Jack 3D containing 1, 3-Dimethylamylamine (DMAA), 2011. Available at: http://www.hc-sc.gc.ca/dhp-mps/compli-conform/recall-retrait/_list/rec-ret_drugs-med_trade-marque_july-sept_2011-eng.php [November 2011]
8. A. Shipley . Chemist's new product contains hidden substance. Washington Post, Monday, May 8th. Washington, DC, 2006. Available at : http://www.highbeam.com/doc/1P2-130087.html [January 2012]
9. P. Gee, S. Jackson, J. Easton . Another bitter pill: a case of toxicity from DMAA party pills. N. Z. Med. J. 2010, 1327, 124.
10. C. Kelleher, J. Fox, R. Christie, M. Bowden, K. Lalor, C. O'Donneli . An overview of new psychoactive substances and the outlets supplying them. National Advisory Committee on Drugs, 2011. Available at: http://www.nacd.ie/publications/HeadSum2011_summary.pdf [January 2012]
11. New Zealand Ministry of Health. Advice to the expert advisory committee on drugs on: Assessment of 1, 3 dimethylamylamine (DMAA), 2009. http://www.ndp.govt.nz/moh.nsf/Files/ndp-advice-docs/$file/advice-to-minister-dmaa-sep-2009.pdf [February 2012]
12. World Anti-Doping Agency. The 2012 prohibited list, 2012. http://www.wada-ama.org/Documents/World_Anti-Doping_Program/WADP-Prohibited-list/2012/WADA_Prohibited_List_2012_EN.pdf [February 2012]
13. L. Perrenoud, M. Saug, C. Saudan . Detection in urine of 4-methyl-2-hexaneamine, a doping agent. J. Chromatog. B 2009, 877, 3767.
14. L. Salinger, B. Daniels, B. Sangalli, M. Bayer . Recreational use of body-building supplement resulting in severe cardiotoxicity. Clin. Toxicol. 2011, 49, 573.
15. US Army Medical Command Public Affairs. Dietary supplements removed from Exchanges due to health concerns, 2011. Available at:http://www.af.mil/news/story.asp?id=123284707 [January 2012]
16. US Food and Drug Administration. FDA challenges marketing of DMAA products for lack of safety evidence, 2012. Available at: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm302133.htm [June 2012]
17. A. Lisi, N. Hasick, R. Kazlauskas, C. Goebel . Studies of methylhexaneamine in supplements and geranium oil. Drug Test. Anal. 2011, 3, 873.
18. Ministreriet for Fedevarer, Landbrug og Fisheri. Advarsel mod farligt og forbudt stof, 2011. Available at:http://www.foedevarestyrelsen.dk/Nyheder/Pressemeddelelser/2011/Sider/Advarsel-mod-dopingstoffer.aspx [February 2012]
19. M.A. ElSohly, W. Gul, K.M. ElSohly, T.P. Murphy, A. Weerasooriya, A.G. Ghittiboyina, B. Avula, I. Khan, A. Eichner, L.D. Bowers. Pelargonium oil and methyl hexaneamine (MHA): analytical approaches supporting the absence of MHA in authenticated Pelargonium graveolens plant material and oil. J. Anal. Toxicol. 2012. DOI:10.1093/jat/bks055