Downregulation of miR-23a and miR-27a following experimental traumatic brain injury induces neuronal cell death through activation of proapoptotic Bcl-2 proteins

Journal of Neuroscience

Volumn 34, Issue 30, 2014, Pages 10055-10071

  Sabirzhanov, Boris ^a   Zhao, Zaorui ^a   Stoica, Bogdan A ^a   Loane, David J ^a   Wu, Junfang ^a   Borroto, Carlos ^b   Dorsey, Susan G ^b,c   Faden, Alan I ^a,c  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF NURSING   (United States)

^c UNIVERSITY OF MARYLAND   (United States)

Author keywords

Apoptosis; Bcl 2 proteins; MicroRNA; Neuroprotection; Traumatic brain injury

Indexed keywords

APOPTOSIS INDUCING FACTOR; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; BETA ACTIN; CASPASE 3; CYTOCHROME C; FODRIN; MICRORNA; MICRORNA 23 A; MICRORNA 27 A; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN NOXA; PROTEIN P53; PUMA PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG;

ADULT; ANIMAL CELL; ARTICLE; CELL VIABILITY ASSAY; CONTROLLED STUDY; DNA DAMAGE; DOWN REGULATION; GENE EXPRESSION; LUCIFERASE ASSAY; MALE; MOUSE; NERVE CELL NECROSIS; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ACTIVATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION; TRAUMATIC BRAIN INJURY; UPREGULATION; WESTERN BLOTTING;

APOPTOSIS; BCL-2 PROTEINS; MICRORNA; NEUROPROTECTION; TRAUMATIC BRAIN INJURY;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BRAIN INJURIES; CELL DEATH; DOWN-REGULATION; MALE; MICE; MICE, INBRED C57BL; MICRORNAS; NEURONS; PROTO-ONCOGENE PROTEINS C-BCL-2; UP-REGULATION;

EID: 84904539034     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1260-14.2014     Document Type: Article

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