Direct synthesis of 4-fluoroisoxazoles through gold-catalyzed cascade cyclization-fluorination of 2-alkynone O-methyl oximes

Journal of Organic Chemistry

Volumn 79, Issue 14, 2014, Pages 6444-6455

  Jeong, Yunkyung ^a   Kim, Bom I ^a   Lee, Jae Kyun ^b   Ryu, Jae Sang ^a  

^a Ewha Womans University   (South Korea)

^b Korea Institute of Science and Technology   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORINATION; FLUORINE; HALOGENATION;

DIRECT SYNTHESIS; HIGH SELECTIVITY; HIGH YIELD; INTRAMOLECULAR CYCLIZATIONS; ISOXAZOLES; MILD REACTION CONDITIONS; ROOM TEMPERATURE; SELECTFLUOR;

CYCLIZATION;

3 (3 METHOXYPHENYL) 5 PHENYLISOXAZOLE; 3 (3 NITROPHENYL) 5 PHENYLISOXAZOLE; 3 (4 CHLOROPHENYL) 4 FLUORO 5 (P TOLYL)ISOXAZOLE; 3 (4 CHLOROPHENYL) 4 FLUORO 5 PHENYLISOXAZOLE; 3 (FURAN 2 YL) 5 (4 METHOXYPHENYL)ISOXAZOLE; 4 FLUORO 3 (2 METHOXYPHENYL) 5 PHENYLISOXAZOLE; 4 FLUORO 3 (3 METHOXYPHENYL) 5 PHENYLISOXAZOLE; 4 FLUORO 3 (3 NITROPHENYL) 5 PHENYLISOXAZOLE; 4 FLUORO 3 (4 FLUOROPHENYL) 5 PHENYLISOXAZOLE; 4 FLUORO 3 (FURAN 2 YL) 5 (4 METHOXYPHENYL)ISOXAZOLE; 4 FLUORO 3 METHYL 5 PHENYLISOXAZOLE; 4 FLUORO 3 PHENYL 5 (P TOLYL)ISOXAZOLE; 4 FLUORO 3,5 DIPHENYLISOXAZOLE; 4 FLUORO 5 (4 METHOXYPHENYL) 3 PHENYLISOXAZOLE; 4 FLUORO 5 (4 PENTYLPHENYL) 3 PHENYLISOXAZOLE; 4 FLUORO 5 HEXYL 3 PHENYLISOXAZOLE; 4 FLUORO 5 PHENYL 3 (P TOLYL)ISOXAZOLE; 4 FLUORO 5 PHENYL 3 [4 (TRIFLUOROMETHYL)PHENYL]ISOXAZOLE; 5 (3 CHLOROPHENYL) 3 PHENYLISOXAZOLE; 5 (3 CHLOROPHENYL) 4 FLUORO 3 PHENYLISOXAZOLE; 5 PHENYL 3 [4 (TRIFLUOROMETHYL)PHENYL]ISOXAZOLE; GOLD; ISOXAZOLE DERIVATIVE; OXIME DERIVATIVE; UNCLASSIFIED DRUG; FLUORINATED HYDROCARBON; ORGANOGOLD COMPOUND; OXIME;

ARTICLE; CATALYSIS; CONTROLLED STUDY; CYCLIZATION; DEMETHYLATION; DRUG STRUCTURE; DRUG SYNTHESIS; FLUORINATION; FLUORINE NUCLEAR MAGNETIC RESONANCE; GOLD CATALYSIS; ONE POT SYNTHESIS; OXIDATION; REACTION TIME; ROOM TEMPERATURE; X RAY CRYSTALLOGRAPHY; CHEMICAL STRUCTURE; CHEMISTRY; SYNTHESIS;

CATALYSIS; CYCLIZATION; HYDROCARBONS, FLUORINATED; ISOXAZOLES; MOLECULAR STRUCTURE; ORGANOGOLD COMPOUNDS; OXIMES;

EID: 84904538157     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo5008702     Document Type: Article

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