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Volumn 34, Issue 2, 2014, Pages 356-367

Depletion of thymosin β4 promotes the proliferation, migration, and activation of human hepatic stellate cells

Author keywords

Hepatic stellate cell; Liver fibrosis; Migration; Proliferation; Thymosin 4

Indexed keywords

8 [4 (1 AMINOCYCLOBUTYL)PHENYL] 9 PHENYL 1,2,4 TRIAZOLO[3,4 F][1,6]NAPHTHYRIDIN 3(2H) ONE; ALPHA SMOOTH MUSCLE ACTIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SMALL INTERFERING RNA; THYMOSIN BETA4; VIMENTIN; ACTA2 PROTEIN, HUMAN; ACTIN; THYMOSIN; THYMOSIN BETA(4);

EID: 84904530393     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000363005     Document Type: Article
Times cited : (52)

References (42)
  • 1
    • 35948964347 scopus 로고    scopus 로고
    • Hepatic stellate cells and liver fibrosis
    • Moreira RK: Hepatic stellate cells and liver fibrosis. Arch Pathol Lab Med 2007;131:1728-1734.
    • (2007) Arch Pathol Lab Med , vol.131 , pp. 1728-1734
    • Moreira, R.K.1
  • 3
    • 0034809804 scopus 로고    scopus 로고
    • Hepatic stellate cells as a target for the treatment of liver fibrosis
    • Bataller R, Brenner DA: Hepatic stellate cells as a target for the treatment of liver fibrosis. Semin Liver Dis 2001;21:437-451.
    • (2001) Semin Liver Dis , vol.21 , pp. 437-451
    • Bataller, R.1    Brenner, D.A.2
  • 4
    • 84856401734 scopus 로고    scopus 로고
    • Liver fibrosis: Signals leading to the amplification of the fibrogenic hepatic stellate cell
    • Gabele E, Brenner DA, Rippe RA: Liver fibrosis: Signals leading to the amplification of the fibrogenic hepatic stellate cell. Front Biosci 2003;8:d69-77.
    • (2003) Front Biosci , vol.8
    • Gabele, E.1    Brenner, D.A.2    Rippe, R.A.3
  • 5
    • 0032731751 scopus 로고    scopus 로고
    • Hepatic stellate cells and the regulation of liver inflammation
    • Marra F: Hepatic stellate cells and the regulation of liver inflammation. J Hepatol 1999;31:1120-1130.
    • (1999) J Hepatol , vol.31 , pp. 1120-1130
    • Marra, F.1
  • 7
    • 47049124833 scopus 로고    scopus 로고
    • Thymosin beta-4 upregulates anti-oxidative enzymes and protects human cornea epithelial cells against oxidative damage
    • Ho JH, Tseng KC, Ma WH, Chen KH, Lee OK, Su Y: Thymosin beta-4 upregulates anti-oxidative enzymes and protects human cornea epithelial cells against oxidative damage. Br J Ophthalmol 2008;92:992-997.
    • (2008) Br J Ophthalmol , vol.92 , pp. 992-997
    • Ho, J.H.1    Tseng, K.C.2    Ma, W.H.3    Chen, K.H.4    Lee, O.K.5    Su, Y.6
  • 9
    • 84884708216 scopus 로고    scopus 로고
    • Trpm7 channel regulates pdgf-bb-induced proliferation of hepatic stellate cells via pi3k and erk pathways
    • Fang L, Zhan S, Huang C, Cheng X, Lv X, Si H, Li J: Trpm7 channel regulates pdgf-bb-induced proliferation of hepatic stellate cells via pi3k and erk pathways. Toxicol Appl Pharmacol 2013;272:713-725.
    • (2013) Toxicol Appl Pharmacol , vol.272 , pp. 713-725
    • Fang, L.1    Zhan, S.2    Huang, C.3    Cheng, X.4    Lv, X.5    Si, H.6    Li, J.7
  • 10
    • 35348990180 scopus 로고    scopus 로고
    • Thymosin beta4 upregulates the expression of hepatocyte growth factor and downregulates the expression of pdgf-beta receptor in human hepatic stellate cells
    • Barnaeva E, Nadezhda A, Hannappel E, Sjogren MH, Rojkind M: Thymosin beta4 upregulates the expression of hepatocyte growth factor and downregulates the expression of pdgf-beta receptor in human hepatic stellate cells. Ann N Y Acad Sci 2007;1112:154-160.
    • (2007) Ann N y Acad Sci , vol.1112 , pp. 154-160
    • Barnaeva, E.1    Nadezhda, A.2    Hannappel, E.3    Sjogren, M.H.4    Rojkind, M.5
  • 11
    • 0033965330 scopus 로고    scopus 로고
    • Hydrogen peroxide: A link between acetaldehyde-elicited alpha1(i) collagen gene up-regulation and oxidative stress in mouse hepatic stellate cells
    • Greenwel P, Dominguez-Rosales JA, Mavi G, Rivas-Estilla AM, Rojkind M: Hydrogen peroxide: A link between acetaldehyde-elicited alpha1(i) collagen gene up-regulation and oxidative stress in mouse hepatic stellate cells. Hepatology 2000;31:109-116.
    • (2000) Hepatology , vol.31 , pp. 109-116
    • Greenwel, P.1    Dominguez-Rosales, J.A.2    Mavi, G.3    Rivas-Estilla, A.M.4    Rojkind, M.5
  • 12
    • 0030926245 scopus 로고    scopus 로고
    • Thymosin beta 4 stimulates directional migration of human umbilical vein endothelial cells
    • Malinda KM, Goldstein AL, Kleinman HK: Thymosin beta 4 stimulates directional migration of human umbilical vein endothelial cells. FASEB J 1997;11:474-481.
    • (1997) FASEB J , vol.11 , pp. 474-481
    • Malinda, K.M.1    Goldstein, A.L.2    Kleinman, H.K.3
  • 13
    • 9644281738 scopus 로고    scopus 로고
    • Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair
    • Bock-Marquette I, Saxena A, White MD, Dimaio JM, Srivastava D: Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature 2004;432:466-472.
    • (2004) Nature , vol.432 , pp. 466-472
    • Bock-Marquette, I.1    Saxena, A.2    White, M.D.3    Dimaio, J.M.4    Srivastava, D.5
  • 14
    • 84900352789 scopus 로고    scopus 로고
    • The balance of thymosin 4 and its metabolite ac-sdkp modulates activity of profibrotic factors
    • Zuo Y PS, Yang HC, Ma LJ, Fogo AB.: The balance of thymosin 4 and its metabolite ac-sdkp modulates activity of profibrotic factors. Modern Pathol 2010;23:Suppl 1.
    • (2010) Modern Pathol , vol.23 , Issue.SUPPL. 1
    • Zuo, Y.P.S.1    Yang, H.C.2    Ma, L.J.3    Fogo, A.B.4
  • 16
    • 79959232291 scopus 로고    scopus 로고
    • Thymosin-beta4 (tbeta4) blunts pdgf-dependent phosphorylation and binding of akt to actin in hepatic stellate cells
    • Reyes-Gordillo K, Shah R, Popratiloff A, Fu S, Hindle A, Brody F, Rojkind M: Thymosin-beta4 (tbeta4) blunts pdgf-dependent phosphorylation and binding of akt to actin in hepatic stellate cells. Am J Pathol 2011;178:2100-2108.
    • (2011) Am J Pathol , vol.178 , pp. 2100-2108
    • Reyes-Gordillo, K.1    Shah, R.2    Popratiloff, A.3    Fu, S.4    Hindle, A.5    Brody, F.6    Rojkind, M.7
  • 17
    • 0034120477 scopus 로고    scopus 로고
    • An oral endothelin - A receptor antagonist blocks collagen synthesis and deposition in advanced rat liver fibrosis
    • Cho JJ, Hocher B, Herbst H, Jia JD, Ruehl M, Hahn EG, Riecken EO, Schuppan D: An oral endothelin-a receptor antagonist blocks collagen synthesis and deposition in advanced rat liver fibrosis. Gastroenterology 2000;118:1169-1178.
    • (2000) Gastroenterology , vol.118 , pp. 1169-1178
    • Cho, J.J.1    Hocher, B.2    Herbst, H.3    Jia, J.D.4    Ruehl, M.5    Hahn, E.G.6    Riecken, E.O.7    Schuppan, D.8
  • 18
    • 0030796417 scopus 로고    scopus 로고
    • Silymarin retards collagen accumulation in early and advanced biliary fibrosis secondary to complete bile duct obliteration in rats
    • Boigk G, Stroedter L, Herbst H, Waldschmidt J, Riecken EO, Schuppan D: Silymarin retards collagen accumulation in early and advanced biliary fibrosis secondary to complete bile duct obliteration in rats. Hepatology 1997;26:643-649.
    • (1997) Hepatology , vol.26 , pp. 643-649
    • Boigk, G.1    Stroedter, L.2    Herbst, H.3    Waldschmidt, J.4    Riecken, E.O.5    Schuppan, D.6
  • 22
    • 80052371597 scopus 로고    scopus 로고
    • Human merkel cell polyomavirus small t antigen is an oncoprotein targeting the 4e-bp1 translation regulator
    • Shuda M, Kwun HJ, Feng H, Chang Y, Moore PS: Human merkel cell polyomavirus small t antigen is an oncoprotein targeting the 4e-bp1 translation regulator. J Clin Invest 2011;121:3623-3634.
    • (2011) J Clin Invest , vol.121 , pp. 3623-3634
    • Shuda, M.1    Kwun, H.J.2    Feng, H.3    Chang, Y.4    Moore, P.S.5
  • 23
    • 0025856003 scopus 로고
    • Thymosin beta 4 and fx, an actin-sequestering peptide, are indistinguishable
    • Safer D, Elzinga M, Nachmias VT: Thymosin beta 4 and fx, an actin-sequestering peptide, are indistinguishable. J Biol Chem 1991;266:4029-4032.
    • (1991) J Biol Chem , vol.266 , pp. 4029-4032
    • Safer, D.1    Elzinga, M.2    Nachmias, V.T.3
  • 24
    • 0026520286 scopus 로고
    • Thymosin beta 4 (fx peptide) is a potent regulator of actin polymerization in living cells
    • Sanders MC, Goldstein AL, Wang YL: Thymosin beta 4 (fx peptide) is a potent regulator of actin polymerization in living cells. Proc Natl Acad Sci U S A 1992;89:4678-4682.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 4678-4682
    • Sanders, M.C.1    Goldstein, A.L.2    Wang, Y.L.3
  • 26
    • 33751225093 scopus 로고    scopus 로고
    • Thymosin beta4 sequesters actin in cystic fibrosis sputum and decreases sputum cohesivity in vitro
    • Rubin BK, Kater AP, Goldstein AL: Thymosin beta4 sequesters actin in cystic fibrosis sputum and decreases sputum cohesivity in vitro. Chest 2006;130:1433-1440.
    • (2006) Chest , vol.130 , pp. 1433-1440
    • Rubin, B.K.1    Kater, A.P.2    Goldstein, A.L.3
  • 32
    • 35348954196 scopus 로고    scopus 로고
    • Determination of thymosin beta4 and protein in human wound fluid after abdominal surgery
    • Bodendorf S, Born G, Hannappel E: Determination of thymosin beta4 and protein in human wound fluid after abdominal surgery. Ann N Y Acad Sci 2007;1112:418-424.
    • (2007) Ann N y Acad Sci , vol.1112 , pp. 418-424
    • Bodendorf, S.1    Born, G.2    Hannappel, E.3
  • 33
    • 0032578596 scopus 로고    scopus 로고
    • Activated rat stellate cells express c-met and respond to hepatocyte growth factor to enhance transforming growth factor beta1 expression and DNA synthesis
    • Ikeda H, Nagoshi S, Ohno A, Yanase M, Maekawa H, Fujiwara K: Activated rat stellate cells express c-met and respond to hepatocyte growth factor to enhance transforming growth factor beta1 expression and DNA synthesis. Biochem Biophys Res Commun 1998;250:769-775.
    • (1998) Biochem Biophys Res Commun , vol.250 , pp. 769-775
    • Ikeda, H.1    Nagoshi, S.2    Ohno, A.3    Yanase, M.4    Maekawa, H.5    Fujiwara, K.6
  • 34
    • 17144366279 scopus 로고    scopus 로고
    • Growth inhibition and apoptosis in liver myofibroblasts promoted by hepatocyte growth factor leads to resolution from liver cirrhosis
    • Kim WH, Matsumoto K, Bessho K, Nakamura T: Growth inhibition and apoptosis in liver myofibroblasts promoted by hepatocyte growth factor leads to resolution from liver cirrhosis. Am J Pathol 2005;166:1017-1028.
    • (2005) Am J Pathol , vol.166 , pp. 1017-1028
    • Kim, W.H.1    Matsumoto, K.2    Bessho, K.3    Nakamura, T.4
  • 36
    • 0034869459 scopus 로고    scopus 로고
    • Oxidative stress-related molecules and liver fibrosis
    • Parola M, Robino G: Oxidative stress-related molecules and liver fibrosis. J Hepatol 2001;35:297-306.
    • (2001) J Hepatol , vol.35 , pp. 297-306
    • Parola, M.1    Robino, G.2
  • 38
    • 80055028395 scopus 로고    scopus 로고
    • Thymosin beta 4 prevents oxidative stress by targeting antioxidant and anti-apoptotic genes in cardiac fibroblasts
    • Kumar S, Gupta S: Thymosin beta 4 prevents oxidative stress by targeting antioxidant and anti-apoptotic genes in cardiac fibroblasts. PLoS One 2011;6:e26912.
    • (2011) PLoS One , vol.6
    • Kumar, S.1    Gupta, S.2
  • 39
    • 0030045346 scopus 로고    scopus 로고
    • Cell migration: A physically integrated molecular process
    • Lauffenburger DA, Horwitz AF: Cell migration: A physically integrated molecular process. Cell 1996;84:359-369.
    • (1996) Cell , vol.84 , pp. 359-369
    • Lauffenburger, D.A.1    Horwitz, A.F.2
  • 40
    • 0037459075 scopus 로고    scopus 로고
    • Cellular motility driven by assembly and disassembly of actin filaments
    • Pollard TD, Borisy GG: Cellular motility driven by assembly and disassembly of actin filaments. Cell 2003;112:453-465.
    • (2003) Cell , vol.112 , pp. 453-465
    • Pollard, T.D.1    Borisy, G.G.2
  • 41
    • 65549110635 scopus 로고    scopus 로고
    • Spatial coordination of actin polymerization and ilk-akt2 activity during endothelial cell migration
    • Fan Y, Gong Y, Ghosh PK, Graham LM, Fox PL: Spatial coordination of actin polymerization and ilk-akt2 activity during endothelial cell migration. Dev Cell 2009;16:661-674.
    • (2009) Dev Cell , vol.16 , pp. 661-674
    • Fan, Y.1    Gong, Y.2    Ghosh, P.K.3    Graham, L.M.4    Fox, P.L.5
  • 42
    • 0037220482 scopus 로고    scopus 로고
    • Liver fibrosis - From bench to bedside
    • Friedman SL: Liver fibrosis - from bench to bedside. J Hepatol 2003;38:S38-53.
    • (2003) J Hepatol , vol.38
    • Friedman, S.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.