Serum tryptase, mast cells positive to tryptase and microvascular density evaluation in early breast cancer patients: Possible translational significance

BMC Cancer

Volumn 14, Issue 1, 2014, Pages

  Marech, Ilaria ^a   Ammendola, Michele ^b   Sacco, Rosario ^b   Capriuolo, Gennaro S ^c   Patruno, Rosa ^c   Rubini, Rosangela ^c   Luposella, Maria ^b   Zuccalà, Valeria ^b   Savino, Eufemia ^a   Gadaleta, Cosmo D ^a   Ribatti, Domenico ^a,d   Ranieri, Girolamo ^a  

^a NATIONAL CANCER INSTITUTE GIOVANNI PAOLO II   (Italy)

^b UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^c Department of Health ASL BAT   (Italy)

^d UNIVERSITY OF BARI MEDICAL SCHOOL   (Italy)

Author keywords

Angiogenesis; Breast cancer; Mast cells; Serum tryptase; Surrogate marker; Tissue tryptase

Indexed keywords

TRYPTASE;

ADULT; AGED; ARTICLE; BLOOD VESSEL PARAMETERS; BREAST CANCER; CANCER PATIENT; CANCER SURGERY; CELL DENSITY; CLINICAL FEATURE; CONTROLLED STUDY; ENZYME BLOOD LEVEL; ENZYME IMMUNOASSAY; FEMALE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MAST CELL; MASTECTOMY; MICROVASCULAR DENSITY; TUMOR VASCULARIZATION; BLOOD; BREAST NEOPLASMS; ENZYMOLOGY; MIDDLE AGED; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; TRANSLATIONAL RESEARCH; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; BREAST NEOPLASMS; FEMALE; HUMANS; MAST CELLS; MIDDLE AGED; NEOVASCULARIZATION, PATHOLOGIC; TRANSLATIONAL MEDICAL RESEARCH; TRYPTASES;

EID: 84904528752     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-14-534     Document Type: Article

References (35)

1. Galli SJ, Kalesnikoff J, Grimbaldeston MA, Piliponsky AM, Williams CM, Tsai M. Mast cells as "tunable" effector and immunoregulatory cells: recent advances. Annu Rev Immunol 2005, 23:749-786. 10.1146/annurev.immunol.21.120601.141025, 15771585.
2. Ribatti D, Crivellato E. Mast cells, angiogenesis and cancer. Adv Exp Med Biol 2011, 716:270-288. 10.1007/978-1-4419-9533-9_14, 21713661.
3. Ribatti D, Guidolin D, Marzullo A, Nico B, Annese T, Benagiano V, Crivellato E. Mast cells and angiogenesis in gastric carcinoma. Int J Exp Pathol 2010, 91:350-356. 10.1111/j.1365-2613.2010.00714.x, 2962893, 20412338.
4. Ranieri G. Hot topic: targeting tumor angiogenesis: an update. Curr Med Chem 2012, 19:937. 10.2174/092986712799320718, 22214460.
5. Theoharides TC, Conti P. Mast cells: the Jekyll and Hyde of tumor growth. Trends Immunol 2004, 25:235-241. 10.1016/j.it.2004.02.013, 15099563.
6. Ranieri G, Coviello M, Chiriatti A, Stea B, Montemurro S, Quaranta M, Dittadi R, Paradiso A. Vascular endothelial growth factor assessment in different blood fractions of gastrointestinal cancer patients and healthy controls. Oncol Rep 2004, 11:435-439.
7. Mangia A, Malfettone A, Rossi R, Paradiso A, Ranieri G, Simone G, Resta L. Tissue remodelling in breast cancer: human mast cell tryptase as an initiator of myofibroblast differentiation. Histopathology 2011, 58:1096-1106. 10.1111/j.1365-2559.2011.03842.x, 21707711.
8. Ranieri G, Ammendola M, Patruno R, Celano G, Zito FA, Montemurro S, Rella A, Di Lecce V, Gadaleta CD, Battista De Sarro G, Ribatti D. Tryptase-positive mast cells correlate with angiogenesis in early breast cancer patients. Int J Oncol 2009, 35:115-120.
9. Ranieri G, Labriola A, Achille G, Florio G, Zito AF, Grammatica L, Paradiso A. Microvessel density, mast cell density and thymidine phosphorylase expression in oral squamous carcinoma. Int J Oncol 2002, 21:1317-1323.
10. Tomita M, Matsuzaki Y, Edagawa M, Shimizu T, Hara M, Sekiya R, Onitsuka T. Association of mast cells with tumor angiogenesis in esophageal squamous cell carcinoma. Dis Esophagus 2001, 14:135-138. 10.1046/j.1442-2050.2001.00171.x, 11553224.
11. Ribatti D, Finato N, Crivellato E, Marzullo A, Mangieri D, Nico B, Vacca A, Beltrami CA. Neovascularization and mast cells with tryptase activity increase simultaneously with pathologic progression in human endometrial cancer. Am J Obstet Gynecol 2005, 193:1961-1965. 10.1016/j.ajog.2005.04.055, 16325597.
12. Ammendola M, Sacco R, Donato G, Zuccalà V, Russo E, Luposella M, Vescio G, Rizzuto A, Patruno R, De Sarro G, Montemurro S, Sammarco G, Ranieri G. Mast cell positivity to tryptase correlates with metastatic lymph nodes in gastrointestinal cancer patients treated surgically. Oncology 2013, 85:111-116. doi:10.1159/000351145, 10.1159/000351145, 23887206.
13. Acikalin MF, Oner U, Topçu I, Yaşar B, Kiper H, Colak E. Tumour angiogenesis and mast cell density in the prognostic assessment of colorectal carcinomas. Dig Liver Dis 2005, 37:162-169. 10.1016/j.dld.2004.09.028, 15888280.
14. Gulubova M, Vlaykova T. Prognostic significance of mast cell number and microvascular density for the survival of patients with primary colorectal cancer. J Gastroenterol Hepatol 2009, 24:1265-1275. 10.1111/j.1440-1746.2007.05009.x, 17645466.
15. Esposito I, Menicagli M, Funel N, Bergmann F, Boggi U, Mosca F, Bevilacqua G, Campani D. Inflammatory cells contribute to the generation of an angiogenic phenotype in pancreatic ductal adenocarcinoma. J ClinPathol 2004, 57:630-636.
16. Tuna B, Yorukoglu K, Unlu M, Mungan MU, Kirkali Z. Association of mast cells with microvessel density in renal cell carcinomas. Eur Urol 2006, 50:530-534. 10.1016/j.eururo.2005.12.040, 16426730.
17. Carlini MJ, Dalurzo MC, Lastiri JM, Smith DE, Vasallo BC, Puricelli LI, de Cidre Lauría LS. Mast cell phenotypes and microvessels in non-small cell lung cancer and its prognostic significance. Hum Pathol 2010, 41:697-705. 10.1016/j.humpath.2009.04.029, 20040391.
18. Ribatti D, Ennas MG, Vacca A, Ferreli F, Nico B, Orru S, Sirigu P. Tumor vascularity and tryptase-positive mast cells correlate with a poor prognosis in melanoma. Eur J Clin Invest 2003, 33:420-425. 10.1046/j.1365-2362.2003.01152.x, 12760367.
19. Benítez-Bribiesca L, Wong A, Utrera D, Castellanos E. The role of mast cell tryptase in neoangiogenesis of premalignant and malignant lesions of the uterine cervix. J Histochem Cytochem 2001, 49:1061-1062. 10.1177/002215540104900816, 11457936.
20. Ranieri G, Patruno R, Lionetti A, Di Summa A, Mattioli E, Bufo P, Pellecchia A, Ribatti D, Zizzo N. Endothelial area and microvascular density in a canine non-Hodgkin's lymphoma: an interspecies model of tumor angiogenesis. Leuk Lymphoma 2005, 46:1639-1643. 10.1080/10428190500205150, 16236617.
21. Nico B, Mangieri D, Crivellato E, Vacca A, Ribatti D. Mast cells contribute to vasculogenic mimicry in multiple myeloma. Stem Cells Dev 2008, 17:19-22. 10.1089/scd.2007.0132, 18205547.
22. Ribatti D, Molica S, Vacca A, Nico B, Crivellato E, Roccaro AM, Dammacco F. Tryptase-positive mast cells correlate positively with bone marrow angiogenesis in B-cell chronic lymphocytic leukemia. Leukemia 2003, 17:1428-1430. 10.1038/sj.leu.2402970, 12835741.
23. Blair RJ, Meng H, Marchese MJ, Ren S, Schwartz LB, Tonnesen MG, Gruber BL. Human mast cells stimulate vascular tube formation. Tryptase is a novel, potent angiogenic factor. J Clin Invest 1997, 99:2691-2700. 10.1172/JCI119458, 508115, 9169499.
24. Stack MS, Johnson DA. Human mast cell tryptase activates single-chain urinary-type plasminogen activator (pro-urokinase). J Biol Chem 1994, 269:9416-9419.
25. Ribatti D, Ranieri G, Nico B, Benagiano V, Crivellato E. Tryptase and chymase are angiogenic in vivo in the chorioallantoic membrane assay. Int J DevBiol 2011, 55:99-102.
26. Itoh Y, Sendo T, Oishi R. Physiology and pathophysiologyof proteinase-activated receptors (P ARs): role of tryptase/P AR-2 in vascular endothelial barrier function. J Pharmacol Sci 2005, 97:14-19. 10.1254/jphs.FMJ04005X3, 15655299.
27. Shpacovitch VM, Brzoska T, Buddenkotte J, Stroh C, Sommerhoff CP, Ansel JC, Schulze-Osthoff K, Bunnett NW, Luger TA, Steinhoff M. Agonists of proteinase-activated receptor-2 induce cytokine release and activation of nuclear transcription factor kappa B in human dermal microvascular endothelial cells. J Invest Dermatol 2002, 118:380-385. 10.1046/j.0022-202x.2001.01658.x, 11841560.
28. Matej R, Mandàkovà P, Netikovà I, Pouckovà P, Olejàr T. Proteinase-activated receptor-2 expression in breast cancer and the role of trypsin on growth and metabolism of breast cancer cell line MDA MB-231. Physiol Res 2007, 56:475-484.
29. Morris DR, Ding Y, Ricks TK, Gullapalli A, Wolfe BL, Trejo J. Protease-activated receptor-2 is essential for factor VIIa and Xa-induced signaling, migration, and invasion of breast cancer cells. Cancer Res 2006, 66:307-314. 10.1158/0008-5472.CAN-05-1735, 16397244.
30. Ribatti D, Finato N, Crivellato E, Guidolin D, Longo V, Mangieri D, Nico B, Vacca A, Beltrami CA. Angiogenesis and mast cells in human breast cancer sentinel lymphnodes with and without micrometastases. Histopathology 2007, 51:837-842. 10.1111/j.1365-2559.2007.02869.x, 17944928.
31. Singletary SE, Connolly JL. Breast cancer staging: working with the sixth edition of the AJCC Cancer Staging Manual. CA Cancer J Clin 2006, 56:37-47. 10.3322/canjclin.56.1.37, 16449185.
32. Bloom HJ, Richardson WW. Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years. Br J Cancer 1957, 11:359-377. 10.1038/bjc.1957.43, 2073885, 13499785.
33. Ranieri G, Grammatica L, Patruno R, Zito AF, Valerio P, Iacobellis S, Gadaleta C, Gasparini G, Ribatti D. A possible role of thymidine phosphorylase expression and 5-fluorouracil increased sensitivity in oropharyngeal cancer patients. J Cell Mol Med 2007, 11:362-368. 10.1111/j.1582-4934.2007.00007.x, 17378915.
34. Liu Y, Mueller BM. Protease-activated receptor-2 regulates vascular endothelial growth factor expression in MDAMB 231 cells via MAPK pathways. Biochem Biophys Res Commun 2006, 344:1263-1270. 10.1016/j.bbrc.2006.04.005, 16650817.
35. Hallegren J, Estrada S, Karlson U, Karlson U, Alving K, Pejler G. Heparin antagonists are potent inhibitors of mast cell tryptase. Biochemistry 2001, 40:7342-7439. 10.1021/bi001988c, 11401583.