메뉴 건너뛰기




Volumn 16, Issue 9, 2014, Pages

Optimal treatment for metastatic bladder cancer

Author keywords

Immunotherapeutics; Metastatic bladder cancer; Molecularmarkers; Targeted therapies; Urothelial carcinoma

Indexed keywords

ALT 801; ANTINEOPLASTIC AGENT; BEVACIZUMAB; BUPARLISIB; CARBOPLATIN; CETUXIMAB; CISPLATIN; DOCETAXEL; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EVEROLIMUS; FIBROBLAST GROWTH FACTOR RECEPTOR 3; GEFITINIB; GEMCITABINE; IFOSFAMIDE; LAPATINIB; MAMMALIAN TARGET OF RAPAMYCIN; METHOTREXATE; OXALIPLATIN; PACLITAXEL; PAZOPANIB; PEMETREXED; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SUNITINIB; TRASTUZUMAB; UNCLASSIFIED DRUG; VASCULOTROPIN; VINBLASTINE; VINFLUNINE; ANGIOGENESIS INHIBITOR;

EID: 84904525746     PISSN: 15233790     EISSN: 15346269     Source Type: Journal    
DOI: 10.1007/s11912-014-0404-2     Document Type: Note
Times cited : (30)

References (70)
  • 3
    • 0033857218 scopus 로고    scopus 로고
    • Gemcitabine and cisplatin versus methotrexate, vinblastine, doxorubicin, and cisplatin in advanced or metastatic bladder cancer: Results of a large, randomized, multinational, multicenter, phase III study
    • Von Der Maase H, Hansen SW, Roberts JT, Dogliotti L, Oliver T, Moore MJ, et al. Gemcitabine and cisplatin versus methotrexate, vinblastine, doxorubicin, and cisplatin in advanced or metastatic bladder cancer: results of a large, randomized, multinational, multicenter, phase III study. J Clin Oncol. 2000;18(17):3068-77.
    • (2000) J Clin Oncol , vol.18 , Issue.17 , pp. 3068-3077
    • Von Der Maase, H.1    Hansen, S.W.2    Roberts, J.T.3    Dogliotti, L.4    Oliver, T.5    Moore, M.J.6
  • 4
    • 55549148741 scopus 로고    scopus 로고
    • A role for neoadjuvant gemcitabine plus cisplatin in muscleinvasive urothelial carcinoma of the bladder: A retrospective experience
    • Dash A, Pettus JA, Herr HW, Bochner BH, Dalbagni G, Donat SM, et al. A role for neoadjuvant gemcitabine plus cisplatin in muscleinvasive urothelial carcinoma of the bladder: a retrospective experience. Cancer. 2008;113(9):2471-7.
    • (2008) Cancer , vol.113 , Issue.9 , pp. 2471-2477
    • Dash, A.1    Pettus, J.A.2    Herr, H.W.3    Bochner, B.H.4    Dalbagni, G.5    Donat, S.M.6
  • 5
    • 23044501890 scopus 로고    scopus 로고
    • Long-term survival results of a randomized trial comparing gemcitabine plus cisplatin, with methotrexate, vinblastine, doxorubicin, plus cisplatin in patients with bladder cancer
    • DOI 10.1200/JCO.2005.07.757
    • von der Maase H, Sengelov L, Roberts JT, Ricci S, Dogliotti L, Oliver T, et al. Long-term survival results of a randomized trial comparing gemcitabine plus cisplatin, with methotrexate, vinblastine, doxorubicin, plus cisplatin in patients with bladder cancer. J Clin Oncol. 2005;23(21):4602-8. (Pubitemid 46224062)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.21 , pp. 4602-4608
    • Von Der, M.H.1    Sengelov, L.2    Roberts, J.T.3    Ricci, S.4    Dogliotti, L.5    Oliver, T.6    Moore, M.J.7    Zimmermann, A.8    Arning, M.9
  • 7
    • 84863897662 scopus 로고    scopus 로고
    • Randomized phase III study comparing paclitaxel/cisplatin/gemcitabine and gemcitabine/cisplatin in patients with locally advanced or metastatic urothelial cancer without prior systemic therapy: EORTC intergroup study 30987
    • Bellmunt J, von der Maase H, Mead GM, Skoneczna I, De Santis M, Daugaard G, et al. Randomized phase III study comparing paclitaxel/cisplatin/gemcitabine and gemcitabine/cisplatin in patients with locally advanced or metastatic urothelial cancer without prior systemic therapy: EORTC intergroup study 30987. J Clin Oncol. 2012;30(10):1107-13.
    • (2012) J Clin Oncol , vol.30 , Issue.10 , pp. 1107-1113
    • Bellmunt, J.1    Von Der Maase, H.2    Mead, G.M.3    Skoneczna, I.4    De Santis, M.5    Daugaard, G.6
  • 8
    • 84886561381 scopus 로고    scopus 로고
    • Prevalence and co-occurrence of actionable genomic alterations in high-grade bladder cancer
    • This discusses the prevalence and cooccurrence of actionable genomic alterations in high-grade UC. This study highlights that most bladder tumors harbor genomic alterations that may predict response to target agents
    • .• Iyer G, Al-Ahmadie H, Schultz N, Hanrahan AJ, Ostrovnaya I, Balar AV, et al. Prevalence and co-occurrence of actionable genomic alterations in high-grade bladder cancer. J Clin Oncol. 2013;31(25):3133-40. This discusses the prevalence and cooccurrence of actionable genomic alterations in high-grade UC. This study highlights that most bladder tumors harbor genomic alterations that may predict response to target agents.
    • (2013) J Clin Oncol , vol.31 , Issue.25 , pp. 3133-3140
    • Iyer, G.1    Al-Ahmadie, H.2    Schultz, N.3    Hanrahan, A.J.4    Ostrovnaya, I.5    Balar, A.V.6
  • 9
    • 80052266351 scopus 로고    scopus 로고
    • Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder
    • Gui Y, Guo G, Huang Y, Hu X, Tang A, Gao S, et al. Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder. Nat Genet. 2011;43(9):875-8.
    • (2011) Nat Genet , vol.43 , Issue.9 , pp. 875-878
    • Gui, Y.1    Guo, G.2    Huang, Y.3    Hu, X.4    Tang, A.5    Gao, S.6
  • 10
    • 84897022815 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of urothelial bladder carcinoma
    • The Cancer Genome Atlas Research Network. This study describes in depth novel insights into disease biology and the potential clinical significance of recurrent molecular alterations in MIBC. Mutations in epigenetic pathways were frequently seen in UC, suggesting the role of targeting chromatin modifications for treatment of the subset of bladder
    • .• The Cancer Genome Atlas Research Network. Comprehensive molecular characterization of urothelial bladder carcinoma. Nature. 2014;507(7492):315- 22. This study describes in depth novel insights into disease biology and the potential clinical significance of recurrent molecular alterations in MIBC. Mutations in epigenetic pathways were frequently seen in UC, suggesting the role of targeting chromatin modifications for treatment of the subset of bladder.
    • (2014) Nature , vol.507 , Issue.7492 , pp. 315-322
  • 11
    • 0021910302 scopus 로고
    • Preliminary results of M-VAC (methotrexate, vinblastine, doxorubicin and cisplatin) for transitional cell carcinoma of the urothelium
    • Sternberg CN, Yagoda A, Scher HI, Watson RC, Ahmed T, Weiselberg LR, et al. Preliminary results of M-VAC (methotrexate, vinblastine, doxorubicin and cisplatin) for transitional cell carcinoma of the urothelium. J Urol. 1985;133(3):403-7. (Pubitemid 15129797)
    • (1985) Journal of Urology , vol.133 , Issue.3 , pp. 403-407
    • Sternberg, C.N.1    Yagoda, A.2    Scher, H.I.3
  • 12
    • 0035873915 scopus 로고    scopus 로고
    • Randomized phase III trial of high-dose-intensity methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) chemotherapy and recombinant human granulocyte colony-stimulating factor versus classic MVAC in advanced urothelial tract tumors: European organization for research and treatment of cancer protocol no. 30924
    • Sternberg CN, de Mulder PH, Schornagel JH, Theodore C, Fossa SD, van Oosterom AT, et al. Randomized phase III trial of high-dose- intensity methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) chemotherapy and recombinant human granulocyte colony-stimulating factor versus classic MVAC in advanced urothelial tract tumors: European Organization for Research and Treatment of Cancer protocol no. 30924. J Clin Oncol. 2001;19(10):2638-46. (Pubitemid 32441368)
    • (2001) Journal of Clinical Oncology , vol.19 , Issue.10 , pp. 2638-2646
    • Sternberg, C.N.1    De Mulder, P.H.M.2    Schornagel, J.H.3    Theodore, C.4    Fossa, S.D.5    Van Oosterom, A.T.6    Witjes, F.7    Spina, M.8    Van Groeningen, C.J.9    De Balincourt, C.10    Collette, L.11
  • 13
    • 79959191493 scopus 로고    scopus 로고
    • Treatment of patients with metastatic urothelial cancer "unfit" for cisplatin-based chemotherapy
    • Galsky MD, Hahn NM, Rosenberg J, Sonpavde G, Hutson T, Oh WK, et al. Treatment of patients with metastatic urothelial cancer "unfit" for cisplatin-based chemotherapy. J Clin Oncol. 2011;29(17):2432-8.
    • (2011) J Clin Oncol , vol.29 , Issue.17 , pp. 2432-2438
    • Galsky, M.D.1    Hahn, N.M.2    Rosenberg, J.3    Sonpavde, G.4    Hutson, T.5    Oh, W.K.6
  • 14
    • 84855583390 scopus 로고    scopus 로고
    • Randomized phase II/III trial assessing gemcitabine/carboplatin and methotrexate/carboplatin/vinblastine in patients with advanced urothelial cancer who are unfit for cisplatin-based chemotherapy: EORTC study 30986
    • De Santis M, Bellmunt J, Mead G, Kerst JM, Leahy M, Maroto P, et al. Randomized phase II/III trial assessing gemcitabine/carboplatin and methotrexate/carboplatin/vinblastine in patients with advanced urothelial cancer who are unfit for cisplatin-based chemotherapy: EORTC study 30986. J Clin Oncol. 2012;30(2):191-9.
    • (2012) J Clin Oncol , vol.30 , Issue.2 , pp. 191-199
    • De Santis, M.1    Bellmunt, J.2    Mead, G.3    Kerst, J.M.4    Leahy, M.5    Maroto, P.6
  • 15
    • 33846665540 scopus 로고    scopus 로고
    • Phase II trial of dose-dense doxorubicin plus gemcitabine followed by paclitaxel plus carboplatin in patients with advanced urothelial carcinoma and impaired renal function
    • DOI 10.1002/cncr.22454
    • Galsky MD, Iasonos A, Mironov S, Scattergood J, Boyle MG, Bajorin DF. Phase II trial of dose-dense doxorubicin plus gemcitabine followed by paclitaxel plus carboplatin in patients with advanced urothelial carcinoma and impaired renal function. Cancer. 2007;109(3):549-55. (Pubitemid 46190963)
    • (2007) Cancer , vol.109 , Issue.3 , pp. 549-555
    • Galsky, M.D.1    Iasonos, A.2    Mironov, S.3    Scattergood, J.4    Boyle, M.G.5    Bajorin, D.F.6
  • 16
    • 0035339940 scopus 로고    scopus 로고
    • Combination paclitaxel, carboplatin, and gemcitabine is an active treatment for advanced urothelial cancer
    • Hussain M, Vaishampayan U, Du W, Redman B, Smith DC. Combination paclitaxel, carboplatin, and gemcitabine is an active treatment for advanced urothelial cancer. J Clin Oncol. 2001;19(9):2527-33. (Pubitemid 32391224)
    • (2001) Journal of Clinical Oncology , vol.19 , Issue.9 , pp. 2527-2533
    • Hussain, M.1    Vaishampayan, U.2    Du, W.3    Redman, B.4    Smith, D.C.5
  • 18
    • 1842477465 scopus 로고    scopus 로고
    • Phase III Trial of Methotrexate, Vinblastine, Doxorubicin, and Cisplatin versus Carboplatin and Paclitaxel in Patients with Advanced Carcinoma of the Urothelium: A Trial of the Eastern Cooperative Oncology Group
    • DOI 10.1002/cncr.20123
    • Dreicer R, Manola J, Roth BJ, See WA, Kuross S, Edelman MJ, et al. Phase III trial of methotrexate, vinblastine, doxorubicin, and cisplatin versus carboplatin and paclitaxel in patients with advanced carcinoma of the urothelium. Cancer. 2004;100(8):1639-45. (Pubitemid 38456340)
    • (2004) Cancer , vol.100 , Issue.8 , pp. 1639-1645
    • Dreicer, R.1    Manola, J.2    Roth, B.J.3    See, W.A.4    Kuross, S.5    Edelman, M.J.6    Hudes, G.R.7    Wilding, G.8
  • 19
    • 33744550572 scopus 로고    scopus 로고
    • Prognostic Significance of Bladder Tumor History and Tumor Location in Upper Tract Transitional Cell Carcinoma
    • DOI 10.1016/S0022-5347(06)00511-8, PII S0022534706005118
    • Akdogan B, Dogan HS, Eskicorapci SY, Sahin A, Erkan I, Ozen H. Prognostic significance of bladder tumor history and tumor location in upper tract transitional cell carcinoma. J Urol. 2006;176(1):48-52. (Pubitemid 43815384)
    • (2006) Journal of Urology , vol.176 , Issue.1 , pp. 48-52
    • Akdogan, B.1    Dogan, H.S.2    Eskicorapci, S.Y.3    Sahin, A.4    Erkan, I.5    Ozen, H.6
  • 20
    • 84905699995 scopus 로고    scopus 로고
    • PECULIAR study: Phase II study of pemetrexed in combinationwith cisplatin in patients with advanced urothelial cancer
    • Lee JLLS, Choi YJ, Ahn JH, Song C, Hong BS, et al. PECULIAR study: phase II study of pemetrexed in combinationwith cisplatin in patients with advanced urothelial cancer. J Clin Oncol. 2014;32(4 Suppl):301.
    • (2014) J Clin Oncol , vol.32 , Issue.4 SUPPL. , pp. 301
    • Lee, J.L.L.S.1    Choi, Y.J.2    Ahn, J.H.3    Song, C.4    Hong, B.S.5
  • 22
    • 0037083580 scopus 로고    scopus 로고
    • Phase II trial of weekly paclitaxel in patients with previously treated advanced urothelial cancer
    • DOI 10.1200/JCO.20.4.937
    • Vaughn DJ, Broome CM, Hussain M, Gutheil JC, Markowitz AB. Phase II trial of weekly paclitaxel in patients with previously treated advanced urothelial cancer. J Clin Oncol. 2002;20(4):937-40. (Pubitemid 34141835)
    • (2002) Journal of Clinical Oncology , vol.20 , Issue.4 , pp. 937-940
    • Vaughn, D.J.1    Broome, C.M.2    Hussain, M.3    Gutheil, J.C.4    Markowitz, A.B.5
  • 24
    • 34248641378 scopus 로고    scopus 로고
    • Phase II trial of pemetrexed as second-line therapy in patients with metastatic urothelial carcinoma
    • DOI 10.1007/s10637-006-9020-9
    • Galsky MD, Mironov S, Iasonos A, Scattergood J, Boyle MG, Bajorin DF. Phase II trial of pemetrexed as second-line therapy in patients with metastatic urothelial carcinoma. Investig New Drugs. 2007;25(3):265-70. (Pubitemid 46774696)
    • (2007) Investigational New Drugs , vol.25 , Issue.3 , pp. 265-270
    • Galsky, M.D.1    Mironov, S.2    Iasonos, A.3    Scattergood, J.4    Boyle, M.G.5    Bajorin, D.F.6
  • 25
    • 84905695959 scopus 로고    scopus 로고
    • Efficacy of single-agent pemetrexed in platinum refractory metastatic urothelial cancer
    • Benjamin DJ BR, Chaim J, Zabor EC, Ostrovnaya I, Garcia-Grossman IR, et al. Efficacy of single-agent pemetrexed in platinum refractory metastatic urothelial cancer. J Clin Oncol. 2014;32(4 Suppl):322.
    • (2014) J Clin Oncol , vol.32 , Issue.4 SUPPL. , pp. 322
    • Benjamin, D.J.B.R.1    Chaim, J.2    Zabor, E.C.3    Ostrovnaya, I.4    Garcia-Grossman, I.R.5
  • 26
    • 84879787404 scopus 로고    scopus 로고
    • Nanoparticle albumin-bound paclitaxel for second-line treatment of metastatic urothelial carcinoma: A single group, multicentre, phase 2 study
    • Ko YJ, Canil CM, Mukherjee SD, Winquist E, Elser C, Eisen A, et al. Nanoparticle albumin-bound paclitaxel for second-line treatment of metastatic urothelial carcinoma: a single group, multicentre, phase 2 study. Lancet Oncol. 2013;14(8):769-76.
    • (2013) Lancet Oncol , vol.14 , Issue.8 , pp. 769-776
    • Ko, Y.J.1    Canil, C.M.2    Mukherjee, S.D.3    Winquist, E.4    Elser, C.5    Eisen, A.6
  • 27
    • 0032127772 scopus 로고    scopus 로고
    • A phase II study of gemcitabine in patients with transitional cell carcinoma of the urinary tract previously treated with platinum
    • DOI 10.1016/S0959-8049(98)00030-6, PII S0959804998000306
    • Lorusso V, Pollera CF, Antimi M, Luporini G, Gridelli C, Frassineti GL, et al. A phase II study of gemcitabine in patients with transitional cell carcinoma of the urinary tract previously treated with platinum. Italian Co-operative Group on Bladder Cancer. Eur J Cancer. 1998;34(8):1208-12. (Pubitemid 28342111)
    • (1998) European Journal of Cancer , vol.34 , Issue.8 , pp. 1208-1212
    • Lorusso, V.1    Pollera, C.F.2    Antimi, M.3    Luporini, G.4    Gridelli, C.5    Frassineti, G.L.6    Oliva, C.7    Pacini, M.8    De Lena, M.9
  • 28
    • 0031017367 scopus 로고    scopus 로고
    • Eastern cooperative oncology group phase II trial of ifosfamide in the treatment of previously treated advanced urothelial carcinoma
    • Witte RS, Elson P, Bono B, Knop R, Richardson RR, Dreicer R, et al. Eastern Cooperative Oncology Group phase II trial of ifosfamide in the treatment of previously treated advanced urothelial carcinoma. J Clin Oncol. 1997;15(2):589-93. (Pubitemid 27074226)
    • (1997) Journal of Clinical Oncology , vol.15 , Issue.2 , pp. 589-593
    • Witte, R.S.1    Elson, P.2    Bono, B.3    Knop, R.4    Richardson, R.R.5    Dreicer, R.6    Loehrer Sr., P.J.7
  • 31
    • 84878442860 scopus 로고    scopus 로고
    • Long-term survival results of a randomized phase III trial of vinflunine plus best supportive care versus best supportive care alone in advanced urothelial carcinoma patients after failure of platinum-based chemotherapy
    • Bellmunt J, Fougeray R, Rosenberg JE, von der Maase H, Schutz FA, Salhi Y, et al. Long-term survival results of a randomized phase III trial of vinflunine plus best supportive care versus best supportive care alone in advanced urothelial carcinoma patients after failure of platinum-based chemotherapy. Ann Oncol. 2013;24(6):1466-72.
    • (2013) Ann Oncol , vol.24 , Issue.6 , pp. 1466-1472
    • Bellmunt, J.1    Fougeray, R.2    Rosenberg, J.E.3    Von Der Maase, H.4    Schutz, F.A.5    Salhi, Y.6
  • 32
    • 78649667759 scopus 로고    scopus 로고
    • Phase II study of eribulin (E7389) in patients (pts) with advanced urothelial cancer (UC): Final report: A California Cancer Consortium-led NCI/CTEPsponsored trial
    • DI Quinn AA, Tsao-Wei DD, et al. Phase II study of eribulin (E7389) in patients (pts) with advanced urothelial cancer (UC): final report: a California Cancer Consortium-led NCI/CTEPsponsored trial. J Clin Oncol. 2010;28(15 Suppl):4529.
    • (2010) J Clin Oncol , vol.28 , Issue.15 SUPPL. , pp. 4529
    • Quinn Aa, D.I.1    Tsao-Wei, D.D.2
  • 33
    • 2142760062 scopus 로고    scopus 로고
    • The expression of vascular endothelial growth factor in transitional cell carcinoma of urinary bladder is correlated with cancer progression
    • Yang CC, Chu KC, Yeh WM. The expression of vascular endothelial growth factor in transitional cell carcinoma of urinary bladder is correlated with cancer progression. Urol Oncol. 2004;22(1):1-6.
    • (2004) Urol Oncol , vol.22 , Issue.1 , pp. 1-6
    • Yang, C.C.1    Chu, K.C.2    Yeh, W.M.3
  • 35
    • 36849022660 scopus 로고    scopus 로고
    • A phase II trial of cisplatin, fixed dose-rate gemcitabine and gefitinib for advanced urothelial tract carcinoma: Results of the Cancer and Leukaemia Group B 90102
    • DOI 10.1111/j.1464-410X.2007.07226.x
    • Philips GK, Halabi S, Sanford BL, Bajorin D, Small EJ. A phase II trial of cisplatin, fixed dose-rate gemcitabine and gefitinib for advanced urothelial tract carcinoma: results of the Cancer and Leukaemia Group B 90102. BJU Int. 2008;101(1):20-5. (Pubitemid 350233568)
    • (2008) BJU International , vol.101 , Issue.1 , pp. 20-25
    • Philips, G.K.1    Halabi, S.2    Sanford, B.L.3    Bajorin, D.4    Small, E.J.5
  • 36
    • 75149171017 scopus 로고    scopus 로고
    • Results of the Southwest Oncology Group phase II evaluation (study S0031) of ZD1839 for advanced transitional cell carcinoma of the urothelium
    • Petrylak DP, Tangen CM, Van Veldhuizen PJ, Jr GJW, Twardowski PW, Atkins JN, et al. Results of the Southwest Oncology Group phase II evaluation (study S0031) of ZD1839 for advanced transitional cell carcinoma of the urothelium. BJU Int. 2010;105(3):317-21.
    • (2010) BJU Int , vol.105 , Issue.3 , pp. 317-321
    • Petrylak, D.P.1    Tangen, C.M.2    Van Veldhuizen Jr., P.J.3    G, J.W.4    Twardowski, P.W.5    Atkins, J.N.6
  • 37
    • 84875901376 scopus 로고    scopus 로고
    • Randomized phase II trial of gemcitabine/ cisplatin (GC) with or without cetuximab (CET) in patients (pts) with advanced urothelial carcinoma (UC)
    • Grivas PAN, Siefker-Radtke AO, Daignault S, Puzanov I, MacVicar GR, et al. Randomized phase II trial of gemcitabine/ cisplatin (GC) with or without cetuximab (CET) in patients (pts) with advanced urothelial carcinoma (UC). J Clin Oncol. 2012;30(15):4506.
    • (2012) J Clin Oncol , vol.30 , Issue.15 , pp. 4506
    • Grivas, P.A.N.1    Siefker-Radtke, A.O.2    Daignault, S.3    Puzanov, I.4    MacVicar, G.R.5
  • 38
    • 84867083523 scopus 로고    scopus 로고
    • Phase II trial of cetuximab with or without paclitaxel in patients with advanced urothelial tract carcinoma
    • Wong YN, Litwin S, Vaughn D, Cohen S, Plimack ER, Lee J, et al. Phase II trial of cetuximab with or without paclitaxel in patients with advanced urothelial tract carcinoma. J Clin Oncol. 2012;30(28):3545-51.
    • (2012) J Clin Oncol , vol.30 , Issue.28 , pp. 3545-3551
    • Wong, Y.N.1    Litwin, S.2    Vaughn, D.3    Cohen, S.4    Plimack, E.R.5    Lee, J.6
  • 39
    • 84905713382 scopus 로고    scopus 로고
    • A randomized phase 2 trial of gemcitabine/ cisplatin with or without cetuximab in patients with advanced urothelial carcinoma
    • doi:10.1002/cncr.2876
    • Hussain M, Daignault S, Agarwal N, Grivas PD, Siefker-Radtke AO, Puzanov I, et al. A randomized phase 2 trial of gemcitabine/ cisplatin with or without cetuximab in patients with advanced urothelial carcinoma. Cancer. 2014. doi:10.1002/cncr.2876.
    • (2014) Cancer
    • Hussain, M.1    Daignault, S.2    Agarwal, N.3    Grivas, P.D.4    Siefker-Radtke, A.O.5    Puzanov, I.6
  • 40
    • 0036331813 scopus 로고    scopus 로고
    • HER-2 - A possible target for therapy of metastatic urinary bladder carcinoma
    • DOI 10.1080/02841860260088836
    • Wester K, Sjostrom A, de la Torre M, Carlsson J, Malmstrom PU. HER-2-a possible target for therapy of metastatic urinary bladder carcinoma. Acta Oncol. 2002;41(3):282-8. (Pubitemid 34833053)
    • (2002) Acta Oncologica , vol.41 , Issue.3 , pp. 282-288
    • Wester, K.1    Sjostrom, A.2    De La, T.M.3    Carlsson, J.4    Malmstrom, P.-U.5
  • 41
    • 0029871183 scopus 로고    scopus 로고
    • Prevalence and clinical significance of HER-2/neu, p53 and Rb expression in primary superficial bladder cancer
    • DOI 10.1016/S0022-5347(01)66198-6
    • Tetu B, Fradet Y, Allard P, Veilleux C, Roberge N, Bernard P. Prevalence and clinical significance of HER/2neu, p53 and Rb expression in primary superficial bladder cancer. J Urol. 1996;155(5):1784-8. (Pubitemid 26127001)
    • (1996) Journal of Urology , vol.155 , Issue.5 , pp. 1784-1788
    • Tetu, B.1    Fradet, Y.2    Allard, P.3    Veilleux, C.4    Roberge, N.5    Bernard, P.6
  • 42
    • 79959556990 scopus 로고    scopus 로고
    • Her2 amplification is significantly more frequent in lymph node metastases from urothelial bladder cancer than in the primary tumours
    • Fleischmann A, Rotzer D, Seiler R, Studer UE, Thalmann GN. Her2 amplification is significantly more frequent in lymph node metastases from urothelial bladder cancer than in the primary tumours. Eur Urol. 2011;60(2):350-7.
    • (2011) Eur Urol , vol.60 , Issue.2 , pp. 350-357
    • Fleischmann, A.1    Rotzer, D.2    Seiler, R.3    Studer, U.E.4    Thalmann, G.N.5
  • 43
    • 67649579849 scopus 로고    scopus 로고
    • A single-arm, multicenter, open-label phase 2 study of lapatinib as the second-line treatment of patients with locally advanced or metastatic transitional cell carcinoma
    • Wulfing C, Machiels JP, Richel DJ, Grimm MO, Treiber U, De Groot MR, et al. A single-arm, multicenter, open-label phase 2 study of lapatinib as the second-line treatment of patients with locally advanced or metastatic transitional cell carcinoma. Cancer. 2009;115(13):2881-90.
    • (2009) Cancer , vol.115 , Issue.13 , pp. 2881-2890
    • Wulfing, C.1    Machiels, J.P.2    Richel, D.J.3    Grimm, M.O.4    Treiber, U.5    De Groot, M.R.6
  • 44
    • 84888862873 scopus 로고    scopus 로고
    • Phase I results from a study of lapatinib with gemcitabine and cisplatin (GC) in advanced/metastatic bladder cancer
    • Daugaard GSL, Agerbaek M, Sternberg CN, Van Herpen C, Collette S, et al. Phase I results from a study of lapatinib with gemcitabine and cisplatin (GC) in advanced/metastatic bladder cancer. J Clin Oncol. 2013;31(6 Suppl):252.
    • (2013) J Clin Oncol , vol.31 , Issue.6 SUPPL. , pp. 252
    • Daugaard, G.S.L.1    Agerbaek, M.2    Sternberg, C.N.3    Van Herpen, C.4    Collette, S.5
  • 46
    • 84888883099 scopus 로고    scopus 로고
    • Final results of a multicenter, open-label phase II trial of dovitinib (TKI258) in patients with advanced urothelial carcinoma with either mutated or nonmutated FGFR3
    • Milowsky MIDC, Duran Martinez I, Jagdev S, Millard FE, Sweeney C, et al. Final results of a multicenter, open-label phase II trial of dovitinib (TKI258) in patients with advanced urothelial carcinoma with either mutated or nonmutated FGFR3. J Clin Oncol. 2013;31(6 Suppl):255.
    • (2013) J Clin Oncol , vol.31 , Issue.6 SUPPL. , pp. 255
    • Milowsky, M.I.D.C.1    Duran Martinez, I.2    Jagdev, S.3    Millard, F.E.4    Sweeney, C.5
  • 47
    • 84873045850 scopus 로고    scopus 로고
    • Oncogenic FGFR3 gene fusions in bladder cancer
    • Williams SV, Hurst CD, Knowles MA. Oncogenic FGFR3 gene fusions in bladder cancer. Hum Mol Genet. 2013;22(4):795-803.
    • (2013) Hum Mol Genet , vol.22 , Issue.4 , pp. 795-803
    • Williams, S.V.1    Hurst, C.D.2    Knowles, M.A.3
  • 48
    • 84881348980 scopus 로고    scopus 로고
    • Expression of VEGF and its receptors VEGFR1/ VEGFR2 is associated with invasiveness of bladder cancer
    • Kopparapu PK, Boorjian SA, Robinson BD, Downes M, Gudas LJ, Mongan NP, et al. Expression of VEGF and its receptors VEGFR1/ VEGFR2 is associated with invasiveness of bladder cancer. Anticancer Res. 2013;33(6):2381-90.
    • (2013) Anticancer Res , vol.33 , Issue.6 , pp. 2381-2390
    • Kopparapu, P.K.1    Boorjian, S.A.2    Robinson, B.D.3    Downes, M.4    Gudas, L.J.5    Mongan, N.P.6
  • 49
    • 80053270703 scopus 로고    scopus 로고
    • Phase II study of sunitinib as first-line treatment of urothelial cancer patients ineligible to receive cisplatin-based chemotherapy: Baseline interleukin-8 and tumor contrast enhancement as potential predictive factors of activity
    • Bellmunt J, Gonzalez-Larriba JL, Prior C, Maroto P, Carles J, Castellano D, et al. Phase II study of sunitinib as first-line treatment of urothelial cancer patients ineligible to receive cisplatin-based chemotherapy: baseline interleukin-8 and tumor contrast enhancement as potential predictive factors of activity. Ann Oncol. 2011;22(12):2646-53.
    • (2011) Ann Oncol , vol.22 , Issue.12 , pp. 2646-2653
    • Bellmunt, J.1    Gonzalez-Larriba, J.L.2    Prior, C.3    Maroto, P.4    Carles, J.5    Castellano, D.6
  • 51
    • 84856071311 scopus 로고    scopus 로고
    • A phase II trial of sorafenib in first-line metastatic urothelial cancer: A study of the PMH Phase II Consortium
    • Sridhar SS, Winquist E, Eisen A, Hotte SJ, McWhirter E, Tannock IF, et al. A phase II trial of sorafenib in first-line metastatic urothelial cancer: a study of the PMH Phase II Consortium. Investig New Drugs. 2011;29(5):1045-9.
    • (2011) Investig New Drugs , vol.29 , Issue.5 , pp. 1045-1049
    • Sridhar, S.S.1    Winquist, E.2    Eisen, A.3    Hotte, S.J.4    McWhirter, E.5    Tannock, I.F.6
  • 52
    • 84864337145 scopus 로고    scopus 로고
    • Pazopanib in advanced and platinum-resistant urothelial cancer: An open-label, single group, phase 2 trial
    • Necchi A, Mariani L, Zaffaroni N, Schwartz LH, Giannatempo P, Crippa F, et al. Pazopanib in advanced and platinum-resistant urothelial cancer: an open-label, single group, phase 2 trial. Lancet Oncol. 2012;13(8):810-6.
    • (2012) Lancet Oncol , vol.13 , Issue.8 , pp. 810-816
    • Necchi, A.1    Mariani, L.2    Zaffaroni, N.3    Schwartz, L.H.4    Giannatempo, P.5    Crippa, F.6
  • 53
    • 84876982362 scopus 로고    scopus 로고
    • Gemcitabine, Cisplatin, and sunitinib formetastatic urothelial carcinoma and as preoperative therapy for muscle-invasive bladder cancer
    • Galsky MD, Hahn NM, Powles T, Hellerstedt BA, Lerner SP, Gardner TA, et al. Gemcitabine, Cisplatin, and sunitinib formetastatic urothelial carcinoma and as preoperative therapy for muscle-invasive bladder cancer. Clin Genitourin Cancer. 2013;11(2):175-81.
    • (2013) Clin Genitourin Cancer , vol.11 , Issue.2 , pp. 175-181
    • Galsky, M.D.1    Hahn, N.M.2    Powles, T.3    Hellerstedt, B.A.4    Lerner, S.P.5    Gardner, T.A.6
  • 54
    • 84905692051 scopus 로고    scopus 로고
    • Phase II trial of pazopanib and weekly paclitaxel in metastatic urothelial cancer (UC)
    • Srinivas SNS, Harshman LC, Lam AP, Vaishampayan UN, Haas D, et al. Phase II trial of pazopanib and weekly paclitaxel in metastatic urothelial cancer (UC). J Clin Oncol. 2014;32(4 Suppl 4):299.
    • (2014) J Clin Oncol , vol.32 , Issue.4 SUPPL. 4 , pp. 299
    • Srinivas, S.N.S.1    Harshman, L.C.2    Lam, A.P.3    Vaishampayan, U.N.4    Haas, D.5
  • 55
    • 84875722132 scopus 로고    scopus 로고
    • Phase II study of gemcitabine, carboplatin, and bevacizumab in patients with advanced unresectable or metastatic urothelial cancer
    • Balar AV, Apolo AB, Ostrovnaya I, Mironov S, Iasonos A, Trout A, et al. Phase II study of gemcitabine, carboplatin, and bevacizumab in patients with advanced unresectable or metastatic urothelial cancer. J Clin Oncol. 2013;31(6):724-30.
    • (2013) J Clin Oncol , vol.31 , Issue.6 , pp. 724-730
    • Balar, A.V.1    Apolo, A.B.2    Ostrovnaya, I.3    Mironov, S.4    Iasonos, A.5    Trout, A.6
  • 56
    • 79955006416 scopus 로고    scopus 로고
    • Phase II trial of cisplatin, gemcitabine, and bevacizumab as first-line therapy for metastatic urothelial carcinoma: Hoosier Oncology Group GU 04-75
    • Hahn NM, Stadler WM, Zon RT, Waterhouse D, Picus J, Nattam S, et al. Phase II trial of cisplatin, gemcitabine, and bevacizumab as first-line therapy for metastatic urothelial carcinoma: Hoosier Oncology Group GU 04-75. J Clin Oncol. 2011;29(12):1525-30.
    • (2011) J Clin Oncol , vol.29 , Issue.12 , pp. 1525-1530
    • Hahn, N.M.1    Stadler, W.M.2    Zon, R.T.3    Waterhouse, D.4    Picus, J.5    Nattam, S.6
  • 57
    • 84860242276 scopus 로고    scopus 로고
    • Neoadjuvant chemotherapy with DD-MVAC and bevacizumab in high-risk urothelial cancer: Results from a phase II trial at the M. D. Anderson Cancer Center
    • Siefker-Radtke AOKA, Corn PG, Matin SF, Grossman HB, Millikan RE, et al. Neoadjuvant chemotherapy with DD-MVAC and bevacizumab in high-risk urothelial cancer: Results from a phase II trial at the M. D. Anderson Cancer Center. J Clin Oncol. 2012;30(5 Suppl):261.
    • (2012) J Clin Oncol , vol.30 , Issue.5 SUPPL. , pp. 261
    • Siefker-Radtke, A.O.K.A.1    Corn, P.G.2    Matin, S.F.3    Grossman, H.B.4    Millikan, R.E.5
  • 59
    • 84902330712 scopus 로고    scopus 로고
    • A phase II study of cabozantinib in patients (pts) with relapsed or refractory metastatic urothelial carcinoma (mUC)
    • Borghese Apolo APH, Amrit Madan R, Gulley JL, Wright JJ, Hoffman-Censits JH, et al. A phase II study of cabozantinib in patients (pts) with relapsed or refractory metastatic urothelial carcinoma (mUC). J Clin Oncol. 2014;32(4 Suppl 4):307.
    • (2014) J Clin Oncol , vol.32 , Issue.4 SUPPL. 4 , pp. 307
    • Borghese Apolo, A.P.H.1    Amrit Madan, R.2    Gulley, J.L.3    Wright, J.J.4    Hoffman-Censits, J.H.5
  • 60
    • 84905701234 scopus 로고    scopus 로고
    • PI3K kinase inhibitor GSK2126458 (GSK458): Clinical activity in select patient (pt) populations defined by predictive markers
    • Abstr 4420
    • Munster PSJ, Werner TL, Dees EC, Tan A, Schellens J, et al. PI3K kinase inhibitor GSK2126458 (GSK458): clinical activity in select patient (pt) populations defined by predictive markers. Ann Oncol. 2012;23 Suppl 9:Abstr 4420.
    • (2012) Ann Oncol , vol.23 , Issue.SUPPL. 9
    • Munster, P.S.J.1    Werner, T.L.2    Dees, E.C.3    Tan, A.4    Schellens, J.5
  • 62
    • 84864369495 scopus 로고    scopus 로고
    • Phase II study of everolimus in patients with locally advanced or metastatic transitional cell carcinoma of the urothelial tract: Clinical activity, molecular response, and biomarkers
    • Seront E, Rottey S, Sautois B, Kerger J, D'Hondt LA, Verschaeve V, et al. Phase II study of everolimus in patients with locally advanced or metastatic transitional cell carcinoma of the urothelial tract: clinical activity, molecular response, and biomarkers. Ann Oncol. 2012;23(10):2663-70.
    • (2012) Ann Oncol , vol.23 , Issue.10 , pp. 2663-2670
    • Seront, E.1    Rottey, S.2    Sautois, B.3    Kerger, J.4    D'Hondt, L.A.5    Verschaeve, V.6
  • 64
    • 84867333656 scopus 로고    scopus 로고
    • Genome sequencing identifies a basis for everolimus sensitivity
    • This article describes how whole-genome sequencing was useful to identify a biomarker of drug sensitivity in a patient who experienced durable remission of metastatic UC after treatment with everolimus. A somatic mutation in TSC1 in this case correlated with everolimus sensitivity
    • .• Iyer G, Hanrahan AJ, Milowsky MI, Al-Ahmadie H, Scott SN, Janakiraman M, et al. Genome sequencing identifies a basis for everolimus sensitivity. Science. 2012;338(6104):221. This article describes how whole-genome sequencing was useful to identify a biomarker of drug sensitivity in a patient who experienced durable remission of metastatic UC after treatment with everolimus. A somatic mutation in TSC1 in this case correlated with everolimus sensitivity.
    • (2012) Science , vol.338 , Issue.6104 , pp. 221
    • Iyer, G.1    Hanrahan, A.J.2    Milowsky, M.I.3    Al-Ahmadie, H.4    Scott, S.N.5    Janakiraman, M.6
  • 65
    • 84899680978 scopus 로고    scopus 로고
    • Activating mTOR mutations in a patient with an extraordinary response on a phase I trial of everolimus and pazopanib
    • Wagle N, Grabiner BC, Van Allen EM, Hodis E, Jacobus S, Supko JG, et al. Activating mTOR mutations in a patient with an extraordinary response on a phase I trial of everolimus and pazopanib. Cancer Discov. 2014;4(5):546-53.
    • (2014) Cancer Discov , vol.4 , Issue.5 , pp. 546-553
    • Wagle, N.1    Grabiner, B.C.2    Van Allen, E.M.3    Hodis, E.4    Jacobus, S.5    Supko, J.G.6
  • 67
    • 77952337834 scopus 로고    scopus 로고
    • Preoperative CTLA-4 blockade: Tolerability and immune monitoring in the setting of a presurgical clinical trial
    • Carthon BC, Wolchok JD, Yuan J, Kamat A, Ng Tang DS, Sun J, et al. Preoperative CTLA-4 blockade: tolerability and immune monitoring in the setting of a presurgical clinical trial. Clin Cancer Res. 2010;16(10):2861-71.
    • (2010) Clin Cancer Res , vol.16 , Issue.10 , pp. 2861-2871
    • Carthon, B.C.1    Wolchok, J.D.2    Yuan, J.3    Kamat, A.4    Ng Tang, D.S.5    Sun, J.6
  • 68
    • 84879513754 scopus 로고    scopus 로고
    • Early outcome results of a phase I/II study for an IL-2/Tcell receptor fusion protein in combination with gemcitabine and cisplatin (GC) in patients with locally advanced or metastatic urothelial cancer
    • Hajdenberg JLD, Vaena DA, Fishman MN, Rosser CJ, Milhem MM, et al. Early outcome results of a phase I/II study for an IL-2/Tcell receptor fusion protein in combination with gemcitabine and cisplatin (GC) in patients with locally advanced or metastatic urothelial cancer. J Clin Oncol. 2012;30(5 Suppl):e15010.
    • (2012) J Clin Oncol , vol.30 , Issue.5 SUPPL.
    • Hajdenberg, J.L.D.1    Vaena, D.A.2    Fishman, M.N.3    Rosser, C.J.4    Milhem, M.M.5
  • 69
    • 84905698694 scopus 로고    scopus 로고
    • Inhibition of PD-L1 by MPDL3280A and clinical activity in pts with metastatic urothelial bladder cancer (UBC)
    • abstr 5011
    • Powles T, Vogelzang NJ, Fine GD, Eder JP, Braiteh FS, Loriot Y, et al. Inhibition of PD-L1 by MPDL3280A and clinical activity in pts with metastatic urothelial bladder cancer (UBC). J Clin Oncol. 2014;32(Suppl; abstr 5011):5s.
    • (2014) J Clin Oncol , vol.32 , Issue.SUPPL.
    • Powles, T.1    Vogelzang, N.J.2    Fine, G.D.3    Eder, J.P.4    Braiteh, F.S.5    Loriot, Y.6
  • 70
    • 84905699435 scopus 로고    scopus 로고
    • Branched evolution and intratumor heterogeneity of urothelial carcinoma of the bladder
    • Cha EKSJ, Al-Ahmadie H, Scott SN, Kim PH, Iyer G, et al. Branched evolution and intratumor heterogeneity of urothelial carcinoma of the bladder. J Clin Oncol. 2014;32(4 Suppl):293.
    • (2014) J Clin Oncol , vol.32 , Issue.4 SUPPL. , pp. 293
    • Cha, E.K.S.J.1    Al-Ahmadie, H.2    Scott, S.N.3    Kim, P.H.4    Iyer, G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.