The synergistic regulation of VEGF-mediated angiogenesis through miR-190 and target genes

RNA

Volumn 20, Issue 8, 2014, Pages 1328-1336

  Hao, Yang ^a   Yang, Junyu ^a   Yin, Shenyi ^a   Zhang, Hanshuo ^a   Fan, Yu ^a   Sun, Changhong ^a   Gu, Jin ^b   Xi, Jianzhong Jeff ^a,c  

^a PEKING UNIVERSITY   (China)

^b PEKING UNIVERSITY CANCER HOSPITAL AND INSTITUTE   (China)

^c Peking University   (China)

Author keywords

Angiogenesis; Metastasis; MiR 190; Synergistic effect; VEGF

Indexed keywords

MICRORNA; MICRORNA 190; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE; GENE TARGETING; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; METASTASIS INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; TRANSCRIPTION REGULATION; TUMOR GROWTH; TUMOR MICROENVIRONMENT; VEGF GENE;

ANGIOGENESIS; METASTASIS; MIR-190; SYNERGISTIC EFFECT; VEGF;

3' UNTRANSLATED REGIONS; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MICRORNAS; NEOPLASM METASTASIS; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; QUANTITATIVE TRAIT, HERITABLE; RNA INTERFERENCE; TUMOR MICROENVIRONMENT; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84904515256     PISSN: 13558382     EISSN: 14699001     Source Type: Journal    
DOI: 10.1261/rna.044651.114     Document Type: Article

References (30)

1. Anand S, Majeti BK, Acevedo LM, Murphy EA, Mukthavaram R, Scheppke L, Huang M, Shields DJ, Lindquist JN, Lapinski PE, et al. 2010. MicroRNA-132-mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis. Nat Med 16: 909-914.
2. Birk DM, Barbato J, Mureebe L, Chaer RA. 2008. Current insights on the biology and clinical aspects of VEGF regulation. Vasc Endovascular Surg 42: 517-530.
3. Clifford RL, Deacon K, Knox AJ. 2008. Novel regulation of vascular endothelial growth factor-A (VEGF-A) by transforming growth factor β1: requirement for Smads, β-catenin, and GSK3β. J Biol Chem 283: 35337-35353.
4. Coultas L, Chawengsaksophak K, Rossant J. 2005. Endothelial cells and VEGF in vascular development. Nature 438: 937-945. (Pubitemid 43093959)
5. Dews M, Homayouni A, Yu D, Murphy D, Sevignani C, Wentzel E, Furth EE, Lee WM, Enders GH, Mendell JT, et al. 2006. Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster. Nat Genet 38: 1060-1065. (Pubitemid 44325933)
6. Diehl F, Rossig L, Zeiher AM, Dimmeler S, Urbich C. 2007. The histone methyltransferase MLL is an upstream regulator of endothelial-cell sprout formation. Blood 109: 1472-1478. (Pubitemid 46239578)
7. Fish JE, Santoro MM, Morton SU, Yu S, Yeh RF, Wythe JD, Ivey KN, Bruneau BG, Stainier DY, Srivastava D. 2008. miR-126 regulates angiogenic signaling and vascular integrity. Dev Cell 15: 272-284.
8. Flanagan JR. 1995. Autologous stimulation of YY1 transcription factor expression: role of an insulin-like growth factor. Cell Growth Differ 6: 185-190.
9. Flynt AS, Lai EC. 2008. Biological principles of microRNA-mediated regulation: shared themes amid diversity. Nat Rev 9: 831-842.
10. Folkman J. 2007. Angiogenesis: an organizing principle for drug discovery? Nat Rev Drug Discov 6: 273-286. (Pubitemid 46505878)
11. Grimson A, Farh KK, Johnston WK, Garrett-Engele P, Lim LP, Bartel DP. 2007. MicroRNA targeting specificity in mammals: determinants beyond seed pairing. Mol Cell 27: 91-105. (Pubitemid 46991392)
12. Hobert O. 2007. miRNAs play a tune. Cell 131: 22-24. (Pubitemid 47498545)
13. Korff T, Augustin HG. 1998. Integration of endothelial cells in multicellular spheroids prevents apoptosis and induces differentiation. J Cell Biol 143: 1341-1352. (Pubitemid 28559834)
14. Kota J, Chivukula RR, O'Donnell KA, Wentzel EA, Montgomery CL, Hwang HW, Chang TC, Vivekanandan P, Torbenson M, Clark KR, et al. 2009. Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model. Cell 137: 1005-1017.
15. Krek A, Grün D, Poy MN, Wolf R, Rosenberg L, Epstein EJ, MacMenamin P, da Piedade I, Gunsalus KC, Stoffel M, et al. 2005. Combinatorial microRNA target predictions. Nat Genet 37: 495-500. (Pubitemid 40617277)
16. Kuehbacher A, Urbich C, Dimmeler S. 2008. Targeting microRNA expression to regulate angiogenesis. Trends Pharmacol Sci 29: 12-15.
17. Kumar MS, Lu J, Mercer KL, Golub TR, Jacks T. 2007. Impaired microRNA processing enhances cellular transformation and tumorigenesis. Nat Genet 39: 673-677. (Pubitemid 46676103)
18. Lei Z, Li B, Yang Z, Fang H, Zhang GM, Feng ZH, Huang B. 2009. Regulation of HIF-1α and VEGF by miR-20b tunes tumor cells to adapt to the alteration of oxygen concentration. PLoS One 4: e7629.
19. Lin D, Huang Y, Jiang Q, Zhang W, Yue X, Guo S, Xiao P, Du Q, Xing J, Deng L, et al. 2011. Structural contributions of blocked or grafted poly(2-dimethylaminoethyl methacrylate) on PEGylated polycaprolactone nanoparticles in siRNA delivery. Biomaterials 32: 8730-8742.
20. Ma L, Teruya-Feldstein J, Weinberg RA. 2007. Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 449: 682-688. (Pubitemid 47552092)
21. Mueller DW, Rehli M, Bosserhoff AK. 2009. miRNA expression profiling in melanocytes and melanoma cell lines reveals miRNAs associated with formation and progression of malignant melanoma. J Invest Dermatol 129: 1740-1751.
22. Nicoli S, Standley C, Walker P, Hurlstone A, Fogarty KE, Lawson ND. 2010. MicroRNA-mediated integration of haemodynamics and Vegf signalling during angiogenesis. Nature 464: 1196-1200.
23. Samani AA, Yakar S, LeRoith D, Brodt P. 2007. The role of the IGF system in cancer growth and metastasis: overview and recent insights. Endocr Rev 28: 20-47. (Pubitemid 46220849)
24. Sullivan R, Graham CH. 2007. Hypoxia-driven selection of the metastatic phenotype. Cancer Metastasis Rev 26: 319-331. (Pubitemid 47101665)
25. Thomas M, Lieberman J, Lal A. 2010. Desperately seeking microRNA targets. Nat Struct Mol Biol 17: 1169-1174.
26. Thomson JM, Newman M, Parker JS, Morin-Kensicki EM, Wright T, Hammond SM. 2006. Extensive post-transcriptional regulation of microRNAs and its implications for cancer. Genes Dev 20: 2202-2207.
27. Wang X. 2008. miRDB: a microRNA target prediction and functional annotation database with a wiki interface. RNA 14: 1012-1017. (Pubitemid 351717482)
28. Wurdinger T, Tannous BA, Saydam O, Skog J, Grau S, Soutschek J, Weissleder R, Breakefield XO, Krichevsky AM. 2008. miR-296 regulates growth factor receptor overexpression in angiogenic endothelial cells. Cancer Cell 14: 382-393.
29. Zhang H, Hao Y, Yang J, Zhou Y, Li J, Yin S, Sun C, Ma M, Huang Y, Xi JJ. 2011. Genome-wide functional screening of miR-23b as a pleiotropic modulator suppressing cancer metastasis. Nat Commun 2: 554.
30. Zheng H, Chu J, Zeng Y, Loh HH, Law PY. 2010. Yin Yang 1 phosphorylation contributes to the differential effects of μ-opioid receptor agonists on microRNA-190 expression. J Biol Chem 285: 21994-22002. Republic of China Republic of China