Distribution study of atorvastatin and its metabolites in rat tissues using combined information from UHPLC/MS and MALDI-Orbitrap-MS imaging

Analytical and Bioanalytical Chemistry

Volumn 406, Issue 19, 2014, Pages 4601-4610

  Jirásko, Robert ^a   Holčapek, Michal ^a   Kuneš, Martin ^b   Svatoš, Aleš ^c  

^a UNIVERSITY OF PARDUBICE   (Czech Republic)

^b UNIVERSITY HOSPITAL HRADEC KRALOVE   (Czech Republic)

^c MAX PLANCK INSTITUTE FOR CHEMICAL ECOLOGY   (Germany)

Author keywords

Atorvastatin; Drug metabolism; MALDI; Mass spectrometry imaging; Ultrahigh performance liquid chromatography; Ultrahigh resolution mass spectrometry

Indexed keywords

BIOMOLECULES; DEPOSITION; HISTOLOGY; IMAGE PROCESSING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MASS SPECTROMETRY; METABOLITES; RATS;

ATORVASTATIN; DRUG METABOLISMS; MALDI; MASS-SPECTROMETRY IMAGING; ULTRA-HIGH PERFORMANCE LIQUID CHROMATOGRAPHIES;

TISSUE;

RATTUS;

ATORVASTATIN; HEPTANOIC ACID DERIVATIVE; PYRROLE DERIVATIVE;

ANIMAL; BLOOD; CHEMISTRY; FECES; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER; MALE; MASS SPECTROMETRY; METABOLISM; PHYSIOLOGY; PROCEDURES; RAT; TANDEM MASS SPECTROMETRY; TISSUE DISTRIBUTION; WISTAR RAT;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FECES; HEPTANOIC ACIDS; LIVER; MALE; PYRROLES; RATS; RATS, WISTAR; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TANDEM MASS SPECTROMETRY; TISSUE DISTRIBUTION;

EID: 84904513121     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-014-7880-y     Document Type: Article

References (29)

1. Curran MP (2010) Amlodipine/atorvastatin: a review of its use in the treatment of hypertension and dyslipidaemia and the prevention of cardiovascular disease. Drugs 70:191-213
2. Nováková L, Satinský D, Solich P (2008) HPLC methods for the determination of simvastatin and atorvastatin. Trac Trends Anal Chem 27:352-367
3. Hermann M, Christensen H, Reubsaet JLE (2005) Determination of atorvastatin and metabolites in human plasma with solid-phase extraction followed by LC-tandem MS. Anal Bioanal Chem 382:1242-1249
4. Black AE, Sinz MW, Hayes RN, Woolf T (1998) Metabolism and excretion studies in mouse after single and multiple oral doses of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor atorvastatin. Drug Metab Dispos 26:755-763
5. Jirásko R, Mikysek T, Chagovets V, Vokřál I, Holčapek M (2013) Structural characterization of electrochemically and in vitro biologically generated oxidation products of atorvastatin using UHPLC/MS/MS. Anal Bioanal Chem 405:7181-7193
6. Kracun M, Kocijan A, Bastarda A, Grahek R, Plavec J, Kocjan D (2009) Isolation and structure determination of oxidative degradation products of atorvastatin. J Pharm Biomed 50:729-736
7. Shah RP, Kumar V, Singh S (2008) Liquid chromatography/mass spectrometric studies on atorvastatin and its stress degradation products. Rapid Commun Mass Spectrom 22:613-622
8. Holčapek M, Kolářová L, Nobilis M (2008) High-performance liquid chromatography-tandem mass spectrometry in the identification and determination of phase I and phase II drug metabolites. Anal Bioanal Chem 391:59-78
9. Norris JL, Caprioli RM (2013) Analysis of tissue specimens by matrix-assisted laser desorption/ionization imaging mass spectrometry in biological and clinical research. Chem Rev 113:2309-2342
10. Prideaux B, Stoeckli M (2012) Mass spectrometry imaging for drug distribution studies. J Proteome 75:4999-5013
11. Römpp A, Spengler B (2013) Mass spectrometry imaging with high resolution in mass and space. Histochem Cell Biol 139:759-783
12. Wu CP, Dill AL, Eberlin LS, Cooks RG, Ifa DR (2013) Mass spectrometry imaging under ambient conditions. Mass Spectrom Rev 32:218-243
13. Fletcher JS, Lockyer NP, Vickerman JC (2011) Developments in molecular SIMS depth profiling and 3D imaging of biological systems using polyatomic primary ions. Mass Spectrom Rev 30:142-174
14. Passarelli MK, Winograd N (2011) Lipid imaging with time-of-flight secondary ion mass spectrometry (ToF-SIMS). Biochim Biophys Acta Mol Cell Biol Lipids 1811:976-990
15. Weidner SM, Falkenhagen J (2009) Imaging mass spectrometry for examining localization of polymeric composition in matrix-assisted laser desorption/ionization samples. Rapid Commun Mass Spectrom 23:653-660
16. Seeley EH, Caprioli RM (2008) Molecular imaging of proteins in tissues by mass spectrometry. Proc Natl Acad Sci U S A 105:18126-18131
17. Karas M, Hillenkamp F (1988) Laser desorption ionization of proteins with molecular masses exceeding 10000 daltons. Anal Chem 60:2299-2301
18. Svatoš A (2010) Mass spectrometric imaging of small molecules. Trends Biotechnol 28:425-434
19. van Kampen JJA, Burgers PC, de Groot R, Gruters RA, Luider TM (2011) Biomedical application of maldi mass spectrometry for small-molecule analysis. Mass Spectrom Rev 30:101-120
20. Law KP, Larkin JR (2011) Recent advances in SALDI-MS techniques and their chemical and bioanalytical applications. Anal Bioanal Chem 399:2597-2622
21. Kawasaki H, Ozawa T, Hisatomi H, Arakawa R (2012) Platinum vapor deposition surface-assisted laser desorption/ionization for imaging mass spectrometry of small molecules. Rapid Commun Mass Spectrom 26:1849-1858
22. Shroff R, Rulíšek L, Doubský J, Svatoš A (2009) Acid-base-driven matrix-assisted mass spectrometry for targeted metabolomics. Proc Natl Acad Sci U S A 106:10092-10096
23. Woo HK, Northen TR, Yanes O, Siuzdak G (2008) Nanostructure-initiator mass spectrometry: a protocol for preparing and applying NIMS surfaces for high-sensitivity mass analysis. Nat Protoc 3:1341-1349
24. Pirman DA, Reich RF, Kiss A, Heeren RMA, Yost RA (2013) Quantitative MALDI tandem mass spectrometric imaging of cocaine from brain tissue with a deuterated internal standard. Anal Chem 85:1081-1089
25. Cornett DS, Frappier SL, Caprioli RM (2008) MALDI-FTICR imaging mass spectrometry of drugs and metabolites in tissue. Anal Chem 80:5648-5653
26. Jun JH, Song ZH, Liu ZJ, Nikolau BJ, Yeung ES, Lee YJ (2010) High-spatial and high-mass resolution imaging of surface metabolites of Arabidopsis thaliana by laser desorption-ionization mass spectrometry using colloidal silver. Anal Chem 82:3255-3265
27. Jungmann JH, Heeren RMA (2012) Emerging technologies in mass spectrometry imaging. J Proteome 75:5077-5092
28. Hankin JA, Barkley RM, Murphy RC (2007) Sublimation as a method of matrix application for mass spectrometric imaging. J Am Soc Mass Spectrom 18:1646-1652
29. Thomas A, Charbonneau JL, Fournaise E, Chaurand P (2012) Sublimation of new matrix candidates for high spatial resolution imaging mass spectrometry of lipids: enhanced information in both positive and negative polarities after 1,5-diaminonaphthalene deposition. Anal Chem 84:2048-2054