Isolation and structure determination of oxidative degradation products of atorvastatin

Journal of Pharmaceutical and Biomedical Analysis

Volumn 50, Issue 5, 2009, Pages 729-736

  Kračun, Matjaž ^a   Kocijan, Andrej ^a   Bastarda, Andrej ^a   Grahek, Rok ^a   Plavec, Janez ^b   Kocjan, Darko ^b  

^a Lek dd   (Slovenia)

^b NATIONAL INSTITUTE OF CHEMISTRY   (Slovenia)

Author keywords

Atorvastatin; HRMS; NMR; Oxidative degradation products; Preparative HPLC

Indexed keywords

ACETONITRILE; ATORVASTATIN; ENDOPEROXIDE; HYDROGEN PEROXIDE; NUCLEOPHILE; OXYGEN; POTASSIUM HYDROXIDE; PYRROLE;

ALKALINITY; AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; DRUG DEGRADATION; DRUG DETERMINATION; DRUG ISOLATION; DRUG STRUCTURE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOLECULAR WEIGHT; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXIDATION; PH; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSED PHASE LIQUID CHROMATOGRAPHY; SUN EXPOSURE; ULTRAVIOLET RADIATION;

ACETONITRILES; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; HEPTANOIC ACIDS; HYDROGEN PEROXIDE; HYDROGEN-ION CONCENTRATION; HYDROXIDES; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; OXYGEN; PHOSPHORIC ACIDS; POTASSIUM COMPOUNDS; PYRROLES; ULTRAVIOLET RAYS;

EID: 70349178661     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2009.06.008     Document Type: Article

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