Targeted inactivation of cerberus like-2 leads to left ventricular cardiac hyperplasia and systolic dysfunction in the mouse

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Arauj́o, Ana Carolina ^a   Marques, Sara ^a   Belo, José António ^a,b  

^a UNIVERSITY OF ALGARVE   (Portugal)

^b NOVA MEDICAL SCHOOL   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

CERBERUS LIKE 2 PROTEIN; CYCLIN D1; NUCLEIC ACID BINDING PROTEIN; PEPTIDES AND PROTEINS; PROTEIN BAF60C; PROTEIN NODAL; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; DTE PROTEIN, MOUSE; SIGNAL PEPTIDE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CYCLE REGULATION; CONTROLLED STUDY; ECHOCARDIOGRAPHY; EMBRYO; EMBRYO DEVELOPMENT; FEMALE; GENE EXPRESSION; HEART DEVELOPMENT; HEART LEFT VENTRICLE HYPERTROPHY; HEART MUSCLE CELL; KNOCKOUT MOUSE; LEFT VENTRICULAR SYSTOLIC DYSFUNCTION; LIFESPAN; MITOSIS INDEX; MOLECULAR PATHOLOGY; MOUSE; NEWBORN; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; CARDIAC MUSCLE CELL; CARDIOMYOPATHY; GENE EXPRESSION REGULATION; HEART LEFT VENTRICLE FUNCTION; HEART VENTRICLE; HYPERPLASIA; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ANIMALS; ANIMALS, NEWBORN; CARDIOMYOPATHIES; CYCLIN D1; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEART VENTRICLES; HYPERPLASIA; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MYOCYTES, CARDIAC; NODAL PROTEIN; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; VENTRICULAR DYSFUNCTION, LEFT;

EID: 84904498005     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0102716     Document Type: Article

References (63)

1. Buckingham M, Meilhac S, Zaffran S (2005) Building the mammalian heart from two sources of myocardial cells. Nat Rev Genet 6: 826-835.
2. Garry DJ, Olson EN (2006) A Common Progenitor at the Heart of Development. Cell 127: 1101-1104. (Pubitemid 44894531)
3. Nemer M (2008) Genetic insights into normal and abnormal heart development. Cardiovasc Pathol 17: 48-54.
4. Garne E, Olsen MS, Johnsen SP, Hjortdal V, Andersen HO, et al. (2012) How Do We Define Congenital Heart Defects for Scientific Studies? Congenit Heart Dis 7: 46-49.
5. DeRuiter MC, Poelmann RE, Vries IV, Mentink MMT, Groot ACG (1992) The development of the myocardium and endocardium in mouse embryos. Fusion of two heart tubes? Anat Embryol (Berl) 185: 461-473.
6. Pérez-Pomares JM, González-Rosa JM, Muñoz- Chápuli R (2009) Building the vertebrate heart - an evolutionary approach to cardiac development. Int J Dev Biol 53: 1427-1443.
7. Kelly RG, Buckingham ME (2002) The anterior heart-forming field: voyage to the arterial pole of the heart. Trends Genet 18: 210-216. (Pubitemid 34273742)
8. Abu-issa R, Kirby ML (2007) Heart Field: From Mesoderm to Heart Tube. Annu Rev Cell Dev Biol 23: 45-68.
9. Brand T (2003) Heart development: molecular insights into cardiac specification and early morphogenesis. Dev Biol 258: 1-19.
10. Ben-Shachar G, Arcilla RA, Lucas R V, Manasek FJ (1985) Ventricular trabeculations in the chick embryo heart and their contribution to ventricular and muscular septal development. Circ Res 57: 759-766. (Pubitemid 16200685)
11. Ieda M, Tsuchihashi T, Ivey KN, Ross RS, Hong T-T, et al. (2009) Cardiac Fibroblasts Regulate Myocardial Proliferation through Beta1 Integrin Signaling. Dev Cell 16: 233-244.
12. Christoffels VM, Burch JBE, Moorman AFM (2004) Architectural plan for the heart: early patterning and delineation of the chambers and the nodes. Trends Cardiovasc Med 14: 301-307. (Pubitemid 41110608)
13. Li J-M, Brooks G (1999) Cell cycle regulatory molecules (cyclins, cyclin-dependent kinases and cyclin-dependent kinase inhibitors) and the cardiovascular system. Potential targets for therapy? Eur Heart J 20: 406-420. (Pubitemid 29116537)
14. Walsh S, Ponte A, Fleischmann BK, Jovinge S (2010) Cardiomyocyte cell cycle control and growth estimation in vivo - an analysis based on cardiomyocyte nuclei. Cardiovasc Res 86: 365-373.
15. Li F, Wang X, Capasso JM, Gerdes AM (1996) Rapid transition of cardiac myocytes from hyperplasia to hypertrophy during postnatal development. J Mol Cell Cardiol 28: 1737-1746. (Pubitemid 26300573)
16. Ikenishi A, Okayama H, Iwamoto N, Yoshitome S, Tane S, et al. (2012) Cell cycle regulation in mouse heart during embryonic and postnatal stages. Dev Growth Differ 54: 731-738.
17. Porrello ER, Mahmoud AI, Simpson E, Hill JA, Richardson JA, et al. (2011) Transient regenerative potential of the neonatal mouse heart. supporting 331: 1078-1080.
18. Mollova M, Bersell K, Walsh S, Savla J, Das TL, et al. (2012) Cardiomyocyte proliferation contributes to heart growth in young humans. Proc Natl Acad Sci U S A 110: 1446-1451.
19. Francou A, Saint-Michel E, Mesbah K, Théveniau-Ruissy M, Rana MS, et al. (2013) Second heart field cardiac progenitor cells in the early mouse embryo. Biochim Biophys Acta 1833: 795-798.
20. Sedmera D, Pexieder T, Vuillemin M, Thompson RP, Anderson RH (2000) Developmental Patterning of the Myocardium. Anat Rec 258: 319-337. (Pubitemid 30187458)
21. Marques S, Borges AC, Silva AC, Freitas S, Cordenonsi M, et al. (2004) The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis. Genes Dev 18: 2342-2347. (Pubitemid 39304680)
22. Inácio JM, Marques S, Nakamura T, Shinohara K, Meno C, et al. (2013) The dynamic right-to-left translocation of Cerl2 is involved in the regulation and termination of Nodal activity in the mouse node. PLoS One 8: e60406.
23. Kathiriya IS, Srivastava D (2000) Left-Right Asymmetry and Cardiac Looping: Implications for Cardiac Development and Congenital Heart Disease. Am J Med Genet 97: 271-279. (Pubitemid 32463491)
24. Tan SY, Rosenthal J, Zhao X-Q, Francis RJ, Chatterjee B, et al. (2007) Heterotaxy and complex structural heart defects in a mutant mouse model of primary ciliary dyskinesia. J Clin Invest 117: 3742-3752. (Pubitemid 350224085)
25. Linde van der D, Konings EEM, Slager MA, Witsenburg M, Helbing WA, et al. (2011) Birth prevalence of congenital heart disease worldwide: a systematic review and meta-analysis. J Am Coll Cardiol 58: 2241-2247.
26. Foley AC, Korol O, Timmer AM, Mercola M (2007) Multiple functions of Cerberus cooperate to induce heart downstream of Nodal. Dev Biol 303: 57-65. (Pubitemid 46242211)
27. Bento M, Correia E, Tavares AT, Becker JD, Belo JA (2011) Identification of differentially expressed genes in the heart precursor cells of the chick embryo. Gene Expr Patterns 11: 437-447.
28. Cai W, Albini S, Wei K, Willems E, Guzzo RM, et al. (2013) Coordinate Nodal and BMP inhibition directs Baf60c-dependent cardiomyocyte commitment. Genes Dev 27: 2332-2344.
29. D'Aniello C, Fiorenzano A, Iaconis S, Liguori GL, Andolfi G, et al. (2013) The G-protein-coupled receptor APJ is expressed in the second heart field and regulates Cerberus-Baf60c axis in embryonic stem cell cardiomyogenesis. Cardiovasc Res 100: 95-104.
30. Stankunas K, Hang CT, Tsun Z-Y, Chen H, Lee N V, et al. (2008) Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis. Dev Cell 14: 298-311. (Pubitemid 351189176)
31. Franco D, de Boer PAJ, de Gier-de Vries C, Lamers WH, Moorman AFM (2001) Methods on In Situ Hybridization, Immunohistochemistry and beta-Galactosidase Reporter Gene Detection. Eur J Morphol 39: 3-25. (Pubitemid 32231832)
32. Nakamura T, Saitoh D, Kawasumi A, Shinohara K, Asai Y, et al. (2012) Fluid Flow and Interlinked Feedback Loops Establish Left-Right Asymmetric Decay of Cerl2 mRNA in the Mouse Embryo. Nat Commun 3: 1322.
33. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408. (Pubitemid 34164012)
34. Stypmann J, Engelen MA, Troatz C, Rothenburger M, Eckardt L, et al. (2009) Echocardiographic assessment of global left ventricular function in mice. Lab Anim 43: 127-137.
35. Kelly RG, Brown NA, Buckingham ME (2001) The Arterial Pole of the Mouse Heart Forms from Fgf10-Expressing Cells in Pharyngeal Mesoderm. Dev Cell 1: 435-440. (Pubitemid 33586092)
36. Ghanem A, Röll W, Hashemi T, Dewald O, Djoufack PC, et al. (2006) Echocardiographic assessment of left ventricular mass in neonatal and adult mice: accuracy of different echocardiographic methods. Echocardiography 23: 900-907. (Pubitemid 44630169)
37. Zheng-Fischhöfer Q, Ghanem A, Kim J-S, Kibschull M, Schwarz G, et al. (2006) Connexin31 cannot functionally replace connexin43 during cardiac morphogenesis in mice. J Cell Sci 119: 693-701.
38. Risebro CA, Riley PR (2006) Formation of the ventricles. Sci World J 6: 1862-1880.
39. Mysliwiec MR, Bresnick EH, Lee Y (2011) Endothelial Jarid2/Jumonji is required for normal cardiac development and proper Notch1 expression. J Biol Chem 286: 17193-17204.
40. Luxán G, Casanova JC, Martínez-Poveda B, Prados B, D'Amato G, et al. (2013) Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy. Nat Med 19: 193-201.
41. Ahuja P, Sdek P, Maclellan WR (2007) Cardiac Myocyte Cell Cycle Control in Development, Disease, and Regeneration. Physiol Rev 87: 521-544. (Pubitemid 47086282)
42. Soonpaa MH, Kim KK, Pajak L, Franklin M, Field LJ (1996) Cardiomyocyte DNA synthesis and binucleation during murine development. Am Physiol Soc 271: H2183-H2189.
43. Chen H, Shi S, Acosta L, Li W, Lu J, et al. (2004) BMP10 is essential for maintaining cardiac growth during murine cardiogenesis. Development 131: 2219-2231. (Pubitemid 38702052)
44. Pasumarthi KBS, Field LJ (2002) Cardiomyocyte Cell Cycle Regulation. Circ Res 90: 1044-1054. (Pubitemid 34627902)
45. Franco D, Meilhac SM, Christoffels VM, Kispert A, Buckingham M, et al. (2006) Left and right ventricular contributions to the formation of the interventricular septum in the mouse heart. Dev Biol 294: 366-375. (Pubitemid 43866676)
46. Sedmera D, Thompson RP (2011) Myocyte proliferation in the developing heart. Dev Dyn 240: 1322-1334.
47. Manabe I, Shindo T, Nagai R (2002) Gene Expression in Fibroblasts and Fibrosis: Involvement in Cardiac Hypertrophy. Circ Res 91: 1103-1113. (Pubitemid 36076358)
48. Akazawa H, Komuro I (2003) Roles of Cardiac Transcription Factors in Cardiac Hypertrophy. Circ Res 92: 1079-1088. (Pubitemid 36665853)
49. Rohini A, Agrawal N, Koyani CN, Singh R (2010) Molecular targets and regulators of cardiac hypertrophy. Pharmacol Res 61: 269-280.
50. Arimura T, Bos JM, Sato A, Kubo T, Okamoto H, et al. (2009) Cardiac Ankyrin Repeat Protein Gene (ANKRD1) Mutations in Hypertrophic Cardiomyopathy. J Am Coll Cardiol 54: 334-342.
51. Clark KL, Yutzey KE, Benson DW (2006) Transcription Factors and Congenital Heart Defects. Annu Rev Physiol 68: 97-121.
52. Zheng B, Wen JK, Han M (2003) Regulatory Factors Involved in Cardiogenesis. Biochemistry 68: 650-657.
53. Qiu Z, Cang Y, Goff SP (2010) c-Abl tyrosine kinase regulates cardiac growth and development. Proc Natl Acad Sci 107: 1136-1141.
54. Ho L, Crabtree GR (2010) Chromatin remodelling during development. Nature 463: 474-484.
55. Wamstad JA, Alexander JM, Truty RM, Shrikumar A, Li F, et al. (2012) Dynamic and coordinated epigenetic regulation of developmental transitions in the cardiac lineage. Cell 151: 206-220.
56. Lickert H, Takeuchi JK, Von Both I, Walls JR, McAuliffe F, et al. (2004) Baf60c is essential for function of BAF chromatin remodelling complexes in heart development. Nature 432: 107-112. (Pubitemid 39490836)
57. Muchardt C, Yaniv M (2001) When the SWI/SNF complex remodels ... the cell cycle. Oncogene 20: 3067-3075. (Pubitemid 32553561)
58. Lamba DA, Hayes S, Karl MO, Reh T (2008) BAF60c is a component of the neural progenitor specific BAF complex in developing retina. Dev Dyn 237: 3016-3023.
59. Schier AF (2003) Nodal Signaling in Vertebrate Development. Annu Rev Cell Dev Biol 19: 589-621.
60. Shen MM (2007) Nodal signaling: developmental roles and regulation. Development 134: 1023-1034.
61. Parisi S, D'Andrea D, Lago CT, Adamson ED, Persico MG, et al. (2003) Nodal-dependent Cripto signaling promotes cardiomyogenesis and redirects the neural fate of embryonic stem cells. J Cell Biol 163: 303-314. (Pubitemid 37363131)
62. Kitamura R, Takahashi T, Nakajima N, Isodono K, Asada S, et al. (2007) Stage-Specific Role of Endogenous Smad2 Activation in Cardiomyogenesis of Embryonic Stem Cells. Circ Res 101: 78-87. (Pubitemid 47094626)
63. Cai W, Guzzo RM, Wei K, Willems E, Davidovics H, et al. (2012) A Nodal-to-TGFbeta Cascade Exerts Biphasic Control Over Cardiopoiesis. Circ Res 111: 876-881.