Aspergillus oryzae type III polyketide synthase CsyA is involved in the biosynthesis of 3,5-dihydroxybenzoic acid

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 16, 2010, Pages 4785-4788

  Seshime, Yasuyo ^a   Juvvadi, Praveen Rao ^b   Kitamoto, Katsuhiko ^b   Ebizuka, Yutaka ^b   Nonaka, Takamasa ^a   Fujii, Isao ^a  

^a IWATE MEDICAL UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

3,5 Dihydroxybenzoic acid; Alkyl resorcinol resorcylic acid synthase; Aspergillus oryzae; csyA; Type III polyketide synthase

Indexed keywords

2' OXOALKYLRESORCYLIC ACID SYNTHASE; ACETIC ACID DERIVATIVE; ALPHA RESORCYLIC ACID; AMYLASE; CARBON 13; METHYL GROUP; ORSELLINIC ACID; POLYKETIDE; POLYKETIDE SYNTHASE; PROTEIN CSYA; SYNTHETASE; UNCLASSIFIED DRUG; ALPHA-RESORCYLIC ACID; FUNGAL PROTEIN; HYDROXYBENZOIC ACID DERIVATIVE; RESORCINOL DERIVATIVE;

ARTICLE; ASPERGILLUS ORYZAE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CSYA GENE; CSYC GENE; CSYD GENE; CYCLIZATION; CYSB GENE; ENZYME MECHANISM; FUNGAL GENE; GENE OVEREXPRESSION; GENOME; MOLECULAR MODEL; MOLECULAR SIZE; NEUROSPORA CRASSA; NONHUMAN; OXIDATION; POLYMERIZATION; PROMOTER REGION; PROTEIN FAMILY; SYNTHESIS; CHEMISTRY; COMPUTER SIMULATION; ENZYMOLOGY; METABOLISM; PROTEIN TERTIARY STRUCTURE;

ASPERGILLUS ORYZAE; COMPUTER SIMULATION; FUNGAL PROTEINS; HYDROXYBENZOIC ACIDS; POLYKETIDE SYNTHASES; PROTEIN STRUCTURE, TERTIARY; HYDROXYBENZOATES; RESORCINOLS;

ASPERGILLUS ORYZAE; FUNGI; NEUROSPORA CRASSA;

EID: 77955422423     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.06.119     Document Type: Article

References (24)

1. J. Staunton, and K.J. Weissman Nat. Prod. Rep. 18 2001 380
2. D.A. Hopwood Chem. Rev. 97 1997 2465
3. R.J. Cox Org. Biomol. Chem. 5 2007 2010
4. Y. Seshime, P.R. Juvvadi, I. Fujii, and K. Kitamoto Biochem. Biophys. Res. Commun. 331 2005 253
5. M.B. Austin, and J.P. Noel Nat. Prod. Rep. 20 2003 79
6. N. Funa, T. Awakawa, and S. Horinouchi J. Biol. Chem. 282 2007 14476
7. M. Machida, K. Asai, T. Sano, T. Tanaka, and T. Kumagai Nature 438 2005 1157
8. Y. Seshime, P.R. Juvvadi, K. Kitamoto, Y. Ebizuka, and I. Fujii Bioorg. Med. Chem. 18 2010 4542
9. T. Fujii, H. Yamaoka, K. Gomi, K. Kitamoto, and C. Kumagai Biosci., Biotechnol., Biochem. 59 1995 1869
10. I. Fujii J. Antibiot. 63 2010 207
11. K. Gomi, Y. Iimura, and S. Hara Agric. Biol. Chem. 51 1987 2549
12. K. Kitamoto Adv. Appl. Microbiol. 51 2002 129
13. S.C. Wenzel, H.B. Bode, I. Kochems, and R. Müller ChemBioChem 9 2008 2711
14. W.B. Turner, and D.C. Aldridge Fungal Metabolites II 1983 Academic Press London
15. S. Gaisser, A. Trefzer, S. Stckert, A. Kirshning, and A. Bechthold J. Bacteriol. 179 1997 6271
16. I. Fujii, A. Watanabe, and Y. Ebizuka J.S. Tkacz, L. Lange, Advances in Fungal Biotechnology for Industrial, Agriculture, and Medicine 2004 Kluwer Academic/Plenum Publishers New York 97
17. V. Schroeckh, K. Scherlach, H.-W. Nützmann, E. Shelest, W. Schmidt-Heck, J. Schuemann, K. Martin, C. Hertwck, and A.A. Brakhage Proc. Natl. Acad. Sci. U.S.A. 106 2009 14558
18. J.F. Sanchez, Y.-M. Chiang, E. Szeczyk, A.D. Davidson, M. Ahuja, C.E. Oakley, J.W. Bok, N. Keller, B.R. Oakley, and C.C.C. Wang Mol. Biosyst. 6 2010 587
19. M.A. Marti-Renom, A. Stuart, A. Fiser, R. Sánchez, F. Melo, and A. Sali Annu. Rev. Biophys. Biomol. Struct. 29 2000 291
20. S.B. Rubin-Pitel, H. Zhang, T. Vu, J.S. Brunzelle, H. Zhao, and S.K. Nair Chem. Biol. 15 2008 1079
21. I. Abe, S. Oguro, Y. Utsumi, Y. Sano, and H. Noguchi J. Am. Chem. Soc. 127 2005 12709
22. I. Abe, Y. Utsumi, S. Oguro, H. Morita, Y. Sano, and H. Noguchi J. Am. Chem. Soc. 127 2005 1362
23. J.-L. Ferrer, J.M. Jez, M.E. Bowman, R.A. Dixon, and J.P. Noel Nat. Struct. Biol. 6 1999 775
24. D. Yu, J. Zeng, D. Chen, and J. Zhan Enzyme Microb. Technol. 46 2010 575