In-vitro cytotoxicity, antioxidant, bleomycin-dependent DNA damage and immunomodulatory evaluation of 1-(4-acetylphenyl)-3-aryloxypyrrolidine-2,5-dione based derivatives

Medicinal Chemistry Research

Volumn 23, Issue 8, 2014, Pages 3907-3915

  Patel, Jigarkumar R ^a   Dhorajiya, Bhaveshkumar D ^a   Dholakiya, Bharatkumar Z ^a   Badria, Farid A ^b   Ibrahim, Ahmed S ^c  

^a SARDAR VALLABHBHAI NATIONAL INSTITUTE OF TECHNOLOGY   (India)

^b Mansoura University 35516   (Egypt)

^c MANSOURA UNIVERSITY   (Egypt)

Author keywords

Antioxidant; Bleomycin dependent DNA damage; Cytotoxicity; Lymphocyte transformation; Oxa michael adducts

Indexed keywords

1 (4 ACETYLPHENYL) 3 (1 NAPHTHYLOXY)PYRROLIDINE 2,5 DIONE; 1 (4 ACETYLPHENYL) 3 (2 METHYLPHENYLOXY)PYRROLIDINE 2,5 DIONE; 1 (4 ACETYLPHENYL) 3 (3 METHYLPHENYLOXY)PYRROLIDINE 2,5 DIONE; 1 (4 ACETYLPHENYL) 3 (4 AMINOPHENYLOXY)PYRROLIDINE 2,5 DIONE; 1 (4 ACETYLPHENYL) 3 (4 BROMOPHENYLOXY)PYRROLIDINE 2,5 DIONE; 1 (4 ACETYLPHENYL) 3 (4 NITROPHENYLOXY)PYRROLIDINE 2,5 DIONE; 1 (4 ACETYLPHENYL) 3 (BIPHENYLOXY)PYRROLIDINE 2,5 DIONE; 2 ((1 (4 ACETYLPHENYL) 2,5 DIOXOPYRROLIDIN 3 YL)OXY)BENZOIC ACID; ASCORBIC ACID; BENZENE DERIVATIVE; BLEOMYCIN; FLUOROURACIL; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ABTS RADICAL SCAVENGING ASSAY; ANALYTIC METHOD; ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; BIOASSAY; CANCER CELL LINE; CONTROLLED STUDY; DNA DAMAGE; DRUG CYTOTOXICITY; DRUG RECEPTOR BINDING; DRUG SCREENING; HUMAN; HUMAN CELL; IMMUNOMODULATION; IN VITRO STUDY; LYMPHOCYTE TRANSFORMATION TEST; NONHUMAN; ONE POT SYNTHESIS; QUANTUM YIELD; STRUCTURE ACTIVITY RELATION;

EID: 84904445304     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-014-0965-5     Document Type: Article

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