Design and synthesis of novel nucleobase-based barbiturate derivatives as potential anticancer agents

Medicinal Chemistry Research

Volumn 23, Issue 2, 2014, Pages 839-847

  Dhorajiya, Bhaveshkumar D ^a   Ibrahim, Ahmed S ^b   Badria, Farid A ^b   Dholakiya, Bharatkumar Z ^a  

^a SARDAR VALLABHBHAI NATIONAL INSTITUTE OF TECHNOLOGY   (India)

^b MANSOURA UNIVERSITY   (Egypt)

Author keywords

Barbiturates; Cytotoxicity; Keywords: Green chemistry

Indexed keywords

1,3 DIMETHYL 5 [(9H PURIN 6 YLAMINO)METHYLENE] 2 THIOXO DIHYDRO PYRIMIDINE 4,6 DIONE; 1,3 DIMETHYL 5 [(9H PURIN 6 YLAMINO)METHYLENE]PYRIMIDINE 2,4,6 TRIONE; 5 [(1,6 DIHYDRO 2 HYDROXYPYRIMIDINE 4 YLAMINO)METHYLENE] 1,3 DIMEHYLPYRIMIDINE 2,4,6(1H,3H,5H) TRIONE; 5 [(1,6 DIHYDRO 2 HYDROXYPYRIMIDINE 4 YLAMINO)METHYLENE] DIHYDRO 1,3 DIMETHYL 2 THIOXOPYRIMIDINE 4,6(1H,5H) DIONE; 5 [(2 HYDROXY 9H PURIN 6 YLAMINO)METHYLENE] 2 THIOXO DIHYDRO PYRIMIDINE 4,6 DIONE; 5 [(2 HYDROXY 9H PURIN 6 YLAMINO)METHYLENE]PYRIMIDINE 2,4,6 TRIONE; 5 [(2 HYDROXYPYRIMIDINE 4 YLAMINO)METHYLENE]DIHYDRO 2 THIOXOPYRIMIDINE 4,6(1H,5H) DIONE; 5 [(5 METHYLTHIAZOL 2 YLAMINO)METHYLENE]PYRIMIDINE 2,4,6(1H,3H,5H) TRIONE; 5 [(9H PURIN 6 YLAMINO)METHYLENE] 2 THIOXO DIHYDROPYRIMIDINE 4,6 DIONE; 5 [(9H PURIN 6 YLAMINO)METHYLENE]PYRIMIDINE 2,4,6 TRIONE; 5 [(PYRIDIN 2 YLAMINO)METHYLENE]PYRIMIDINE 2,4,6(1H,3H,5H) TRIONE; 5 [[(2 HYDROXYPYRIMIDIN 4 YL)AMINO]METHYLENE]PYRIMIDINE 2,4,6 (1H,3H,5H) TRIONE; ADENINE; ANTINEOPLASTIC AGENT; AROMATIC AMINE; BARBITURIC ACID DERIVATIVE; CYTOSINE; FLUOROURACIL; FORMIC ACID; GUANINE; HETEROCYCLIC AMINE; NUCLEIC ACID BASE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG SYNTHESIS; GREEN CHEMISTRY; HETERONUCLEAR MULTIPLE BOND CORRELATION; HUMAN; HUMAN CELL; IC 50; INFRARED SPECTROSCOPY; KNOEVENAGEL CONDENSATION; MONOLAYER CULTURE; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; ULTRAVIOLET SPECTROSCOPY;

EID: 84893784193     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-013-0683-4     Document Type: Article

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