High resolution metabolite imaging in the hippocampus following neonatal exposure to the environmental toxin BMAA using ToF-SIMS

ACS Chemical Neuroscience

Volumn 5, Issue 7, 2014, Pages 568-575

  Hanrieder, Jörg ^a,b   Gerber, Lorenz ^c   Persson Sandelius, Åsa ^a   Brittebo, Eva B ^d   Ewing, Andrew G ^a,b   Karlsson, Oskar ^d  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b CHALMERS UNIVERSITY OF TECHNOLOGY   (Sweden)

^c SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^d UPPSALA UNIVERSITY   (Sweden)

Author keywords

ALS PDC; beta N methylamino l alanine (BMAA); hippocampus; Imaging mass spectrometry; ToF SIMS

Indexed keywords

2 AMINO 3 METHYLAMINOPROPIONIC ACID; GLIAL FIBRILLARY ACIDIC PROTEIN; PHOSPHATIDYLCHOLINE; PHOSPHOLIPID; POTASSIUM; PROTEIN S100B; BETA-N-METHYLAMINO-L-ALANINE; DANGEROUS GOODS; DIAMINO ACID;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTOSIS; CELL ACTIVATION; CELL DEATH; CELL DIVISION; CONTROLLED STUDY; DATA ANALYSIS; DENTATE GYRUS; ENVIRONMENTAL EXPOSURE; HIPPOCAMPAL CA1 REGION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MALE; MOLECULAR WEIGHT; NEURAL STEM CELL; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CONTENT; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; SIGNAL TRANSDUCTION; TIME OF FLIGHT MASS SPECTROMETRY; TIME OF FLIGHT SECONDARY ION MASS SPECTROMETRY; UBIQUITINATION; UPREGULATION; ANIMAL; BRAIN DISEASE; CHEMICALLY INDUCED; DANGEROUS GOODS; DISEASE MODEL; GLIOSIS; GROWTH, DEVELOPMENT AND AGING; HIPPOCAMPUS; MASS SPECTROMETRY; MULTIVARIATE ANALYSIS; PATHOPHYSIOLOGY; PROCEDURES; SIGNAL PROCESSING; TOXICITY; WISTAR RAT;

AMINO ACIDS, DIAMINO; ANIMALS; ANIMALS, NEWBORN; BRAIN DISEASES; DISEASE MODELS, ANIMAL; GLIOSIS; HAZARDOUS SUBSTANCES; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MALE; MASS SPECTROMETRY; MULTIVARIATE ANALYSIS; RATS, WISTAR; SIGNAL PROCESSING, COMPUTER-ASSISTED;

EID: 84904440233     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn500039b     Document Type: Article

References (32)

1. Banack, S. A. and Cox, P. A. (2003) Biomagnification of cycad neurotoxins in flying foxes: implications for ALS-PDC in Guam Neurology 61, 387-389 (Pubitemid 36975972)
2. Spencer, P. S., Nunn, P. B., Hugon, J., Ludolph, A. C., Ross, S. M., Roy, D. N., and Robertson, R. C. (1987) Guam amyotrophic lateral sclerosis-parkinsonism-dementia linked to a plant excitant neurotoxin Science 237, 517-522 (Pubitemid 17125919)
3. Pablo, J., Banack, S. A., Cox, P. A., Johnson, T. E., Papapetropoulos, S., Bradley, W. G., Buck, A., and Mash, D. C. (2009) Cyanobacterial neurotoxin BMAA in ALS and Alzheimer's disease Acta Neurol. Scand. 216-225
4. Cox, P. A., Banack, S. A., Murch, S. J., Rasmussen, U., Tien, G., Bidigare, R. R., Metcalf, J. S., Morrison, L. F., Codd, G. A., and Bergman, B. (2005) Diverse taxa of cyanobacteria produce beta- N -methylamino-L-alanine, a neurotoxic amino acid Proc. Natl. Acad. Sci. U.S.A. 102, 5074-5078
5. Jiang, L., Eriksson, J., Lage, S., Jonasson, S., Shams, S., Mehine, M., Ilag, L. L., and Rasmussen, U. (2014) Diatoms: A Novel Source for the Neurotoxin BMAA in Aquatic Environments PLoS One 9, e84578
6. Jonasson, S., Eriksson, J., Berntzon, L., Spacil, Z., Ilag, L. L., Ronnevi, L. O., Rasmussen, U., and Bergman, B. (2010) Transfer of a cyanobacterial neurotoxin within a temperate aquatic ecosystem suggests pathways for human exposure Proc. Natl. Acad. Sci. U.S.A. 107, 9252-9257
7. Brand, L. E., Pablo, J., Compton, A., Hammerschlag, N., and Mash, D. C. (2010) Cyanobacterial Blooms and the Occurrence of the neurotoxin beta- N -methylamino- l -alanine (BMAA) in South Florida Aquatic Food Webs Harmful Algae 9, 620-635
8. Copani, A., Canonico, P. L., Catania, M. V., Aronica, E., Bruno, V., Ratti, E., van Amsterdam, F. T., Gaviraghi, G., and Nicoletti, F. (1991) Interaction between beta-N-methylamino-L-alanine and excitatory amino acid receptors in brain slices and neuronal cultures Brain Res. 558, 79-86
9. Rao, S. D., Banack, S. A., Cox, P. A., and Weiss, J. H. (2006) BMAA selectively injures motor neurons via AMPA/kainate receptor activation Exp. Neurol. 201, 244-252 (Pubitemid 44226467)
10. Karlsson, O., Jiang, L., Andersson, M., Ilag, L. L., and Brittebo, E. B. (2014) Protein association of the neurotoxin and non-protein amino acid BMAA (beta- N -methylamino- l -alanine) in the liver and brain following neonatal administration in rats Toxicol. Lett. 226, 1-5
11. Smith, Q. R., Nagura, H., Takada, Y., and Duncan, M. W. (1992) Facilitated transport of the neurotoxin, beta- N -methylamino- l -alanine, across the blood-brain barrier J. Neurochem. 58, 1330-1337
12. Karlsson, O., Berg, C., Brittebo, E. B., and Lindquist, N. G. (2009) Retention of the cyanobacterial neurotoxin beta- N -methylamino- l -alanine in melanin and neuromelanin-containing cells - a possible link between Parkinson-dementia complex and pigmentary retinopathy Pigm. Cell Melanoma Res. 22, 120-130
13. Karlsson, O., Lindquist, N. G., Brittebo, E. B., and Roman, E. (2009) Selective brain uptake and behavioral effects of the cyanobacterial toxin BMAA (beta- N -methylamino- l -alanine) following neonatal administration to rodents Toxicol. Sci. 109, 286-295
14. Karlsson, O., Berg, A.-L., Lindstrom, A.-K., Hanrieder, J., Arnerup, G., Roman, E., Bergquist, J., Lindquist, N. G., Brittebo, E. B., and Andersson, M. (2012) Neonatal Exposure to the Cyanobacterial Toxin BMAA Induces Changes in Protein Expression and Neurodegeneration in Adult Hippocampus Toxicol. Sci. 130, 391-404
15. Karlsson, O., Kultima, K., Wadensten, H., Nilsson, A., Roman, E., Andren, P. E., and Brittebo, E. B. (2013) Neurotoxin-Induced Neuropeptide Perturbations in Striatum of Neonatal Rats J. Proteome Res. 12, 1678-1690
16. Karlsson, O., Bergquist, J., and Andersson, M. (2014) Quality Measures of Imaging Mass Spectrometry Aids in Revealing Long-term Striatal Protein Changes Induced by Neonatal Exposure to the Cyanobacterial Toxin beta-N-methylamino-L- alanine (BMAA) Mol. Cell. Proteomics 13, 93-104
17. Karlsson, O., Berg, A. L., Hanrieder, J., Arnerup, G., Lindstrom, A. K., and Brittebo, E. (2014) Intracellular fibril formation, calcification and enrichment of chaperones, cytoskeletal and intermediate filament proteins in the adult hippocampus CA1 following neonatal exposure to the non-protein amino acid BMAA Arch. Toxicol. (in press) 10.1007/s00204-014-1262-2
18. Cornett, D. S., Reyzer, M. L., Chaurand, P., and Caprioli, R. M. (2007) MALDI imaging mass spectrometry: molecular snapshots of biochemical systems Nat. Methods 4, 828-833 (Pubitemid 350055580)
19. Hanrieder, J., Ekegren, T., Andersson, M., and Bergquist, J. (2013) MALDI imaging of post-mortem human spinal cord in amyotrophic lateral sclerosis J. Neurochem. 124, 695-707
20. Hanrieder, J., Ljungdahl, A., and Andersson, M. (2012) MALDI imaging mass spectrometry of neuropeptides in Parkinson's disease J. Visualized Exp. 60, e3445
21. Passarelli, M. K. and Winograd, N. (2011) Lipid imaging with time-of-flight secondary ion mass spectrometry (ToF-SIMS) Biochim. Biophys. Acta, Mol. Cell Biol. Lipids 1811, 976-990
22. Lazar, A. N., Bich, C., Panchal, M., Desbenoit, N., Petit, V. W., Touboul, D., Dauphinot, L., Marquer, C., Laprevote, O., Brunelle, A., and Duyckaerts, C. (2013) Time-of-flight secondary ion mass spectrometry (TOF-SIMS) imaging reveals cholesterol overload in the cerebral cortex of Alzheimer disease patients Acta Neuropathol. 125, 133-144
23. Hanrieder, J., Phan, N. T. N., Kurczy, M. E., and Ewing, A. G. (2013) Imaging Mass Spectrometry in Neuroscience ACS Chem. Neurosci. 4, 666-679
24. Hanrieder, J., Malmberg, P., Lindberg, O. R., Fletcher, J. S., and Ewing, A. G. (2013) Time-of-flight secondary ion mass spectrometry based molecular histology of human spinal cord tissue and motor neurons Anal. Chem. 85, 8741-8748
25. Henderson, A., Fletcher, J. S., and Vickerman, J. C. (2009) A comparison of PCA and MAF for ToF-SIMS image interpretation Surf. Interface Anal. 41, 666-674
26. Karlsson, O., Roman, E., and Brittebo, E. B. (2009) Long-term cognitive impairments in adult rats treated neonatally with beta- N -Methylamino- l -alanine Toxicol. Sci. 112, 185-195
27. Karlsson, O., Roman, E., Berg, A. L., and Brittebo, E. B. (2011) Early hippocampal cell death, and late learning and memory deficits in rats exposed to the environmental toxin BMAA (beta- N -methylamino- l -alanine) during the neonatal period Behav. Brain Res. 219, 310-320
28. + currents and volume regulation in astrocytes Pfluegers Arch. 453, 839-849 (Pubitemid 46294922)
29. Farina, C., Aloisi, F., and Meinl, E. (2007) Astrocytes are active players in cerebral innate immunity Trends Immunol. 28, 138-145 (Pubitemid 46283692)
30. Paxinos, G. and Watson, C. (2007) The rat brain in stereotaxic coordinates, 6 th ed., Academic Press, Oxford.
31. Sodhi, R. N. S. (2004) Time-of-flight secondary ion mass spectrometry (TOF-SIMS): Versatility in chemical and imaging surface analysis Analyst 129, 483-487 (Pubitemid 38813511)
32. Bylesjö, M., Rantalainen, M., Cloarec, O., Nicholson, J. K., Holmes, E., and Trygg, J. (2007) OPLS discriminant analysis: combining the strengths of PLS-DA and SIMCA classification J. Chemom. 20, 341-351