Inhibition of aurora-B suppresses HepG2 cell invasion and migration via the PI3K/Akt/NF-κB signaling pathway in vitro

Experimental and Therapeutic Medicine

Volumn 8, Issue 3, 2014, Pages 1005-1009

  Shan, Ren Feng ^a   Zhou, Yun Fei ^a   Peng, Ai Fen ^b   Jie, Zhi Gang ^a  

^a NANCHANG UNIVERSITY   (China)

^b JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Aurora B; HepG2; Invasion; Migration; Phosphoinositide 3 kinase Akt nuclear factor B signaling pathway

Indexed keywords

AURORA B KINASE; GELATINASE A; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TRANSCRIPTION FACTOR RELA;

ARTICLE; CELL CULTURE; CELL INVASION; CELL INVASION ASSAY; CELL MIGRATION; CELL MIGRATION ASSAY; CONTROLLED STUDY; ENZYME ACTIVITY; GENE TARGETING; GENETIC TRANSFECTION; HEPG2 CELL LINE; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; PROTEINASE INHIBITION; RECOMBINANT PLASMID; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

EID: 84904406821     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2014.1844     Document Type: Article

References (23)

1. Chen CJ, You SL, Lin LH, Hsu WL and Yang YW: Cancer epidemiology and control in Taiwan: a brief review. Jpn J Clin Oncol 32 (Suppl): S66-S81, 2002.
2. El-Serag HB: Hepatocellular carcinoma: an epidemiologic view. J Clin Gastroenterol 35: S72-S78, 2002.
3. Keen N and Taylor S: Aurora-kinase inhibitors as anticancer agents. Nat Rev Cancer 4: 927-936, 2004.
4. Tuncel H, Shimamoto F, Kaneko Guangying Qi H, et al: Nuclear Aurora B and cytoplasmic Survivin expression is involved in lymph node metastasis of colorectal cancer. Oncol Lett 3: 1109-1114, 2012.
5. Takeshita M, Koga T, Takayama K, et al: Aurora-B overexpression is correlated with aneuploidy and poor prognosis in non-small cell lung cancer. Lung Cancer 80: 85-90, 2013.
6. Chen YJ, Chen CM, Twu NF, et al: Overexpression of Aurora B is associated with poor prognosis in epithelial ovarian cancer patients. Virchows Arch 455: 431-440, 2009.
7. Qi G, Ogawa I, Kudo Y, et al: Aurora-B expression and its correlation with cell proliferation and metastasis in oral cancer. Virchows Arch 450: 297-302, 2007.
8. Tovuu LO, Utsunomiya T, Imura S, et al: The role of Aurora B expression in non-tumor liver tissues of patients with hepatocellular carcinoma. Int J Clin Oncol: Jul 27, 2013 (Epub ahead of print).
9. Sun DQ, Wang Y and Liu DG: Overexpression of hnRNPC2 induces multinucleation by repression of Aurora B in hepatocellular carcinoma cells. Oncol Lett 5: 1243-1249, 2013.
10. Lin ZZ, Jeng YM, Hu FC, et al: Significance of Aurora B overexpression in hepatocellular carcinoma. Aurora B overexpression in HCC. BMC Cancer 10: 461, 2010.
11. Benten D, Keller G, Quaas A, et al: Aurora kinase inhibitor PHA-739358 suppresses growth of hepatocellular carcinoma in vitro and in a xenograft mouse model. Neoplasia 11: 934-944, 2009.
12. Tao T, Cheng C, Ji Y, et al: Numbl inhibits glioma cell migration and invasion by suppressing TRAF5-mediated NF-κB activation. Mol Biol Cell 23: 2635-2644, 2012.
13. Jiang L, Wu J, Yang Y, et al: Bmi-1 promotes the aggressiveness of glioma via activating the NF-κB/MMP-9 signaling pathway. BMC Cancer 12: 406, 2012.
14. Long ZJ, Xu J, Yan M, et al: ZM 447439 inhibition of aurora kinase induces Hep2 cancer cell apoptosis in three-dimensional culture. Cell Cycle 7: 1473-1479, 2008.
15. Tatsuka M, Katayama H, Ota T, et al: Multinuclearity and increased ploidy caused by overexpression of the aurora-and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells. Cancer Res 58: 4811-4816, 1998.
16. Kurai M, Shiozawa T, Shih HC, et al: Expression of Aurora kinases A and B in normal, hyperplastic, and malignant human endometrium: Aurora B as a predictor for poor prognosis in endometrial carcinoma. Hum Pathol 36: 1281-1288, 2005.
17. Sorrentino R, Libertini S, Pallante PL, et al: Aurora B overexpression associates with the thyroid carcinoma undifferentiated phenotype and is required for thyroid carcinoma cell proliferation. J Clin Endocrinol Metab 90: 928-935, 2005.
18. Spartà AM, Bressanin D, Chiarini F, et al: Therapeutic targeting of Polo-like kinase-1 and Aurora kinases in T-cell acute lymphoblastic leukemia. Cell Cycle 13: May 29, 2014 (Epub ahead of print).
19. Lu Y, Liu Y, Jiang J, et al: Knocking down the expression of Aurora-A gene inhibits cell proliferation and induces G2/M phase arrest in human small cell lung cancer cells. Oncol Rep 32: 243-249, 2014.
20. Zhu XP, Liu ZL, Peng AF, et al: Inhibition of Aurora-B suppresses osteosarcoma cell migration and invasion. Exp Ther Med 7: 560-564, 2014.
21. Graham TR, Odero-Marah VA, Chung LW, Agrawal KC, Davis R and Abdel-Mageed AB: PI3K/Akt-dependent transcriptional regulation and activation of BMP-2-Smad signaling by NF-kappaB in metastatic prostate cancer cells. Prostate 69: 168-180, 2009.
22. Andela VB, Gordon AH, Zotalis G, et al: NF-κB: a pivotal transcription factor in prostate cancer metastasis to bone. Clin Orthop Relat Res (415 Suppl): S75-S85, 2003.
23. Felx M, Guyot MC, Isler M, et al: Endothelin-1 (ET-1) promotes MMP-2 and MMP-9 induction involving the transcription factor NF-κB in human osteosarcoma. Clin Sci (Lond) 110: 645-654, 2006.