Protective effects of quercetin and hyperoside on renal fibrosis in rats with unilateral ureteral obstruction

Experimental and Therapeutic Medicine

Volumn 8, Issue 3, 2014, Pages 727-730

  Yan, Yang ^a   Feng, Yuan ^b   Li, Wei ^a   Che, Jian Ping ^a   Wang, Guang Chun ^a   Liu, Min ^a   Zheng, Jun Hua ^a  

^a TONGJI UNIVERSITY   (China)

^b THE AFFILIATED DRUM TOWER HOSPITAL OF NANJING UNIVERSITY MEDICAL SCHOOL   (China)

Author keywords

Experimental; Fibrosis; Hyperoside; Obstructive nephropathy; Quercetin

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; FIBRONECTIN; HYPERIN; LEUKIN 1BETA; QUERCETIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; FIBROSING ALVEOLITIS; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; KIDNEY FIBROSIS; MALE; MESANGIUM CELL; NONHUMAN; PROTEIN EXPRESSION; RAT; URETER OBSTRUCTION; WESTERN BLOTTING;

EID: 84904403571     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2014.1841     Document Type: Article

References (23)

1. Seikaly MG, Ho PL, Emmett L, et al: Chronic renal insufficiency in children: the 2001 Annual Report of the NAPRTCS. Pediatr Nephrol 18: 796-804, 2003.
2. Bek K, Akman S, Bilge I, et al: Chronic kidney disease in children in Turkey. Pediatr Nephrol 24: 797-806, 2009.
3. Acikgoz Y, Can B, Bek K, et al: The effect of simvastatin and erythropoietin on renal fibrosis in rats with unilateral ureteral obstruction. Ren Fail 36: 252-257, 2014.
4. Sagar SK, Zhang C, Guo Q, et al: Role of expression of endothelin-1 and angiotensin-II and hypoxia-inducible factor-1α in the kidney tissues of patients with diabetic nephropathy. Saudi J Kidney Dis Transpl 24: 959-964, 2013.
5. Carew RM, Wang B and Kantharidis P: The role of EMT in renal fibrosis. Cell Tissue Res 347: 103-116, 2012.
6. Chevalier RL, Forbes MS and Thornhill BA: Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy. Kidney Int 75: 1145-1152, 2009.
7. Shen Y, Ward NC, Hodgson JM, et al: Dietary quercetin attenuates oxidant-induced endothelial dysfunction and atherosclerosis in apolipoprotein E knockout mice fed a high-fat diet: a critical role for heme oxygenase-1. Free Radic Biol Med 65: 908-915, 2013.
8. Kobori M, Masumoto S, Akimoto Y and Oike H: Chronic dietary intake of quercetin alleviates hepatic fat accumulation associated with consumption of a Western-style diet in C57/BL6J mice. Mol Nutr Food Res 55: 530-540, 2011.
9. Boesch-Saadatmandi C, Wagner AE, Wolffram S and Rimbach G: Effect of quercetin on inflammatory gene expression in mice liver in vivo-role of redox factor 1, miRNA-122 and miRNA-125b. Pharmacol Res 65: 523-530, 2012.
10. Choi YJ, Arzuaga X, Kluemper CT, et al: Quercetin blocks caveolae-dependent pro-inflammatory responses induced by co-planar PCBs. Environ Int 36: 931-934, 2010.
11. Noorafshan A, Karbalay-Doust S and Poorshahid M: Stereological survey of the ameliorative effects of sulforaphane and quercetin on renal tissue in unilateral ureteral obstruction in rats. Acta Clin Croat 51: 555-562, 2012.
12. Li W, Liu M, Xu YF, et al: Combination of quercetin and hyperoside has anticancer effects on renal cancer cells through inhibition of oncogenic microRNA-27a. Oncol Rep 31: 117-124, 2014.
13. Tan R, Zhang J, Tan X, et al: Downregulation of SnoN expression in obstructive nephropathy is mediated by an enhanced ubiquitin-dependent degradation. J Am Soc Nephrol 17: 2781-2791, 2006.
14. Su J, Yin LP, Zhang X, et al: Chronic allograft nephropathy in rats is improved by the intervention of rhein. Transplant Proc 45: 2546-2552, 2013.
15. Papiez MA, Cierniak A, Krzysciak W, et al: The changes of antioxidant defense system caused by quercetin administration do not lead to DNA damage and apoptosis in the spleen and bone marrow cells of rats. Food Chem Toxicol 46: 3053-3058, 2008.
16. Lu NH, Chen C, He YJ, et al: Effects of quercetin on hemoglobin-dependent redox reactions: relationship to iron-overload rat liver injury. J Asian Nat Prod Res 15: 1265-1276, 2013
17. Chidambaram U, Pachamuthu V, Natarajan S, et al: In vitro evaluation of free radical scavenging activity of Codariocalyx motorius root extract. Asian Pac J Trop Med 6: 188-194, 2013.
18. Lee S, Park HS, Notsu Y, et al: Effects of hyperin, isoquercitrin and quercetin on lipopolysaccharide-induced nitrite production in rat peritoneal macrophages. Phytother Res 22: 1552-1556, 2008.
19. Kicel A and Wolbiś M: Phenolic content and DPPH radical scavenging activity of the flowers and leaves of Trifolium repens. Nat Prod Commun 8: 99-102, 2013.
20. Li ZL, Hu J, Li YL, et al: The effect of hyperoside on the functional recovery of the ischemic/reperfused isolated rat heart: potential involvement of the extracellular signal-regulated kinase 1/2 signaling pathway. Free Radic Biol Med 57: 132-140, 2013.
21. Ito K, Chen J, El Chaar M, et al: Renal damage progresses despite improvement of renal function after relief of unilateral ureteral obstruction in adult rats. Am J Physiol Renal Physiol 287: F1283-F1293, 2004.
22. Tan R, He W, Lin X, et al: Smad ubiquitination regulatory factor-2 in the fibrotic kidney: regulation, target specificity, and functional implication. Am J Physiol Renal Physiol 294: F1076-F1083, 2008.
23. Wu T, Zhang B, Ye F and Xiao Z: A potential role for caveolin-1 in VEGF-induced fibronectin upregulation in mesangial cells: involvement of VEGFR2 and Src. Am J Physiol Renal Physiol 304: F820-F830, 2013.