The E3 ligase PARC mediates the degradation of cytosolic cytochrome c to promote survival in neurons and cancer cells

Science Signaling

Volumn , Issue 334, 2014, Pages

  Gama, Vivian ^a   Swahari, Vijay ^a   Schafer, Johanna ^a,c   Kole, Adam J ^a   Evans, Allyson ^a,d   Huang, Yolanda ^a,e   Cliffe, Anna ^a   Golitz, Brian ^a,b   Sciaky, Noah ^a,b   Pei, Xin Hai ^a,b   Xiong, Yue ^a,b   Deshmukh, Mohanish ^a,b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c VANDERBILT UNIVERSITY   (United States)

^d Cell Press   (United States)

^e NewYork Presbyterian Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CYTOCHROME C; PARKIN LIKE CYTOPLASMIC PROTEIN; PROTEASOME; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; APAF1 PROTEIN, MOUSE; CARRIER PROTEIN; H7-AP1 PROTEIN, HUMAN; ETOPOSIDE; PROTEIN PARC; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; STAUROSPORINE;

ANIMAL CELL; ARTICLE; CANCER CELL; CELL STRESS; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; EMBRYO; EMBRYO CELL; FIBROBLAST; GENE OVEREXPRESSION; GLIOMA CELL; HEART MUSCLE CELL; HUMAN; HUMAN CELL; MITOCHONDRIAL STRESS; MOUSE; MYOTUBE; NERVE CELL; NERVE CELL DIFFERENTIATION; NONHUMAN; PROTEIN DEGRADATION; PROTEIN TARGETING; RNA INTERFERENCE; ANIMAL; CELL CULTURE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; FLUORESCENT ANTIBODY TECHNIQUE; HEK293 CELL LINE; HELA CELL LINE; IMMUNOPRECIPITATION; METABOLISM; NEOPLASM; PATHOPHYSIOLOGY; PHYSIOLOGY; UBIQUITINATION; WESTERN BLOTTING; CANCER SURVIVAL; CELL FRACTIONATION; CYTOSOL; FEMALE; GLIOMA; IMMUNOFLUORESCENCE; LONG TERM SURVIVAL; NEUROBLASTOMA; NEUROBLASTOMA CELL; NEWBORN; PC12 CELL LINE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RAT; SYMPATHETIC NERVE CELL;

ANIMALS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; BLOTTING, WESTERN; CARRIER PROTEINS; CELL SURVIVAL; CELLS, CULTURED; CYTOCHROMES C; FLUORESCENT ANTIBODY TECHNIQUE; HEK293 CELLS; HELA CELLS; HUMANS; IMMUNOPRECIPITATION; MICE; MITOCHONDRIAL DISEASES; NEOPLASMS; NEURONS; PROTEOLYSIS; RNA INTERFERENCE; UBIQUITINATION;

MUS;

EID: 84904399920     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2005309     Document Type: Article

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