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Volumn 8, Issue 3, 2014, Pages 836-840

The effect of the Ras homolog gene family (Rho), member A/Rho associated coiled-coil forming protein kinase pathway in atrial fibrosis of type 2 diabetes in rats

Author keywords

Atrial arrhythmogenicity; Atrial fibrosis; Fasudil; Member A (RhoA) Rho associated coiled coil forming protein kinase pathway; Ras homolog gene family

Indexed keywords


EID: 84904398101     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2014.1843     Document Type: Article
Times cited : (17)

References (21)
  • 1
    • 33746047722 scopus 로고    scopus 로고
    • What are arrhythmogenic substrates in diabetic rat atria?
    • Kato T, Yamashita T, Sekiguchi A, et al: What are arrhythmogenic substrates in diabetic rat atria? J Cardiovasc Electrophysiol 17: 890-894, 2006.
    • (2006) J Cardiovasc Electrophysiol , vol.17 , pp. 890-894
    • Kato, T.1    Yamashita, T.2    Sekiguchi, A.3
  • 2
    • 24144498411 scopus 로고    scopus 로고
    • Rho-kinase is an important therapeutic target in cardiovascular medicine
    • Shimokawa H and Takeshita A: Rho-kinase is an important therapeutic target in cardiovascular medicine. Arterioscler Thromb Vasc Biol 25: 1767-1775, 2005.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 1767-1775
    • Shimokawa, H.1    Takeshita, A.2
  • 3
    • 0036182417 scopus 로고    scopus 로고
    • Rho-kinase as a novel therapeutic target in treatment of cardiovascular diseases
    • Shimokawa H: Rho-kinase as a novel therapeutic target in treatment of cardiovascular diseases. J Cardiovasc Pharmacol 39: 319-327, 2002.
    • (2002) J Cardiovasc Pharmacol , vol.39 , pp. 319-327
    • Shimokawa, H.1
  • 5
    • 30344435268 scopus 로고    scopus 로고
    • RhoA, Rho kinase, JAK2, and STAT3 may be the intracellular determinants of longevity implicated in the progeric influence of obesity: Insulin, IGF-1, and leptin may all conspire to promote stem cell exhaustion
    • Tapia PC: RhoA, Rho kinase, JAK2, and STAT3 may be the intracellular determinants of longevity implicated in the progeric influence of obesity: Insulin, IGF-1, and leptin may all conspire to promote stem cell exhaustion. Med Hypotheses 66: 570-576, 2006.
    • (2006) Med Hypotheses , vol.66 , pp. 570-576
    • Tapia, P.C.1
  • 6
    • 78650982203 scopus 로고    scopus 로고
    • Smad linker region phosphorylation in the regulation of extracellular matrix synthesis
    • Burch ML, Zheng W and Little PJ: Smad linker region phosphorylation in the regulation of extracellular matrix synthesis. Cell Mol Life Sci 68: 97-107, 2011.
    • (2011) Cell Mol Life Sci , vol.68 , pp. 97-107
    • Burch, M.L.1    Zheng, W.2    Little, P.J.3
  • 7
    • 0035876878 scopus 로고    scopus 로고
    • Rethinking cystic fibrosis pathology: The critical role of abnormal reduced glutathione (GSH) transport caused by CFTR mutation
    • Hudson VM: Rethinking cystic fibrosis pathology: the critical role of abnormal reduced glutathione (GSH) transport caused by CFTR mutation. Free Radic Biol Med 30: 1440-1461, 2001.
    • (2001) Free Radic Biol Med , vol.30 , pp. 1440-1461
    • Hudson, V.M.1
  • 9
    • 33947364443 scopus 로고    scopus 로고
    • A Rho-kinase inhibitor, fasudil, prevents development of diabetes and nephropathy in insulin-resistant diabetic rats
    • Kikuchi Y, Yamada M, Imakiire T, et al: A Rho-kinase inhibitor, fasudil, prevents development of diabetes and nephropathy in insulin-resistant diabetic rats. J Endocrinol 192: 595-603, 2007.
    • (2007) J Endocrinol , vol.192 , pp. 595-603
    • Kikuchi, Y.1    Yamada, M.2    Imakiire, T.3
  • 10
    • 40949137434 scopus 로고    scopus 로고
    • Targeting of RhoA/ROCK signaling ameliorates progression of diabetic nephropathy independent of glucose control
    • Kolavennu V, Zeng L, Peng H, et al: Targeting of RhoA/ROCK signaling ameliorates progression of diabetic nephropathy independent of glucose control. Diabetes 57: 714-723, 2008.
    • (2008) Diabetes , vol.57 , pp. 714-723
    • Kolavennu, V.1    Zeng, L.2    Peng, H.3
  • 11
    • 84864371060 scopus 로고    scopus 로고
    • Fasudil, a rho-kinase inhibitor, attenuates bleomycin-induced pulmonary fibrosis in mice
    • Jiang C, Huang H, Liu J, et al: Fasudil, a rho-kinase inhibitor, attenuates bleomycin-induced pulmonary fibrosis in mice. Int J Mol Sci 13: 8293-8307, 2012.
    • (2012) Int J Mol Sci , vol.13 , pp. 8293-8307
    • Jiang, C.1    Huang, H.2    Liu, J.3
  • 12
    • 80051534873 scopus 로고    scopus 로고
    • Involvement of RhoA/ROCK in myocardial fibrosis in a rat model of type 2 diabetes
    • Zhou H, Li YJ, Wang M, et al: Involvement of RhoA/ROCK in myocardial fibrosis in a rat model of type 2 diabetes. Acta Pharmacol Sin 32: 999-1008, 2011.
    • (2011) Acta Pharmacol Sin , vol.32 , pp. 999-1008
    • Zhou, H.1    Li, Y.J.2    Wang, M.3
  • 13
    • 84874607208 scopus 로고    scopus 로고
    • The role of the Rho/Rock signaling pathway in the pathogenesis of acute ischemic myocardial fibrosis in rat models
    • Gao HC, Zhao H, Zhang WQ, et al: The role of the Rho/Rock signaling pathway in the pathogenesis of acute ischemic myocardial fibrosis in rat models. Exp Ther Med 5: 1123-1128, 2013.
    • (2013) Exp Ther Med , vol.5 , pp. 1123-1128
    • Gao, H.C.1    Zhao, H.2    Zhang, W.Q.3
  • 14
    • 35848951395 scopus 로고    scopus 로고
    • High-fat diet impairs the effects of a single bout of endurance exercise on glucose transport and insulin sensitivity in rat skeletal muscle
    • Tanaka S, Hayashi T, Toyoda T, et al: High-fat diet impairs the effects of a single bout of endurance exercise on glucose transport and insulin sensitivity in rat skeletal muscle. Metabolism 56: 1719-1728, 2007.
    • (2007) Metabolism , vol.56 , pp. 1719-1728
    • Tanaka, S.1    Hayashi, T.2    Toyoda, T.3
  • 15
    • 46749158301 scopus 로고    scopus 로고
    • High-fat diets promote insulin resistance through cytokine gene expression in growing female rats
    • Flanagan AM, Brown JL, Santiago CA, et al: High-fat diets promote insulin resistance through cytokine gene expression in growing female rats. J Nutr Biochem 19: 505-513, 2008.
    • (2008) J Nutr Biochem , vol.19 , pp. 505-513
    • Flanagan, A.M.1    Brown, J.L.2    Santiago, C.A.3
  • 16
    • 0033761823 scopus 로고    scopus 로고
    • A new rat model of type 2 diabetes: The fat-fed, streptozotocin-treated rat
    • Reed MJ, Meszaros K, Entes LJ, et al: A new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat. Metabolism 49: 1390-1394, 2000.
    • (2000) Metabolism , vol.49 , pp. 1390-1394
    • Reed, M.J.1    Meszaros, K.2    Entes, L.J.3
  • 17
    • 84860142048 scopus 로고    scopus 로고
    • Long-term administration of fasudil improves cardiomyopathy in streptozotocin-induced diabetic rats
    • Guan SJ, Ma ZH, Wu YL, et al: Long-term administration of fasudil improves cardiomyopathy in streptozotocin-induced diabetic rats. Food Chem Toxicol 50: 1874-1882, 2012.
    • (2012) Food Chem Toxicol , vol.50 , pp. 1874-1882
    • Guan, S.J.1    Ma, Z.H.2    Wu, Y.L.3
  • 18
    • 0036460051 scopus 로고    scopus 로고
    • Rho/Rho-kinase mediated signaling in physiology and pathophysiology
    • Wettschureck N and Offermanns S: Rho/Rho-kinase mediated signaling in physiology and pathophysiology. J Mol Med (Berl) 80: 629-638, 2002.
    • (2002) J Mol Med (Berl) , vol.80 , pp. 629-638
    • Wettschureck, N.1    Offermanns, S.2
  • 19
    • 26444518165 scopus 로고    scopus 로고
    • Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection
    • Rikitake Y, Kim HH, Huang Z, et al: Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection. Stroke 36: 2251-2257, 2005.
    • (2005) Stroke , vol.36 , pp. 2251-2257
    • Rikitake, Y.1    Kim, H.H.2    Huang, Z.3
  • 20
    • 66449126949 scopus 로고    scopus 로고
    • Targeted disruption of ROCK1 causes insulin resistance in vivo
    • Lee DH, Shi J, Jeoung NH, et al: Targeted disruption of ROCK1 causes insulin resistance in vivo. J Biol Chem 284: 11776-11780, 2009.
    • (2009) J Biol Chem , vol.284 , pp. 11776-11780
    • Lee, D.H.1    Shi, J.2    Jeoung, N.H.3
  • 21
    • 79551507167 scopus 로고    scopus 로고
    • Rho kinase inhibition protects kidneys from diabetic nephropathy without reducing blood pressure
    • Komers R, Oyama TT, Beard DR, et al: Rho kinase inhibition protects kidneys from diabetic nephropathy without reducing blood pressure. Kidney Int 79: 432-442, 2011.
    • (2011) Kidney Int , vol.79 , pp. 432-442
    • Komers, R.1    Oyama, T.T.2    Beard, D.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.