Quantification of tumour budding, lymphatic vessel density and invasion through image analysis in colorectal cancer

Journal of Translational Medicine

Volumn 12, Issue 1, 2014, Pages

  Caie, Peter D ^a,b   Turnbull, Arran K ^a,b   Farrington, Susan M ^b   Oniscu, Anca ^a,c   Harrison, David J ^a,c  

^a ROYAL INFIRMARY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c UNIVERSITY OF ST ANDREWS   (United Kingdom)

Author keywords

Colorectal; Digital pathology; Image analysis; Lymphatic vessel density; Lymphatic vessel invasion; Prognosis; Tumour budding

Indexed keywords

ADULT; ALGORITHM; ARTICLE; BLOOD VESSEL PARAMETERS; CANCER STAGING; CANCER SURVIVAL; CANCER TISSUE; CLINICAL ARTICLE; COLORECTAL CANCER; EPIFLUORESCENCE MICROSCOPE; EPITHELIUM; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNOFLUORESCENCE; LYMPH VESSEL; LYMPHATIC VESSEL DENSITY; LYMPHATIC VESSEL INVASION; MALE; PROGNOSIS; TISSUE SECTION; TUMOR BUDDING; TUMOR INVASION; COHORT ANALYSIS; COLORECTAL TUMOR; FOLLOW UP; IMAGE PROCESSING; KAPLAN MEIER METHOD; MIDDLE AGED; MULTIVARIATE ANALYSIS; PATHOLOGY; PROPORTIONAL HAZARDS MODEL;

ADULT; COHORT STUDIES; COLORECTAL NEOPLASMS; FEMALE; FOLLOW-UP STUDIES; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; KAPLAN-MEIER ESTIMATE; LYMPHATIC VESSELS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASM INVASIVENESS; PROPORTIONAL HAZARDS MODELS;

EID: 84904393656     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-12-156     Document Type: Article

References (41)

1. Standards and Datasets for Reporting Cancers Dataset for colorectal cancer 2007, 2, [http://www.rcpath.org/Resources/RCPath/Migrated%20Resources/Documents/G/G049-ColorectalDataset-Sep07.pdf].
2. Lan YT, Yang SH, Chang SC, Liang WY, Li AF, Wang HS, Jiang JK, Chen WS, Lin TC, Lin JK. Analysis of the seventh edition of American Joint Committee on colon cancer staging. Int J Colorectal Dis 2012, 27:657-663.
3. Poston GJ, Tait D, O'Connell S, Bennett A, Berendse S. Diagnosis and management of colorectal cancer: summary of NICE guidance. BMJ 2011, 343:d6751.
4. O'Connell JB, Maggard MA, Ko CY. Colon cancer survival rates with the new American Joint Committee on Cancer sixth edition staging. J Natl Cancer Inst 2004, 96:1420-1425.
5. Huh JW, Lee JH, Kim HR, Kim YJ. Prognostic significance of lymphovascular or perineural invasion in patients with locally advanced colorectal cancer. Am J Surg 2013, 206:758-763.
6. Chang S-C, Lin C-C, Wang H-S, Yang S-H, Jiang J-K, Lan Y-T, Lin T-C, Li AF-Y, Chen W-S, Lin J-K. Lymphovascular invasion determines the outcome of stage I colorectal cancer patients. Formosan J Surgery 2012, 45:141-145.
7. Betge J, Pollheimer MJ, Lindtner RA, Kornprat P, Schlemmer A, Rehak P, Vieth M, Hoefler G, Langner C. Intramural and extramural vascular invasion in colorectal cancer: prognostic significance and quality of pathology reporting. Cancer 2012, 118:628-638.
8. Barresi V, Reggiani-Bonetti L, Di Gregorio C, De Leon MP, Barresi G. Lymphatic vessel density and its prognostic value in stage I colorectal carcinoma. J Clin Pathol 2011, 64:6-12.
9. Cacchi C, Arnholdt HM, Jahnig H, Anthuber M, Probst A, Oruzio DV, Markl B. Clinical significance of lymph vessel density in T3 colorectal carcinoma. Int J Colorectal Dis 2012, 27:721-726.
10. Royston D, Jackson DG. Mechanisms of lymphatic metastasis in human colorectal adenocarcinoma. J Pathol 2009, 217:608-619.
11. Betge J, Kornprat P, Pollheimer MJ, Lindtner RA, Schlemmer A, Rehak P, Vieth M, Langner C. Tumour budding is an independent predictor of outcome in AJCC/UICC stage II colorectal cancer. Ann Surg Oncol 2012, 19:3706-3712.
12. Karamitopoulou E, Zlobec I, Kolzer V, Kondi-Pafiti A, Patsouris ES, Gennatas K, Lugli A. Proposal for a 10-high-power-fields scoring method for the assessment of tumour budding in colorectal cancer. Mod Pathol 2013, 26:295-301.
13. Ueno H, Murphy J, Jass JR, Mochizuki H, Talbot IC. Tumour 'budding' as an index to estimate the potential of aggressiveness in rectal cancer. Histopathology 2002, 40:127-132.
14. Mitrovic B, Schaeffer DF, Riddell RH, Kirsch R. Tumour budding in colorectal carcinoma: time to take notice. Mod Pathol 2012, 25:1315-1325.
15. Lugli A, Karamitopoulou E, Zlobec I. Tumour budding: a promising parameter in colorectal cancer. Br J Cancer 2012, 106:1713-1717.
16. Mou S, Soetikno R, Shimoda T, Rouse R, Kaltenbach T. Pathologic predictive factors for lymph node metastasis in submucosal invasive (T1) colorectal cancer: a systematic review and meta-analysis. Surg Endosc 2013, 27:2692-2703.
17. Glasgow SC, Bleier JI, Burgart LJ, Finne CO, Lowry AC. Meta-analysis of histopathological features of primary colorectal cancers that predict lymph node metastases. J Gastrointest Surg 2012, 16:1019-1028.
18. Uribarrena AR, Ortego J, Fuentes J, Raventos N, Parra P, Uribarrena ER. Prognostic value of microvascular density in dukes a and B (t1-t4, n0, m0) colorectal carcinomas. Gastroenterol Res Pract 2009, 2009:679830.
19. Suzuki A, Togashi K, Nokubi M, Koinuma K, Miyakura Y, Horie H, Lefor AT, Yasuda Y. Evaluation of venous invasion by Elastica van Gieson stain and tumour budding predicts local and distant metastases in patients with T1 stage colorectal cancer. Am J Surg Pathol 2009, 33:1601-1607.
20. Doyle B, Hagan S, Al-Mulla F, Scott L, Harden S, Paul J, Mulcahy H, Murray GI, Sheahan K, O'Sullivan J, Kolch W. Raf kinase inhibitor protein expression combined with peritoneal involvement and lymphovascular invasion predicts prognosis in Dukes' B colorectal cancer patients. Histopathology 2013, 62:505-510.
21. Betge J, Kornprat P, Pollheimer MJ, Lindtner RA, Schlemmer A, Rehak P, Vieth M, Langner C. Tumour Budding is an Independent Predictor of Outcome in AJCC/UICC Stage II Colorectal Cancer. Ann Surg Oncol 2012, 19:3706-3712.
22. Barresi V, Reggiani Bonetti L, Vitarelli E, Di Gregorio C, Ponz De Leon M, Barresi G. Immunohistochemical assessment of lymphovascular invasion in stage I colorectal carcinoma: prognostic relevance and correlation with nodal micrometastases. Am J Surg Pathol 2012, 36:66-72.
23. Puppa G, Senore C, Sheahan K, Vieth M, Lugli A, Zlobec I, Pecori S, Wang LM, Langner C, Mitomi H, Nakamura T, Watanabe M, Ueno H, Chasle J, Conley SA, Herlin P, Lauwers GY, Risio M. Diagnostic reproducibility of tumour budding in colorectal cancer: a multicentre, multinational study using virtual microscopy. Histopathology 2012, 61:562-575.
24. Horcic M, Koelzer VH, Karamitopoulou E, Terracciano L, Puppa G, Zlobec I, Lugli A. Tumour budding score based on 10 high-power fields is a promising basis for a standardised prognostic scoring system in stage II colorectal cancer. Hum Pathol 2013, 44:697-705.
25. Hasan J, Byers R, Jayson GC. Intra-tumoural microvessel density in human solid tumours. Br J Cancer 2002, 86:1566-1577.
26. Roxburgh CS, McMillan DC, Anderson JH, McKee RF, Horgan PG, Foulis AK. Elastica staining for venous invasion results in superior prediction of cancer-specific survival in colorectal cancer. Ann Surg 2010, 252:989-997.
27. Kingston EF, Goulding H, Bateman AC. Vascular invasion is underrecognized in colorectal cancer using conventional hematoxylin and eosin staining. Dis Colon Rectum 2007, 50:1867-1872.
28. Ohtsuki K, Koyama F, Tamura T, Enomoto Y, Fujii H, Mukogawa T, Nakagawa T, Uchimoto K, Nakamura S, Nonomura A, Nakajima Y. Prognostic value of immunohistochemical analysis of tumour budding in colorectal carcinoma. Anticancer Res 2008, 28:1831-1836.
29. Lin M, Ma SP, Lin HZ, Ji P, Xie D, Yu JX. Intratumoural as well as peritumoural lymphatic vessel invasion correlates with lymph node metastasis and unfavourable outcome in colorectal cancer. Clin Exp Metastasis 2010, 27:123-132.
30. Kazama S, Watanabe T, Ajioka Y, Kanazawa T, Nagawa H. Tumour budding at the deepest invasive margin correlates with lymph node metastasis in submucosal colorectal cancer detected by anticytokeratin antibody CAM5.2. Br J Cancer 2006, 94:293-298.
31. Tetu B, Evans A. Canadian Licensure for the Use of Digital Pathology for Routine Diagnoses. Arch Pathol Lab Med 2013, 138:302-304.
32. Pages F, Berger A, Camus M, Sanchez-Cabo F, Costes A, Molidor R, Mlecnik B, Kirilovsky A, Nilsson M, Damotte D, Meatchi T, Bruneval P, Cugnenc PH, Trajanoski Z, Fridman WH, Galon J. Effector memory T cells, early metastasis, and survival in colorectal cancer. N Engl J Med 2005, 353:2654-2666.
33. Angell HK, Gray N, Womack C, Pritchard DI, Wilkinson RW, Cumberbatch M. Digital pattern recognition-based image analysis quantifies immune infiltrates in distinct tissue regions of colorectal cancer and identifies a metastatic phenotype. Br J Cancer 2013, 109:1618-1624.
34. Hase K, Shatney C, Johnson D, Trollope M, Vierra M. Prognostic value of tumour budding in patients with colorectal cancer. Dis Colon Rectum 1993, 36:627-635.
35. Camp RL, Dolled-Filhart M, Rimm DL. X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization. Clin Cancer Res 2004, 10:7252-7259.
36. Lubbock AL, Katz E, Harrison DJ, Overton IM. TMA Navigator: Network inference, patient stratification and survival analysis with tissue microarray data. Nucleic Acids Res 2013, 41:W562-W568.
37. Midgley R, Kerr DJ. Adjuvant chemotherapy for stage II colorectal cancer: the time is right!. Nat Clin Pract Oncol 2005, 2:364-369.
38. Wang TB, Chen ZG, Wei XQ, Wei B, Dong WG. Serum vascular endothelial growth factor-C and lymphoangiogenesis are associated with the lymph node metastasis and prognosis of patients with colorectal cancer. ANZ J Surg 2011, 81:694-699.
39. Gao J, Knutsen A, Arbman G, Carstensen J, Franlund B, Sun XF. Clinical and biological significance of angiogenesis and lymphangiogenesis in colorectal cancer. Dig Liver Dis 2009, 41:116-122.
40. Longatto-Filho A, Pinheiro C, Ferreira L, Scapulatempo C, Alves VA, Baltazar F, Schmitt F. Peritumoural, but not intratumoural, lymphatic vessel density and invasion correlate with colorectal carcinoma poor-outcome markers. Virchows Arch 2008, 452:133-138.
41. Matsumoto K, Nakayama Y, Inoue Y, Minagawa N, Katsuki T, Shibao K, Tsurudome Y, Hirata K, Nagata N, Itoh H. Lymphatic microvessel density is an independent prognostic factor in colorectal cancer. Dis Colon Rectum 2007, 50:308-314.