Sorbitol-modified hyaluronic acid reduces oxidative stress, apoptosis and mediators of inflammation and catabolism in human osteoarthritic chondrocytes

Inflammation Research

Volumn 63, Issue 8, 2014, Pages 691-701

  Mongkhon, John Max ^a   Thach, Maryane ^a   Shi, Qin ^a,b   Fernandes, Julio C ^a,b   Fahmi, Hassan ^c   Benderdour, Mohamed ^a,b  

^a HÔPITAL DU SACRÉ COEUR DE MONTRÉAL   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c NOTRE DAME HOSPITAL   (Canada)

Author keywords

Apoptosis; Chondrocytes; Hyaluronic acid sorbitol; Inflammation; Osteoarthritis; Oxidative stress

Indexed keywords

4-HYDROXY-2-NONENAL; ALDEHYDE; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; COLLAGENASE 3; GLUTATHIONE TRANSFERASE; HYALURONIC ACID; HYDROGEN PEROXIDE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; LEUKOTRIENE-C4 SYNTHASE; NITRIC OXIDE; NOS2 PROTEIN, HUMAN; PROSTAGLANDIN E2; REACTIVE OXYGEN METABOLITE; SORBITOL;

AGED; APOPTOSIS; CARTILAGE CELL; CELL CULTURE; CELL SURVIVAL; CHEMISTRY; DNA FRAGMENTATION; DRUG EFFECTS; HUMAN; METABOLISM; MIDDLE AGED; OSTEOARTHRITIS; OXIDATIVE STRESS;

AGED; ALDEHYDES; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; APOPTOSIS; CELL SURVIVAL; CELLS, CULTURED; CHONDROCYTES; DINOPROSTONE; DNA FRAGMENTATION; GLUTATHIONE TRANSFERASE; HUMANS; HYALURONIC ACID; HYDROGEN PEROXIDE; INTERLEUKIN-1BETA; MATRIX METALLOPROTEINASE 13; MIDDLE AGED; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; OSTEOARTHRITIS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SORBITOL;

EID: 84904393162     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-014-0742-4     Document Type: Article

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