Nicotinamide mononucleotide improves energy activity and survival rate in an in vitro model of Parkinson's disease

Experimental and Therapeutic Medicine

Volumn 8, Issue 3, 2014, Pages 943-950

  Lu, Lei ^a,b   Tang, Le ^c,d   Wei, Wenshi ^c   Hong, Yunyi ^b   Chen, Heyu ^b   Ying, Weihai ^b,d   Chen, Shengdi ^d  

^a FUDAN UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

^c FUDAN UNIVERSITY   (China)

^d SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Cell survival; Energy activity; Nicotinamide mononucleotide; Parkinson's disease

Indexed keywords

3 (4, 5 DIMETHYL 2 THIAZOLYL) 2, 5 DIPHENYLTETRAZOLIUM BROMIDE; 4 [5 (4 METHYL 1 PIPERAZINYL) [2, 5' BI 1H BENZIMIDAZOL] 2' YL] PHENOL; 7 AMINODACTINOMYCIN; ADENOSINE TRIPHOSPHATE; LACTATE DEHYDROGENASE; LIPOCORTIN 5; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; NICOTINAMIDE NUCLEOTIDE; ROTENONE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CULTURE MEDIUM; ENERGY METABOLISM; FLOW CYTOMETRY; IN VITRO STUDY; INTRACELLULAR SIGNALING; MTT ASSAY; NEUROPROTECTION; NONHUMAN; PARKINSON DISEASE; PC12 CELL LINE; RAT; WESTERN BLOTTING;

EID: 84904392253     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2014.1842     Document Type: Article

References (24)

1. + and NADH in cellular functions and cell death. Front Biosci 11: 3129-3148, 2006.
2. +/NADPH in cellular functions and cell death: regulation and biological consequences. Antioxid Redox Signal 10: 179-206, 2008.
3. Xia W, Wang Z, Wang Q, et al: Roles of NAD(+) / NADH and NADP(+) / NADPH in cell death. Curr Pharm Des 15: 12-19, 2009.
4. Alano CC, Ying W and Swanson RA: Poly(ADP-ribose) polymerase-1-mediated cell death in astrocytes requires NAD+ depletion and mitochondrial permeability transition. J Biol Chem 279: 18895-18902, 2004.
5. + repletion prevents PARP-1-induced glycolytic blockade and cell death in cultured mouse astrocytes. Biochem Biophys Res Commun 308: 809-813, 2003.
6. Wang S, Xing Z, Vosler PS, et al: Cellular NAD replenishment confers marked neuroprotection against ischemic cell death: role of enhanced DNA repair. Stroke 39: 2587-2595, 2008.
7. Ying W, Wei G, Wang D, et al: Intranasal administration with NAD+ profoundly decreases brain injury in a rat model of transient focal ischemia. Front Biosci 12: 2728-2734, 2007.
8. Fearnley JM and Lees AJ: Ageing and Parkinson's disease: substantia nigra regional selectivity. Brain 114: 2283-2301, 1991.
9. Beal MF: Mitochondria, oxidative damage, and inflammation in Parkinson's disease. Ann NY Acad Sci 991: 120-131, 2003.
10. Bredesen DE, Rao RV and Mehlen P: Cell death in the nervous system. Nature 443: 796-802, 2006.
11. Simola N, Pinna A and Fenu S: Pharmacological therapy of Parkinson's disease: current options and new avenues. Recent Pat CNS Drug Discov 5: 221-238, 2010.
12. Beal MF: Therapeutic approaches to mitochondrial dysfunction in Parkinson's disease. Parkinsonism Relat Disord 15 (Suppl 3): S189-S194, 2009.
13. Olanow CW: The pathogenesis of cell death in Parkinson's disease - 2007. Mov Disord 22 (Suppl 17): S335-S342, 2007.
14. Bové J, Prou D, Perier C and Przedborski S: Toxin-induced models of Parkinson's disease. NeuroRx 2: 484-494, 2005.
15. Ying W and Swanson RA: The poly(ADP-ribose) glycohydrolase inhibitor gallotannin blocks oxidative astrocyte death. Neuroreport 11: 1385-1388, 2000.
16. Ying W, Han SK, Miller JW and Swanson RA: Acidosis potentiates oxidative neuronal death by multiple mechanisms. J Neurochem 73: 1549-1556, 1999.
17. Roy MK, Takenaka M, Kobori M, Nakahara K, Isobe S and Tsushida T: Apoptosis, necrosis and cell proliferation-inhibition by cyclosporine A in U937 cells (a human monocytic cell line). Pharmacol Res 53: 293-302, 2006.
18. Ma Y, Chen H, Xia W and Ying W: Oxidative stress and PARP activation mediate the NADH-induced decrease in glioma cell survival. Int J Physiol Pathophysiol Pharmacol 3: 21-28, 2011.
19. Nie H, Chen H, Han J, et al: Silencing of SIRT2 induces cell death and a decrease in the intracellular ATP level of PC12 cells. Int J Physiol Pathophysiol Pharmacol 3: 65-70, 2011.
20. Zimmermann M and Meyer N: Annexin V/7-AAD staining in keratinocytes. Methods Mol Biol 740: 57-63, 2011.
21. + depletion is necessary and sufficient for poly(ADP-ribose) polymerase-1-mediated neuronal death. J Neurosci 30: 2967-2978, 2010.
22. Huang F, Vemuri MC and Schneider JS: Modulation of ATP levels alters the mode of hydrogen peroxide-induced cell death in primary cortical cultures: effects of putative neuroprotective agents. Brain Res 997: 79-88, 2004.
23. Schulz JB: Anti-apoptotic gene therapy in Parkinson's disease. J Neural Transm Suppl: 467-476, 2006.
24. Liou AK, Clark RS, Henshall DC, Yin XM and Chen J: To die or not to die for neurons in ischemia, traumatic brain injury and epilepsy: a review on the stress-activated signaling pathways and apoptotic pathways. Prog Neurobiol 69: 103-142, 2003.