Environmental levels of the antidepressant venlafaxine impact the metabolic capacity of rainbow trout

Aquatic Toxicology

Volumn 155, Issue , 2014, Pages 190-198

  Best, Carol ^a,b   Melnyk Lamont, Nataliya ^a   Gesto, Manuel ^a,c   Vijayan, Mathilakath M ^a  

^a UNIVERSITY OF WATERLOO   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

^c UNIVERSITY OF VIGO   (Spain)

Author keywords

Environmental pharmaceuticals; Fish; Intermediary metabolism; Salmonid; Serotonin norepinephrine reuptake inhibitor; Stress response

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CYTOCHROME P450; GLUCOCORTICOID RECEPTOR; GLUCOSE; GLUCOSE TRANSPORTER 2; HYDROCORTISONE; LACTATE DEHYDROGENASE; VENLAFAXINE;

AQUATIC ENVIRONMENT; DRUG; EFFLUENT; ENVIRONMENTAL IMPACT; ENZYME ACTIVITY; METABOLISM; POLLUTION EXPOSURE; SALMONID; WASTEWATER;

AMINO ACID METABOLISM; AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; AQUATIC ENVIRONMENT; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL STRESS; ENZYME ACTIVITY; GLUCONEOGENESIS; GLUCOSE TRANSPORTER 2 GENE; GLYCOGEN ANALYSIS; GLYCOLYSIS; HYDROCORTISONE BLOOD LEVEL; METABOLIC CAPACITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAINBOW TROUT; STEROIDOGENESIS;

ENVIRONMENTAL PHARMACEUTICALS; FISH; INTERMEDIARY METABOLISM; SALMONID; SEROTONIN-NOREPINEPHRINE REUPTAKE INHIBITOR; STRESS RESPONSE;

ANIMALS; ANTIDEPRESSIVE AGENTS; BLOOD GLUCOSE; CYCLOHEXANOLS; GLUCONEOGENESIS; GLUCOSE; GLYCOLYSIS; HANDLING (PSYCHOLOGY); HYDROCORTISONE; LIVER; LIVER GLYCOGEN; ONCORHYNCHUS MYKISS; RECEPTORS, GLUCOCORTICOID; STRESS, PHYSIOLOGICAL; WATER POLLUTANTS, CHEMICAL;

EID: 84904368606     PISSN: 0166445X     EISSN: 18791514     Source Type: Journal    
DOI: 10.1016/j.aquatox.2014.06.014     Document Type: Article

References (50)

1. Aluru N., Vijayan M.M. beta-Naphthoflavone disrupts cortisol production and liver glucocorticoid responsiveness in rainbow trout. Aquat. Toxicol. 2004, 67:273-285.
2. Aluru N., Renaud R., Leatherland J.F., Vijayan M.M. Ah receptor-mediated impairment of interrenal steroidogenesis involves StAR protein and P450scc gene attenuation in rainbow trout. Toxicol. Sci. 2005, 84:260-269.
3. Aluru N., Vijayan M.M. Hepatic transcriptome response to glucocorticoid receptor activation in rainbow trout. Physiol. Genomics 2007, 31:483-491.
4. Alsop D., Ings J.S., Vijayan M.M. Adrenocorticotropic hormone suppresses gonadotropin-stimulated estradiol release from zebrafish ovarian follicles. PLoS One 2009, 4:e6463.
5. Andersen D.E., Reid S.D., Moon T.W., Perry S.F. Metabolic effects associated with chronically elevated cortisol in rainbow trout (Oncorhynchus mykiss). Can. J. Fish. Aquat. Sci. 1991, 48:1811-1817.
6. Arukwe A. Steroidogenic acute regulatory (StAR) protein and cholesterol side-chain cleavage (P450scc)-regulated steroidogenesis as an organ-specific molecular and cellular target for endocrine disrupting chemicals in fish. Cell Biol. Toxicol. 2008, 24:527-540.
7. Boone A.N., Ducouret B., Vijayan M.M. Glucocorticoid-induced glucose release is abolished in trout hepatocytes with elevated hsp70 content. J. Endocrinol. 2002, 172:R1-R5.
8. Bury N.R., Sturm A. Evolution of the corticosteroid receptor signalling pathway in fish. Gen. Comp. Endocrinol. 2007, 153:47-56.
9. Corcoran J., Winter M.J., Tyler C.R. Pharmaceuticals in the aquatic environment: a critical review of the evidence for health effects in fish. Crit. Rev. Toxicol. 2010, 40:287-304.
10. Daughton C.G., Ternes T.A. Pharmaceuticals and personal care products in the environment: agents of subtle change?. Environ. Health Perspect. 1999, 107:907-938.
11. Dindia L., Faught E., Leonenko Z., Thomas R., Vijayan M.M. Rapid cortisol signaling in response to acute stress involves changes in plasma membrane order in rainbow trout liver. Am. J. Physiol. Endocrinol. Metab. 2013, 304:E1157-E1166.
12. Fabbri E., Capuzzo A., Moon T.W. The role of circulating catecholamines in the regulation of fish metabolism: an overview. Comp. Biochem. Physiol. C: Pharmacol. Toxicol. Endocrinol. 1998, 120:177-192.
13. Geslin M., Auperin B. Relationship between changes in mRNAs of the genes encoding steroidogenic acute regulatory protein and P450 cholesterol side chain cleavage in head kidney and plasma levels of cortisol in response to different kinds of acute stress in the rainbow trout (Oncorhynchus mykiss). Gen. Comp. Endocrinol. 2004, 135:70-80.
14. Gravel A., Vijayan M.M. Salicylate impacts the physiological responses to an acute handling disturbance in rainbow trout. Aquat. Toxicol. 2007, 85:87-95.
15. Hancock D., Johnston J., Dimauro J., Denyer G. Student-designed enzyme-linked metabolite assay kits. Biochem. Mol. Biol. Educ. 2004, 32:326-330.
16. Hemre G.I., Kahrs F. 14C-glucose injection in Atlantic cod, Gadus morhua, metabolic responses and excretion via the gill membrane. Aquacult. Nutr. 1997, 3:3-8.
17. Horst W.D., Preskorn S.H. Mechanisms of action and clinical characteristics of three atypical antidepressants: venlafaxine, nefazodone, bupropion. J. Affective Disord. 1998, 51:237-254.
18. Ings J.S. Stress and metabolic responses to municipal wastewater effluent exposure in rainbow trout. Ph.D. Thesis 2011, 235. University of Waterloo, Waterloo, ON.
19. Ings J.S., Servos M.R., Vijayan M.M. Exposure to municipal wastewater effluent impacts stress performance in rainbow trout. Aquat. Toxicol. 2011, 103:85-91.
20. Ings J.S., George N., Peter M.C.S., Servos M.R., Vijayan M.M. Venlafaxine and atenolol disrupt epinephrine-stimulated glucose production in rainbow trout hepatocytes. Aquat. Toxicol. 2012, 106-107:48-55.
21. Iwama G.K., Afonso L.O.B., Vijayan M.M. Stress in Fish. The Physiology of Fishes 2006, 319-342. CRC Press, Boca Raton, FL. third ed. D.H. Evans, J.B. Claiborne (Eds.).
22. Krasnov A., Teerijoki H., Mölsä H. Rainbow trout (Onchorhynchus mykiss) hepatic glucose transporter. Biochim. Biophys. Acta 2001, 1520:174-178.
23. Kusakabe M., Todo T., McQuillan H.J., Goetz F.W., Young G. Characterization and expression of steroidogenic acute regulatory protein and MLN64 cDNAs in trout. Endocrinology 2002, 143:2062-2070.
24. Lajeunesse A., Gagnon C., Gagné F., Louis S., Cejka P., Sauvé S. Distribution of antidepressants and their metabolites in brook trout exposed to municipal wastewaters before and after ozone treatment-evidence of biological effects. Chemosphere 2011, 83:564-571.
25. Melnyk-Lamont N. Impact of the antidepressant venlafaxine on the hypothalamic-pituitary-interrenal axis function in rainbow trout. Ph.D. Thesis 2014, 216. University of Waterloo, Waterloo, ON.
26. Mennigen J.A., Stroud P., Zamora J.M., Moon T.W., Trudeau V.L. Pharmaceuticals as neuroendocrine disruptors: lessons learned from fish on Prozac. J. Toxicol. Environ. Health B: Crit. Rev. 2011, 14:387-412.
27. Metcalfe C.D., Chu S., Judt C., Li H., Oakes K.D., Servos M.R., Andrews D.M. Antidepressants and their metabolites in municipal wastewater, and downstream exposure in an urban watershed. Environ. Toxicol. Chem. 2010, 29:79-89.
28. Mommsen T.P. Biochemical characterization of the rainbow trout gill. J. Comp. Physiol. B: Biochem. Syst. Environ. Physiol. 1984, 25:135-198.
29. Mommsen T.P., Vijayan M.M., Moon T.W. Cortisol in teleosts: dynamics, mechanisms of action, and metabolic regulation. Rev. Fish Biol. Fish. 1999, 9:211-268.
30. - transport. Aquat. Toxicol. 1997, 38:145-163.
31. Perry S.F., Walsh P.J., Mommsen T.P., Moon T.W. Metabolic consequences of hypercapnia in the rainbow trout, Salmo gairdneri: β-adrenergic effects. Gen. Comp. Endocrinol. 1988, 69:439-447.
32. Plagnes-Juan E., Lansard M., Seiliez I., Médale F., Corraze G., Kaushik S., Panserat S., Skiba-Cassy S. Insulin regulates the expression of several metabolism-related genes in the liver and primary hepatocytes of rainbow trout (Oncorhynchus mykiss). J. Exp. Biol. 2008, 211:2510-2518.
33. Polakof S., Míguez J.M., Moon T.W., Soengas J.L. Evidence for the presence of a glucosensor in hypothalamus, hindbrain, and Brockmann bodies of rainbow trout. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2007, 292:R1657-R1666.
34. Prunet P., Sturm A., Milla S. Multiple corticosteroid receptors in fish: from old ideas to new concepts. Gen. Comp. Endocrinol. 2006, 147:17-23.
35. Reid S.G., Bernier N.J., Perry S.F. The adrenergic stress response in fish: control of catecholamine storage and release. Comp. Biochem. Physiol. C: Pharmacol. Toxicol. Endocrinol. 1998, 120:1-27.
36. Roseboom P.H., Kalin N.H. Neuropharmacology of venlafaxine. Depress. Anxiety 2000, 12(S1):20-29.
37. Sandhu N., Vijayan M.M. Cadmium-mediated disruption of cortisol biosynthesis involves suppression of corticosteroidogenic genes in rainbow trout. Aquat. Toxicol. 2011, 103:92-100.
38. Sandhu N., McGeer J.C., Vijayan M.M. Exposure to environmental levels of waterborne cadmium impacts corticosteroidogenic and metabolic capacities, and compromises secondary stressor performance in rainbow trout. Aquat. Toxicol. 2014, 146:20-27.
39. Sathiyaa R., Vijayan M.M. Autoregulation of glucocorticoid receptor by cortisol in rainbow trout hepatocytes. Am. J. Physiol. Cell Physiol. 2003, 284:1508-1515.
40. Schultz M.M., Furlong E.T., Kolpin D.W., Werner S.L., Schoenfuss H.L., Barber L.B., Blazer V.S., Norris D.O., Vajda A.M. Antidepressant pharmaceuticals in two U.S. effluent-impacted streams: occurrence and fate in water and sediment, and selective uptake in fish neural tissue. Environ. Sci. Technol. 2010, 44:1918-1925.
41. Soengas J., Barciela P., Aldegunde M., Andres D. Gill carbohydrate metabolism of rainbow trout is modified during gradual adaptation to sea water. J. Fish Biol. 1995, 46:845-856.
42. Stroud P. Corticosteroidogenesis as a target of endocrine disruption for the antidepressant fluoxetine in the head kidney of rainbow trout (Oncorhynchus mykiss). M.Sc. Thesis 2012, 114. University of Ottawa, Ottawa, ON.
43. Vijayan M.M., Prunet P., Boone A.N. Xenobiotic impact on corticosteroid signaling. Biochemistry and Molecular Biology of Fishes 2005, vol. 6:87-101. Elsevier, Amsterdam.
44. Vijayan M.M., Aluru N., Maule A.G., Jørgensen E.H. Fasting augments PCB impact on liver metabolism in anadromous arctic char. Toxicol. Sci. 2006, 91:431-439.
45. Vijayan M.M., Aluru N., Leatherland J.F. Stress response and the role of cortisol. Fish Diseases and Disorders 2010, vol. 2:182-201. CAB International, Wallingford.
46. Walsh L.P., Webster D.R., Stocco D.M. Dimethoate inhibits steroidogenesis by disrupting transcription of the steroidogenic acute regulatory (StAR) gene. J. Endocrinol. 2000, 167:253-263.
47. Wendelaar Bonga S.E. The stress response in fish. Physiol. Rev. 1997, 77:591-625.
48. Wilson J.M., Leitão A., Gonçalves A.F., Ferreira C., Reis-Santos P., Fonseca A.-V., da Silva J.M., Antunes J.C., Pereira-Wilson C., Coimbra J. Modulation of branchial ion transport protein expression by salinity in glass eels (Anguilla anguilla L.). Mar. Biol. 2007, 151:1633-1645.
49. Wiseman S., Vijayan M.M. Aroclor 1254 disrupts liver glycogen metabolism and enhances acute stressor-mediated glycogenolysis in rainbow trout. Comp. Biochem. Physiol. C: Toxicol. Pharmacol. 2011, 154:254-260.
50. Wright P.A., Perry S.F., Moon T.W. Regulation of hepatic gluconeogenesis and glycogenolysis by catcholamines in rainbow trout during environmental hypoxia. J. Exp. Biol. 1989, 147:169-188.