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Volumn 15, Issue 2, 2014, Pages 177-184

A review of biomarkers and physiomarkers in pediatric sepsis

Author keywords

Biomarker; C reactive protein; CD 64; Interleukin 6; Interleukin 8; Lactate; Pediatrics; Procalcitonin; Sepsis; Soluble triggering receptor expressed on myeloid cells 1

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; INTERLEUKIN 8; LACTIC ACID; PROCALCITONIN; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 1;

EID: 84904352218     PISSN: 15228401     EISSN: 15582310     Source Type: Journal    
DOI: 10.1016/j.cpem.2014.04.008     Document Type: Article
Times cited : (14)

References (57)
  • 1
    • 33947173607 scopus 로고    scopus 로고
    • Patient and hospital correlates of clinical outcomes and resource utilization in severe pediatric sepsis
    • Odetola F.O., Gebremariam A., Freed G.L. Patient and hospital correlates of clinical outcomes and resource utilization in severe pediatric sepsis. Pediatrics 2007, 119:487-494.
    • (2007) Pediatrics , vol.119 , pp. 487-494
    • Odetola, F.O.1    Gebremariam, A.2    Freed, G.L.3
  • 3
    • 66149103003 scopus 로고    scopus 로고
    • Clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock: 2007 update from the American College of Critical Care Medicine
    • Brierley J., Carcillo J.A., Choong K., et al. Clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock: 2007 update from the American College of Critical Care Medicine. Crit Care Med 2009, 37:666-688.
    • (2009) Crit Care Med , vol.37 , pp. 666-688
    • Brierley, J.1    Carcillo, J.A.2    Choong, K.3
  • 4
    • 84864514502 scopus 로고    scopus 로고
    • Adherence to PALS sepsis guidelines and hospital length of stay
    • Paul R., Newman M.I., Monuteaux M.C., et al. Adherence to PALS sepsis guidelines and hospital length of stay. Pediatrics 2012, 130:e273-e280.
    • (2012) Pediatrics , vol.130
    • Paul, R.1    Newman, M.I.2    Monuteaux, M.C.3
  • 5
    • 79952241027 scopus 로고    scopus 로고
    • Implementation of goal-directed therapy for children with suspected sepsis in the emergency department
    • Cruz A.T., Perry A.M., Williams E.A., et al. Implementation of goal-directed therapy for children with suspected sepsis in the emergency department. Pediatrics 2011, 127:e758-e766.
    • (2011) Pediatrics , vol.127
    • Cruz, A.T.1    Perry, A.M.2    Williams, E.A.3
  • 6
    • 79957903859 scopus 로고    scopus 로고
    • An emergency department septic shock protocol and care guideline for children initiated at triage
    • Larsen G.Y., Mecham N., Greenberg R. An emergency department septic shock protocol and care guideline for children initiated at triage. Pediatrics 2011, 127:e1585-e1592.
    • (2011) Pediatrics , vol.127
    • Larsen, G.Y.1    Mecham, N.2    Greenberg, R.3
  • 7
    • 0035100888 scopus 로고    scopus 로고
    • Biomarkers and surrogate endpoints: preferred definitions and conceptual framework
    • Biomarkers Definitions Working Group
    • Biomarkers Definitions Working Group Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther 2001, 69:89-95.
    • (2001) Clin Pharmacol Ther , vol.69 , pp. 89-95
  • 8
  • 9
    • 0042744797 scopus 로고    scopus 로고
    • C-reactive protein: a critical update
    • Pepys M.B., Hirschfield G.M. C-reactive protein: a critical update. J Clin Invest 2003, 111:1805-1812.
    • (2003) J Clin Invest , vol.111 , pp. 1805-1812
    • Pepys, M.B.1    Hirschfield, G.M.2
  • 10
    • 51649084231 scopus 로고    scopus 로고
    • Systematic review of the diagnostic accuracy of C-reactive protein to detect bacterial infection in nonhospitalized infants and children with fever
    • Sanders S., Barnett A., Correa-Velez I., et al. Systematic review of the diagnostic accuracy of C-reactive protein to detect bacterial infection in nonhospitalized infants and children with fever. J Pediatr 2008, 153:570-574.
    • (2008) J Pediatr , vol.153 , pp. 570-574
    • Sanders, S.1    Barnett, A.2    Correa-Velez, I.3
  • 11
    • 33748878798 scopus 로고    scopus 로고
    • Values of C-reactive protein, procalcitonin, and Staphylococcus-specific PCR in neonatal late-onset sepsis
    • Makhoul I.R., Yacoub A., Smolkin T., et al. Values of C-reactive protein, procalcitonin, and Staphylococcus-specific PCR in neonatal late-onset sepsis. Acta Paediatr 2006, 95:1218-1223.
    • (2006) Acta Paediatr , vol.95 , pp. 1218-1223
    • Makhoul, I.R.1    Yacoub, A.2    Smolkin, T.3
  • 12
    • 44449113393 scopus 로고    scopus 로고
    • Procalcitonin assay in systemic inflammation, infection, and sepsis: clinical utility and limitations
    • Becker K.L., Snider R., Nylen E.S. Procalcitonin assay in systemic inflammation, infection, and sepsis: clinical utility and limitations. Crit Care Med 2008, 36:941-952.
    • (2008) Crit Care Med , vol.36 , pp. 941-952
    • Becker, K.L.1    Snider, R.2    Nylen, E.S.3
  • 13
    • 61749083263 scopus 로고    scopus 로고
    • Procalcitonin and C-reactive protein as markers of bacterial infection in critically ill children at onset of systemic inflammatory response syndrome
    • Simon L., Saint-Louis P., Amre D.K., et al. Procalcitonin and C-reactive protein as markers of bacterial infection in critically ill children at onset of systemic inflammatory response syndrome. Pediatr Crit Care Med 2008, 9:407-413.
    • (2008) Pediatr Crit Care Med , vol.9 , pp. 407-413
    • Simon, L.1    Saint-Louis, P.2    Amre, D.K.3
  • 14
    • 3242810355 scopus 로고    scopus 로고
    • Serum procalcitonin and C-reactive protein levels as markers of bacterial infection: a systematic review and meta-analysis
    • Simon L., Gauvin F., Amre D.K., et al. Serum procalcitonin and C-reactive protein levels as markers of bacterial infection: a systematic review and meta-analysis. Clin Infect Dis 2004, 39:206-217.
    • (2004) Clin Infect Dis , vol.39 , pp. 206-217
    • Simon, L.1    Gauvin, F.2    Amre, D.K.3
  • 15
    • 0033847145 scopus 로고    scopus 로고
    • Discrimination of sepsis and systemic inflammatory response syndrome by determination of circulating plasma concentrations of procalcitonin, protein complement 3a, and interleukin-6
    • Selberg O., Hecker H., Martin M., et al. Discrimination of sepsis and systemic inflammatory response syndrome by determination of circulating plasma concentrations of procalcitonin, protein complement 3a, and interleukin-6. Crit Care Med 2000, 28:2793-2798.
    • (2000) Crit Care Med , vol.28 , pp. 2793-2798
    • Selberg, O.1    Hecker, H.2    Martin, M.3
  • 16
    • 0035421655 scopus 로고    scopus 로고
    • Diagnostic value of procalcitonin, interleukin-6, and interleukin-8 in critically ill patients admitted with suspected sepsis
    • Harbarth S., Holeckova K., Froidevaux C., et al. Diagnostic value of procalcitonin, interleukin-6, and interleukin-8 in critically ill patients admitted with suspected sepsis. Am J Respir Crit Care Med 2001, 164:396-402.
    • (2001) Am J Respir Crit Care Med , vol.164 , pp. 396-402
    • Harbarth, S.1    Holeckova, K.2    Froidevaux, C.3
  • 17
    • 33644822345 scopus 로고    scopus 로고
    • Procalcitonin does discriminate between sepsis and systemic inflammatory response syndrome
    • Arkader R., Troster E.J., Lopes M.R., et al. Procalcitonin does discriminate between sepsis and systemic inflammatory response syndrome. Arch Dis Child 2006, 91:117-120.
    • (2006) Arch Dis Child , vol.91 , pp. 117-120
    • Arkader, R.1    Troster, E.J.2    Lopes, M.R.3
  • 18
    • 33745622134 scopus 로고    scopus 로고
    • Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: a systematic review and meta-analysis
    • Uzzan B., Cohen R., Nicolas P., et al. Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: a systematic review and meta-analysis. Crit Care Med 2006, 34:1996-2003.
    • (2006) Crit Care Med , vol.34 , pp. 1996-2003
    • Uzzan, B.1    Cohen, R.2    Nicolas, P.3
  • 19
    • 84869443816 scopus 로고    scopus 로고
    • The utility of early lactate testing in undifferentiated pediatric systemic inflammatory response syndrome
    • Scott H.F., Donoghue A.J., Gaieski D.F., et al. The utility of early lactate testing in undifferentiated pediatric systemic inflammatory response syndrome. Acad Emerg Med 2012, 19:1276-1280.
    • (2012) Acad Emerg Med , vol.19 , pp. 1276-1280
    • Scott, H.F.1    Donoghue, A.J.2    Gaieski, D.F.3
  • 20
    • 67650489580 scopus 로고    scopus 로고
    • Serum lactate is associated with mortality in severe sepsis independent of organ failure and shock
    • Mikkelsen M.E., Miltiades A.N., Gaieski D.F., et al. Serum lactate is associated with mortality in severe sepsis independent of organ failure and shock. Crit Care Med 2009, 37:1670-1677.
    • (2009) Crit Care Med , vol.37 , pp. 1670-1677
    • Mikkelsen, M.E.1    Miltiades, A.N.2    Gaieski, D.F.3
  • 21
    • 84873700349 scopus 로고    scopus 로고
    • Revisiting the white blood cell count: immature granulocytes count as a diagnostic marker to discriminate between SIRS and sepsis-a prospective, observational study
    • Nierhaus A., Klatte S., Linssen J., et al. Revisiting the white blood cell count: immature granulocytes count as a diagnostic marker to discriminate between SIRS and sepsis-a prospective, observational study. BMC Immunol 2013, 14:8.
    • (2013) BMC Immunol , vol.14 , pp. 8
    • Nierhaus, A.1    Klatte, S.2    Linssen, J.3
  • 22
    • 0032752726 scopus 로고    scopus 로고
    • Diagnostic markers of infection: comparison of procalcitonin with C reactive protein and leucocyte count
    • Hatherill M., Tibby S.M., Sykes K., et al. Diagnostic markers of infection: comparison of procalcitonin with C reactive protein and leucocyte count. Arch Dis Child 1999, 81:417-421.
    • (1999) Arch Dis Child , vol.81 , pp. 417-421
    • Hatherill, M.1    Tibby, S.M.2    Sykes, K.3
  • 23
    • 70349478739 scopus 로고    scopus 로고
    • Neutrophil CD64: a diagnostic marker for infection and sepsis
    • Hoffmann J.J. Neutrophil CD64: a diagnostic marker for infection and sepsis. Clin Chem Lab Med 2009, 47:903-916.
    • (2009) Clin Chem Lab Med , vol.47 , pp. 903-916
    • Hoffmann, J.J.1
  • 24
    • 77952514852 scopus 로고    scopus 로고
    • Neutrophil CD64 expression as marker of bacterial infection: a systematic review and meta-analysis
    • Cid J., Aguinaco R., Sanchez R., et al. Neutrophil CD64 expression as marker of bacterial infection: a systematic review and meta-analysis. J Infect 2010, 60:313-319.
    • (2010) J Infect , vol.60 , pp. 313-319
    • Cid, J.1    Aguinaco, R.2    Sanchez, R.3
  • 25
    • 33646535439 scopus 로고    scopus 로고
    • Diagnostic markers for neonatal sepsis
    • Ng P.C., Lam H.S. Diagnostic markers for neonatal sepsis. Curr Opin Pediatr 2006, 18:125-131.
    • (2006) Curr Opin Pediatr , vol.18 , pp. 125-131
    • Ng, P.C.1    Lam, H.S.2
  • 26
    • 73949091184 scopus 로고    scopus 로고
    • Neutrophil and monocyte CD64 indexes, lipopolysaccharide-binding protein, procalcitonin and C-reactive protein in sepsis of critically ill neonates and children
    • Groselj-Grenc M., Ihan A., Pavcnik-Arnol M., et al. Neutrophil and monocyte CD64 indexes, lipopolysaccharide-binding protein, procalcitonin and C-reactive protein in sepsis of critically ill neonates and children. Intensive Care Med 2009, 35:1950-1958.
    • (2009) Intensive Care Med , vol.35 , pp. 1950-1958
    • Groselj-Grenc, M.1    Ihan, A.2    Pavcnik-Arnol, M.3
  • 27
    • 59849119415 scopus 로고    scopus 로고
    • Neutrophil CD64 expression as a diagnostic marker of bacterial infection in febrile children presenting to a hospital emergency department
    • Rudensky B., Sirota G., Erlichman M., et al. Neutrophil CD64 expression as a diagnostic marker of bacterial infection in febrile children presenting to a hospital emergency department. Pediatr Emerg Care 2008, 24:745-748.
    • (2008) Pediatr Emerg Care , vol.24 , pp. 745-748
    • Rudensky, B.1    Sirota, G.2    Erlichman, M.3
  • 28
    • 0034657890 scopus 로고    scopus 로고
    • Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes
    • Bouchon A., Dietrich J., Colonna M. Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J Immunol 2000, 164:4991-4995.
    • (2000) J Immunol , vol.164 , pp. 4991-4995
    • Bouchon, A.1    Dietrich, J.2    Colonna, M.3
  • 29
    • 84870056881 scopus 로고    scopus 로고
    • Accuracy of plasma sTREM-1 for sepsis diagnosis in systemic inflammatory patients: a systematic review and meta-analysis
    • Wu Y., Wang F., Fan X., et al. Accuracy of plasma sTREM-1 for sepsis diagnosis in systemic inflammatory patients: a systematic review and meta-analysis. Crit Care 2012, 16:R229.
    • (2012) Crit Care , vol.16
    • Wu, Y.1    Wang, F.2    Fan, X.3
  • 30
    • 84862827407 scopus 로고    scopus 로고
    • Measurement of plasma sTREM-1 in patients with severe sepsis receiving early goal-directed therapy and evaluation of its usefulness
    • Jeong S.J., Song Y.G., Kim C.O., et al. Measurement of plasma sTREM-1 in patients with severe sepsis receiving early goal-directed therapy and evaluation of its usefulness. Shock 2012, 37:574-578.
    • (2012) Shock , vol.37 , pp. 574-578
    • Jeong, S.J.1    Song, Y.G.2    Kim, C.O.3
  • 31
    • 0035753742 scopus 로고    scopus 로고
    • Proinflammatory cytokines (IL-6, IL-8), cytokine inhibitors (IL-6sR, sTNFRII) and anti-inflammatory cytokines (IL-10, IL-13) in the pathogenesis of sepsis in newborns and infants
    • Sikora J.P., Chlebna-Sokol D., Krzyzanska-Oberbek A. Proinflammatory cytokines (IL-6, IL-8), cytokine inhibitors (IL-6sR, sTNFRII) and anti-inflammatory cytokines (IL-10, IL-13) in the pathogenesis of sepsis in newborns and infants. Arch Immunol Ther Exp (Warsz) 2001, 49:399-404.
    • (2001) Arch Immunol Ther Exp (Warsz) , vol.49 , pp. 399-404
    • Sikora, J.P.1    Chlebna-Sokol, D.2    Krzyzanska-Oberbek, A.3
  • 32
    • 9144265427 scopus 로고    scopus 로고
    • Role of interleukin 6 in myocardial dysfunction of meningococcal septic shock
    • Pathan N., Hemingway C.A., Alizadeh A.A., et al. Role of interleukin 6 in myocardial dysfunction of meningococcal septic shock. Lancet 2004, 363:203-209.
    • (2004) Lancet , vol.363 , pp. 203-209
    • Pathan, N.1    Hemingway, C.A.2    Alizadeh, A.A.3
  • 33
    • 84876114236 scopus 로고    scopus 로고
    • IL-8 predicts pediatric oncology patients with febrile neutropenia at low risk for bacteremia
    • Cost C.R., Stegner M.M., Leonard D., et al. IL-8 predicts pediatric oncology patients with febrile neutropenia at low risk for bacteremia. J Pediatr Hematol Oncol 2013, 35:206-211.
    • (2013) J Pediatr Hematol Oncol , vol.35 , pp. 206-211
    • Cost, C.R.1    Stegner, M.M.2    Leonard, D.3
  • 34
    • 48249148704 scopus 로고    scopus 로고
    • Interlukin-8 as a stratification tool for interventional trials involving pediatric septic shock
    • Wong H.R., Cvijanovich N., Wheeler D.S., et al. Interlukin-8 as a stratification tool for interventional trials involving pediatric septic shock. Am J Respir Crit Care Med 2008, 178:276-282.
    • (2008) Am J Respir Crit Care Med , vol.178 , pp. 276-282
    • Wong, H.R.1    Cvijanovich, N.2    Wheeler, D.S.3
  • 35
    • 0031970813 scopus 로고    scopus 로고
    • The erythrocyte sedimentation rate: old and new clinical applications
    • Saadeh C. The erythrocyte sedimentation rate: old and new clinical applications. South Med J 1998, 91:220-225.
    • (1998) South Med J , vol.91 , pp. 220-225
    • Saadeh, C.1
  • 36
    • 47649124819 scopus 로고    scopus 로고
    • Comparison of WBC, ESR, CRP, and PCT serum levels in septic and non-septic burn cases
    • Barati M., Alinejad F., Bahar M.A., et al. Comparison of WBC, ESR, CRP, and PCT serum levels in septic and non-septic burn cases. Burns 2008, 34:770-774.
    • (2008) Burns , vol.34 , pp. 770-774
    • Barati, M.1    Alinejad, F.2    Bahar, M.A.3
  • 37
    • 38649094909 scopus 로고    scopus 로고
    • The alteration of autonomic function in multiple organ dysfunction syndrome
    • Schmidt H., Hoyer D., Wilhelm J., et al. The alteration of autonomic function in multiple organ dysfunction syndrome. Crit Care Clin 2008, 24:149-163.
    • (2008) Crit Care Clin , vol.24 , pp. 149-163
    • Schmidt, H.1    Hoyer, D.2    Wilhelm, J.3
  • 38
    • 0242609242 scopus 로고    scopus 로고
    • Heart rate variability as early marker of multiple organ dysfunction syndrome in septic patients
    • Pontet J., Contreras P., Curbelo A., et al. Heart rate variability as early marker of multiple organ dysfunction syndrome in septic patients. J Crit Care 2003, 18:156-163.
    • (2003) J Crit Care , vol.18 , pp. 156-163
    • Pontet, J.1    Contreras, P.2    Curbelo, A.3
  • 39
    • 24944441887 scopus 로고    scopus 로고
    • Autonomic dysfunction predicts mortality in patients with multiple organ dysfunction syndrome of different age groups
    • Schmidt H., Muller-Werdan U., Hoffmann T., et al. Autonomic dysfunction predicts mortality in patients with multiple organ dysfunction syndrome of different age groups. Crit Care Med 2005, 33:1994-2002.
    • (2005) Crit Care Med , vol.33 , pp. 1994-2002
    • Schmidt, H.1    Muller-Werdan, U.2    Hoffmann, T.3
  • 40
    • 65249101633 scopus 로고    scopus 로고
    • Impaired regulation of cardiac function in sepsis, SIRS, and MODS
    • Werdan K., Schmidt H., Ebelt H., et al. Impaired regulation of cardiac function in sepsis, SIRS, and MODS. Can J Physiol Pharmacol 2009, 87:266-274.
    • (2009) Can J Physiol Pharmacol , vol.87 , pp. 266-274
    • Werdan, K.1    Schmidt, H.2    Ebelt, H.3
  • 41
    • 80455127394 scopus 로고    scopus 로고
    • Septic shock prediction by real time monitoring of heart rate variability
    • T. Jobbágy (Ed.)
    • Yokota Y., Kawamura Y., Matsumaru N., et al. Septic shock prediction by real time monitoring of heart rate variability. 5th European IFMBE Conference, IFMBE Proceedings 2011, 37:195-198. T. Jobbágy (Ed.).
    • (2011) 5th European IFMBE Conference, IFMBE Proceedings , vol.37 , pp. 195-198
    • Yokota, Y.1    Kawamura, Y.2    Matsumaru, N.3
  • 42
    • 0035491304 scopus 로고    scopus 로고
    • Uncoupling and recoupling of autonomic regulation of the heart beat in pediatric septic shock
    • Ellenby M.S., McNames J., Lai S., et al. Uncoupling and recoupling of autonomic regulation of the heart beat in pediatric septic shock. Shock 2001, 16:274-277.
    • (2001) Shock , vol.16 , pp. 274-277
    • Ellenby, M.S.1    McNames, J.2    Lai, S.3
  • 43
    • 0038278614 scopus 로고    scopus 로고
    • Abnormal heart rate characteristics preceding neonatal sepsis and sepsis-like illness
    • Griffin M.P., O'Shea T.M., Bissonette E.A., et al. Abnormal heart rate characteristics preceding neonatal sepsis and sepsis-like illness. Pediatr Res 2003, 53:920-926.
    • (2003) Pediatr Res , vol.53 , pp. 920-926
    • Griffin, M.P.1    O'Shea, T.M.2    Bissonette, E.A.3
  • 44
    • 34247145917 scopus 로고    scopus 로고
    • Characteristics of heart rate variability can predict impending septic shock in emergency department patients with sepsis
    • Chen W.-L., Kuo C.-D. Characteristics of heart rate variability can predict impending septic shock in emergency department patients with sepsis. Acad Emerg Med 2007, 14:392-397.
    • (2007) Acad Emerg Med , vol.14 , pp. 392-397
    • Chen, W.-L.1    Kuo, C.-D.2
  • 45
    • 0030032080 scopus 로고    scopus 로고
    • Blood pressure and arterial lactate level are early indicators of short-term survival in human septic shock
    • Bernardin G., Pradier C., Tiger F., et al. Blood pressure and arterial lactate level are early indicators of short-term survival in human septic shock. Intensive Care Med 1996, 22:17-25.
    • (1996) Intensive Care Med , vol.22 , pp. 17-25
    • Bernardin, G.1    Pradier, C.2    Tiger, F.3
  • 46
    • 0026465325 scopus 로고
    • Continuous central venous oximetry and shock index in the emergency department: use in the evaluation of clinical shock
    • Rady M.Y., Rivers E.P., Martin G.B., et al. Continuous central venous oximetry and shock index in the emergency department: use in the evaluation of clinical shock. Am J Emerg Med 1992, 10:538-541.
    • (1992) Am J Emerg Med , vol.10 , pp. 538-541
    • Rady, M.Y.1    Rivers, E.P.2    Martin, G.B.3
  • 47
    • 0026700848 scopus 로고
    • Shock index: a re-evaluation in acute circulatory failure
    • Rady M.Y., Nightingale P., Little R.A., et al. Shock index: a re-evaluation in acute circulatory failure. Resuscitation 1992, 23:227-234.
    • (1992) Resuscitation , vol.23 , pp. 227-234
    • Rady, M.Y.1    Nightingale, P.2    Little, R.A.3
  • 48
    • 84879091612 scopus 로고    scopus 로고
    • Shock index and early recognition of sepsis in the emergency department: pilot study
    • Berger T., Green J., Horeczko T., et al. Shock index and early recognition of sepsis in the emergency department: pilot study. West J Emerg Med 2013, 14:168-174.
    • (2013) West J Emerg Med , vol.14 , pp. 168-174
    • Berger, T.1    Green, J.2    Horeczko, T.3
  • 49
    • 84885587184 scopus 로고    scopus 로고
    • Is shock index associated with outcome in children with sepsis/septic shock?
    • Yasaka Y., Khemani R.G., Markovitz B.P. Is shock index associated with outcome in children with sepsis/septic shock?. Pediatr Crit Care Med 2013, 14:e372-e379.
    • (2013) Pediatr Crit Care Med , vol.14
    • Yasaka, Y.1    Khemani, R.G.2    Markovitz, B.P.3
  • 50
    • 0033028128 scopus 로고    scopus 로고
    • Capillary refill and core-peripheral temperature gap as indicators of haemodynamic status in paediatric intensive care patients
    • Tibby S.M., Hatherill M., Murdoch I.A. Capillary refill and core-peripheral temperature gap as indicators of haemodynamic status in paediatric intensive care patients. Arch Dis Child 1999, 80:163-166.
    • (1999) Arch Dis Child , vol.80 , pp. 163-166
    • Tibby, S.M.1    Hatherill, M.2    Murdoch, I.A.3
  • 51
    • 84873339299 scopus 로고    scopus 로고
    • Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012
    • Dellinger R.P., Levy M.M., Rhodes A., et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 2013, 41:580-637.
    • (2013) Crit Care Med , vol.41 , pp. 580-637
    • Dellinger, R.P.1    Levy, M.M.2    Rhodes, A.3
  • 53
    • 46149111424 scopus 로고    scopus 로고
    • ACCM/PALS haemodynamic support guidelines for paediatric septic shock: an outcomes comparison with and without monitoring central venous oxygen saturation
    • de Oliveira C.F., de Oliveira D.S.F., Gottschald A.F.C., et al. ACCM/PALS haemodynamic support guidelines for paediatric septic shock: an outcomes comparison with and without monitoring central venous oxygen saturation. Intensive Care Med 2008, 34:1065-1075.
    • (2008) Intensive Care Med , vol.34 , pp. 1065-1075
    • de Oliveira, C.F.1    de Oliveira, D.S.F.2    Gottschald, A.F.C.3
  • 54
    • 0037351815 scopus 로고    scopus 로고
    • Mortality in emergency department sepsis (MEDS) score: a prospectively derived and validated clinical prediction rule
    • Shapiro N.I., Wolfe R.E., Moore R.B., et al. Mortality in emergency department sepsis (MEDS) score: a prospectively derived and validated clinical prediction rule. Crit Care Med 2003, 31:670-675.
    • (2003) Crit Care Med , vol.31 , pp. 670-675
    • Shapiro, N.I.1    Wolfe, R.E.2    Moore, R.B.3
  • 55
    • 38549104105 scopus 로고    scopus 로고
    • Validation of the mortality in emergency department sepsis (MEDS) score in patients with the systemic inflammatory response syndrome (SIRS)
    • Sankoff J.D., Goyal M., Gaieski D.F., et al. Validation of the mortality in emergency department sepsis (MEDS) score in patients with the systemic inflammatory response syndrome (SIRS). Crit Care Med 2008, 36:421-426.
    • (2008) Crit Care Med , vol.36 , pp. 421-426
    • Sankoff, J.D.1    Goyal, M.2    Gaieski, D.F.3
  • 56
    • 84866792152 scopus 로고    scopus 로고
    • The pediatric sepsis biomarker risk model
    • Wong H.R., Salisbury S., Xiao Q., et al. The pediatric sepsis biomarker risk model. Crit Care 2012, 16:R174.
    • (2012) Crit Care , vol.16
    • Wong, H.R.1    Salisbury, S.2    Xiao, Q.3
  • 57
    • 84896595576 scopus 로고    scopus 로고
    • A multibiomarker-based outcome risk stratification model for adult septic shock
    • Wong H.R., Lindsell C.J., Pettila V., et al. A multibiomarker-based outcome risk stratification model for adult septic shock. Crit Care Med 2014, 42:781-789.
    • (2014) Crit Care Med , vol.42 , pp. 781-789
    • Wong, H.R.1    Lindsell, C.J.2    Pettila, V.3


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