A systematic review of fMRI studies in generalized anxiety disorder: Evaluating its neural and cognitive basis

Journal of Affective Disorders

Volumn 167, Issue , 2014, Pages 336-342

  Mochcovitch, Marina Dyskant ^a   Da Rocha Freire, Rafael Christophe ^a   Garcia, Rafael Ferreira ^a   Nardi, Antonio E ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

fMRI; Generalized anxiety disorder

Indexed keywords

ANTIDEPRESSANT AGENT;

AMYGDALOID NUCLEUS; ANTERIOR CINGULATE; BRAIN FUNCTION; COGNITIVE DEFECT; DIFFUSION TENSOR IMAGING; EMOTIONAL DISORDER; EMOTIONALITY; FEAR; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENERALIZED ANXIETY DISORDER; HUMAN; INSULA; MINDFULNESS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PANIC; PREFRONTAL CORTEX; PRIORITY JOURNAL; REVIEW; SOCIAL PHOBIA; SOMATOSENSORY CORTEX; SUPPLEMENTARY MOTOR AREA; SYSTEMATIC REVIEW; VENTROMEDIAL PREFRONTAL CORTEX; ANXIETY DISORDER; BRAIN CORTEX; BRAIN MAPPING; NERVE CELL NETWORK; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PSYCHOLOGY;

AMYGDALA; ANXIETY DISORDERS; BRAIN MAPPING; CEREBRAL CORTEX; COGNITION DISORDERS; HUMANS; MAGNETIC RESONANCE IMAGING; NERVE NET;

EID: 84904343839     PISSN: 01650327     EISSN: 15732517     Source Type: Journal    
DOI: 10.1016/j.jad.2014.06.041     Document Type: Review

References (33)

1. American Psychiatric Association (APA) Diagnostic and Statistical Manual of Mental Disorders 2013 American Psychiatric Association Washington, DC
2. C. Andreescu, J.J. Gross, E. Lenze, K.D. Edelman, S. Snyder, C. Tanase, and H. Aizenstein Altered cerebral blood flow patterns associated with pathologic worry in the elderly Depress. Anxiety 28 3 2011 202 209
3. E. Behar, I.D. DiMarco, E.B. Hekler, J. Mohlman, and A.M. Staples Current theoretical models of generalized anxiety disorder (GAD): concetal review and treatment implications J. Anxiety Disord. 23 8 2009 1011 1023
4. E. Behar, A.R. Zuellig, and T.D. Borkovec Thought and imaginal activity during worry and trauma recall Behav. Ther. 36 2005 157 158
5. T.D. Borkovec, and L. Roemer Perceived functions of worry among generalized anxiety disorder subjects: distraction from more emotionally distressing topics? J. Behav. Ther. Exp. Psychiatry 26 1995 25 30
6. K. Blair, J. Shaywitz, B.W. Smith, R. Rhodes, M. Geraci, M. Jones, D. McCaffrey, M. Vythilingam, E. Finger, K. Mondillo, M. Jacobs, D.S. Charney, R.J. Blair, W.C. Drevets, and D.S. Pine Response to emotional expressions in generalized social phobia and generalized anxiety disorder: evidence for separate disorders Am. J. Psychiatry 165 9 2008 1193 1202
7. T.M. Ball, H.J. Ramsawh, L. Campbell-Sills, M.P. Paulus, and M.B. Stein Prefrontal dysfunction during emotion regulation in generalized anxiety and panic disorders Psychol. Med. 43 7 2013 1475 1486
8. K.S. Blair, M. Geraci, B.W. Smith, N. Hollon, J. DeVido, M. Otero, J.R. Blair, and D.S. Pine Reduced dorsal anterior cingulate cortical activity during emotional regulation and top-down attentional control in generalized social phobia, generalized anxiety disorder, and comorbid generalized social phobia/generalized anxiety disorder Biol. Psychiatry 72 6 2012 476 482
9. G.C.L. Davey, F. Tallis, and N. Capuzzo Beliefs about the consequences of worrying Cognit. Ther. Res. 20 1996 499 520
10. M. Davis, D.L. Walker, L. Miles, and C. Grillon Phasic vs sustained fear in rats and humans: role of the extended amygdala in fear vs anxiety Neuropsychopharmacology 35 2010 105 135
11. A. Etkin, and T.D. Wager Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia Am. J. Psychiatry 164 10 2007 1476 1488
12. P.F. Ekman, and W.V. Friesen Pictures of Facial Affect 1976 Consulting Psychologists Press Palo Alto, CA
13. A. Etkin, K.E. Prater, F. Hoeft, V. Menon, and A.F. Schatzberg Failure of anterior cingulate activation and connectivity with the amygdala during implicit regulation of emotional processing in generalized anxiety disorder Am. J. Psychiatry 167 5 2010 545 554
14. A. Etkin, K.E. Prater, A.F. Schatzberg, V. Menon, and M.D. Greicius Disrupted amygdalar subregion functional connectivity and evidence of a compensatory network in generalized anxiety disorder Arch. Gen. Psychiatry 66 12 2009 1361 1372
15. J.J. Gross Emotion regulation: affective, cognitive, and social consequences Psychophysiology 39 2002 281 291
16. T. Greenberg, J.M. Carlson, J. Cha, G. Hajcak, and L.R. Mujica-Parodi Neural reactivity tracks fear generalization gradients Biol. Psychol. 92 1 2013 2 8
17. T. Greenberg, J.M. Carlson, J. Cha, G. Hajcak, and L.R. Mujica-Parodi Ventromedial prefrontal cortex reactivity is altered in generalized anxiety disorder during feargeneralization Depress. Anxiety 30 3 2013 242 250
18. D.L. Hoffman, E.M. Dukes, and H.U. Wittchen Human and economic burden of generalized anxiety disorder Depress. Anxiety 25 2008 72 90
19. R. Hoehn-Saric, M.W. Schlund, and S.H.Y. Wong Effects of citalopram on worry and brain activation in patients with generalized anxiety disorder Psychiatry Res.: Neuroimaging 131 2004 11 21
20. B.K. Hölzel, E.A. Hoge, D.N. Greve, T. Gard, J.D. Creswell, K.W. Brown, L.F. Barrett, C. Schwartz, D. Vaitl, and S.W. Lazar Neural mechanisms of symptom improvements in generalized anxiety disorder following mindfulness training Neuroimage Clin. 25 2 2013 448 458
21. R.C. Kessler, M.B. Keller, and H.U. Wittchen The epidemiology of generalized anxiety disorder Psychiatr. Clin. N. Am. 24 1 2001 19 39
22. J. Kabat-Zinn Full Catastrophe Living 1990 Delta Publishing New York, NY
23. P.J. Lang, M.M. Bradley, and B.N. Cuthbert (Technical Report A-8) International Affective Picture System (IAPS): Affective Ratings of Pictures and Instruction Manual 2008 University of Florida Gainesville, FL
24. S. Lissek Toward an account of clinical anxiety predicated on basic, neurally mapped mechanisms of pavlovian fear-learning: the case for conditioned overgeneralization Depress. Anxiety 29 2012 257 263
25. D.S. Mennin, R.G. Heimberg, C.L. Turk, and D.M. Fresco Preliminary evidence for an emotion dysregulation model of generalized anxiety disorder Behav. Res. Ther. 43 10 2005 1281 1310
26. E.B. McClure, C.S. Monk, E.E. Nelson, J.M. Parrish, A. Adler, R.J. Blair, S. Fromm, D.S. Charney, E. Leibenluft, M. Ernst, and D.S. Pine Abnormal attention modulation of fear circuit function in pediatric generalized anxiety disorder Arch. Gen. Psychiatry 64 2007 97 106
27. C.S. Monk, E.H. Telzer, K. Mogg, B.P. Bradley, X. Mai, H.M. Louro, G. Chen, E.B. McClure-Tone, M. Ernst, and D.S. Pine Amygdala and ventrolateral prefrontal cortex activation to masked angry faces in children and adolescents with generalized anxiety disorder Arch. Gen. Psychiatry 65 2008 568 576
28. J. Maslowsky, K. Mogg, B.P. Bradley, E. McClure-Tone, M. Ernst, D.S. Pine, and C.S. Monk A preliminary investigation of neural correlates of treatment in adolescents with generalized anxiety disorder J. Child Adolesc. Psychopharmacol. 20 2010 105 111
29. J.B. Nitschke, I. Sarinopoulos, D.J. Oathes, T. Johnstone, P.J. Whalen, R.J. Davidson, and N.H. Kalin Anticipatory activation in the amygdala and anterior cingulate in generalized anxiety disorder and prediction of treatment response Am. J. Psychiatry 166 2009 302 310
30. M.E. Palm, R. Elliott, S. McKie, J.F. Deakin, and I.M. Anderson Attenuated responses to emotional expressions in women with generalized anxiety disorder Psychol. Med. 41 5 2011 1009 1018
31. E. Paulesu, E. Sambugaro, T. Torti, L. Danelli, F. Ferri, G. Scialfa, M. Sberna, G.M. Ruggiero, G. Bottini, and S. Sassaroli Neural correlates of worry in generalized anxiety disorder and in normal controls: a functional MRI study Psychol. Med. 40 1 2010 117 124
32. P.J. Whalen, T. Johnstone, L.H. Somerville, J.B. Nitschke, S. Polis, A.L. Alexander, R.J. Davidson, and N.H. Kalin A functional magnetic resonance imaging predictor of treatment response to venlafaxine in generalized anxiety disorder Biol. Psychiatry 63 2008 858 863
33. M.A. Yassa, R.L. Hazlett, C.E.L. Stark, and R. Hoehn-Saric Functional MRI of the amygdala and bed nucleus of the stria terminalis during conditions of uncertainty in generalized anxiety disorder J. Psychiatr. Res. 46 2012 1045 1052