-
1
-
-
84904294844
-
Complete protection against aflatoxin B1-induced liver cancer with a triterpenoid: DNA adduct dosimetry, molecular signature and genotoxicity threshold
-
Johnson NM, Egner PA, Baxter VK, Sporn MB, Wilbe RS, Sutter TR, et al. Complete protection against aflatoxin B1-induced liver cancer with a triterpenoid: DNA adduct dosimetry, molecular signature and genotoxicity threshold. Cancer Prev Res 2014;7:658-65.
-
(2014)
Cancer Prev Res
, vol.7
, pp. 658-665
-
-
Johnson, N.M.1
Egner, P.A.2
Baxter, V.K.3
Sporn, M.B.4
Wilbe, R.S.5
Sutter, T.R.6
-
2
-
-
79952088976
-
Aflatoxin: A 50-year odyssey of mechanistic and translational toxicology
-
Kensler TW, Roebuck BD, Wogan GN, Groopman JD. Aflatoxin: a 50-year odyssey of mechanistic and translational toxicology. Toxicol Sci 2011;120(Suppl 1):S28-48.
-
(2011)
Toxicol Sci
, vol.120
, Issue.SUPPL. 1
-
-
Kensler, T.W.1
Roebuck, B.D.2
Wogan, G.N.3
Groopman, J.D.4
-
3
-
-
0024781837
-
Mechanisms of induction of enzymes that protect against chemical carcinogenesis
-
Talalay P. Mechanisms of induction of enzymes that protect against chemical carcinogenesis. Adv Enzyme Regul 1989;28:237-50.
-
(1989)
Adv Enzyme Regul
, vol.28
, pp. 237-250
-
-
Talalay, P.1
-
4
-
-
33847050801
-
Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway
-
Kensler TW, Wakabayashi N, Biswal S. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol 2007;47:89-116.
-
(2007)
Annu Rev Pharmacol Toxicol
, vol.47
, pp. 89-116
-
-
Kensler, T.W.1
Wakabayashi, N.2
Biswal, S.3
-
5
-
-
84885944468
-
The emerging role of the Nrf2-Keap1 signaling pathway in cancer
-
Jaramillo MC, Zhang DD. The emerging role of the Nrf2-Keap1 signaling pathway in cancer. Genes Dev 2013;27:2179-91.
-
(2013)
Genes Dev
, vol.27
, pp. 2179-2191
-
-
Jaramillo, M.C.1
Zhang, D.D.2
-
6
-
-
0343545529
-
Oltipraz chemoprevention trial in Qidong, People's Republic of China: Modulation of serum aflatoxin albumin adduct biomarkers
-
Kensler TW, He X, Otieno M, Egner PA, Jacobson LP, Chen B, et al. Oltipraz chemoprevention trial in Qidong, People's Republic of China: modulation of serum aflatoxin albumin adduct biomarkers. Cancer Epidemiol Biomarkers Prev 1998;7:127-34. (Pubitemid 28109844)
-
(1998)
Cancer Epidemiology Biomarkers and Prevention
, vol.7
, Issue.2
, pp. 127-134
-
-
Kensler, T.W.1
He, X.2
Otieno, M.3
Egner, P.A.4
Jacobson, L.P.5
Chen, B.6
Wang, J.-S.7
Zhu, Y.-R.8
Zhang, B.-C.9
Wang, J.-B.10
Wu, Y.11
Zhang, Q.-N.12
Qian, G.-S.13
Kuang, S.-Y.14
Fang, X.15
Li, Y.-F.16
Yu, L.-Y.17
Prochaska, H.J.18
Davidson, N.E.19
Gordon, G.B.20
Gorman, M.B.21
Zarba, A.22
Enger, C.23
Munoz, A.24
Helzlsouer, K.J.25
Groopman, J.D.26
more..
-
7
-
-
28644450910
-
Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo Township, Qidong, People's Republic of China
-
DOI 10.1158/1055-9965.EPI-05-0368
-
Kensler TW, Chen JG, Egner PA, Fahey JW, Jacobson LP, Stephenson KK, et al. Effects of glucosinolate-rich broccoli sprouts on urinary levels of a flatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China. Cancer Epidemiol Biomarkers Prev 2005;14:2605-13. (Pubitemid 41752722)
-
(2005)
Cancer Epidemiology Biomarkers and Prevention
, vol.14
, Issue.11 I
, pp. 2605-2613
-
-
Kensler, T.W.1
Chen, J.-G.2
Egner, P.A.3
Fahey, J.W.4
Jacobson, L.P.5
Stephenson, K.K.6
Ye, L.7
Coady, J.L.8
Wang, J.-B.9
Wu, Y.10
Sun, Y.11
Zhang, Q.-N.12
Zhang, B.-C.13
Zhu, Y.-R.14
Qian, G.-S.15
Carmella, S.G.16
Hecht, S.S.17
Benning, L.18
Gange, S.J.19
Groopman, J.D.20
Talalay, P.21
more..
-
8
-
-
0033577057
-
1 oltipraz in residents of Qidong, People's Republic of China
-
Wang JS, Shen X, He X, Zhu YR, Zhang BC, Wang JB, et al. Protective alterations in phase I and 2 metabolism of aflatoxin B1 by oltipraz in residents of Qidong, People's Republic of China. J Natl Cancer Inst 1999;91:347-54. (Pubitemid 29102334)
-
(1999)
Journal of the National Cancer Institute
, vol.91
, Issue.4
, pp. 347-354
-
-
Wang, J.-S.1
Shen, X.2
He, X.3
Zhu, Y.-R.4
Zhang, B.-C.5
Wang, J.-B.6
Qian, G.-S.7
Kuang, S.-Y.8
Zarba, A.9
Egner, P.A.10
Jacobson, L.P.11
Munoz, A.12
Helzlsouer, K.J.13
Groopman, J.D.14
Kensler, T.W.15
-
9
-
-
0026614344
-
Comparison of the aflatoxin B1-8,9- epoxide conjugating activities of two bacterially expressed alpha class glutathione S-transferase isozymes from mouse and rat
-
Buetler TM, Slone D, Eaton DL. Comparison of the aflatoxin B1-8,9- epoxide conjugating activities of two bacterially expressed alpha class glutathione S-transferase isozymes from mouse and rat. Biochem Biophys Res Commun 1992;188:597-603.
-
(1992)
Biochem Biophys Res Commun
, vol.188
, pp. 597-603
-
-
Buetler, T.M.1
Slone, D.2
Eaton, D.L.3
-
10
-
-
0029883290
-
1 biotransformation in rat liver: Implications for human chemointervention
-
Buetler TM, Bammler TK, Hayes JD, Eaton DL. Oltipraz-mediated changes in aflatoxin B1- biotransformation in rat liver: implications for human chemointervention. Cancer Res 1996;56:2306-13. (Pubitemid 26154079)
-
(1996)
Cancer Research
, vol.56
, Issue.10
, pp. 2306-2313
-
-
Buetler, T.M.1
Bammler, T.K.2
Hayes, J.D.3
Eaton, D.L.4
-
11
-
-
0033935601
-
1-8,9-epoxide- conjugating activity in the nonhuman primate Macaca fascicularis liver
-
Wang CH, Bammler TK, Ou YY, Kelly EJ, Eaton DL. Mu-class GSTs are responsible for aflatoxin B1-8, 9-epoxide conjugating activity in the non-human primate Macaca fascicularis liver. Toxicol Sci 2000;56:26-36. (Pubitemid 30441462)
-
(2000)
Toxicological Sciences
, vol.56
, Issue.1
, pp. 26-36
-
-
Wang, C.1
Bammler, T.K.2
Guo, Y.3
Kelly, E.J.4
Eaton, D.L.5
-
12
-
-
0036850523
-
Complementary DNA cloning, protein expression, and characterization of alpha-class GSTs from Macaca fascicularis liver
-
DOI 10.1093/toxsci/70.1.20
-
Wang C, Bammler TK, Eaton DL. Complementary DNA cloning, protein expression and characterization of alpha-class GSTs from Macaca Fasicularis Liver. Toxicol Sci 2002;70:20-6. (Pubitemid 35331787)
-
(2002)
Toxicological Sciences
, vol.70
, Issue.1
, pp. 20-26
-
-
Wang, C.1
Bammler, T.K.2
Eaton, D.L.3
-
13
-
-
0034118377
-
1 biotransformation in non-human primates
-
Bammler TK, Slone DH, Eaton DL. Effects of dietary oltipraz and ethoxyquin on afl atoxin B1 biotransformation in non-human primates. Toxicol Sci 2000;54:30-41. (Pubitemid 30152453)
-
(2000)
Toxicological Sciences
, vol.54
, Issue.1
, pp. 30-41
-
-
Bammler, T.K.1
Slone, D.H.2
Eaton, D.L.3
-
15
-
-
0030894660
-
1 exo-8,9-epoxide catalyzed by rat and human glutathione transferases: Estimation of kinetic parameters
-
DOI 10.1021/bi962537o
-
Johnson WW, Ueng YF, Widersten M, Mannervik B, Hayes JD, Sherratt PJ, et al. Conjugation of highly reactive afl atoxin B1 exo-8,9-epoxide catalyzed by rat and human glutathione transferases: estimation of kinetic parameters. Biochemistry 1997;36:3056-60. (Pubitemid 27142375)
-
(1997)
Biochemistry
, vol.36
, Issue.11
, pp. 3056-3060
-
-
Johnson, W.W.1
Ueng, Y.-F.2
Widersten, M.3
Mannervik, B.4
Hayes, J.D.5
Sherratt, P.J.6
Ketterer, B.7
Guengerich, F.P.8
-
16
-
-
84862904621
-
Dietary modulation of the biotransformation and genotoxicity of a flatoxin B(1)
-
Gross-Steinmeyer K, Eaton DL. Dietary modulation of the biotransformation and genotoxicity of a flatoxin B(1). Toxicology 2012;299:69-79.
-
(2012)
Toxicology
, vol.299
, pp. 69-79
-
-
Gross-Steinmeyer, K.1
Eaton, D.L.2
-
17
-
-
77955079408
-
Sulforaphane- and phenethyl isothiocyanate-induced inhibition of aflatoxin B1 mediated genotoxicity in human hepatocytes: Role of GSTM1 genotype and CYP3A4 gene expression
-
Gross-Steinmeyer K, Stapleton PL, Tracy JH, Bammler TK, Strom SC, Eaton DL. Sulforaphane- and phenethyl isothiocyanate-induced inhibition of aflatoxin B1 mediated genotoxicity in human hepatocytes: role of GSTM1 genotype and CYP3A4 gene expression. Toxicol Sci 2010;116:422-32.
-
(2010)
Toxicol Sci
, vol.116
, pp. 422-432
-
-
Gross-Steinmeyer, K.1
Stapleton, P.L.2
Tracy, J.H.3
Bammler, T.K.4
Strom, S.C.5
Eaton, D.L.6
-
18
-
-
33845904129
-
The dietary isothiocyanate sulforaphane is an antagonist of the human steroid and xenobiotic nuclear receptor
-
DOI 10.1124/mol.106.029264
-
Zhou C, Poulton EJ, Grun F, Bammler TK, Blumberg B, Thummel KE, et al. The dietary isothiocyanate sulforaphane is an antagonist of the human steroid and xenobiotic nuclear receptor. Mol Pharmacol 2007;71:220-9. (Pubitemid 46020992)
-
(2007)
Molecular Pharmacology
, vol.71
, Issue.1
, pp. 220-229
-
-
Zhou, C.1
Poulton, E.-J.2
Grun, F.3
Bammler, T.K.4
Blumberg, B.5
Thummel, K.E.6
Eaton, D.L.7
-
19
-
-
0028216664
-
Structure and function of the 5′ flanking sequences of the human alpha class glutathione S-transferase genes
-
Suzuki T, Smith S, Board PG. Structure and function of the 5′ flanking sequences of the human alpha class glutathione S-transferase genes. Biochem Biophys Res Commun 1994;200:1665-71.
-
(1994)
Biochem Biophys Res Commun
, vol.200
, pp. 1665-1671
-
-
Suzuki, T.1
Smith, S.2
Board, P.G.3
-
20
-
-
84904343827
-
Absence of upstream consensus regulatory element sequences for NRF2 in human glutathione S-transferase genes
-
Schaupp CM, Bammler TK, Beyer RK, Kavanagh TJ, Eaton DL. Absence of upstream consensus regulatory element sequences for NRF2 in human glutathione S-transferase genes. The Toxicologist 2013;13:2025.
-
(2013)
The Toxicologist
, vol.13
, pp. 2025
-
-
Schaupp, C.M.1
Bammler, T.K.2
Beyer, R.K.3
Kavanagh, T.J.4
Eaton, D.L.5
-
21
-
-
84899896501
-
Genetic or pharmacologic activation of Nrf2 signaling fails to protect against aflatoxin genotoxicity in hypersensitive GSTA3 knockout mice
-
Apr 20. [Epub ahead of print]
-
Kensler KH, Slocum SL, Chartoumpekis DV, Dolan PM, Johnson NM, Ilic Z, et al. Genetic or pharmacologic activation of Nrf2 signaling fails to protect against aflatoxin genotoxicity in hypersensitive GSTA3 knockout mice. Toxicol Sci. 2014 Apr 20. [Epub ahead of print].
-
(2014)
Toxicol Sci
-
-
Kensler, K.H.1
Slocum, S.L.2
Chartoumpekis, D.V.3
Dolan, P.M.4
Johnson, N.M.5
Ilic, Z.6
-
22
-
-
73449104673
-
Glutathione Stransferase A3 knockout mice are sensitive to acute cytotoxic and genotoxic effects of aflatoxin B1
-
Ilic Z, Crawford D, Vakharia D, Egner PA, Sell S. Glutathione Stransferase A3 knockout mice are sensitive to acute cytotoxic and genotoxic effects of aflatoxin B1. Toxicol Appl Pharmacol 2010;242:241-6.
-
(2010)
Toxicol Appl Pharmacol
, vol.242
, pp. 241-246
-
-
Ilic, Z.1
Crawford, D.2
Vakharia, D.3
Egner, P.A.4
Sell, S.5
-
23
-
-
0024397306
-
1-DNA adducts: Linear correlation with hepatic cancer risk
-
DOI 10.1016/0273-2300(89)90014-7
-
Bechtel DH. Molecular dosimetry of hepatic alfatoxin B1DNA adducts: line arm correlation with hepatic cancer risk. Regul Toxicol Pharmacol 1989;10:74-81. (Pubitemid 19202680)
-
(1989)
Regulatory Toxicology and Pharmacology
, vol.10
, Issue.1
, pp. 74-81
-
-
Bechtel, D.H.1
-
24
-
-
81855161788
-
The rainbow trout liver cancer model: Response to environmental chemicals and studies on promotion and chemoprevention
-
Williams DE. The rainbow trout liver cancer model: response to environmental chemicals and studies on promotion and chemoprevention. Comp Biochem Physiol C Toxicol Pharmacol 2012;155:121-7.
-
(2012)
Comp Biochem Physiol C Toxicol Pharmacol
, vol.155
, pp. 121-127
-
-
Williams, D.E.1
-
25
-
-
84877809314
-
New player on an old fi eld; the Keap1/Nrf2 pathway as a target for treatment of type 2 diabetes and metabolic syndrome
-
Chartoumpekis DV, Kensler TW. New player on an old fi eld; the Keap1/Nrf2 pathway as a target for treatment of type 2 diabetes and metabolic syndrome. Curr Diabetes Rev 2013;9:137-45.
-
(2013)
Curr Diabetes Rev
, vol.9
, pp. 137-145
-
-
Chartoumpekis, D.V.1
Kensler, T.W.2
-
26
-
-
33846253173
-
The synthetic triterpenoid 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28- oyl]imidazole blocks nuclear factor-κB activation through direct inhibition of IκB kinase β
-
DOI 10.1158/1535-7163.MCT-06-0444
-
Yore MM, Liby KT, Honda T, Gribble GW, Sporn MB. The synthetic triterpenoid 1-[2-cyano-3, 12-dioxooleana-1, 9 (11)-dien-28-oyl]imidazole blocks nuclear factor-κB activation through direct inhibition of IκB kinase β. Mol Cancer Ther 2006;5:3232-9. (Pubitemid 46092066)
-
(2006)
Molecular Cancer Therapeutics
, vol.5
, Issue.12
, pp. 3232-3239
-
-
Yore, M.M.1
Liby, K.T.2
Honda, T.3
Gribble, G.W.4
Sporn, M.B.5
-
27
-
-
30344443429
-
-
United States Environmental Protection Agency (EPA) EPA/630/P-03/001B, March
-
United States Environmental Protection Agency (EPA). Guidelines for Carcinogen Risk Assessment EPA/630/P-03/001B, March 2005.
-
(2005)
Guidelines for Carcinogen Risk Assessment
-
-
|