Scientific uses of animals: Harm-benefit analysis and complementary approaches to implementing the Three Rs

OIE Revue Scientifique et Technique

Volumn 33, Issue 1, 2014, Pages 265-272

  Griffin, G ^a   MacArthur Clark, J ^b   Zurlo, J ^c   Ritskes Hoitinga, M ^d  

^a Canadian Council on Animal Care   (Canada)

^b Home Office Central Research Establishment   (United Kingdom)

^c JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^d RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Experimental design; Harm benefit analysis; Meta analysis; Publication standard; Reduction; Refinement; Systematic review; Three Rs

Indexed keywords

ANIMAL; ANIMAL RIGHTS; ANIMAL TESTING ALTERNATIVE; ANIMAL WELFARE; ARTICLE; METHODOLOGY; STANDARD;

ANIMAL RIGHTS; ANIMAL TESTING ALTERNATIVES; ANIMAL WELFARE; ANIMALS; RESEARCH DESIGN;

EID: 84904311711     PISSN: 02531933     EISSN: 16080645     Source Type: Journal    
DOI: 10.20506/rst.33.1.2283     Document Type: Article

References (41)

1. Russell W.M.S. & Burch R.L. (1959). - The principles of humane experimental technique. Methuen, London.
2. National Centre for Replacement, Refinement and Reduction of Animals in Research (NC3Rs) (2008). - Views on the Three Rs: Survey Report 2008. Available at: www.nc3rs.org.uk/downloaddoc.asp?id=836 (accessed on 9 July 2013).
3. Fenwick N., Danielson F & Griffin G. (2011). - Survey of Canadian animal-based researchers' views on the Three Rs: replacement, reduction and refinement. PLoS ONE, 6, e22478. doi:10.1371/joumal.pone.0022478.
4. Guillén J. (ed.) (2013). - Laboratory animals: regulations and recommendations for global collaborative research. Academic Press, Waltham, MA.
5. Bentham J. (1776). - Preface. In A fragment on Government. T. Payne, R Elmsly & E. Brooke, London.
6. Animal Welfare Act (1985). - 9 CFR Subchapter A. Office of the Federal Register, Washington, DC.
7. Animals (Scientific Procedures) Act (1986). - Chapter 14: an Act to make new provision for the protection of animals used for experimental or other scientific purposes (20 May 1986). Her Majesty's Stationery Office, London. Available at: www.legislation.gov.uk/ukpga/1986/14/enacted (accessed on 4 July 2013).
8. Williams VM., Mellor D.J. & Marbrook J. (2006). - Revision of a scale for assessing the severity of live animal manipulations. ALTEX, 23, Special Issue, 163-169.
9. Animal Procedures Committee (1994). - Report of the Animal Procedures Committee for 1993. Her Majesty's Stationery Office, London, 27-30. Available at: www.official-documents.gov.uk/document/cm27/2730/2730.pdf (accessed on 14 July 2013).
10. Animal Procedures Committee (2003). - Review of cost-benefit assessment in the use of animals in research. Her Majesty's Stationery Office, London. Available at: www.gov.uk/government/uploads/system/uploads/attachment-data/file/ 119027/cost-benefit-assessment.pdf (accessed on 15 July 2013).
11. Mellor D.J. & Reid C.S.W (1994). - Concepts of animal well-being and predicting the impact of procedures on experimental animals. In Improving the well-being of animals in the research environment (R. Baker, G. Jenkin & D.J. Mellor, eds). Australian and New Zealand Council for the Care of Animals in Research and Teaching, Glen Osmond, South Australia, 3-18.
12. European Union (2010). - Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010 on the protection of animals used for scientific purposes, Article 38.2 (d). Off. J. Eur. Union., L276, 47. Available at: eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2010:276:0033:0079:en: PDF (accessed on 9 July 2013).
13. National Research Council (2011). - Guide for the care and use of laboratory animals, 8th Ed. National Academy Press, Washington, DC.
14. World Organisation for Animal Health (OIE) (2011). - Use of animals in research and education. In Terrestrial Animal Health Code, 20th Ed. OIE, Paris, 397-407.
15. Demers G., Griffin G., De Vroey G., Haywood J.R., Zurlo J. & Bédard M. (2006). - Harmonization of animal care and use guidance. Saence, 312 (5771), 700-701.
16. Smith J.A., van den Broek E.A.R., Canto Martorell J., Hackbarth H., Ruksenas O. & Zeller W (2007). - Principles and practice in ethical review of animal experiments across Europe: summary of the report of a FELASA working group on ethical evaluation of animal experiments. Lab. Anim., 41, 143-160. (Pubitemid 46733403)
17. Balls M., Goldberg A.M., Fernem J.H., Broadhead C.L., Burch R.L., Festtag M.E.W. & van Zutphen B.F.M. (1995). - The three Rs: the way forward. The report and recommendations of the ECVAM workshop 11. Alternatives Lab. Anim., 23, 838-866.
18. Weary D.M. (2012). - A good life for laboratory animals: how far must refinement go? In Proc. of the 8th World Congress on Alternatives and Animal Use in the Life Sciences, 21-25 August 2011, Montreal. ALTEX Proc, 1/12, 11-13.
19. Howard B., Nevalainen T. & Perretta G. (eds) (2010). - The COST manual of laboratory animal care and use: refinement, reduction and research. CRC Press, Boca Raton.
20. Institute for Laboratory Animal Research (ILAR) (2001). - Impact of non-invasive technology on animal research. ILAR J., 42 (3), 187-262.
21. Institute for Laboratory Animal Research (ILAR) (2002). - Advanced physiological monitoring in rodents. ILAR J., 43 (3), 121-182.
22. Laule G.E., Bloomsmith M.A. & Schapiro S.J. (2003). - The use of positive reinforcement training techniques to enhance the care, management and welfare of primates in the laboratory. J. appl. anim. Welf. Sci., 6, 163-173. (Pubitemid 39172252)
23. Fenwick N. & Griffin G. (2013). - Balancing reduction and refinement. Alternatives Lab. Anim., 41 (3), P1-P3.
24. Leenaars M., Savenije B., Nachtegaal A., van der Vaart L. & Ritskes-Hoitinga M. (2009). - Assessing the search for and implementation of the three Rs: a survey among scientists. Alternatives Lab. Anim., 37 (3), 297-305.
25. Roi A.J., Richmond J. & Grune B. (2011). - The ECVAM search guide: good search practice on animal alternatives. European Commission, Joint Research Centre, Ispra, Italy. doi:10.2788/98187.
26. Altweb Project Team (2013). - A stet-by-step approach to an alternatives search. Alternatives to Animal Testing Website. Available at: altweb.jhsph.edu/resources/searchalt/index.html (accessed on 9 July 2013).
27. Canadian Council on Animal Care (CCAC) (2013). - Three Rs Search Guide. A step-by-step strategy for Three Rs information searches. CCAC, Ottawa. Available at: 3rs.ccac.ca/en/searches-and-animal-index/guide/step-by-step-guide/ (accessed on 9 July 2013).
28. Van Luijk J., Leenaars M., van Dongen A.M., van der Vaart L. & Ritskes-Hoitinga M. (2012). - Outcomes of a Dutch workshop on improvements for the 3Rs in daily practice. ALTEX, 29 (4), 440-443.
29. De Vries R.B., Buma P., Leenaars M., Ritskes-Hoitinga M. & Gordijn B. (2012). - Reducing the number of laboratory animals used in tissue engineering research by restricting the variety of animal models. Articular cartilage engineering as a case study. Tissue Engin. Part B Rev., 18 (6), 427-435. doi:10.1089/ten.TEB.2012.0059.
30. Sena E.S., Briscoe C.L., Howells D.W, Donnan G.A., Sandercock P.A. & Macleod M.R. (2010). - Factors affecting the apparent efficacy and safety of tissue plasminogen activator in thrombotic occlusion models of stroke: systematic review and meta-analysis. J. cereb. Blood Flow Metab., 30, 1905-1913.
31. Horn J., De Haan R.J., Vermeulen M., Luiten P.G.M. & Limburg M. (2001). - Nimodipine in animal model experiments of focal cerebral ischemia: a systematic review. Stroke, 32 (10), 2433-2438. doi:10.1161/hsl001.096009. (Pubitemid 32954819)
32. Pound P., Ebrahim S., Sandercock P., Bracken M.B., Roberts I. & Reviewing Animal Trials Systematically (RATS) Group (2004). - Where is the evidence that animal research benefits humans? BMJ, 328, 514-517. (Pubitemid 38293622)
33. Kilkenny C, Parsons N., Kadyszewski E., Festing M.F.W., Cuthill I.C., Fry D., Hutton J. & Altman D.G. (2009). - Survey of the quality of experimental design, statistical analysis and reporting of research using animals. PLoS ONE, 4, e7824. doi:10.1371/jouraal.pone.000782443:194-201.
34. Leenaars M., Ritskes-Hoitinga M., Griffin G. & Ormandy E. (2012). - Background to the Montréal Declaration on the synthesis of evidence to advance the 3Rs principles in science, as adopted by the 8th World Congress on Alternative and Animal Use in the Life Sciences, Montréal, Canada, on 25 August 2011. ALTEX Proc, 1/12, 35-38
35. Kilkenny C, Browne W.J., Cuthill I.C., Emerson M. & Altman D.G. (2010). - Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. PLoS Biol, 8 (6), e1000412. doi:10.1371/joumal.pbio. 1000412.
36. Hooijmans CR., Leenaars M. & Ritskes-Hoitinga M. (2010). - A gold standard publication checklist for improving quality of animal studies, fully integrate the 3Rs and to make systematic reviews feasible. Alternatives Lab. Anim., 38, 167-182.
37. National Research Council (2011). - Guidance for the description of animal research in scientific publications. National Academies Press, Washington, DC.
38. Landis S.C., Amara S.G., Asadullah K., Austin C.P., Blumenstein R., Bradley E.W, Crystal R.G., Darnell R.B., Ferrante R.J., Fillit H., Finkelstein R., Fisher M., Gendelman H.E., Golub R.M., Goudreau J.L., Gross R.A., Gubitz A.K., Hesterlee S.E., Howells D.W, Huguenard J., Keiner K., Koroshetz W., Krainc D., Lazic S.E., Levine M.S., Macleod M.R., McCall J.M., Moxley III R.T., Narasimhan K., Noble L.J., Perrin S., Porter J.D., Steward O., Unger E., Utz U. & Silberberg S.D. (2012). - A call for transparent reporting to optimize the predictive value of preclinical research. Nature, 490 (7419), 187-191. doi:10.1038/naturell5537.
39. Ioannidis J.E.A. (2012). - Extrapolating from animals to humans. Sci. transi Med., 4 (151), 151ps15. doi:10.1126/scitranslmed.3004631.
40. De Vries R.B., Leenaars M., Tra J., Jan Huijbregtse R., Bongers E., Jansen J.A., Gordijn B. & Ritskes-Hoitinga M. (2013). - The potential of tissue engineering for developing alternatives to animal experiments: a systematic review. J. Tissue Eng. regen. Med. E-pub. ahead of print: 3 April. doi:10.1002/term.l703.
41. Hooijmans C. & Ritskes-Hoitinga M. (2013). - Progress in systematic reviews of animal studies in the context of translational research. PLoS Med, 10 (7), e1001482. doi:10.1371/joumal.pmed.1001482.