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Volumn 175, Issue 2, 2014, Pages 233-239

Ferric carboxymaltose improves exercise capacity and quality of life in patients with pulmonary arterial hypertension and iron deficiency: A pilot study

Author keywords

Ferric carboxymaltose; Iron; Iron deficiency; Pulmonary arterial hypertension (PAH)

Indexed keywords

FERRIC CARBOXYMALTOSE; FERRITIN; IRON; TRANSFERRIN; FERRIC ION; MALTOSE;

EID: 84904268951     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2014.04.233     Document Type: Article
Times cited : (82)

References (38)
  • 1
    • 84890776626 scopus 로고    scopus 로고
    • Definition and diagnosis of pulmonary hypertension
    • M. Hoeper, H.J. Bogaard, and R. Condliffe et al. Definition and diagnosis of pulmonary hypertension J Am Coll Cardiol 62 Suppl. D 2013 D42 D50
    • (2013) J Am Coll Cardiol , vol.62 , Issue.SUPPL. D
    • Hoeper, M.1    Bogaard, H.J.2    Condliffe, R.3
  • 2
    • 70049112901 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and treatment of pulmonary hypertension: The Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT)
    • N. Galiè, M.M. Hoeper, and M. Humbert et al. Guidelines for the diagnosis and treatment of pulmonary hypertension: The Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT) Eur Heart J 30 2009 2493 2537
    • (2009) Eur Heart J , vol.30 , pp. 2493-2537
    • Galiè, N.1    Hoeper, M.M.2    Humbert, M.3
  • 3
    • 64849109410 scopus 로고    scopus 로고
    • ACCF/AHA 2009 expert consensus document on pulmonary hypertension: A report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association developed in collaboration with the American College of Chest Physicians; American Thoracic Society, Inc.; And the Pulmonary Hypertension Association
    • V.V. McLaughlin, S.L. Archer, and D.B. Badesch et al. ACCF/AHA 2009 expert consensus document on pulmonary hypertension: a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents and the American Heart Association developed in collaboration with the American College of Chest Physicians; American Thoracic Society, Inc.; and the Pulmonary Hypertension Association J Am Coll Cardiol 53 2009 1573 1619
    • (2009) J Am Coll Cardiol , vol.53 , pp. 1573-1619
    • McLaughlin, V.V.1    Archer, S.L.2    Badesch, D.B.3
  • 4
    • 77954759389 scopus 로고    scopus 로고
    • Predicting survival in pulmonary arterial hypertension: Insights from the Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL)
    • R.L. Benza, D.P. Miller, and M. Gomberg-Maitland et al. Predicting survival in pulmonary arterial hypertension: insights from the Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL) Circulation 122 2010 164 172
    • (2010) Circulation , vol.122 , pp. 164-172
    • Benza, R.L.1    Miller, D.P.2    Gomberg-Maitland, M.3
  • 5
    • 77954758530 scopus 로고    scopus 로고
    • Survival in patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension in the modern management era
    • M. Humbert, O. Sitbon, and A. Chaouat et al. Survival in patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension in the modern management era Circulation 122 2010 156 163
    • (2010) Circulation , vol.122 , pp. 156-163
    • Humbert, M.1    Sitbon, O.2    Chaouat, A.3
  • 6
    • 84885316129 scopus 로고    scopus 로고
    • Idiopathic pulmonary arterial hypertension in the elderly: Results from the COMPERA registry
    • M.M. Hoeper, D. Huscher, and A.H. Ghofrani et al. Idiopathic pulmonary arterial hypertension in the elderly: results from the COMPERA registry Int J Cardiol 168 2013 871 880
    • (2013) Int J Cardiol , vol.168 , pp. 871-880
    • Hoeper, M.M.1    Huscher, D.2    Ghofrani, A.H.3
  • 7
    • 84890574392 scopus 로고    scopus 로고
    • Updated treatment algorithm of pulmonary arterial hypertension
    • N. Galiè, P.A. Corris, and A. Frost et al. Updated treatment algorithm of pulmonary arterial hypertension J Am Coll Cardiol 62 Suppl. D 2013 D60 D72
    • (2013) J Am Coll Cardiol , vol.62 , Issue.SUPPL. D
    • Galiè, N.1    Corris, P.A.2    Frost, A.3
  • 8
    • 84855374692 scopus 로고    scopus 로고
    • Treatment of pulmonary arterial hypertension: Updated recommendations of the Cologne Consensus Conference 2011
    • H.A. Ghofrani, O. Distler, and F. Gerhardt et al. Treatment of pulmonary arterial hypertension: updated recommendations of the Cologne Consensus Conference 2011 Int J Cardiol 154 Suppl. 2011 S20 S33
    • (2011) Int J Cardiol , vol.154 , Issue.SUPPL.
    • Ghofrani, H.A.1    Distler, O.2    Gerhardt, F.3
  • 9
    • 79958005700 scopus 로고    scopus 로고
    • Iron deficiency is common in idiopathic pulmonary arterial hypertension
    • G. Ruiter, S. Lankhorst, A. Boonstra, and A. Vonk-Noordegraaf et al. Iron deficiency is common in idiopathic pulmonary arterial hypertension Eur Respir J 37 2011 1386 1391
    • (2011) Eur Respir J , vol.37 , pp. 1386-1391
    • Ruiter, G.1    Lankhorst, S.2    Boonstra, A.3    Vonk-Noordegraaf, A.4
  • 10
    • 79953027647 scopus 로고    scopus 로고
    • Unexplained iron deficiency in idiopathic and heritable pulmonary arterial hypertension
    • E. Soon, C.M. Treacy, and M.R. Toshner et al. Unexplained iron deficiency in idiopathic and heritable pulmonary arterial hypertension Thorax 66 2011 326 332
    • (2011) Thorax , vol.66 , pp. 326-332
    • Soon, E.1    Treacy, C.M.2    Toshner, M.R.3
  • 11
    • 79960031695 scopus 로고    scopus 로고
    • Iron deficiency and raised hepcidin in idiopathic pulmonary arterial hypertension: Clinical prevalence, outcomes and mechanistic insights
    • C.J. Rhodes, L.S. Howard, and M. Busbridge et al. Iron deficiency and raised hepcidin in idiopathic pulmonary arterial hypertension: clinical prevalence, outcomes and mechanistic insights J Am Coll Cardiol 58 2011 300 309
    • (2011) J Am Coll Cardiol , vol.58 , pp. 300-309
    • Rhodes, C.J.1    Howard, L.S.2    Busbridge, M.3
  • 12
    • 69449099102 scopus 로고    scopus 로고
    • Usefulness of red cell distribution width as a prognostic marker in pulmonary hypertension
    • C.V. Hampole, A.K. Mehrotra, T. Thenappan, M. Gomberg-Maitland, and S.J. Shah Usefulness of red cell distribution width as a prognostic marker in pulmonary hypertension Am J Cardiol 104 2009 868 872
    • (2009) Am J Cardiol , vol.104 , pp. 868-872
    • Hampole, C.V.1    Mehrotra, A.K.2    Thenappan, T.3    Gomberg-Maitland, M.4    Shah, S.J.5
  • 13
    • 79960558103 scopus 로고    scopus 로고
    • Association of anaemia and long-term survival in patients with pulmonary hypertension
    • R. Krasuski, S. Hart, B. Smith, A. Wang, J. Harrison, and T. Bashore Association of anaemia and long-term survival in patients with pulmonary hypertension Int J Cardiol 150 2010 291 295
    • (2010) Int J Cardiol , vol.150 , pp. 291-295
    • Krasuski, R.1    Hart, S.2    Smith, B.3    Wang, A.4    Harrison, J.5    Bashore, T.6
  • 14
    • 84892533041 scopus 로고    scopus 로고
    • Iron deficiency in systemic sclerosis patients with and without pulmonary hypertension
    • G. Ruiter, I.J. Lanser, and F.S. de Man et al. Iron deficiency in systemic sclerosis patients with and without pulmonary hypertension Rheumatology 53 2014 285 292
    • (2014) Rheumatology , vol.53 , pp. 285-292
    • Ruiter, G.1    Lanser, I.J.2    De Man, F.S.3
  • 15
    • 72449156527 scopus 로고    scopus 로고
    • Ferric carboxymaltose in patients with heart failure and iron deficiency
    • S. Anker, J. Comin Colet, and G. Filippatos et al. Ferric carboxymaltose in patients with heart failure and iron deficiency N Engl J Med 36125 2009 2436 2448
    • (2009) N Engl J Med , vol.3612 , pp. 2436-2448
    • Anker, S.1    Comin Colet, J.2    Filippatos, G.3
  • 16
    • 77954249308 scopus 로고    scopus 로고
    • Two to tango: Regulation of mammalian iron metabolism
    • M.W. Hentze, M.U. Muckenthaler, B. Galy, and C. Camaschella Two to tango: regulation of mammalian iron metabolism Cell 142 2010 24 38
    • (2010) Cell , vol.142 , pp. 24-38
    • Hentze, M.W.1    Muckenthaler, M.U.2    Galy, B.3    Camaschella, C.4
  • 17
    • 77953661132 scopus 로고    scopus 로고
    • Guidelines for the echocardiographic assessment of the right heart in adults: A report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography
    • L.G. Rudski, W.W. Lai, and J. Afilalo et al. Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography J Am Soc Echocardiogr 7 2010 685 713
    • (2010) J Am Soc Echocardiogr , vol.7 , pp. 685-713
    • Rudski, L.G.1    Lai, W.W.2    Afilalo, J.3
  • 18
    • 34547575036 scopus 로고    scopus 로고
    • Measurements during integrative cardiopulmonary exercise testing
    • 5th ed Lippincott Williams & Wilkins Philadelphia
    • K. Wasserman, J.E. Hansen, and D.Y. Sue et al. Measurements during integrative cardiopulmonary exercise testing Principles of exercise testing and interpretation 5th ed 2012 Lippincott Williams & Wilkins Philadelphia 71 103
    • (2012) Principles of Exercise Testing and Interpretation , pp. 71-103
    • Wasserman, K.1    Hansen, J.E.2    Sue, D.Y.3
  • 19
    • 0036644465 scopus 로고    scopus 로고
    • ATS statement: Guidelines for the six-minute walk test
    • ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories
    • ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories ATS statement: guidelines for the six-minute walk test Am J Respir Crit Care Med 166 2002 111 117
    • (2002) Am J Respir Crit Care Med , vol.166 , pp. 111-117
  • 20
    • 0026679838 scopus 로고
    • Structure/histotoxicity relationship of parenteral iron preparations
    • P. Geisser, M. Baer, and E. Schaub Structure/histotoxicity relationship of parenteral iron preparations Arzneimittelforschung 42 1992 1439 1452
    • (1992) Arzneimittelforschung , vol.42 , pp. 1439-1452
    • Geisser, P.1    Baer, M.2    Schaub, E.3
  • 21
    • 17944391767 scopus 로고
    • Intravenous iron-dextran: Therapeutic and experimental possibilities
    • A.M. Ganzoni Intravenous iron-dextran: therapeutic and experimental possibilities Schweiz Med Wochenschr 100 1970 301 303
    • (1970) Schweiz Med Wochenschr , vol.100 , pp. 301-303
    • Ganzoni, A.M.1
  • 22
    • 0017074814 scopus 로고
    • Iron deficiency in the rat. Physiological and biochemical studies of muscle dysfunction
    • C.A. Finch, L.R. Miller, and A.R. Inamdar et al. Iron deficiency in the rat. Physiological and biochemical studies of muscle dysfunction J Clin Invest 58 1976 447 453
    • (1976) J Clin Invest , vol.58 , pp. 447-453
    • Finch, C.A.1    Miller, L.R.2    Inamdar, A.R.3
  • 23
    • 76549117399 scopus 로고    scopus 로고
    • Peripheral muscle dysfunction in idiopathic pulmonary arterial hypertension
    • V. Mainguy, F. Maltais, and D. Saey et al. Peripheral muscle dysfunction in idiopathic pulmonary arterial hypertension Thorax 65 2010 113 117
    • (2010) Thorax , vol.65 , pp. 113-117
    • Mainguy, V.1    Maltais, F.2    Saey, D.3
  • 24
    • 84890044082 scopus 로고    scopus 로고
    • Intravenous ferric carboxymaltose in iron-deficient chronic heart failure patients with and without anaemia: A subanalysis of the FAIR-HF trial
    • G. Filippatos, D. Farmakis, and J.C. Colet et al. Intravenous ferric carboxymaltose in iron-deficient chronic heart failure patients with and without anaemia: a subanalysis of the FAIR-HF trial Eur J Heart Fail 15 2013 1267 1276
    • (2013) Eur J Heart Fail , vol.15 , pp. 1267-1276
    • Filippatos, G.1    Farmakis, D.2    Colet, J.C.3
  • 25
    • 84864493727 scopus 로고    scopus 로고
    • ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012
    • J.J. McMurray, S. Adamopoulos, and S.D. Anker et al. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012 Eur Heart J 33 2012 1787 1847
    • (2012) Eur Heart J , vol.33 , pp. 1787-1847
    • McMurray, J.J.1    Adamopoulos, S.2    Anker, S.D.3
  • 26
    • 84875500204 scopus 로고    scopus 로고
    • Treatment of anemia with darbepoetin alfa in systolic heart failure
    • K. Swedberg, J.B. Young, and I.S. Anand et al. Treatment of anemia with darbepoetin alfa in systolic heart failure N Engl J Med 368 2013 1210 1219
    • (2013) N Engl J Med , vol.368 , pp. 1210-1219
    • Swedberg, K.1    Young, J.B.2    Anand, I.S.3
  • 27
    • 0037046175 scopus 로고    scopus 로고
    • Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor
    • C. Atkinson, S. Stewart, and P.D. Upton et al. Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor Circulation 105 2002 1672 1678
    • (2002) Circulation , vol.105 , pp. 1672-1678
    • Atkinson, C.1    Stewart, S.2    Upton, P.D.3
  • 28
    • 84890687841 scopus 로고    scopus 로고
    • Genetics and genomics of pulmonary arterial hypertension
    • F. Soubrier, W.K. Chung, and R. Machado et al. Genetics and genomics of pulmonary arterial hypertension J Am Coll Cardiol 63 Suppl. D 2013 D13 D21
    • (2013) J Am Coll Cardiol , vol.63 , Issue.SUPPL. D
    • Soubrier, F.1    Chung, W.K.2    Machado, R.3
  • 29
    • 63449103712 scopus 로고    scopus 로고
    • BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism
    • B. Andriopoulos Jr., E. Corradini, and Y. Xia et al. BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism Nat Genet 41 2009 482 487
    • (2009) Nat Genet , vol.41 , pp. 482-487
    • Andriopoulos Jr., B.1    Corradini, E.2    Xia, Y.3
  • 30
    • 72249109128 scopus 로고    scopus 로고
    • Iron-induced expression of bone morphogenic protein 6 in intestinal cells is the main regulator of hepatic hepcidin expression in vivo
    • S. Arndt, U. Maegdefrau, C. Dorn, K. Schardt, C. Hellerbrand, and A.K. Bosserhoff Iron-induced expression of bone morphogenic protein 6 in intestinal cells is the main regulator of hepatic hepcidin expression in vivo Gastroenterology 138 2010 372 382
    • (2010) Gastroenterology , vol.138 , pp. 372-382
    • Arndt, S.1    Maegdefrau, U.2    Dorn, C.3    Schardt, K.4    Hellerbrand, C.5    Bosserhoff, A.K.6
  • 31
    • 84865804912 scopus 로고    scopus 로고
    • The minimal important difference in the 6 minute walk test for patiens with pulmonary arterial hypertension
    • S.C. Mattei, M.A. Puhan, D. Lam, and R.A. Wise The minimal important difference in the 6 minute walk test for patiens with pulmonary arterial hypertension Am J Respir Crit Care Med 186 2012 428 433
    • (2012) Am J Respir Crit Care Med , vol.186 , pp. 428-433
    • Mattei, S.C.1    Puhan, M.A.2    Lam, D.3    Wise, R.A.4
  • 32
    • 84883108940 scopus 로고    scopus 로고
    • For the SERAPHIN Investigators. Macitentan and morbidity and mortality in pulmonary arterial hypertension
    • T. Pulido, I. Adzerikho, and R.N. Channick et al. for the SERAPHIN Investigators. Macitentan and morbidity and mortality in pulmonary arterial hypertension N Engl J Med 369 2013 809 818
    • (2013) N Engl J Med , vol.369 , pp. 809-818
    • Pulido, T.1    Adzerikho, I.2    Channick, R.N.3
  • 33
    • 84880721470 scopus 로고    scopus 로고
    • For the PATENT Investigators. Riociguat for the treatment of pulmonary arterial hypertension
    • H.A. Ghofrani, N. Galiè, and F. Grimminger et al. for the PATENT Investigators. Riociguat for the treatment of pulmonary arterial hypertension N Engl J Med 369 2013 330 340
    • (2013) N Engl J Med , vol.369 , pp. 330-340
    • Ghofrani, H.A.1    Galiè, N.2    Grimminger, F.3
  • 34
    • 84867355830 scopus 로고    scopus 로고
    • Iron chelation inhibits the development of pulmonary vascular remodeling
    • C.M. Wong, I.R. Preston, N.S. Hill, and Y.J. Suzuki Iron chelation inhibits the development of pulmonary vascular remodeling Free Radic Biol Med 53 2012 1738 1747
    • (2012) Free Radic Biol Med , vol.53 , pp. 1738-1747
    • Wong, C.M.1    Preston, I.R.2    Hill, N.S.3    Suzuki, Y.J.4
  • 35
    • 70349909823 scopus 로고    scopus 로고
    • Effects of iron supplementation and depletion on hypoxic pulmonary hypertension: Two randomized controlled trials
    • T.G. Smith, N.P. Talbot, and C. Privat et al. Effects of iron supplementation and depletion on hypoxic pulmonary hypertension: two randomized controlled trials JAMA 302 2009 1444 1450
    • (2009) JAMA , vol.302 , pp. 1444-1450
    • Smith, T.G.1    Talbot, N.P.2    Privat, C.3
  • 36
    • 84873338684 scopus 로고    scopus 로고
    • Deletion of iron regulatory protein 1 causes polycythemia and pulmonary hypertension in mice through translational depression of HIF2a
    • M.C. Ghosh, D.L. Zhang, and S.Y. Jeong et al. Deletion of iron regulatory protein 1 causes polycythemia and pulmonary hypertension in mice through translational depression of HIF2a Cell Metab 17 2013 271 281
    • (2013) Cell Metab , vol.17 , pp. 271-281
    • Ghosh, M.C.1    Zhang, D.L.2    Jeong, S.Y.3
  • 37
    • 84863116742 scopus 로고    scopus 로고
    • A systematic survey of loss-of-function variants in human protein-coding genes
    • D.G. MacArthur, S. Balasubramanian, and A. Frankish et al. A systematic survey of loss-of-function variants in human protein-coding genes Science 335 2012 823 828
    • (2012) Science , vol.335 , pp. 823-828
    • Macarthur, D.G.1    Balasubramanian, S.2    Frankish, A.3
  • 38
    • 0025042548 scopus 로고
    • Serum transferrin receptor as an index of iron absorption
    • J.D. Cook, S. Dassenko, and B.S. Skikne et al. Serum transferrin receptor as an index of iron absorption Br J Hematol 75 1990 603 609
    • (1990) Br J Hematol , vol.75 , pp. 603-609
    • Cook, J.D.1    Dassenko, S.2    Skikne, B.S.3


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