A splice variant of the two-pore domain potassium channel TREK-1 with only one pore domain reduces the surface expression of full-length TREK-1 channels

Pflugers Archiv European Journal of Physiology

Volumn 466, Issue 8, 2014, Pages 1559-1570

  Rinné, Susanne ^a   Renigunta, Vijay ^a   Schlichthörl, Günter ^a   Zuzarte, Marylou ^a   Bittner, Stefan ^b   Meuth, Sven G ^b   Decher, Niels ^a   Daut, Jürgen ^a   Preisig Müller, Regina ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Alternative splicing; Potassium channels; Splice variant; TREK 1

Indexed keywords

CD8 ANTIGEN; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR2.1; NEUROMODULIN; POTASSIUM CHANNEL; POTASSIUM CHANNEL TREK 1; POTASSIUM CHANNEL TREK 1C; POTASSIUM CHANNEL TREK 1D; POTASSIUM CHANNEL TREK 1E; UNCLASSIFIED DRUG; ISOPROTEIN; POTASSIUM CHANNEL PROTEIN TREK-1; TANDEM PORE DOMAIN POTASSIUM CHANNEL;

ADRENAL GLAND; ALTERNATIVE RNA SPLICING; AMINO ACID SEQUENCE; AMYGDALOID NUCLEUS; ANIMAL CELL; ARTICLE; CELL SURFACE; CONTROLLED STUDY; EXON SKIPPING; FEMALE; FRAMESHIFT MUTATION; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; KIDNEY; MUTAGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; RAT; STOP CODON; TRANSLATION INITIATION; XENOPUS LAEVIS; ANIMAL; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOLECULAR GENETICS; PROTEIN TERTIARY STRUCTURE; PROTEIN TRANSPORT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SITE DIRECTED MUTAGENESIS; TWO HYBRID SYSTEM; WESTERN BLOTTING;

AMINO ACID SEQUENCE; ANIMALS; BLOTTING, WESTERN; GENE EXPRESSION REGULATION; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; POTASSIUM CHANNELS, TANDEM PORE DOMAIN; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 84904267859     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-013-1384-z     Document Type: Article

References (26)

1. Bittner S, Ruck T, Schuhmann MK, Herrmann AM, Maati HM, Bobak N, Gobel K, Langhauser F, Stegner D, Ehling P, Borsotto M, Pape HC, Nieswandt B, Kleinschnitz C, Heurteaux C, Galla HJ, Budde T, Wiendl H, Meuth SG (2013) Endothelial TWIK-related potassium channel-1 (TREK1) regulates immune-cell trafficking into the CNS. Nat Med 19:1161-1165. doi:10.1038/nm.3303
2. Bockenhauer D, Zilberberg N, Goldstein SA (2001) KCNK2 : reversible conversion of a hippocampal potassium leak into a voltage-dependent channel. Nat Neurosci 4:486-491. doi:10.1038/87434 (Pubitemid 32397185)
3. + ion channel. Science 335:436-441. doi:10.1126/science.1213808
4. + channel. EMBO J 15:6854-6862, PMID: 9003761
5. Franks NP, Honore E (2004) The TREK K2P channels and their role in general anaesthesia and neuroprotection. Trends Pharmacol Sci 25:601-608. doi:10.1016/j.tips.2004.09.003 (Pubitemid 39371151)
6. Gu W, Schlichthörl G, Hirsch JR, Engels H, Karschin C, Karschin A, Derst C, Steinlein OK, Daut J (2002) Expression pattern and functional characteristics of two novel splice variants of the two-pore-domain potassium channel TREK-2. J Physiol 539:657-668. doi:10.1113/jphysiol.2001.013432 (Pubitemid 35175418)
7. Han J, Kang D, Kim D (2003) Functional properties of four splice variants of a human pancreatic tandem-pore K+ channel, TALK-1. Am J Physiol Cell Physiol 285:C529-C538. doi:10.1152/ajpcell.00601.2002 (Pubitemid 37022050)
8. Kim D (2005) Physiology and pharmacology of two-pore domain potassium channels. Curr Pharm Des 11:2717-2736. doi:10.2174/1381612054546824
9. + channel subunits: kinetic properties and expression in rat heart. Am J Physiol 277:H1669-H1678, PMID: 10564119
10. 2+-gated (Slo1) potassium channels. FEBS Lett 581:1000-1008. doi:10.1016/j.febslet.2007.01.077
11. Ma D, Zerangue N, Lin YF, Collins A, YuM, Jan YN, Jan LY (2001) Role of ER export signals in controlling surface potassium channel numbers. Science 291:316-319. doi:10.1126/science.291.5502.316 (Pubitemid 32096319)
12. Miller AN, Long SB (2012) Crystal structure of the human two-pore domain potassium channel K2P1. Science 335:432-436. doi:10.1126/science.1213274
13. + channel gene KCNK4 . Chromosomal localization, tissue distribution and functional expression. Brain Res Mol Brain Res 102:18-27
14. + channel. J Biol Chem 275:28722-28730. doi:10.1074/jbc.M003755200
15. Renigunta V, Yuan H, Zuzarte M, Rinné S, Koch A, Wischmeyer E, Schlichthörl G, Gao Y, Karschin A, Jacob R, Schwappach B, Daut J, Preisig-Müller R (2006) The retention factor p11 confers an endoplasmic reticulum-localization signal to the potassium channel TASK-1. Traffic 7:168-181. doi:10.1111/j.1600-0854.2005.00375.x
16. Schutze MP, Peterson PA, Jackson MR (1994) An N-terminal double-arginine motif maintains type II membrane proteins in the endoplasmic reticulum. EMBO J 13:1696-1705 (Pubitemid 24114722)
17. Simkin D, Cavanaugh EJ, Kim D (2008) Control of the single channel conductance of K2P10.1 (TREK-2) by the amino-terminus: role of alternative translation initiation. J Physiol 586:5651-5663. doi:10.1113/jphysiol.2008. 161927
18. + channels. J Physiol 589:3709-3720. doi:10.1113/jphysiol.2011.210666
19. Thomas D, Plant LD, Wilkens CM, McCrossan ZA, Goldstein SA (2008) Alternative translation initiation in rat brain yields K2P2.1 potassium channels permeable to sodium. Neuron 58:859-870. doi:10.1016/j.neuron.2008.04.016 (Pubitemid 351842748)
20. Veale EL, Rees KA, Mathie A, Trapp S (2010) Dominant negative effects of a non-conducting TREK1 splice variant expressed in brain. J Biol Chem 285:29295-29304. doi:10.1074/jbc.M110.108423
21. Wu YY, Singer CA, Buxton IL (2012) Variants of stretch-activated two-pore potassium channel TREK-1 associated with preterm labor in humans. Biol Reprod 87:96. doi:10.1095/biolreprod.112.099499
22. Xian Tao L, Dyachenko V, Zuzarte M, Putzke C, Preisig-Müller R, Isenberg G, Daut J (2006) The stretch-activated potassium channel TREK-1 in rat cardiac ventricular muscle. Cardiovasc Res 69:86-97. doi:10.1016/j.cardiores. 2005.08.018 (Pubitemid 41814814)
23. Zerangue N, Schwappach B, Jan YN, Jan LY (1999) A new ER trafficking signal regulates the subunit stoichiometry of plasma membrane KATP channels. Neuron 22:537-548 (Pubitemid 29159852)
24. Zerangue N, Malan MJ, Fried SR, Dazin PF, Jan YN, Jan LY, Schwappach B (2001) Analysis of endoplasmic reticulum trafficking signals by combinatorial screening in mammalian cells. Proc Natl Acad Sci U S A 98:2431-2436. doi:10.1073/pnas.05163019898/5/2431 (Pubitemid 32209499)
25. Zuzarte M, Rinné S, Schlichthörl G, Schubert A, Daut J, Preisig-Müller R (2007) A di-acidic sequence motif enhances the surface expression of the potassium channel TASK-3. Traffic 8:1093-1100. doi:10.1111/j.1600-0854.2007.00593.x (Pubitemid 47074041)
26. + channels TASK-1 and TASK-3: role of N- and C-terminal sorting signals and interaction with 14-3-3 proteins. J Physiol 587:929-952. doi:10.1113/jphysiol.2008.164756