Interactions of beta-blockers with model lipid membranes: Molecular view of the interaction of acebutolol, oxprenolol, and propranolol with phosphatidylcholine vesicles by time-dependent fluorescence shift and molecular dynamics simulations

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 87, Issue 3, 2014, Pages 559-569

  Först, Gesche ^a   Cwiklik, Lukasz ^b   Jurkiewicz, Piotr ^b   Schubert, Rolf ^a   Hof, Martin ^b  

^a UNIVERSITY OF FREIBURG   (Germany)

^b J HEYROVSKÝ INSTITUTE OF PHYSICAL CHEMISTRY   (Czech Republic)

Author keywords

Drug membrane interactions; Dtmac; Generalized polarization; Laurdan; Lipid hydration; MD; NME; Prodan; Solvent relaxation

Indexed keywords

ACEBUTOLOL; DTMAC; FLUORESCENT DYE; GLYCEROL; LAURDAN; OLEOYLPALMITOYLLECITHIN; OXPRENOLOL; PHOSPHATIDYLCHOLINE; PRODAN; PROPRANOLOL; UNCLASSIFIED DRUG; 1-PALMITOYL-2-OLEOYLPHOSPHATIDYLCHOLINE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; LIPID BILAYER; LIPOSOME; MEMBRANE LIPID;

ANALYTIC METHOD; ARTICLE; CONTROLLED STUDY; DRUG DIFFUSION; DRUG PENETRATION; FLAME PHOTOMETRY; GENERALIZED POLARIZATION; LIPID BILAYER; LIPID MEMBRANE; MEMBRANE VESICLE; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; POLARIZATION; STEADY STATE; TIME DEPENDENT FLUORESCENCE SHIFT; TIME RESOLVED EMISSION SPECTROSCOPY; FLUORESCENCE; METABOLISM;

ACEBUTOLOL; ADRENERGIC BETA-ANTAGONISTS; FLUORESCENCE; FLUORESCENT DYES; GLYCEROL; LIPID BILAYERS; LIPOSOMES; MEMBRANE LIPIDS; MOLECULAR DYNAMICS SIMULATION; OXPRENOLOL; PHOSPHATIDYLCHOLINES; PROPRANOLOL;

EID: 84904254877     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2014.03.013     Document Type: Article

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