Chlorine gas exposure disrupts nitric oxide homeostasis in the pulmonary vasculature

Toxicology

Volumn 321, Issue 1, 2014, Pages 96-102

  Honavar, Jaideep ^a   Bradley, Eddie ^b   Bradley, Kelley ^a   Oh, Joo Yeun ^a   Vallejo, Matthew O ^a   Kelley, Eric E ^e   Cantu Medellin, Nadiezhda ^e   Doran, Stephen ^c   Dell'italia, Louis J ^b,f   Matalon, Sadis ^c,d   Patel, Rakesh P ^a,d  

^a University of Alabama at Birmingham   (United States)

^b University of Alabama at Birmingham   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^e UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^f BIRMINGHAM VA MEDICAL CENTER   (United States)

Author keywords

Halogen; Inflammation; Lung

Indexed keywords

CHLORINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GUANYLATE CYCLASE; NITRIC OXIDE; NITRITE; SUPEROXIDE; SUPEROXIDE DISMUTASE; ENZYME INHIBITOR; HALOGEN; NITRIC OXIDE SYNTHASE;

AMBIENT AIR; ANIMAL EXPERIMENT; ARTERY CONSTRICTION; ARTICLE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LUNG ARTERY PRESSURE; LUNG BLOOD VESSEL; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY ARTERY; PULMONARY HYPERTENSION; RAT; VASODILATATION; WESTERN BLOTTING; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; GAS; HOMEOSTASIS; INFLAMMATION; LUNG; LUNG CIRCULATION; LUNG WEDGE PRESSURE; MALE; METABOLISM; MUSCLE TONE; SPRAGUE DAWLEY RAT; VASCULAR SMOOTH MUSCLE; VASOCONSTRICTION;

HALOGEN; INFLAMMATION; LUNG;

ANIMALS; CHLORINE; ENZYME INHIBITORS; GASES; HOMEOSTASIS; LUNG; MALE; MUSCLE TONUS; MUSCLE, SMOOTH, VASCULAR; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITES; PULMONARY ARTERY; PULMONARY CIRCULATION; PULMONARY WEDGE PRESSURE; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDES; VASOCONSTRICTION; VASODILATION;

EID: 84904252643     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2014.04.005     Document Type: Article

References (35)

1. Bessac B.F., Jordt S.E. Sensory detection and responses to toxic gases: mechanisms, health effects, and countermeasures. Proc. Am. Thorac. Soc. 2010, 7:269-277.
2. Cevik Y., Onay M., Akmaz I., Sezigen S. Mass casualties from acute inhalation of chlorine gas. South Med. J. 2009, 102:1209-1213.
3. Chen J., Mo Y., Schlueter C.F., Hoyle G.W. Inhibition of chlorine-induced pulmonary inflammation and edema by mometasone and budesonide. Toxicol. Appl. Pharmacol. 2013, 272:408-413.
4. Donnelly S.C., FitzGerald M.X. Reactive airways dysfunction syndrome (RADS) due to chlorine gas exposure. Ir. J. Med. Sci. 1990, 159:275-276. discussion 276-277.
5. Evans R.B. Chlorine: state of the art. Lung 2005, 183:151-167.
6. Fanucchi M.V., Bracher A., Doran S.F., Squadrito G.L., Fernandez S., Postlethwait E.M., Bowen L., Matalon S. Post-exposure antioxidant treatment in rats decreases airway hyperplasia and hyperreactivity due to chlorine inhalation. Am. J. Respir. Cell Mol. Biol. 2012, 46:599-606.
7. Gunnarsson M., Walther S.M., Seidal T., Bloom G.D., Lennquist S. Exposure to chlorine gas: effects on pulmonary function and morphology in anaesthetised and mechanically ventilated pigs. J. Appl. Toxicol. 1998, 18:249-255.
8. Honavar J., Samal A.A., Bradley K.M., Brandon A., Balanay J., Squadrito G.L., MohanKumar K., Maheshwari A., Postlethwait E.M., Matalon S., Patel R.P. Chlorine gas exposure causes systemic endothelial dysfunction by inhibiting endothelial nitric oxide synthase-dependent signaling. Am. J. Respir. Cell Mol. Biol. 2011, 45:419-425.
9. Hoyle G.W. Mitigation of chlorine lung injury by increasing cyclic AMP levels. Proc. Am. Thorac. Soc. 2010, 7:284-289.
10. Jones R., Wills B., Kang C. Chlorine gas: an evolving hazardous material threat and unconventional weapon. West J. Emerg. Med. 2010, 11:151-156.
11. + channels by ERK1/2 in chlorine-breathing mice. Am. J. Respir. Cell Mol. Biol. 2012, 46:342-354.
12. Leikauf G.D., Pope-Varsalona H., Concel V.J., Liu P., Bein K., Berndt A., Martin T.M., Ganguly K., Jang A.S., Brant K.A., Dopico R.A., Upadhyay S., Di Y.P., Li Q., Hu Z., Vuga L.J., Medvedovic M., Kaminski N., You M., Alexander D.C., McDunn J.E., Prows D.R., Knoell D.L., Fabisiak J.P. Integrative assessment of chlorine-induced acute lung injury in mice. Am. J. Respir. Cell Mol. Biol. 2012, 47:234-244.
13. Leustik M., Doran S., Bracher A., Williams S., Squadrito G.L., Schoeb T.R., Postlethwait E., Matalon S. Mitigation of chlorine-induced lung injury by low-molecular-weight antioxidants. Am. J. Physiol. Lung Cell. Mol. Physiol. 2008, 295:L733-L743.
14. Martin J.G., Campbell H.R., Iijima H., Gautrin D., Malo J.L., Eidelman D.H., Hamid Q., Maghni K. Chlorine-induced injury to the airways in mice. Am. J. Respir. Crit. Care Med. 2003, 168:568-574.
15. Matalon S., Maull E.A. Understanding and treating chlorine-induced lung injury. Proc. Am. Thorac. Soc. 2010, 7:253.
16. McGovern T.K., Powell W.S., Day B.J., White C.W., Govindaraju K., Karmouty-Quintana H., Lavoie N., Tan J.J., Martin J.G. Dimethylthiourea protects against chlorine induced changes in airway function in a murine model of irritant induced asthma. Respir. Res. 2010, 11:138.
17. McGovern T., Day B.J., White C.W., Powell W.S., Martin J.G. AEOL10150: a novel therapeutic for rescue treatment after toxic gas lung injury. Free Radic. Biol. Med. 2011, 50:602-608.
18. Moncada S. Nitric oxide: discovery and impact on clinical medicine. J. R. Soc. Med. 1999, 92:164-169.
19. Napoli C., Ignarro L.J. Nitric oxide and pathogenic mechanisms involved in the development of vascular diseases. Arch. Pharm. Res. 2009, 32:1103-1108.
20. O'Koren E.G., Hogan B.L., Gunn M.D. Loss of basal cells precedes bronchiolitis obliterans-like pathological changes in a murine model of chlorine gas inhalation. Am. J. Respir. Cell Mol. Biol. 2013, 49:788-797.
21. Rabinovitch M., Gamble W., Nadas A.S., Miettinen O.S., Reid L. Rat pulmonary circulation after chronic hypoxia: hemodynamic and structural features. Am. J. Physiol. 1979, 236:H818-H827.
22. Rafikov R., Fonseca F.V., Kumar S., Pardo D., Darragh C., Elms S., Fulton D., Black S.M. eNOS activation and NO function: structural motifs responsible for the posttranslational control of endothelial nitric oxide synthase activity. J. Endocrinol. 2011, 210:271-284.
23. Samal A., Honovar J., White C.R., Patel R.P. Potential for chlorine gas-induced injury in the extrapulmonary vasculature. Proc. Am. Thorac. Soc. 2010, 7:290-293.
24. Samal A.A., Honavar J., Brandon A., Bradley K.M., Doran S., Liu Y., Dunaway C., Steele C., Postlethwait E.M., Squadrito G.L., Fanucchi M.V., Matalon S., Patel R.P. Administration of nitrite after chlorine gas exposure prevents lung injury: effect of administration modality. Free Radic. Biol. Med. 2012, 53:1431-1439.
25. Song W., Wei S., Zhou Y., Lazrak A., Liu G., Londino J.D., Squadrito G.L., Matalon S. Inhibition of lung fluid clearance and epithelial Na+ channels by chlorine, hypochlorous acid, and chloramines. J. Biol. Chem. 2010, 285:9716-9728.
26. Song W., Wei S., Liu G., Yu Z., Estell K., Yadav A.K., Schwiebert L.M., Matalon S. Postexposure administration of a β2-agonist decreases chlorine-induced airway hyperreactivity in mice. Am. J. Respir. Cell Mol. Biol. 2011, 45:88-94.
27. Tian X., Tao H., Brisolara J., Chen J., Rando R.J., Hoyle G.W. Acute lung injury induced by chlorine inhalation in C57BL/6 and FVB/N mice. Inhal. Toxicol. 2008, 20:783-793.
28. Tuck S.A., Ramos-Barbon D., Campbell H., McGovern T., Karmouty-Quintana H., Martin J.G. Time course of airway remodelling after an acute chlorine gas exposure in mice. Respir. Res. 2008, 9:61.
29. Van Sickle D., Wenck M.A., Belflower A., Drociuk D., Ferdinands J., Holguin F., Svendsen E., Bretous L., Jankelevich S., Gibson J.J., Garbe P., Moolenaar R.L. Acute health effects after exposure to chlorine gas released after a train derailment. Am. J. Emerg. Med. 2009, 27:1-7.
30. Wenck M.A., Van Sickle D., Drociuk D., Belflower A., Youngblood C., Whisnant M.D., Taylor R., Rudnick V., Gibson J.J. Rapid assessment of exposure to chlorine released from a train derailment and resulting health impact. Public Health Rep. 2007, 122:784-792.
31. White C.W., Martin J.G. Chlorine gas inhalation: human clinical evidence of toxicity and experience in animal models. Proc. Am. Thorac. Soc. 2010, 7:257-263.
32. White C.R., Brock T.A., Chang L.Y., Crapo J., Briscoe P., Ku D., Bradley W.A., Gianturco S.H., Gore J., Freeman B.A., et al. Superoxide and peroxynitrite in atherosclerosis. Proc. Natl. Acad. Sci. U. S. A. 1994, 91:1044-1048.
33. Yadav A.K., Bracher A., Doran S.F., Leustik M., Squadrito G.L., Postlethwait E.M., Matalon S. Mechanisms and modification of chlorine-induced lung injury in animals. Proc. Am. Thorac. Soc. 2010, 7:278-283.
34. Yadav A.K., Doran S.F., Samal A.A., Sharma R., Vedagiri K., Postlethwait E.M., Squadrito G.L., Fanucchi M.V., Roberts L.J., Patel R.P., Matalon S. Mitigation of chlorine gas lung injury in rats by postexposure administration of sodium nitrite. Am. J. Physiol. Lung Cell. Mol. Physiol. 2011, 300:L362-L369.
35. Zielonka J., Vasquez-Vivar J., Kalyanaraman B. Detection of 2-hydroxyethidium in cellular systems: a unique marker product of superoxide and hydroethidine. Nat. Protoc. 2008, 3:8-21.